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| 1 | Surface Rupture and Co-seismic Displacement Produced by the Ms 8.0 Wenchuan Earthquake of May ^(12)th,2008,Sichuan,China:Eastwards Growth of the Qinghai-Tibet Plateau显示文摘女士 8 的地震给 Wenchuan 以县,西方的四川,中国,在 2008 年 5 月 12 日并且导致了长表面破裂(> 300 km ) 。关于表面破裂的第一手的观察在 Yingxiu, Beichuan 和 Qingchuan 的最糟点击的区域由地震生产了,查明地震的原因的结构在 Longmenshan 构造的带的中央差错地区。沿着 Yingxiu-Beichuan 破裂地区活动范围 2.5-4 m 的单个差错的平均 co 地震的垂直排水量和越过中央、正面的 Longmenshan 差错的累积垂直排水量系上带子是大约 56 m。表面破裂力量从 Beichuan 的北方被归结为 Qingchuan 县和表演 23 m 右罢工滑倒部件。Wenchuan 指责戳的地震是在印度、欧亚的大陆的连续集中的行动下面的西藏的高原的东方生长的表明。 | DONG Shuwen ZHANG Yueqiao WU Zhenhan YANG Non MA Yinsheng SHI Wei CHEN Zhengle LONG Changxin AN Meijian | 2008 | Acta Geologica Sinica(English Edition)2008，82，5： | 59 |
| 2 | Using Remote Sensing and GIS Technologies to Estimate Grass Yield and Livestock Carrying Capacity of Alpine Grasslands in Golog Prefecture,China显示文摘Remote sensing data from the Terra Moderate-Resolution Imaging Spectroradiometer (MODIS) and geospatial data were used to estimate grass yield and livestock carrying capacity in the Tibetan Autonomous Prefecture of Golog, Qing-hai, China. The MODIS-derived normalized difference vegetation index (MODIS-NDVI) data were correlated with the aboveground green biomass (AGGB) data from the aboveground harvest method. Regional regression model between the MODIS-NDVI and the common logarithm (LOG10) of the AGGB was significant (r2 = 0.51, P < 0.001), it was, there-fore, used to calculate the maximum carrying capacity in sheep-unit year per hectare. The maximum livestock carrying capacity was then adjusted to the theoretical livestock carrying capacity by the reduction factors (slope, distance to water, and soil erosion). Results indicated that the grassland conditions became worse, with lower aboveground palatable grass yield, plant height, and cover compared with the results obtained in 1981. At the same time, although the actual livestock numbers decreased, they still exceeded the proper theoretical livestock carrying capacity, and overgrazing rates ranged from 27.27% in Darlag County to 293.99% in Baima County. Integrating remote sensing and geographical information system technologies, the spatial and temporal conditions of the alpine grassland, trend, and projected stocking rates could be forecasted for decision making. | YU Long ZHOU Li LIU Wei ZHOU Hua-Kun | 2010 | Pedosphere2010，20，3： | 32 |
| 3 | Patterns of synonymous codon usage bias in chloroplast genomes of seed plants显示文摘Codon usage in chloroplast genome of six seed plants (Arabidopsis thaliana, Populus alba, Zea mays, Triticum aestivum, Pinus koraiensis and Cycas taitungensis) was analyzed to find general patterns of codon usage in chloroplast genomes of seed plants. The results show that chloroplast genomes of the six seed plants had similar codon usage patterns, with a strong bias towards a high representation of NNA and NNT codons. In chloroplast genomes of the six seed plants, the effective number of codons (ENC) for most genes was similar to that of the expected ENC based on the GC content at the third codon position, but several genes with low ENC values were laying below the expected curve. All of these data indicate that codon usage was dominated by a mutational bias in chloroplast genomes of seed plants and that selection appeared to be limited to a subset of genes and to only subtly affect codon us-age. Meantime, four, six, eight, nine, ten and 12 codons were defined as the optimal codons in chloroplast genomes of the six seed plants. | ZHOU Meng LONG Wei LI Xia | 2008 | Forestry Studies in China2008，10，4： | 30 |
| 4 | Detection of HBV DNA and its existence status in liver tissues and peripheral blood lymphocytes from chronic hepatitis B patients显示文摘INTRODUCTIONCumulativeclinicalandexperimentalevidenceindicatesthathostimmuneresponsestohepatitisBvirus(HBV)areresponsibleforl... | TANG Ren Xian, GAO Feng Guang, ZENG Ling Yu, WANG Ying Wei and WANG Yu Long | 1999 | World Journal of Gastroenterology1999，5，4： | 27 |
