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| 1 | Liver expression of steroid hormones and Apolipoprotein D receptors in hepatocellular carcinoma显示文摘AIM: To evaluate the tissular expression of Androgen (A), Estrogen (E) and Progesterone (Pg) receptors, and Apolipoprotein D (ApoD), in liver tumors from resected hepatocellular carcinoma (HCC) cases in order to assess their possible relationship to prognosis. METHODS: We performed an immunohistochemical study using tissue microarrays (containing more than 260 cancer specimens, from 31 HCC patients and controls) to determine the presence of specif ic antibodies against AR, ER, PgR and ApoD, correlating their findings with several clinico-pathological and biological variables. The staining results were categorized using a semi-quantitive score based on their intensity, and the percentage of immunostained cells was measured. RESULTS: A total of 21 liver tumors (67.7%) were positive for AR; 16 (51.6%) for ER; 26 (83.9%) for PgR and 12 (38.7%) stained for ApoD. We have found a wide variability in the immunostaining score values for each protein, with a median (range) of 11.5 (11.5-229.5) for AR; 11.1 (8.5-65) for ER; 14.2 (4-61) for PgR; and 37.7 (13.8-81.1) for ApoD. A history of heavy ethanol consumption, correlated positively with AR and PgR and negatively with ER status. HCV chronic infection also correlated positively with AR and PgR status. However, the presence of ApoD immunostaining did not correlate with any of these variables. Tumors with a positive immuno-staining for PgR showed a better prognosis. CONCLUSION: Our results indicate a moderate clinical value of the steroid receptor status in HCC, emphasizing the need to perform further studies in order to evaluate the possible role of new hormonal-based therapies. | FJ Vizoso M Rodriguez A Altadill ML González-Diéguez A Linares LO González S Junquera F Fresno-Forcelledo MD Corte L Rodrigo | 2007 | World Journal of Gastroenterology2007，13，23： | 11 |
| 2 | Lead distribution in a simulated aquatic environment:effects of bacterial biofilms and iron oxide显示文摘 | Nelson Y M Lo W Lion L W | 1995 | Water Research1995，29，8： | 2 |
| 3 | Presence of fetal DNA in maternal plasma and serum显示文摘 | Y M Dennis Lo Noemi Corbetta Paul F Chamberlain Vik Rai Ian L Sargent Christopher WG Redman James S Wainscoat | 1997 | The Lancet1997，，9076： | 2 |
| 4 | Cancer Genome Scanning in Plasma: Detection of Tumor-Associated Copy Number Aberrations, Single-Nucleotide Variants, and Tumoral Heterogeneity by Massively Parallel Sequencing显示文摘 | Chan K C Allen Jiang Peiyong Zheng Yama W L Liao Gary J W Sun Hao Wong John Siu Shing Shun N Chan Wing C Chan Stephen L Chan Anthony T C Lai Paul B S Chiu Rossa W K Lo Y M D | 2013 | Clinical Chemistry2013，，1： | 2 |
| 5 | Different patterns of atrial remodeling after catheter ablation of chronic atrial fibrillation 显示文摘 | LO L W TSAO H M LIN Y J | 2011 | J Cardiovasc Electrophysiol2011，22，4： | 1 |
| 6 | Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, 2012-2013显示文摘 | Meijer A Rebelo-de-Andrade H Correia V Besselaar T Drager-Dayal R Fry A Gregory V Gubareva L Kageyama T Laekenby A Lo J Odagiri T Pere- yaslov D Siqueira M M Takashita E Tashiro M Wang D Wong S Zhang W Daniels R S Hurt A C | 2014 | An- tiviral Research2014，110，： | 1 |
| 7 | Kinetics g plasma Epstein-Barr virus DNA during radiation therapy for nasopharyngeal carcinoma 显示文摘 | Lo Y M Leung S F Chart L Y | 2000 | Cancer Res2000，60，： | 1 |
| 8 | Lead Distribution in a Simulated Aquatic Environment:Effects of Bacterial Biofilms Components 显示文摘 | Nelson Y M Lo W Lion L W | 1995 | Wat Res1995，29，8： | 1 |
| 9 | Lead distribution in a simulated aquatic environment: effect of bacteria biofilms and iron oxides显示文摘 | Nelson Y M Lo W Lion L W | 1995 | Water Res1995，29，8： | 1 |
| 10 | An epididymis-specific beta-defensin is important for the initiation of sperm maturation显示文摘 | Zhou CX Zhang YL Xiao L Zheng M Leung KM Chan MY Lo PS Tsang LL Wong HY Ho LS | | 0，，05： | 1 |
| 11 | An empirical approach for ranking environmental and energy saving measures in the hotel sector 显示文摘 | Beccali M La Gennusa M Lo Coco L | 2009 | Renewable Energy2009，34，1： | 1 |
| 12 | Molecular prognostication of nasopharygeal carcinoma by quantitative analysis Of circulating Epstein-Barr virus DNA 显示文摘 | LO Y M LEUNG S F CHAN L Y | 2000 | CancerRes2000，60，： | 1 |
| 13 | A genome scan for quantitative trait loci affecting growth-related traits in an F1 family of Asian seabass (Lares calcarifer) 显示文摘 | Wang C M Lo L C Zhu Z Y | 2006 | BMC Genom2006，7，1： | 1 |
| 14 | Application of two stage fuzzy set theory to river quality evaluation in Taiwan显示文摘 | Liou S M Lo S L Hu C Y | 2003 | Water Research2003，37，： | 1 |
| 15 | Factors affecting foaming behavior in cellulase fermentation by Trichoderma reesei Rut C-30 显示文摘 | Zhang Q Lo C M Ju L K | 2007 | Bioresource Technology2007，98，4： | 1 |
| 16 | Adakites from continental collision zones: Melting of thickened lower crust beneath southern Tibet 显示文摘 | Chung S L Liu D Y Ji J Q Chu M F Lee H Y Wen D J Lo C H Lee T Y Qian Q Zhang Q | 2003 | Geology2003，31，11： | 1 |
| 17 | Estimation of glomerular filtration rate in patients with systemic lupus erythematosus 显示文摘 | Leung Y Y Lo K M Tam L S | 2006 | Lupus2006，15，5： | 1 |
| 18 | Neonatal streptozotocin-induced glu- cose intolerance: different consequences in Lyon normotensive and hypertensive rats显示文摘 | Emonnot L Cohen R Lo M | 2007 | J Hypertens2007，25，2： | 1 |
| 19 | Texture - based analysis of COPD: a data - driven approach显示文摘 | Sorensen L Nielsen M Lo P | 2012 | IEEE Trans Med Imaging2012，31，1： | 1 |
| 20 | Portal hyperperfusion injury as the cause of primary nonfunction in a small-for-size liver graft-successful treatment with splenic artery ligation显示文摘 | Lo C M Liu C L Fan S T | 2003 | Liver Transpl2003，9，6： | 1 |
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