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| 1 | Discriminating mild from critical COVID-19 by innate and adaptive immune single-cell profiling of bronchoalveolar lavages显示文摘How the innate and adaptive host immune system miscommunicate to worsen COVID-19 immunopathology has not been fully elucidated.Here,we perform single-cell deep-immune profiling of bronchoalveolar lavage(BAL)samples from 5 patients with mild and 26 with critical COVID-19 in comparison to BALs from non-COVID-19 pneumonia and normal lung.We use pseudotime inference to build T-cell and monocyte-to-macrophage trajectories and model gene expression changes along them.In mild COVID-19,CD8^(+)resident-memory(TRM)and CD4^(+)T-helper-17(T_(H17))cells undergo active(presumably antigen-driven)expansion towards the end of the trajectory,and are characterized by good effector functions,while in critical COVID-19 they remain more naïve.Vice versa,CD4^(+)T-cells with T-helper-1 characteristics(TH1-like)and CD8^(+)T-cells expressing exhaustion markers(T_(EX)-like)are enriched halfway their trajectories in mild COVID-19,where they also exhibit good effector functions,while in critical COVID-19 they show evidence of inflammation-associated stress at the end of their trajectories.Monocyte-to-macrophage trajectories show that chronic hyperinflammatory monocytes are enriched in critical COVID-19,while alveolar macrophages,otherwise characterized by anti-inflammatory and antigen-presenting characteristics,are depleted.In critical COVID-19,monocytes contribute to an ATP-purinergic signaling-inflammasome footprint that could enable COVID-19 associated fibrosis and worsen disease-severity.Finally,viral RNA-tracking reveals infected lung epithelial cells,and a significant proportion of neutrophils and macrophages that are involved in viral clearance. | Els Wauters Pierre Van Mol Abhishek Dinkarnath Garg Sander Jansen Yannick Van Herck Lore Vanderbeke Ayse Bassez Bram Boeckx Bert Malengier-Devlies Anna Timmerman Thomas Van Brussel Tina Van Buyten Rogier Schepers Elisabeth Heylen Dieter Dauwe Christophe Dooms Jan Gunst Greet Hermans Philippe Meersseman Dries Testelmans Jonas Yserbyt Sabine Tejpar Walter De Wever Patrick Matthys CONTAGIOUS collaborators Johan Neyts Joost Wauters Junbin Qian Diether Lambrechts | 2021 | Cell Research2021，31，3： | 11 |
| 2 | Risk of myocardial infarction associated with chronic hepatitis C virus infection: a population‐based cohort study*显示文摘 | K. A.Forde K.Haynes A. B.Troxel S.Trooskin M. T.Osterman S. E.Kimmel J. D.Lewis V. LoRe | 2012 | Journal of Viral Hepatitis2012，，4： | 3 |
| 3 | Protein post-translational modifications and regulation of pluripotency in human stem cells显示文摘translational 以后修正(PTM ) 被知道是真核细胞的房间过去常多样化他们的蛋白质函数和动态地并列的他们的发信号网络的必要机制。在 PTM 的缺点被连接了到众多的发展混乱和人的疾病,强调在维持正常细胞的状态的 PTM 的重要性。包括胚胎的干细胞(hESCs ) 和导致的 pluripotent 干细胞(hiPSCs ) ,人的 pluripotent 干细胞(hPSCs ) 能够自强和区别进许多功能的体的房间;这些房间为生物医学的研究和临床的治疗的前进保持一条大诺言。在人的房间位于细胞的 pluripotency 下面的机制广泛地在过去的十年被探索了。除了获得从的知识的广阔数量基因并且在 hPSCs 的 transcriptional 研究,干细胞生物学领域里有很快成长的兴趣在蛋白质和 PTM 水平检验 pluripotency。这评论向在细胞的 pluripotency 的规定理解 PTM (glycosylation, phosphorylation, acetylation 和 methylation ) 的角色探讨最近的进步。 | Yu-Chieh Wang Suzanne E Peterson Jeanne F Loring | 2014 | Cell Research2014，24，2： | 3 |
| 4 | The occurrence of N -nitrosamines, residual nitrite and biogenic amines in commercial dry fermented sausages and evaluation of their occasional relation显示文摘 | Eveline De Mey Katrijn De Klerck Hannelore De Maere Lore Dewulf Guy Derdelinckx Marie-Christine Peeters Ilse Fraeye Yvan Vander Heyden Hubert Paelinck | 2014 | Meat Science2014，，2： | 2 |