| 5 | Features of Sandy Debris Flows of the Yanchang Formation in the Ordos Basin and Its Oil and Gas Exploration Significance显示文摘Sandy debris flow is a new genetic type of sand bodies,which has gained much attention in recent years and its corresponding theory is proved to be a significant improvement and even partial denial to the 'Bouma Sequence' and 'turbidite fan' deep-water sedimentary theories to some point. Oil exploration researchers are highly concerned with sandy debris flows for its key role in controlling oil and gas accumulation processes.In this article,by applying sandy debris flows theory and combining a lot work o... | LI Xiangbo CHEN Qilin LIU Huaqing WAN Yanrong WEI Lihua LIAO Jianbo LONG Liwen | 2011 | Acta Geologica Sinica(English Edition)2011，85，5： | 24 |
| 6 | Application of LICOM to the numerical study of the water exchange between the South China Sea and its adjacent oceans显示文摘On the basis of 900-year integration of a global ocean circulation model—LICOM driven by ECMWF reanalysis wind data with uni-form 0.5°-grids, a quantitative estimate of the annual and monthly mean water exchange of the South China Sea (SCS) with its adjacentoceans through 5 straits is obtained. Among them, the annual transport is the largest in the Luzon Strait, then in the Taiwan Strait, andthen in the Sunda Shelf, in the Balabac Strait and in the Mindoro Strait in turn, the largest monthly transport variation appears in theLuzon Strait and Sunda shelf. It is shown that the mass transport through the Taiwan Strait is affected by monsoon, while the transportthrough the Luzon Strait may be associated with the bifurcation position of the North Equatorial Current off the east Philippines shore;the transports in the Luzon Strait and Sunda Shelf are out of phase in direction but well correlated in magnitude. The annual andmonthly mean heat and salinity exchange of the SCS through the straits are also calculated and shown to be in phase with the masstransport. The Kuroshio water carries about 0.43 PW heat transport and 151.33 kt/s salinity transport into the SCS, while most of themis carried out of the SCS through the Taiwan Strait and Sunda Shelf annually. The further model integration based on the 900-year inte-gration for another 44 a from 1958 to 2001 driven by real wind data (ERA40 data) shows that the monthly mean mass transport viathese straits varies annually with a large variation range, which may be associated with the seasonal and interannual variations in thecurrent field and sea surface height in the SCS. The mean mass transport through the Taiwan Strait, Luzon Strait, Mindoro Strait, Bal-abac Strait and Sunda Shelf is 2.012 × 106, -4.063 × 106, -0.124 × 106, -0.083 × 106 and 2.258 × 106 m3/s, respectively. | CAI Shuqun LIU Hailong LI Wei LONG Xiaomin | 2005 | Acta Oceanologica Sinica2005，24，4： | 24 |
| 7 | Large-scale wind turbine blade design and aerodynamic analysis显示文摘Incorporating controlled elitism and dynamic distance crowding strategies, a modified NSGA-II algorithm based on a fast and genetic non-dominated sorting algorithm is developed with the aim of obtaining a novel multi-objective optimization design algorithm for wind turbine blades. As an example, a high-performance 1.5 MW wind turbine blade, taking maximum annual energy production and minimum blade mass as the optimization objectives, was designed. A 1/16-scale model of this blade was tested in a 12 m × 16 m wind tunnel and the experimental results validated the high performance. Moreover, both the computational fluid dynamics (CFD) method and a free-vortex method (FVM) were applied to calculating the aerodynamic performance, which was consistent with the experimental data. For completeness, the CFD and FVM were used to analyze the wake structure, and good and consistent results were obtained between them. | WANG TongGuang WANG Long ZHONG Wei XU BoFeng CHEN Li | 2012 | Chinese Science Bulletin2012，57，5： | 23 |
