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| 1 | Synthetic FXR Agonist GW4064 Prevents Diet-Induced Hepatic Steatosis and Insulin Resistance显示文摘 | Yongjie Ma Yixian Huang Linna Yan Mingming Gao Dexi Liu | 2013 | Pharmaceutical Research2013，，5： | 3 |
| 2 | Potential Deformation and Its Application to the Diagnosis of Heavy Precipitation in Mesoscale Convective Systems显示文摘Many observational studies have shown that deformation, like vertical vorticity and divergence, is closely related to the occurrence and distribution of strong precipitation. In this paper, to involve deformation in precipitation diagnosis, a new parameter called potential deformation(PD) is derived and then applied to precipitation detection within a simulated mesoscale convective system(MCS). It is shown that PD includes both stretching deformation and shearing deformation and shares similar characteristics with deformation insofar as it does not change with the rotating coordinate. Diagnosis of the simulated MCS reveals that PD performs well in tracing the MCS' precipitation. In terms of their distributional pattern, the large-value areas of PD are similar to the precipitation in the different development stages of the MCS. A detailed analysis of the physical processes contained within the PD shows that it can reflect the three-dimensional moisture variation,vertical wind shear and wind deformation within the MCS. These structures are usually a comprehensive reflection of the characteristics of the surface cold pool, rear inflow jet, downward cold air flow and upward warm moist flow within the precipitating convective cells. For this reason, the PD shows much stronger anomalies in the precipitating atmosphere than the non-precipitating atmosphere, which implies considerable potential for its application in detecting heavy precipitation within MCSs. | Na LI Lingkun RAN Linna ZHANG Shouting GAO | 2017 | Advances in Atmospheric Sciences2017，34，7： | 2 |
| 3 | Temperature-induced Sn(Ⅱ) supramolecular isomeric frameworks as promising heterogeneous catalysts for cyanosilylation of aldehydes显示文摘Two novel Sn(Ⅱ) supramolecular isomeric frameworks,with the identical formula of {(NH2Me2)2[Sn(BDC)(SO4)]}n,Sn-CP-1-α(1) and Sn-CP-1-β(2)(H2BDC=terephthalic acid) were synthesized under solvothermal condition and fully characterized by single crystal X-ray diffraction(SCXRD),Fourier transform infrared spectroscopy(FTIR),ultraviolet-visible spectroscopy(UVVis),elemental analyses,and thermogravimetric analysis(TGA).Interestingly,the structures of 1 and 2 are governed by the temperature of the reaction,suggesting a temperature-induced supramolecular isomerism.The supramolecular isomers are primarily caused by the different bridging alignments of SO42–.Compounds 1 and 2 display 2 D layer and 3 D framework with different topologies,non-interpenetrated 44-sql and two-fold interpenetrated 4-connected dia topology,respectively.Due to Lewis acid properties of coordinatively unsaturated Sn(Ⅱ) sites in CPs,they have been utilized as heterogeneous catalyst for the cyanosilylation of aldehydes with an excellent conversion yield over 99% under solvent-free conditions. | Kai Sheng Li-Ming Fan Xue-Fei Tian Rakesh Kumar Gupta Linna Gao Chen-Ho Tung Di Sun | 2020 | Science China Chemistry2020，63，2： | 1 |
| 4 | CCGD-ESCC: A Comprehensive Database for Genetic Variants Associated with Esophageal Squamous Cell Carcinoma in Chinese Population显示文摘Esophageal squamous-cell carcinoma(ESCC) is one of the most lethal malignancies in the world and occurs at particularly higher frequency in China. While several genome-wide association studies(GWAS) of germline variants and whole-genome or whole-exome sequencing studies of somatic mutations in ESCC have been published, there is no comprehensive database publically available for this cancer. Here, we developed the Chinese Cancer Genomic Database-Esophageal Squamous Cell Carcinoma(CCGD-ESCC) database, which contains the associations of 69,593 single nucleotide polymorphisms(SNPs) with ESCC risk in 2022 cases and 2039 controls, survival time of 1006 ESCC patients(survival GWAS) and gene expression(expression quantitative trait loci,eQTL) in 94 ESCC patients. Moreover, this database also provides the associations between8833 somatic mutations and survival time in 675 ESCC patients. Our user-friendly database is a resource useful for biologists and oncologists not only in identifying the associations of genetic variants or somatic mutations with the development and progression of ESCC but also in studying the underlying mechanisms for tumorigenesis of the cancer. CCGD-ESCC is freely accessible at http://gffzzdf7d528e3a264cb9h0k0wup05p0bc65up.ffgz.tsg.suse.edu.cn/ccgd/ESCCdb. | Linna Peng Sijin Cheng Yuan Lin Qionghua Cui Yingying Luo Jiahui Chu Mingming Shao Wenyi Fan Yamei Chen Ai Lin Yiyi Xi Yanxia Sun Lei Zhang Chao Zhang Wen Tan Ge Gao Chen Wu Dongxin Lin | 2018 | Genomics, Proteomics & Bioinformatics2018，16，4： | 1 |
