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| 1 | Effects of Mahuang(Herba Ephedra Sinica) and Wuweizi(Fructus Schisandrae Chinensis) medicated serum on chemotactic migration of alveolar macrophages and inters regions macrophages in rats显示文摘OBJECTIVE: To observe the effects of serum containing Mahuang(Herba Ephedra Sinica) or Wuweizi(Fructus Schisandrae Chinensis) on the migration of alveolar macrophages(AM) and interstitial macrophages(IM) from normal rats, and to analyze and compare the mechanisms leading to cell migration differences.METHODS: Rats were randomly divided into three groups: Mahuang(Herba Ephedra Sinica), Wuweizi(Fructus Schisandrae Chinensis), and blank serum. After treatment with the herbs, serum was extracted from the rats. AM and IM were isolated from normal rats and cultured. The effects of Mahuang(Herba Ephedra Sinica) and Wuweizi(Fructus Schisandrae Chinensis) medicated serum on normal rat AM and IM chemotactic migration were determined by transwell assays. The CC chemokine receptor(CCR) 2, CCR5, voltage-gated Kvl. 3 K^+channel(Kv1. 3), and voltage-gated Kvl. 5 K^+channel(Kv1. 5) protein levels were analyzed by western blotting.RESULTS: The migration quantities of AM and IM in the Mahuang(Herba Ephedra Sinica) and Wuweizi(Fructus Schisandrae Chinensis) medicated serum groups were significantly higher than those in the blank serum group(P < 0.01). Compared with the Wuweizi(Fructus Schisandrae Chinensis) medicated serum group, the migration quantity of cultured rat AM in the Mahuang(Herba Ephedra Sinica) medicated serum group was significantly increased(P <0.01). Meanwhile, compared with the Mahuang(Herba Ephedra Sinica) medicated serum group, the migration quantity of cultured rat IM in the Wuweizi(Fructus Schisandrae Chinensis) medicated serum group was significantly increased(P < 0.01).CCR2, CCR5, Kv1. 3, and Kv1. 5 proteins were expressed on the AM cell surface, and showed significantly higher expression in the Mahuang(Herba Ephedra Sinica) medicated serum group compared with the Wuweizi(Fructus Schisandrae Chinensis)medicated serum group. In contrast, CCR5, Kv1.3,and Kv1.5 proteins were expressed on the IM cell surface, and showed significantly higher expression in the Wuweizi(Fructus Schisandrae Chinensis)medicated serum group compared with the Mahuang(Herba Ephedra Sinica) medicated serum group.CONCLUSION: Mahuang(Herba Ephedra Sinica)and Wuweizi(Fructus Schisandrae Chinensis) can promote AM and IM migration ability, with Mahuang(Herba Ephedra Sinica) targeting AM more apparently and Wuweizi(Fructus Schisandrae Chinensis) targeting IM more apparently. The mechanism may be that, by stimulating cells, Mahuang(Herba Ephedra Sinica) and Wuweizi(Fructus Schisandrae Chinensis) promote expression of CCR2 and CCR5 receptors on the AM and IM cell surface,which pass signals to Kvl.3 and Kvl.5 ion channels,leading to changes in the cytoskeleton, and ultimately promoting chemotactic cell migration. | Yuan Yiping Zhai Huaqiang Zhang Tian Guo Zhaojuan Kong Liting Jia Xiaoyu Wang Ningning Dai Ying Liu Guoxiu Wang Yanping | 2017 | Journal of Traditional Chinese Medicine2017，37，5： | 3 |
| 2 | Tunable Electronic and Magnetic Properties from Structure Phase Transition of Layered Vanadium Diselenide显示文摘The atomic geometry, structure stability, electronic and magnetic properties of VSe_2 were systematically investigated based on the density functional theory(DFT). Varying from 3D to 2D four VSe_2 structures, bulk 2H-VSe_2 and 1T-VSe_2, monolayer H-VSe_2 and T-VSe_2 are all demonstrated as thermodynamically stable by lattice dynamic calculations. More interestingly, the phase transition temperature is dramatically different due to the lattice size. Finally, owing to different crystal structures, H-VSe_2 is semimetallic whereas T-VSe_2 is totally metallic and also they have different magnetic moments. Our main argument is that being exfoliated from bulk to monolayer, 2H-VSe_2 transforms to T-VSe_2, accompanied by both semimetallic-metallic transition and dramatic magnetic moment variation. Our calculations provide a novel structure phase transition and an efficient way to modulate the electronic structure and magnetic moment of layered VSe_2, which suggests potential applications as high-performance functional nanomaterial. | 张会 SUN Liting DAI Yumei TONG Chuanjia 韩笑 | 2017 | Journal of Wuhan University of Technology(Materials Science)2017，32，3： | 1 |