| 8 | Clinical trial with traditional Chinese medicine intervention ''tonifying the kidney to promote liver regeneration and repair by affecting stem cells and their microenvironment'' for chronic hepatitis B-associated liver failure显示文摘AIM:To study the clinical efficacy of traditional Chinese medicine(TCM)intervention'tonifying the kidney to promote liver regeneration and repair by affecting stem cells and their microenvironment'('TTK')for treating liver failure due to chronic hepatitis B.METHODS:We designed the study as a randomized controlled clinical trial.Registration number of Chinese Clinical Trial Registry is Chi CTR-TRC-12002961.A total of 144 patients with liver failure due to infection with chronic hepatitis B virus were enrolled in this randomized controlled clinical study.Participants were randomly assigned to the following three groups:(1)a modern medicine control group(MMC group,36patients);(2)a'tonifying qi and detoxification'('TQD')group(72 patients);and(3)a'tonifying the kidney to promote liver regeneration and repair by affecting stem cells and their microenvironment'('TTK')group(36patients).Patients in the MMC group received general internal medicine treatment;patients in the'TQD'group were given a TCM formula'tonifying qi and detoxification'and general internal medicine treatment;patients in the'TTK'group were given a TCM formula of'TTK'and general internal medicine treatment.All participants were treated for 8 wk and then followed at 48 wk following their final treatment.The primaryefficacy end point was the patient fatality rate in each group.Measurements of various virological and biochemical indicators served as secondary endpoints.The one-way analysis of variance and the t-test were used to compare patient outcomes in the different treatment groups.RESULTS:At the 48-wk post-treatment time point,the patient fatality rates in the MMC,'TQD',and'TTK'groups were 51.61%,35.38%,and 16.67%,respectively,and the differences between groups were statistically significant(P<0.05).However,there were no significant differences in the levels of hepatitis B virus DNA or prothrombin activity among the three groups(P>0.05).Patients in the'TTK'group had significantly higher levels of serum total bilirubin compared to MMC subjects(339.40μmol/L±270.09μmol/L vs 176.13μmol/L±185.70μmol/L,P=0.014).Serum albumin levels were significantly increased in both the'TQD'group and'TTK'group as compared with the MMC group(31.30 g/L±4.77g/L,30.72 g/L±2.89 g/L vs 28.57 g/L±4.56 g/L,P<0.05).There were no significant differences in levels of alanine transaminase among the three groups(P>0.05).Safety data showed that there was one case of stomachache in the'TQD'group and one case of gastrointestinal side effect in the'TTK'group.CONCLUSION:Treatment with'TTK'improved the survival rates of patients with liver failure due to chronic hepatitis B.Additionally,liver tissue was regenerated and liver function was restored. | Han-Min Li Zhi-Hua Ye Jun Zhang Xiang Gao Yan-Ming Chen Xin Yao Jian-Xun Gu Lei Zhan Yang Ji Jian-Liang Xu Ying-He Zeng Fan Yang Lin Xiao Guo-Guang Sheng Wei Xin Qi Long Qing-Jing Zhu Zhao-Hong Shi Lian-Guo Ruan Jia-Yao Yang Chang-Chun Li Hong-Bin Wu Sheng-Duo Chen Xin-La Luo | 2014 | World Journal of Gastroenterology2014，20，48： | 20 |
| 9 | 银白杨叶绿体基因组密码子用法分析(英文)显示文摘通过计算银白杨叶绿体基因组中各基因的ENc值、RSCU值、CAI值和GC3s的含量,分析银白杨叶绿体基因组密码子用法,并采用目前普遍使用的多变量统计分析方法(对应分析)和ENc.plot方法探讨了若干重要因子对银白杨叶绿体基因组密码子用法的效应。对应分析结果显示在影响最大的第一条向量轴上,基因的坐标位置与GC3s(r=349)极显著相关,而与该基因的表达水平(CAI)无显著相关性,但是在第二、三向量轴上基因的坐标位置与该基因的表达水平(CAI)呈极显著相关(r=-0.348和r=0.602,),说明碱基突变是影响密码子发挥作用的主要因素,而少数基因密码子用法受到翻译选择的作用;ENC-plot分析结果也证明了这一点。图2表2参34。 | ZHOU Meng LONG Wei LI Xia | 2008 | Journal of Forestry Research2008，19，4： | 17 |
| 10 | Track-before-detect for Infrared Maneuvering Dim Multi-target via MM-PHD显示文摘In this paper, we present a novel and efficient track-before-detect (TBD) algorithm based on multiple-model probability hypothesis density (MM-PHD) for tracking infrared maneuvering dim multi-target. Firstly, the standard sequential Monte Carlo probability hypothesis density (SMC-PHD) TBD-based algorithm is introduced and sequentially improved by the adaptive process noise and the importance re-sampling on particle likelihood, which result in the improvement in the algorithm robustness and convergence speed. Secondly, backward recursion of SMC-PHD is derived in order to ameliorate the tracking performance especially at the time of the multi-target arising. Finally, SMC-PHD is extended with multiple-model to track maneuvering dim multi-target. Extensive experiments have proved the efficiency of the presented algorithm in tracking infrared maneuvering dim multi-target, which produces better performance in track detection and tracking than other TBD-based algorithms including SMC-PHD, multiple-model particle filter (MM-PF), histogram probability multi-hypothesis tracking (H-PMHT) and Viterbi-like. | LONG Yunli XU Hui AN Wei LIU Li | 2012 | Chinese Journal of Aeronautics2012，25，2： | 17 |