| 5 | Mixed neuroendocrine-non-neuroendocrine neoplasms of the digestive system:A mini-review显示文摘Mixed neuroendocrine-non-neuroendocrine neoplasms(MiNENs)are rare mixed tumors containing both neuroendocrine(NE)and non-NE components.Each component must occupy at least 30%of the tumor volume by definition.Recent molecular evidence suggests MiNENs are clonal neoplasms and potentially harbor targetable mutations similar to conventional carcinomas.There have been multiple changes in the nomenclature and classification of MiNENs which has created some confusion among pathologists on how to integrate the contributions of each component in a MiNEN,an issue which in turn has resulted in confusion in communication with front-line treating oncologists.This mini review summarizes our current understanding of MiNENs and outline diagnosis,prognosis,and management of these neoplasms.The authors emphasize the importance of treating the most aggressive component of the tumor regardless of its percentage volume. | Deepak Toor Jonathan M Loree Zu-Hua Gao Gang Wang Chen Zhou | 2022 | World Journal of Gastroenterology2022，28，19： | 2 |
| 6 | Differential cognitive effects of carbamazepine and gabapentin显示文摘 | MEADOR K J LORING DW RAY PG | 1999 | Epilepsia1999，40，11： | 1 |
| 7 | The trade-off between hospital cost and quality of care:An exploratory empirical analysis 显示文摘 | Morey RC Fine DJ Loree SW | 1992 | Med Care1992，30，8： | 1 |
| 8 | Comparative cognitive effects of phenobarbital,phenytoin and valproate in healthy subjects显示文摘 | Loring DW Moore EE | 1995 | Neurology1995，45，： | 1 |
| 9 | Lymph nodes and human tumors (review) 显示文摘 | Lores B Garca-Estevez JM Arias C | 1998 | Int J Mol Med1998，1，： | 1 |
| 10 | Resection and reconstruction of the carotid ar-tery inmetastatic squamous cell carcinoma显示文摘 | Lore JM Boulos EJ | 1981 | Am J Surg1981，142，： | 1 |
| 11 | Research advances in dry anaerobic digestion process of solid organic wastes 显示文摘 | JHA A K LI J LORING N | 2011 | Africa Journal of Biotechnology2011，10，14： | 1 |
| 12 | Adsorption, desorption, and surface-promoted hydrolysis of glucose- 1-phosphate in aqueous goethite ( et-FeOOH ) suspensions 显示文摘 | Olsson R Giesler R Loring J S | 2010 | Langmuir2010，26，18： | 1 |
| 13 | Differential susceptibility to human immu- nodeficiency virus type 1 infection of myeloid and plasmacytoid dendritic cells显示文摘 | Smed-S6rensen A Lore K Vasudevan J Louder MK Andersson J Mascola JR | 2005 | J Virol2005，79，14： | 1 |
| 14 | Anaplastic thyroid cancer evolved from papillary carcinoma:demonstration of anaplastic transformation by means of the inter-simple sequence repeat polymerase chain reaction 显示文摘 | Wiseman SM Loree TR Hicks WL Jr | 2003 | Arch Otolaryngol Head Neck Surg2003，129，1： | 1 |
| 15 | Transgenic expression of Fas ligand on thyroid follicular cells prevents autoimmune thyroiditis显示文摘 | Lores P Buccchini D | 2000 | J Immunol2000，164，： | 1 |
| 16 | On RA abstracts: From rhetorical structure to thematic organization 显示文摘 | Lores R | 2004 | English for Specific Purposes2004，，23： | 1 |
| 17 | Evaluating strict and con- ventional left bundle branch block criteria using electrocardio- graphic simulations 显示文摘 | Galeotti L van Dam PM Loring Z | 2013 | Europace2013，15，12： | 1 |
| 18 | Differential susceptibility to human immunodeficiency virus type 1 infection of myeloid and plasmacytoid dendritic cells显示文摘 | Smed-Sorensen A Lore K Vasudevan J | 2005 | J Virol2005，79，14： | 1 |
| 19 | Effect,s of fibrous cap thickness on peak circumferential stress in model atherosclerotic vessels 显示文摘 | Loree HM Kamm PD Striagfellow PG | 1992 | Circ Res1992，71，： | 1 |
| 20 | Mechanical properties of model atherosclerotic lesion lipid pools显示文摘 | Loree HM Tobias BJ Gibson LJ | 1994 | Arterioscler Thromb1994，14，2： | 1 |
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