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| 1 | Prognosis of lymphotropic invasive micropapillary breast carcinoma analyzed by using data from the National Cancer Database显示文摘Background:Invasive micropapillary carcinoma(IMPC)is an uncommon subtype of breast cancer.Previous studies of this subtype demonstrated a higher propensity for lymph node metastases as compared with invasive ductal carci-noma(IDC).The purpose of the present study was to determine the clinical characteristics,outcomes,and propensity for lymph node metastasis of patients with IMPC of the breast recorded in the National Cancer Database(NCDB).Methods:Records of patients with IMPC diagnosed between 2004 and 2014 were retrieved from the NCDB.Log-rank test was performed to evaluate associations of clinical characteristics with overall survival(OS).Cox proportional hazards model was used to determine variables associated with OS.Results:Overall,2660 patients with IMPC met the selection criteria;the 5-year OS rate was 87.5%and 24.9%of patients had nodal involvement at presentation.Patients with≥4 positive lymph nodes had shorter OS than node-negative patients,whereas patients with 1-3 positive nodes had similar OS to node-negative patients.Age<65 years,receipt of radiotherapy,and estrogen receptor positivity were also associated with prolonged OS.The benefit of radiotherapy was limited to IMPC patients undergoing lumpectomy;there was no benefit for the patients undergoing mastectomy(regardless of nodal positivity/negativity).Conclusions:Favorable prognostic factors of IMPC patients included age<65 years,<4 positive lymph nodes,receipt of radiotherapy,and estrogen receptor positivity.The results presented herein suggest a survival benefit asso-ciated with radiotherapy in IMPC treatment,though this may be limited to the patients treated with lumpectomy. | Gary D.Lewis Yan Xing Waqar Haque Tejal Patel Mary Schwartz Albert Chen Andrew Farach Sandra S.Hatch E.Brian Butler Jenny Chang Bin S.Teh | 2019 | Cancer Communications2019，39，1： | 7 |
| 2 | Long-term outcome of a moderately hypofractionated, intensity-modulated radiotherapy approach using an endorectal balloon for patients with localized prostate cancer显示文摘Background:Technical advances in radiotherapy delivery have simultaneously enabled dose escalation and enhanced bladder and rectal sparing.However,the optimal radiation fractionation regimen for localized prostate cancer is unclear.Laboratory and clinical evidence suggest that hypofractionation may improve the therapeutic ratio of radiotherapy.We report our institutional outcomes using moderately hypofractionated,intensity-modulated radio-therapy(IMRT),and an endorectal balloon,with emphasis on long-term biochemical control and treatment-related adverse events in patients with localized prostate cancer.Methods:Between January 1997 and April 2004,596 patients with cT1-T3 prostate cancer underwent IMRT using a moderate hypofractionation regimen(76.70 Gy at 2.19 Gy/fraction)with an endorectal balloon.Using D’Amico clas-sification,226(37.9%),264(44.3%),and 106(17.8%)patients had low-,intermediate-,or high-risk disease,respectively.The majority of intermediate-and high-risk patients received androgen deprivation therapy.Biochemical relapse-free survival(bRFS)was evaluated using 2005 Phoenix criteria and estimated using the Kaplan-Meier method.Results:The median follow-up was 62 months.Overall 5-and 10-year bRFS rates were 92.7%and 87.7%.For low-,intermediate-,and high-risk patients,the 5-year bRFS rates were 96.9%,93.3%,and 82.0%,respectively;the 10-year bRFS rates were 91.4%,89.3%,and 76.2%,respectively.Prostate-specific antigen,Gleason score,and T stage were significant predictors of bRFS(all P<0.01).The 5-year rates of severe(≥Grade 3)adverse events were very low:1.2%for gastrointestinal events and 1.1%for genitourinary events.Conclusions:Long-term outcomes after moderately hypofractionated IMRT are encouraging.Moderate hypofrac-tionation represents a safe,efficacious,alternative regimen in the treatment of localized prostate cancer. | Bin S.Teh Gary D.Lewis Weiyuan Mai Ramiro Pino Hiromichi Ishiyama Edward Brian Butler | 2018 | Cancer Communications2018，38，1： | 4 |
| 3 | Risk of myocardial infarction associated with chronic hepatitis C virus infection: a population‐based cohort study*显示文摘 | K. A.Forde K.Haynes A. B.Troxel S.Trooskin M. T.Osterman S. E.Kimmel J. D.Lewis V. LoRe | 2012 | Journal of Viral Hepatitis2012，，4： | 3 |
| 4 | Dependents and the Demand for Life Insurance显示文摘 | Frank D.Lewis | | 0，，03： | 1 |
| 5 | Probabilities of conditionals and conditional probabilities显示文摘 | D.Lewis | | 0，，： | 1 |