| 11 | Effectiveness of Different Waist Circumference Cut-off Values in Predicting Metabolic Syndrome Prevalence and Risk Factors in Adults in China显示文摘Objective To study the effectiveness of waist circumference cut-off values in predicting the prevalence of metabolic syndrome(MetS) and risk factors in adults in China. Methods A cross-sectional survey was condcuted in 14 provinces(autonomous region, municipality) in China. A total of 47 325 adults aged ≥20 years were selected by multistage stratified sampling, and questionnaire survey and physical and clinical examination were conducted among them. MetS was defined according to the International Diabetes Federation(IDF) criteria and modified IDF criteria.Results The age-standardized prevalence of MetS was 24.2%(22.1% in men and 25.8% in women) and 19.5%(22.1% in men and 18.0% in women) according to the IDF criteria and modified IDF criteria respectively. The age-standardized prevalence of pre-MetS was 8.1%(8.6% in men and 7.8% in women) according to the modified IDF criteria. The prevalence of MetS was higher in urban residents than rural residents and in northern China residents than in southern China residents. The prevalence of central obesity was about 30% in both men and women according to the ethnicity-specific cut-off values of waist circumference for central obesity(90 cm for men and 85 cm for women). Multivariate regression analysis revealed no significant difference in risk factors between the two MetS definitions. Conclusion Using both the modified IDF criteria and ethnicity-specific cut-off values of waist circumference can provide more useful information about the prevalence of MetS in China. | ZHOU Hai Cheng LAI Ya Xin SHAN Zhong Yan JIA Wei Ping YANG Wen Ying LU Ju Ming WENG Jian Ping JI Li Nong LIU Jie TIAN Hao Ming JI Qiu He ZHU Da Long CHEN Li GUO Xiao Hui ZHAO Zhi Gang Li Qiang ZHOU Zhi Guang GE Jia Pu SHAN Guang Liang | 2014 | Biomedical and Environmental Sciences2014，27，5： | 17 |
| 12 | Potential Toxicological and Cardiopulmonary Effects of PM2,5 Exposure and Related Mortality:Findings of Recent Studies Published during 2003-2013显示文摘INTRODUCTION Air pollution has become a serious environmental issue owing to its diverse harmful effects on the physical and biological environment.According to the Environmental Protection Agency(EPA)and the World Health Organization(WHO)[1-2],air pollution affects millions of people worldwide.Hundreds of thousands of deaths each year and a range of diseases, | Mohammed O.A.Mohammed SONG Wei Wei MA Wan Li LI Wen Long LI Yi Fan Afed Ullah Khan Mohammed A.E.M.Ibrahim Osman Adam Maarouf Alshebli A Ahmed John J.Ambuchi | 2016 | Biomedical and Environmental Sciences2016，29，1： | 16 |
| 13 | Prognostic factors and survival in patients with gastric stump cancer显示文摘AIM:To elucidate the clinicopathological characteristics and prognostic factors of gastric stump cancer(GSC).METHODS:The clinical data for 92 patients with GSC were collected at Fudan University Shanghai Cancer Center.The prognostic factors were analyzed with Cox proportional hazard models.RESULTS:GSC tended to occur within 25 years following the primary surgery,when the initial disease is benign,whereas it primarily occurred within the first15 years post-operation for gastric cancer.Patients with regular follow-up after primary surgery had a better survival rate.The multivariate Cox regression analysis revealed that Borrmann type?