| 3 | Thermal and Mechanical Properties of Polyurethane Rigid Foam Based on Epoxidized Soybean Oil显示文摘 | Yang Liting Zhao Chengshan Dai Chunlan | 2012 | Journal of Polymers and theEnvironment2012，20，： | 1 |
| 4 | Conjugation of soybean oil and it's free-radical copolymerization with acrylonitrile 显示文摘 | Liting Yang Chunlan Dai Lijun Ma | 2011 | J Polym Environ2011，19，1： | 1 |
| 5 | Thermal and mechanical properties of acrylated expoxidized-soybean oil-based thermosets 显示文摘 | Liyu Fu Liting Yang Chunlan Dai | 2010 | Journal of Applied Polymer Science2010，117，7： | 1 |
| 6 | Thermal and Mechanical Properties of Polyurethane Rigid Foam Based on Epoxidized Soybean Oil显示文摘 | Yang Liting Zhao Chengshan Dai Chunlan | 2012 | Journal of Polymers andthe Environment2012，20，1： | 1 |
| 7 | 通过鉴定关键靶标蛋白探究青蒿素抗疟机制显示文摘The widespread use of artemisinin(ART)and its derivatives has significantly reduced the global burden of malaria;however,malaria still poses a serious threat to global health.Although significant progress has been achieved in elucidating the antimalarial mechanisms of ART,the most crucial target proteins and pathways of ART remain unknown.Knowledge on the exact antimalarial mechanisms of ART is urgently needed,as signs of emerging ART resistance have been observed in some regions of the world.Here,we used a combined strategy involving mass spectrometry-coupled cellular thermal shift assay(MS-CETSA)and transcriptomics profiling to identify a group of putative antimalarial targets of ART.We then conducted a series of validation experiments on five prospective protein targets,demonstrating that ART may function against malaria parasites by interfering with redox homeostasis,lipid metabolism,and protein synthesis processes.Taken together,this study provides fresh perspectives on the antimalarial mechanisms of ART and identifies several crucial proteins involved in parasite survival that can be targeted to combat malaria. | Peng Gao Jianyou Wang Jiayun Chen Liwei Gu Chen Wang Liting Xu Yin Kwan Wong Huimin Zhang Chengchao Xu Lingyun Dai Jigang Wang | 2023 | Engineering2023，31，12： | 0 |
| 8 | Breeding and Cultivation Techniques of a New Spring Wheat Variety Kechun 140103显示文摘Kechun 140103 is a new spring wheat variety with high and stable yield bred by Keshan Branch of Heilongjiang Academy of Agricultural Sciences.This paper summarizes the breeding process,characteristics,yield performance and cultivation techniques of Kechun 140103,in order to promote the popularization and application of the variety. | Chao TIAN Ligang SHAO Jingyu CHE Yong MA Qichang ZHANG Ningtao LIU Zhikun WANG Xuewei YIN Liting DAI | 2023 | Plant Diseases and Pests2023，14，3： | 0 |
| 9 | Continuous synthesis for zirconium metal-organic frameworks with high quality and productivity via microdroplet flow reaction显示文摘Zirconium metal-organic frameworks(Zr-MOFs) represent the most promising candidates among MOFs for industrial utilizations owing to their high porosity and excellent stability. However, the efficient synthesis of Zr-MOFs combining with continuous production, high productivity and good product quality still remains a critical issue for practical applications. Herein, we report an efficient method of synthesizing a series of Zr-MOFs through a microdroplet flow reaction, which is more accommodate the requirements of industrial production. Four types of Zr-based MOFs with different ligands and topologies(MOF-801, MOF-804, DUT-67 and MOF-808) were produced as a pure phase of high quality crystalline with uniform morphologies. Furthermore, this series of Zr-MOFs were obtained in a continuous way and at a space-time yield(STY) highly up to 367.2 kg m^(-3) d^(-1). These MOFs exhibit the similar pore structure and thermal stability with that prepared from conventional solvothermal synthesis. CO_2 sorption studies on these MOFs demonstrate that the hydroxyl groups on ligand can render MOFs with high CO_2/N_2 selectivity. | Ying Wang Liangjun Li Liting Yan Lei Cao Pengcheng Dai Xin Gu Xuebo Zhao | 2018 | Chinese Chemical Letters2018，29，6： | 0 |
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