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| 1 | The effect of acupuncture on motor cortex excitability and plasticity显示文摘 | Yew Long Lo Cui S L Chong S Fook | 2005 | Neuroscience Letters2005，384，： | 1 |
| 2 | Diacylglycerol oil-properties,processes and products: a review 显示文摘 | Lo S K Tan C P Long K | 2008 | Food and BioprocessTechnology2008，1，3： | 1 |
| 3 | Diacylglycerol oil- properties, processes and products: a review 显示文摘 | Lo S K Tan C P Long K | 2008 | Food and Bioproeess Technology2008，1，3： | 1 |
| 4 | COX-2 gene promoter haplotypes and prostate cancer risk 显示文摘 | Panguluri RC Long LO Chen W | 2004 | Carcinogenesis2004，25，6： | 1 |
| 5 | COX-2 gene promoter haplotypes and prostate cancer risk 显示文摘 | Panguluri RC Long LO Chen W | 2004 | Carcinogenesis2004，25，6： | 1 |
| 6 | Risk factors of surgical failure following transvaginal mesh repair for the treat ment of pelvic organ prolapse显示文摘 | Long CY Lo TS Wang CL | 2012 | Eur J Obstet Gynecol Reprod Biol2012，161，2： | 1 |
| 7 | Doppler ureteric jet in urogen- ital prolapse显示文摘 | Lo TS Long CY Lin YH | 2012 | Int Urogynecol J2012，23，： | 1 |
| 8 | A Prospective and Randomized Comparison of Limited Versus Extensive Atrial Substrate Modification After Circumferential Pulmonary Vein Isolation in Nonparoxysmal Atrial Fibrillation显示文摘 | YENN‐JIANG LIN SHIH‐LIN CHANG LI‐WEI LO YU‐FENG HU ERIC CHONG TZE‐FAN CHAO FA‐PO CHUNG JONAN LIAO CHENG‐HUNG LI HSUAN‐MING TSAO TSAIR KAO YUN‐YU CHEN JIN‐LONG HUANG SHIH‐ANN CHEN | 2014 | J Cardiovasc Electrophysiol2014，，： | 1 |
| 9 | Diacylglycerol oil-properties, processes and products: a review 显示文摘 | LO S K TAN C P LONG K | 2008 | Food and Bioprocess Technology2008，1，3： | 1 |
| 10 | COX-2 gene promoter haplotypes and prostate cancer risk 显示文摘 | Panguluri RC Long LO Chen Weidong | 2004 | Carcinogenesis2004，25，： | 1 |
| 11 | Observer-based robust H∞ control for fuzzy systems using two-step procedure显示文摘 | Lo J C Long M L | 2004 | IEEE Transaction on Fuzzy Systems2004，12，3： | 1 |
| 12 | Total thyroideetomy for multinodular goiter in the elderly显示文摘 | Long B H Lo C Y | 2005 | Am J Surg2005，190，3： | 1 |
| 13 | MFSD7c functions as a transporter of choline at the blood–brain barrier显示文摘Mutations in the orphan transporter MFSD7c(also known as Flvcr2),are linked to Fowler syndrome.Here,we used Mfsd7c knockout(Mfsd7c–/–)mice and cell-based assays to reveal that MFSD7c is a choline transporter at the blood–brain barrier(BBB).We performed comprehensive metabolomics analysis and detected differential changes of metabolites in the brains and livers of Mfsd7c–/–embryos.Particularly,we found that choline-related metabolites were altered in the brains but not in the livers of Mfsd7c–/–embryos.Thus,we hypothesized that MFSD7c regulates the level of choline in the brain.Indeed,expression of human MFSD7c in cells significantly increased choline uptake.Interestingly,we showed that choline uptake by MFSD7c is greatly increased by choline-metabolizing enzymes,leading us to demonstrate that MFSD7c is a facilitative transporter of choline.Furthermore,single-cell patch clamp analysis showed that the import of choline by MFSD7c is electrogenic.Choline transport function of MFSD7c was shown to be conserved in vertebrates,but not in yeasts.We demonstrated that human MFSD7c is a functional ortholog of HNM1,the yeast choline importer.We also showed that several missense mutations identified in patients exhibiting Fowler syndrome had abolished or reduced choline transport activity.Mice lacking Mfsd7c in endothelial cells of the central nervous system suppressed the import of exogenous choline from blood but unexpectedly had increased choline levels in the brain.Stable-isotope tracing study revealed that MFSD7c was required for exporting choline derived from