Ⅰ/Ⅱ(HR=3.165,95%CI:1.055-9.500,P=0.040)and radical resection(HR=1.780,95%CI:1.061-2.987,P=0.029)were independent prognostic factors for GSC.The overall 1-,3-,and 5-year survival rates of the 92 patients were78.3%,45.6%and 27.6%,respectively.The 1-,3-,and 5-year survival rates of those undergoing radical resection were 79.3%,52.2%,and 37.8%,respectively.The 5-year survival rates for stages?Ⅰ,Ⅱ,Ⅲ,andⅣwere 85.7%,47.4%,16.0%,and 13.3%,respectively(P=0.005).CONCLUSION:The appearance of GSC occurs sooner in patients with primary malignant cancer than in patients with a primary benign disease.Therefore,close follow-up is necessary.The overall survival of patients with GSC is poor,and curative resection can improve their prognosis. | Hua Huang Wei Wang Zhong Chen Jie-Jie Jin Zi-Wen Long Hong Cai Xiao-Wen Liu Ye Zhou Ya-Nong Wang | 2015 | World Journal of Gastroenterology2015，21，6： | 16 |
| 14 | Infantile hepatic hemangioendothelioma:A clinicopathologic study in a Chinese population显示文摘AIM:To investigate whether the clinicopathologic features of infantile hemangioendothelioma(IHE) of the liver in a Chinese population are similar to the features observed in other races.METHODS:The clinical data,radiological findings,histopathological changes and outcome of 12 cases of IHE diagnosed by the Department of Pathology,West China Hospital over the last 10 years were analyzed retrospectively.Immunohistochemical studies were carried out using antibodies against CD31,CD34,Factor Ⅷ,cytokeratin 8 and cytokeratin 18.RESULTS:The 12 patients were aged from fetal to 5 years(three males and nine females).The tumor was presented with different clinical manifestations,mainly as an asymptomatic,palpable,upper abdominal mass,except for the two fetuses who were detected antena-tally by ultrasound.In one patient,this presentation was accompanied by an initial severe pneumothorax.No symptoms of congestive heart failure were present and neither congenital abnormalities nor vascular tumors in the skin or other organs were found.Laboratory abnormalities included leukocytosis(40%),anemia(60%),thrombocytosis(60%),hyperbilirubinemia(16.7%),abnormal liver function(50%) and increased α-fetoprotein(80%).Based on radiological findings and gross specimens,the tumor presented as a solitary lesion or a multifocal space-occupying lesion.The tumor size ranged from 5.0 cm × 3.5 cm × 2.0 cm to 13.8 cm × 9.0 cm × 7.7 cm,and the 0.2-1.1 cm nodules were diffusely distributed within the multifocal tumor.Seven cases were surgically resected,three cases underwent biopsy and the two fetuses were aborted.Histologically,nine cases were classified as typeⅠ and three as type Ⅱ,presenting aggressive morphologic features,immature vessels,active mitosis and necrosis.An inflammatory component,predominantly eosinophilic granulocytes,sometimes obscured the nature of the tumor.Ten patients are alive after a follow-up of 1-9 years.Based on immunohistochemistry,the endothelial cells in all cases were positive for CD31,CD34 and polyclonal factor Ⅷ antigen,whereas the scattered hyperplasia bile ducts were positive for cytokeratin 8 and cytokeratin 18.CONCLUSION:The clinical manifestations of IHE are non-specific.There is no significant correlation between histological type and prognosis.The clinicopathologic features of IHE in Chinese patients may provide a clue to further evidence-based studies. | Zhang Zhang,Hui-Jiao Chen,Wen-Juan Yang,Hong Bu,Bing Wei,Xiao-Yu Long,Jing Fu,Rui Zhang,Yun-Bi Ni,Hong-Ying Zhang,Department of Pathology,West China Hospital,Sichuan University,Guoxuexiang 37,Chengdu 610041,Sichuan Province,China | 2010 | World Journal of Gastroenterology2010，16，36： | 16 |
