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| 1 | Strategies to tackle the challenges of external beam radiotherapy for liver tumors显示文摘Primary and metastatic liver cancer is an increasingly common and difficult to control disease entity.Radiation offers a non-invasive treatment alternative for these patients who often have few options and a poor prognosis.However,the anatomy and aggressiveness of liver cancer poses significant challenges such as accurate localization at simulation and treatment,management of motion and appropriate selection of dose regimen.This article aims to review the options available and provide information for the practical implementation and/or improvement of liver cancer radiation programs within the context of stereotactic body radiotherapy and image-guided radiotherapy guidelines.Specific patient inclusion and exclusion criteria are presented given the significant toxicity found in certain sub-populations treated with radiation.Indeed,certain sub-populations,such as those with tumor thrombosis or those with larger lesions treated with transarterial chemoembolization,have been shown to have significant improvements in outcome with the addition of radiation and merit special consideration.Implementing a liver radiation programrequires three primary challenges to be addressed:(1) immobilization and motion management;(2) localization;and(3) dose regimen and constraint selection.Strategies to deal with motion include simple internal target volume(ITV) expansions,non-gated ITV reduction strategies,breath hold methods,and surrogate marker methods to enable gating or tracking.Localization of the tumor and organs-at-risk are addressed using contrast infusion techniques to take advantage of different normal liver and cancer vascular anatomy,imaging modalities,and margin management.Finally,a dose response has been demonstrated and dose regimens appear to be converging.A more uniform approach to treatment in terms of technique,dose selection and patient selection will allow us to study liver radiation in larger and,hopefully,multicenter randomized studies. | Michael I Lock Jonathan Klein Hans T Chung Joseph M Herman Edward Y Kim William Small Nina A Mayr Simon S Lo | 2017 | World Journal of Hepatology2017，9，14： | 2 |
| 2 | The Dispositional Causes of Job Satisfaction:A core Evaluations Approach 显示文摘 | Judge T A Locke E A Durham C C | 1997 | Research in Organizational Behavior1997，，： | 1 |
| 3 | Personality and Job Satisfaction: The Mediating Role of Job Characteristics显示文摘 | JUDGE T A BONO J E LOCKE E A | 2000 | Journal of Applied Psychology2000，85，2： | 1 |
| 4 | Spred-2 steady-state levels are regulated by phosphorylation and Cbl-mediated ubiquitination 显示文摘 | LOCK P STACEY T T STRAFFON A F | 2006 | Biochem Biophys Res Commun2006，351，4： | 1 |
| 5 | Dispositional effects on job and life satisfaction:The role of core evaluations 显示文摘 | Judge T A Locke E A Durham C C | 1998 | Journal of Applied Psychology1998，83，1： | 1 |
| 6 | Outcomes following repair of quadriceps tendon ruptures显示文摘 | Konrath GA Chen D Lock T | 1998 | J Orthop Trauma1998，12，4： | 1 |
| 7 | The Occurrence of carbendazim resistance in Rhynchosporium secalis on winter barley in england and wales in 1992 and 1993显示文摘 | LOCKE T PHILLIPS A N | 1995 | Plant Pathology1995，44，： | 1 |
| 8 | A Dynamic Estimation of Governance Structures and Financial Performance for Singaporean Companies 显示文摘 | Nguyen T Locke S Reddy K | 2013 | Available at SSRN 23147732013，，： | 1 |
| 9 | Transgenic canola and soybean seeds with increased lysine显示文摘 | Falco S C Cuisa T Locke M | 1995 | Bio Technol1995，13，： | 1 |
| 10 | Current practice in autologous fat transplantation: suggested clinical guidelines based on a review of recent literature显示文摘 | LOCKE M B de CHALAIN T M | 2008 | Ann Plast Surg2008，60，1： | 1 |
| 11 | The Occurrence of Carbendazim Resistance in Rhynchosporium secalis on Winter Barley in England and Wales in 1992 and 1993显示文摘 | LOCKE T PHILLIPS A N | 1995 | Plant Pathology1995，44，： | 1 |
| 12 | Core self- evaluations and job and life satisfaction: the roleof self-concordance and goal attainment 显示文摘 | Judge T A Bono J E Erez A & Locke E A | 2005 | Journal of Applied Psychology2005，90，： | 1 |
| 13 | Dietary decontaminated fish oil has no negative impact on fish performance,flesh quality or production-related diseases in Atlantic salmon(Salmo salar)显示文摘 | Lock E.J Fjelldal P.G Torstensen B.E Bjornevik M Breck O Johansen J Reynolds P Sigholt T Joerum N Jakobsen J.V Ruohonen K Waagbo R Berntssen M.H.G | | 0，，： | 1 |
| 14 | A novelmethed for measuring antioxidant capacity and its application to monitoring the antioxidant status in premature neonates显示文摘 | Miller N J Dip lock A T Rice E C | 1993 | Clin Sci1993，84，： | 1 |
| 15 | The structure and dynamics of 2-dimensional fluids in swelling clays显示文摘 | Skipper N T Lock P A Titiloye J O | 2006 | Chemical Geology2006，230，： | 1 |
| 16 | Immunotherapy strategies for multiple myeloma: the present and the future 显示文摘 | Locke FL Nishihori T Alsina M | 2013 | Immunotherapy2013，5，9： | 1 |
| 17 | Developmental Expression and Assembly of Connexins into Homomeric and Heteromeric Gap Junction Hemichannels in the Mouse Mammary Gland显示文摘 | Locke D Perusinghe N Newman T | 2000 | J Cell Physiol2000，183，2： | 1 |
| 18 | Population analysis of the pharmacokinetics of Tiagabine in patients with epilepsy显示文摘 | Gustavson LE El-Shourbagy T Locke C Granneman GR Sommerville KW | 1998 | Epilepsia1998，39，： | 1 |
| 19 | 5 years显示文摘 | Ehlinger M Adam P Moser T Type C periprosthetic fractures treated with locking plate fixation with a mean follow up of 2 | 2010 | Orthop Traumatol Surg Res2010，96，1： | 1 |
| 20 | Disposit- ional effects on job and life satisfaction: The role of core evaluations显示文摘 | Judge T A Locke E A Durham C C | 1998 | Journal of Applied Psychology1998，83，1： | 1 |
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