| 6 | Use and perceived effectiveness of non‐analgesic medical therapies for chronic pancreatitis in the United States显示文摘 | F.Burton S.Alkaade D.Collins V.Muddana A.Slivka R. E.Brand A.Gelrud P. A.Banks S.Sherman M. A.Anderson J.Romagnuolo C.Lawrence J.Baillie T. B.Gardner M. D.Lewis S. T.Amann J. G.Lieb M.O’Connell E. D.Kennard D.Yadav D. C.Whitcomb C. E.Forsmark | 2010 | Alimentary Pharmacology & Therapeutics2010，，1： | 1 |
| 7 | Use and perceived effectiveness of non‐analgesic medical therapies for chronic pancreatitis in the United States显示文摘 | F.Burton S.Alkaade D.Collins V.Muddana A.Slivka R. E.Brand A.Gelrud P. A.Banks S.Sherman M. A.Anderson J.Romagnuolo C.Lawrence J.Baillie T. B.Gardner M. D.Lewis S. T.Amann J. G.Lieb M.O’Connell E. D.Kennard D.Yadav D. C.Whitcomb C. E.Forsmark | 2010 | Alimentary Pharmacology & Therapeutics2010，，1： | 1 |
| 8 | 104例肌萎缩性脊髓侧索硬化病人蘑菇头胃造口引流管放置的单中心5年经验总结显示文摘回顾总结在X线引导下对肌萎缩性脊髓侧索硬化(ALS)病人放置蘑菇头状胃造口引流管(Entristar,Tyco Healthcare,Mansfield,MA)的经验。所有操作均使用局麻.未使用镇静剂。分别记录术前24h和术后24h内的主要和次要围手术期并发症。死亡病例按死亡原因与基础病ALS相关或继发于X线引导插管胃造口术(RIG)分别记录。 | D.Lewis M.A.Ampong A.Rio E.Willey J.Johnson C.E.Shaw 赵艳萍 | 2009 | 国际医学放射学杂志2009，32，5： | 0 |
| 9 | 对局限性前列腺癌患者采用直肠内球囊中度低分割调强放射治疗的长期结局显示文摘背景与目的放射治疗的技术进步使兼顾剂量递增和提升膀胱和直肠保留成为可能。然而,对于局限性前列腺癌的最佳辐射剂量分割方案尚不清楚。实验室和临床证据表明,低分割可提高放疗的治疗率。在此报道我们医院采用中度低分割调强放疗(intensity?modulated radiotherapy,IMRT)和直肠内球囊对局限性前列腺癌患者的治疗结局,重点关注患者的长期生化控制和治疗相关不良事件。方法从1997年1月到2004年4月,596例c T1–T3前列腺癌患者使用带直肠内球囊的中度低分割方案(76.70 Gy,2.19 Gy/次)进行IMRT。根据D'Amico分类低风险、中风险或高风险患者分别226(37.9%)例、264(44.3%)例和106(17.8%)例。大多数中、高风险患者接受雄激素剥夺治疗。使用2005年Phoenix标准评估无生化复发生存(biochemical relapse?freeSurvival,bRFS),并使用Kaplan?Meier法进行估算。结果中位随访时间为62个月。总的5年bRFS和10年bRFS率分别为92.7%和87.7%。低风险、中风险和高风险患者的5年bRFS率分别为96.9%、93.3%和82.0%,10年bRFS率分别为91.4%、89.3%和76.2%。前列腺特异性抗原、Gleason评分和T分期是bRFS的重要预测因子(均P<0.01)。重度(≥3级)不良事件的5年发生率非常低:胃肠道不良事件和泌尿生殖系统不良事件的发生率分别为1.2%和1.1%。结论中度低分割IMRT后的长期结局令人鼓舞。中度低分割是治疗局限性前列腺癌的安全、有效的替代方案。 | Bin S.Teh Gary D.Lewis Weiyuan Mai Ramiro Pino Hiromichi Ishiyama Edward Brian Butler | 2018 | 癌症2018，37，12： | 0 |
| 10 | Prenatal risk factors for internalizing and externalizing problems in childhood显示文摘Background A growing body of research has documented the effects of prenatal risk factors on a wide spectrum of adverse offspring health outcomes.Childhood behavior problems,such as externalizing and internalizing problems,are no exception.This comprehensive literature review aims to summarize and synthesize current research about commonly experienced prenatal risk factors associated with internalizing and externalizing problems,with a focus on their impact during childhood and adolescence.Potential mechanisms as well as implications are also outlined.Data sources The EBSCO,Web of Science,PubMed,Google Scholar,and Scopus databases were searched for studies examining the association between prenatal risk factors and offspring internalizing/externalizing problems,using keywords“prenatal”or“perinatal”or“birth complications”in combination with“internalizing”or“externalizing”.Relevant articles,including experimental research,systematic reviews,meta-analyses,cross-sectional and longitudinal cohort studies,and theoretical literature,were reviewed and synthesized to form the basis of this integrative review.Results Prenatal risk factors that have been widely investigated with regards to offspring internalizing and externalizing problems encompass health-related risk factors,including maternal overweight/obesity,substance use/abuse,environmental toxicant exposure,maternal infection/inflammation,as well as psychosocial risk factors,including intimate partner violence,and anxiety/depression.Collectively,both epidemiological and experimental studies support the adverse associations between these prenatal factors and increased risk of emotional/behavioral problem development during childhood and beyond.Potential mechanisms of action underlying these associations include hormonal and immune system alterations.Implications include prenatal education,screening,and intervention strategies.Conclusions Prenatal risk factors are associated with a constellation of offspring internalizing and externalizing problems.Identifying these risk factors and understanding potential mechanisms will help to develop effective,evidence-based prevention,and intervention strategies. | Joyce Tien Gary D.Lewis Jianghong Liu | 2020 | World Journal of Pediatrics2020，16，4： | 0 |
| 11 | Lectures on Hodge Theory and Algebraic Cycles显示文摘Notes for a mini course at the University of Science and Technology ofChina in Hefei,China,June 23-July 12,2014. | James D.Lewis | 2016 | Communications in Mathematics and Statistics2016，4，2： | 0 |
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