| 15 | Leakage Prediction Method for Contacting Mechanical Seals with Parallel Faces显示文摘Since the beginning of the 20th century, many researches on the sealing characteristic of mechanical seals were carried out broadly and in depth by various methods and some leakage models were built. But due to the lack of the way to characterize the main factors of influence on the leakage, most of the early researches were based on the assumptions that the seal faces topography and the frictional conditions were invariant. In the early built models, the effect of the surface topography change of the seal face on the leakage rate was neglected. Based on the fractal theory, the contact of end faces of the rotary and stationary rings was simplified to be the contact of a rough surface and an ideal rigid smooth surface, and the contact interface’s cavity size-distribution function as well as the fractal characteristic of the cavity profile curve was discussed. By analyzing the influence of abrasion on the seal face topography and the leakage channel, the time-correlation leakage prediction model of mechanical seals based on the fractal theory was established and the method for predicting the leakage rate of mechanical seals with parallel plane was proposed. The values of the leakage rate predicted theoretically are similar to the measured values of the leakage rate in the model test and in situ test. The experimental results indicate that the leakage rate of mechanical seals is a transient value. The surface topography of the end faces of the seal rings and its change during the frictional wear of mechanical seals can be accurately characterized by the fractal parameters. Under the work conditions of changeless frictional mechanism, the fractal parameters measured or calculated based on the accelerated testing equation can be used to predict the leakage rate of mechanical seal in service. The proposed research provides the basis for determining the leakage state and predicting working life of mechanical seal. | SUN Jianjun WEI Long FENG Xiu GU Boqin | 2010 | Chinese Journal of Mechanical Engineering2010，23，1： | 16 |
| 16 | Clinical value of preoperative methylated septin 9 in Chinese colorectal cancer patients显示文摘BACKGROUND The methylated septin 9(mSEPT9) assay was the first blood-based test approved by the United States Food and Drug Administration as a colorectal screening test.However, the diagnostic and prognostic role of preoperative mSEPT9 for colorectal cancer(CRC) in Chinese patients is still unknown.AIM To improve the understanding of diagnostic and prognostic factors, serum m SEPT9 was detected in Chinese CRC patients.METHODS A retrospective analysis of 354 cases, of which 300 had CRC and 54 were normal,was performed in China. Patients' characteristics, treatments, and laboratory data, including age, the date of surgery, Union for International Cancer Control(UICC) stages, distant metastasis(M), and so on, were collected. Methylation levels of SEPT9 were quantified by quantitative, methylation-specific polymerase chain reaction before surgery. In addition, the effects of mSEPT9 on the occurrence and prognosis of 330 CRC cases from The Cancer Genome Atlas(TCGA) database were evaluated using bioinformatics analyses. Potential prognostic factors for overall survival(OS) and progression-free survival(PFS)were evaluated by Kaplan-Meier univariate analysis.RESULTSIn Chinese CRC patients, positive mSEPT9 was strongly associated with advanced UICC stages, deeper invasion by the primary tumor, and more distant metastasis. Methylation levels of SEPT9 were stage-dependent and showed a stepwise increase in UICC stages(I–IV), primary tumor categories(T1–T4),regional node categories(N0–N2), and distant metastasis categories(M0–M1).The patients with positive mSEPT9 showed a tendency toward lower PFS. After analyzing TCGA clinical data, the high mSEPT9 group was found to be obviously correlated only with more distant metastasis. The patients with high mSEPT9 levels showed a tendency toward lower OS. Besides, nine meaningful mSEPT9 sites were found to provide guidance for the follow-up studies.CONCLUSION MSEPT9 analysis may add valuable information to current tumor staging. Serum m SEPT9 in Chinese CRC patients appears to offer promising novel prognostic markers and might be considered for monitoring CRC recurrence. | Xue Yang Zhi-Jie Xu Xi Chen Shuang-Shuang Zeng Long Qian Jie Wei Mei Peng Xiang Wang Wan-Li Liu Hong-Ying Ma Zhi-Cheng Gong Yuan-Liang Yan | 2019 | World Journal of Gastroenterology2019，25，17： | 16 |