| 5 | Age-related changes of senescence-accelerated mouse prone 10 (SAMP10) mice as an animal model for AD显示文摘Background: To explore the influence of age-related changes in learning and memory capacity of SAMP10, an Alzheimer's disease (AD) model mice, and provide theoretical foundation for the selection of month age in related experiment. Methods: SAMP10 female mice with the age of 3, 6 and 9 months were used as the objects of experiment, while the age-matched female SAMR1 were used as the controls, with 12 in each group. The learning memory capacity of mice at different age was detected through Morris water maze and step-down passive avoidance test;meanwhile, the acetylcholine, acetylcholinesterase, choline acetyltransferase, and M-cholinergic receptor binding capacity levels were determined to detect the cholinergic system damage degree in mice with different month age. In addition, the contents of monoamine neurotransmitters such as dopamine, 3,4-dihydroxyphenyl acetic acid, homovanillic acid, norepinephrine and 5-HT, as well as those of amino acid transmitters such as glutamic acid, glutamine, aspartic acid,γ-aminobutyric acid, taurine and glycine in the brain cortex were detected by high performance liquid chromatography-electrochemical deposition. Besides, changes in hippocampal neurons were observed through Nissl staining, and the changes of Aβ in hippocampal CA1 and CA2 regions of SAMP10 were also detected by immunohistochemistry so as to explore the effects of age on the memory capacity of SAMP10. Results: It was discovered in the behavior test and AD-related index tests that: there was no significant difference between the age-matched SAMR1 and the SAMP10 at the age of 3 and 6 months. But the 9-months-old mice suffered remarkable senescence characteristics, including obviously declined learning memory capacity;down-regulated neurotransmitter levels, enzyme activities and amino acid expression;reduced hippocampal neuron number;and increased deposition of hippocampal Aβ protein. Conclusion: It is discovered in this study through behavior tests and AD-related indexs detection that, the learning memory capacity of SAMP10 shows age-dependence, which is gradually decreased with the increase of age, and the 9-months-old mice have developed marked memory impairment and senescence characteristics. SAMP10 is the recognized AD model, the appropriate month age for preventive medication is about 7 months, while that for therapeutic medication is 8-9 months. | Lei Yu Linna Gao Xue Bai Ruomei Che Xiaoli He | 2019 | Life Research2019，2，4： | 0 |
| 6 | Effects of icariin on the expression of β-amyloid in hippocampus of SAMP 10 in rapidly aging mice显示文摘To investigate the expression of beta-amyloid protein on icariin in the hippocampal of senescence accelerated mouse SAMP10.The 8-month-old SAMP10 were randomly divided into model group,Donepezil Hydrochloride(DON)-treated SAMP10 group(1 mg·kg^-1)and ICA-treated SAMP10 groups(50、100、200 mg·kg^-1),with 6 mice in each group.while the age-matched senescence accelerated mouse/resistance1(SAMR1)were used as the normal control.After 30 days of oral administration,the method of Nissl was used to detect neurons on icariin in the hippocampal of senescence accelerated mouse SAMP10.The expression of betaamyloid protein on icariin in the hippocampal of senescence accelerated mouse SAMP10 was detected by the method of immunohistochemical.It was discovered that the nerve cells in groups of ICA arranged regularly,and the number of neurons increasing.We can conduct that ICA may reduce the average optical density of beta-amyloid protein in the CA1 and CA3 region of hippocampal on SAMP10.ICA may reduce the beta-amyloid protein deposition in CA1 and CA3 region of hippocampal on SAMP10 to improve learning and memory ability. | Lei Yu Xue Bai Linna Gao Xiaoli He | 2019 | TMR Aging2019，1，1： | 0 |
| 7 | Adaptive Optimal Output Regulation of Interconnected Singularly Perturbed Systems With Application to Power Systems显示文摘This article studies the adaptive optimal output regulation problem for a class of interconnected singularly perturbed systems(SPSs) with unknown dynamics based on reinforcement learning(RL).Taking into account the slow and fast characteristics among system states,the interconnected SPS is decomposed into the slow time-scale dynamics and the fast timescale dynamics through singular perturbation theory.For the fast time-scale dynamics with interconnections,we devise a decentralized optimal control strategy by selecting appropriate weight matrices in the cost function.For the slow time-scale dynamics with unknown system parameters,an off-policy RL algorithm with convergence guarantee is given to learn the optimal control strategy in terms of measurement data.By combining the slow and fast controllers,we establish the composite decentralized adaptive optimal output regulator,and rigorously analyze the stability and optimality of the closed-loop system.The proposed decomposition design not only bypasses the numerical stiffness but also alleviates the high-dimensionality.The efficacy of the proposed methodology is validated by a load-frequency control application of a two-area power system. | Jianguo Zhao Chunyu Yang Weinan Gao Linna Zhou Xiaomin Liu | 2024 | IEEE/CAA Journal of Automatica Sinica2024，11，3： | 0 |