lysophosphatidylcholine in the brain.Collectively,our work identifies MFSD7c as a choline exporter at the BBB and provides a foundation for future work to reveal the disease mechanisms of Fowler syndrome. | Xuan Thi Anh Nguyen Thanh Nha Uyen Le Toan Q.Nguyen Hoa Thi Thuy Ha Anna Artati Nancy C.P.Leong Dat T.Nguyen Pei Yen Lim Adelia Vicanatalita Susanto Qianhui Huang Ling Fam Lo Ngah Leong Isabelle Bonne Angela Lee Jorge L.Granadillo Catherine Gooch Dejie Yu Hua Huang Tuck Wah Soong Matthew Wook Chang Markus R.Wenk Jerzy Adamski Amaury Cazenave-Gassiot Long N.Nguyen | 2024 | Cell Research2024，34，3： | 0 |
| 14 | Minimizing the risk of community spread of COVID-19 via institutional quarantine of high-risk travelers with serial viral RNA testing: A successful experience from Macao SAR, China显示文摘Macao,a special administrative region(SAR)of the People’s Republic of China,is located in southern China and shares the border with China's Mainland.It is the most densely populated region in the world,with a population of 667400 and a total land area of 32.9 square kilometers in 2019.Since the first case diagnosed on January 22,2020,there was a total of 45 laboratory-confirmed coronavirus disease 2019(COVID-19)cases in Macao,of which 43 patients(96%)were imported cases.To date,all patients had been discharged successfully from Centro Hospitalar Conde de São Januário,a designated hospital to manage all COVID-19 patients in Macao.Eventually,no patient died,and no local community outbreak was noted.This opinion review describes the underlying factors that could have contributed to the successful experience in Macao SAR,China,which include the following:(1)Early implementation of containment measures;(2)Large-scale quarantine using hotel rooms to reduce the risk of a local outbreak;and(3)Multidisciplinary co-operation and transparency of information to the public.Although the successful experience in Macao SAR,China,may not be generalized to other regions,it should not be unreasonable to be well prepared with sufficient logistic support to conduct timely containment and early detection of episodic cases to prevent the backsliding of COVID-19 outbreak. | Chon Fu Lio Hou Hon Cheong Chin Ion Lei Iek Long Lo Chong Lam Iek Hou Leong | 2020 | World Journal of Clinical Cases2020，8，13： | 0 |
| 15 | Npac Is A Co-factor of Histone H3K36me3 and Regulates Transcriptional Elongation in Mouse Embryonic Stem Cells显示文摘Chromatin modification contributes to pluripotency maintenance in embryonic stem cells(ESCs).However,the related mechanisms remain obscure.Here,we show that Npac,a'reader'of histone H3 lysine 36 trimethylation(H3K36me3),is required to maintain mouse ESC(mESC)pluripotency since knockdown of Npac causes mESC differentiation.Depletion of Npac in mouse embryonic fibroblasts(MEFs)inhibits reprogramming efficiency.Furthermore,our chromatin immunoprecipitation followed by sequencing(ChIP-seq)results of Npac reveal that Npac co-localizes with histone H3K36me3 in gene bodies of actively transcribed genes in mESCs.Interestingly,we find that Npac interacts with positive transcription elongation factor b(p-TEFb),Ser2-phosphorylated RNA PolⅡ(RNA PolⅡSer2P),and Ser5-phosphorylated RNA PolⅡ(RNA PolⅡSer5 P).Furthermore,depletion of Npac disrupts transcriptional elongation of the pluripotency genes Nanog and Rif1.Taken together,we propose that Npac is essential for the transcriptional elongation of pluripotency genes by recruiting p-TEFb and interacting with RNA PolⅡSer2P and Ser5P. | Sue Yu Jia Li Guanxu Ji Zhen Long Ng Jiamin Siew Wan Ning Lo Ying Ye Yuan Yuan Chew Yun Chau Long Wensheng Zhang Ernesto Guccione Yuin Han Loh Zhi-Hong Jiang Henry Yang Qiang Wu | 2022 | Genomics, Proteomics & Bioinformatics2022，20，1： | 0 |
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