| 17 | Effects of soil water and nitrogen availability on photosynthesis and water use efficiency of Robinia pseudoacacia seedlings显示文摘The efficient use of water and nitrogen (N) to promote growth and increase yield of fruit trees and crops is well studied.However,little is known about their effects on woody plants growing in arid and semiarid areas with limited water and N availability.To examine the effects of water and N supply on early growth and water use efficiency (WUE) of trees on dry soils,one-year-old seedlings of Robinia pseudoacacia were exposed to three soil water contents (non-limiting,medium drought,and severe drought) as well as to low and high N levels,for four months.Photosynthetic parameters,leaf instantaneous WUE (WUEi) and whole tree WUE (WUEb) were determined.Results showed that,independent of N levels,increasing soil water content enhanced the tree transpiration rate (Tr),stomatal conductance (Gs),intercellular CO2 concentration (Ci),maximum net assimilation rate (Amax),apparent quantum yield (AQY),the range of photosynthetically active radiation (PAR) due to both reduced light compensation point and enhanced light saturation point,and dark respiration rate (Rd),resulting in a higher net photosynthetic rate (Pn) and a significantly increased whole tree biomass.Consequently,WUEi and WUEb were reduced at low N,whereas WUE i was enhanced at high N levels.Irrespective of soil water availability,N supply enhanced Pn in association with an increase of Gs and Ci and a decrease of the stomatal limitation value (Ls),while Tr remained unchanged.Biomass and WUEi increased under non-limiting water conditions and medium drought,as well as WUEb under all water conditions;but under severe drought,WUEi and biomass were not affected by N application.In conclusion,increasing soil water availability improves photosynthetic capacity and biomass accumulation under low and high N levels,but its effects on WUE vary with soil N levels.N supply increased Pn and WUE,but under severe drought,N supply did not enhance WUEi and biomass. | Xiping Liu Yangyang Fan Junxia Long Ruifeng Wei Roger Kjelgren Chunmei Gong Jun Zhao | 2013 | Journal of Environmental Sciences2013，25，3： | 15 |
| 18 | Clinical role of (18)~F-fluorodeoxyglucose positron emission tomography/computed tomography in post-operative follow up of gastric cancer: Initial results显示文摘AIM: To evaluate the clinical role of 18F-fluorodeo-xyglucose positron emission and computed tomography (18F-FDG PET/CT) in detection of gastric cancer recurrence after initial surgical resection. METHODS: In the period from January 2007 to May 2008, 23 patients who had previous surgical resection of histopathologically diagnosed gastric cancer underwent a total of 25 18F-FDG PET/CT scans as follow-up visits in our center. The standard of reference for tumor recurrence consisted of histopathologic confirmation or clinical follow-up information for at least 5 mo after PET/CT examinations. RESULTS: PET/CT was positive in 14 patients (61%) and negative in 9 (39%). When correlated with final diagnosis, which was confirmed by histopathologic evidence of tumor recurrence in 8 of the 23 patients (35%) and by clinical follow-up in 15 (65%), PET/CT was true positive in 12 patients, false positive in 2, true negative in 8 and false negative in 2. Overall, the accuracy of PET/CT was 82.6%, the negative predictive value (NPV) was 77.7%, and the positive predictive value (PPV) was 85.7%. The 2 false positive PET/CT findings were actually chronic inflammatory tissue lesions. For the two patients with false negativePET/CT, the f inal diagnosis was recurrence of mucinous adenocarcinoma in the anastomosis in one patient and abdominal wall metastasis in the other. Importantly, PET/CT revealed true-positive findings in 11 (47.8%) patients who had negative or no definite findings by CT. PET/CT revealed extra-abdominal metastases in 7 patients and additional esophageal carcinoma in one patient. Clinical treatment decisions were changed in 7 (30.4%) patients after introducing PET/CT into their conventional post-operative follow-up program. CONCLUSION: Whole body 18F-FDG PET/CT was highly effective in discriminating true recurrence in post-operative patients with gastric cancer and had important impacts on clinical decisions in a considerable portion of patients. | Long Sun Xin-Hui Su Yong-Song Guan Wei-Ming Pan Zuo-Ming Luo Ji-Hong Wei Hua Wu | 2008 | World Journal of Gastroenterology2008，14，29： | 14 |