| 8 | cFos-ANAB:A cFos-based Web Tool for Exploring Activated Neurons and Associated Behaviors显示文摘cFos is one of the most widely-studied genes in the field of neuroscience.Currently,there is no systematic database focusing on cFos in neuroscience.We developed a curated database-cFos-ANAB-a cFos-based web tool for exploring activated neurons and associated behaviors in rats and mice,comprising 398 brain nuclei and sub-nuclei,and five associated behaviors:pain,fear,feeding,aggression,and sexual behavior.Direct relationships among behaviors and nuclei(even cell types)under specific stimulating conditions were constructed based on cFos expression profiles extracted from original publications.Moreover,overlapping nuclei and sub-nuclei with potentially complex functions among different associated behaviors were emphasized,leading to results serving as important clues to the development of valid hypotheses for exploring as yet unknown circuits.Using the analysis function of cFos-ANAB,multi-layered pictures of networks and their relationships can quickly be explored depending on users’purposes.These features provide a useful tool and good reference for early exploration in neuroscience.The cFos-ANAB database is available at www.cfos-db.net. | Fan Wang Wenjie Sun Lei Chang Kefang Sun Leying Hou Linna Qian Chaoyin Jin Jiandong Chen Jiali Pu Panmeng Ye Shuang Qiu Jianhong Luo Shumin Duan Baorong Zhang Zhihua Gao Xiaojun Hu | 2021 | Neuroscience Bulletin2021，37，10： | 0 |
| 9 | Synthesis, structure and magnetic properties of a decanuclear Fe(Ⅲ)/oxo cluster显示文摘An iron(Ⅲ) cluster,namely [Fe10(μ3-O)8L8(NO3)6](1),has been synthesized by treatment of Fe(NO3)3·9 H2O with 3,5-dimethyl-l-(hydroxymethyl)-pyrazole(HL) under ambient temperature.The core skeleton of {FeⅢ10) can be regarded as a pear-like cage with eight triangular {FeⅢ3(μ3-O)} units,in which each three FeⅢ centers is held together by one μ3-O2- group with FeⅢ centers as corner-sharing triangle units.Importantly,{FeⅢ10} cluster is not only stable in solid state but also in solution,which is confirmed by powder X-ray diffraction(PXRD) pattern and electrospray ionization mass spectrometry(ESI-MS),respectively.Furthermore,1 shows anti ferromagnetic exchange behavior arising from the interactions between the iron(Ⅲ) centers. | Waseem Muhammad Jie Ni Zvonko Jaglicic Ping Cui Linna Gao Di Sun | 2020 | Chinese Chemical Letters2020，31，9： | 0 |
| 10 | Research on multi-color OLED with bi-directional charge transfer using Ag:Mg as intermediate electrode显示文摘Organic light-emitting devices(OLEDs) have received widespread attention due to their excellent luminescence performance and flexibility.In this work,we demonstrate a novel two-color OLED,in which the forward and reverse units are vertically stacked together using Ag:Mg as an intermediate electrode for charge injection and transfer.Due to the extremely thin Ag:Mg film layer has a relatively smooth surface,it plays a critical role in the reverse unit light emission of the device.Thus,it is realized that the device emits green and red light when forward and reverse voltages are applied respectively.This provides a new possibility for future OLEDs lighting and display developments.The OLEDs were prepared by using such Ag:Mg intermediate electrodes,and a maximum brightness of 451.14 cd/m^(2) and an external quantum efficiency(EQE) of 3.82% were obtained at a small current density. | LIU Linna GAO Xiongwei WAN Chunchen ZHANG Fanghui | 2023 | Optoelectronics Letters2023，19，6： | 0 |
| 11 | Interfacial modification using the cross-linkable tannic acid for highly-efficient perovskite solar cells with excellent stability显示文摘Although the performance of perovskite solar cells(PSCs)has been dramatically increased in recent years,stability is still the main obstacle preventing the PSCs from being commercial.PSC device instability can be caused by a variety of reasons,including ions diffusion,surface and grain boundary defects,etc.In this work,the cross-linkable tannic acid(TA)is introduced to modify perovskite film through post-treatment method.The numerous organic functional groups(–OH and C=O)in TA can interact with the uncoordinated Pb^(2+)and I^(-)ions in perovskite,thus passivating defects and inhibiting ions diffusion.In addition,the formed TA network can absorb a small amount of the residual moisture inside the device to protect the perovskite layer.Furthermore,TA modification regulates the energy level of perovskite,and reduces interfacial charge recombination.Ultimately,following TA treatment,the device efficiency is increased significantly from 21.31%to 23.11%,with a decreased hysteresis effect.Notably,the treated device shows excellent air,thermal,and operational stability.In light of this,the readily available,inexpensive TA has the potential to operate as a multipurpose interfacial modifier to increase device efficiency while also enhancing device stability. | Xing Gao Lirong Rong Fei Wu Yen-Hung Lin Ye Zeng Junhong Tan Rongxing He Cheng Zhong Linna Zhu | 2024 | Journal of Energy Chemistry2024，91，4： | 0 |
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