| 19 | Xiaotan Sanjie decoction attenuates tumor angiogenesis by manipulating Notch-1-regulated proliferation of gastric cancer stem-like cells显示文摘AIM: To determine the underlying mechanisms of action and influence of Xiaotan Sanjie(XTSJ) decoction on gastric cancer stem-like cells(GCSCs). METHODS: The gastric cancer cell line MKN-45 line was selected and sorted by FACS using the cancer stem cell marker CD44; the stemness of these cells was checked in our previous study. In an in vitro study, the expression of Notch-1, Hes1, Vascular endothelial growth factor(VEGF), and Ki-67 in both CD44-positive gastric cancer stem-like cells(GCSCs) and CD44-negative cells was measured by Western blot. The effect of XTSJ serum on cell viability and on the above markers was measured by MTT assay and Western blot, respectively. In an in vivo study, the ability to induce angiogenesis and maintenance of GCSCs in CD44-positive-MKN-45- and CD44-negative-engrafted mice were detected by immunohistochemical staining using markers for CD34 and CD44, respectively. The role of XTSJ decoction in regulating the expression of Notch-1, Hes1, VEGF and Ki-67 was measured by Western blot and real-time polymerase chain reaction.RESULTS: CD44+ GCSCs showed more cell proliferation and VEGF secretion than CD44-negative cells in vitro, which were accompanied by the high expression of Notch-1 and Hes1 and positively associated with tumor growth(GCSCs vs CD44-negative cells, 2.72 ± 0.25 vs 1.46 ± 0.16, P < 0.05) and microvessel density(MVD)(GCSCs vs CD44-negative cells, 8.15 ± 0.42 vs 3.83 ± 0.49, P < 0.001) in vivo. XTSJ decoction inhibited the viability of both cell types in a dose-dependent manner in vitro. Specifically, a significant difference in the medium-(82.87% ± 6.53%) and high-dose XTSJ groups(77.43% ± 7.34%) was detected at 24 h in the CD44+ GCSCs group compared with the saline group(95.42% ± 5.76%) and the low-dose XTSJ group(90.74% ± 6.57%)(P < 0.05). However, the efficacy of XTSJ decoction was reduced in the CD44- groups; significant differences were only detected in the high-dose XTSJ group at 48 h(78.57% ± 6.94%) and 72 h(72.12% ± 7.68%) when compared with the other CD44- groups(P < 0.05). Notably, these differences were highly consistent with the Notch-1, Hes1, VEGF and Ki-67 expression in these cells. Similarly, in vivo, XTSJ decoction inhibited tumor growth in a dose-dependent manner. A significant difference was observed in the medium(1.76 ± 0.15) and high-dose XTSJ(1.33 ± 0.081) groups compared with the GCSCs control group(2.72 ± 0.25) and the low-dose XTSJ group(2.51 ± 0.25)(P < 0.05). We also detected a remarkable decrease of MVD in the medium-(7.10 ± 0.60) and high-dose XTSJ(5.99 ± 0.47) groups compared with the GCSC control group(8.15 ± 0.42) and the low-dose XTSJ group(8.14 ± 0.46)(P < 0.05). Additionally, CD44 expression was decreased in these groups [medium-(4.43 ± 0.45) and high-dose XTSJ groups(3.56 ± 0.31) vs the GCSC control(5.96 ± 0.46) and low dose XTSJ groups(5.91 ± 0.38)](P < 0.05). The significant differences in Notch-1, Hes1, VEGF and Ki-67 expression highly mirrored the results of XTSJ decoction in inhibiting tumor growth, MVD and CD44 expression.CONCLUSION: Notch-1 may play an important role in regulating the proliferation of GCSCs; XTSJ decoction could attenuate tumor angiogenesis, at least partially, by inhibiting Notch-1. | Bing Yan Long Liu Ying Zhao Li-Juan Xiu Da-Zhi Sun Xuan Liu Ye Lu Jun Shi Yin-Cheng Zhang Yong-Jin Li Xiao-Wei Wang Yu-Qi Zhou Shou-Han Feng Can Lv Pin-Kang Wei Zhi-Feng Qin | 2014 | World Journal of Gastroenterology2014，20，36： | 14 |
| 20 | DIFFUSION COUPLE BETWEEN HIGHSTRENGTH WEAR-RESISTING ALUMINUM BRONZE AND MACHINING TOOLS MATERIALS显示文摘INTRODUCTIONAluminumbronzeisanimportantengineeringmaterial.Itsexcelentphysical,mechanical,anticorosionandwearresistingprop... | Li, Yuanyuan Zhang, Datung Ngai Tungwai, Leo Xia, Wei Long, Yan | 1999 | 中国有色金属学会会刊:英文版1999，9，1： | 14 |
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