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| 1 | Comparison of sentinel lymph node detection performances using blue dye in conjunction with indocyanine green or radioisotope in breast cancer patients: a prospective singlecenter randomized study显示文摘Objective:This randomized study aimed to compare the clinical efficacy between the novel dual tracer composed of indocyanine green(ICG)and blue dye(BD)and the conventional dual tracer composed of radioisotope and BD for sentinel lymph node(SLN)mapping in patients with breast cancer.Methods:This study enrolled 471 clinically lymph node-negative patients with primary breast cancer.All patients underwent mastectomy,and those undergoing sentinel lymph node biopsy(SLNB)were randomized to receive blue dye plus radioisotope(RB group)or BD plus ICG(IB group).The detection performances on SLN identification rate,positive SLN counts,detection sensitivity,and false-negative rate were compared between the two groups.Results:In the IB group,97%(194/200)of the patients who underwent the ICG and BD dual tracer injection showed fluorescentpositive lymphatic vessels within 2–5 min.The identification rate of SLNs was comparable between the IB group(99.0%,198/200)and the RB group(99.6%,270/271)(P=0.79).No significant differences were observed in the identification rate of metastatic SLNs(22.5%vs.22.9%,P>0.05,RB group vs.IB group,the same below),positive SLN counts(3.72±2.28 vs.3.91±2.13,P>0.05),positive metastatic SLN counts(0.38±0.84 vs.0.34±0.78,P>0.05),SLNB detection sensitivity(94.4%vs.92.5%,P>0.05),or false-negative rate(5.6%vs.7.5%,P>0.05)between the two groups.Conclusions:ICG can be used as a promising alternative tracer for radioisotope in SLN mapping,and when it is combined with BD in lymphangiography,it offers comparable detection sensitivity compared to the conventional lymphatic mapping strategies that are widely used in clinical practice. | Long Yuan Xiaowei Qi Yi Zhang Xinhua Yang Fan Zhang Linjun Fan Li Chen Kongyong Zhang Ling Zhong Yanling Li Sijie Gan Wenying Fu Jun Jiang | 2018 | Cancer Biology & Medicine2018，15，4： | 9 |
| 2 | CO2 capture over molecular basket sorbents:Effects of SiO2 supports and PEG additive显示文摘The objective of this work is to study the influences of silica supports and PEG additive on the sorption performance of molecular basket sorbent(MBS) for CO_2 capture consisting of polyethylenimine and one of the following supports: SBA-15(2-D structure), TUD-1(3-D sponge-like structure) and fumed silica HS-5(3-D disordered structure). Effects of the supports regarding pore structures and pore properties, the PEI loading amount as well as the sorption temperature were examined. Furthermore, polyethylene glycol(PEG) was introduced as an additive into the sorbents and its effect was investigated at different PEI loadings and sorption temperatures. The results suggest that the pore properties of MBS(after PEI loading) play a more important role in the CO_2 sorption capacity, rather than those of the supports alone.MBS with 3D pore structure exhibits higher CO_2 sorption capacity and amine efficiency than those with 2D-structured support. Among the sorbents studied, fumed silica(HS-5) based MBS showed the highest CO_2 sorption capacity in the temperature range of 30-95 °C, probably due to its unique interstitial pores formed by the aggregation of polymer-loaded SiO_2 particles. It was found that the temperature dependence is directly related to the PEI surface coverage layers. The more PEI surface coverage layers, the higher diffusion barrier for CO_2 and the stronger temperature dependence of CO_2 capacity. 3D MBS exceeds 2D MBS at the same PEI coverage layers due to lower diffusion barrier. Adding PEG can significantly enhance the CO_2 sorption capacity and improve amine efficiency of all MBS, most likely by alleviating the diffusion barrier within PEI bulk layers through the inter-molecular interaction between PEI and PEG. | Lin Zhang Xiaoxing Wang Mamoru Fujii Linjun Yang Chunshan Song | 2017 | Journal of Energy Chemistry2017，26，5： | 3 |
| 3 | Oxidative stress response and gene expression with atrazine exposure in adult female zebrafish ( Danio rerio )显示文摘 | Yuanxiang Jin Xiangxiang Zhang Linjun Shu Lifang Chen Liwei Sun Haifeng Qian Weiping Liu Zhengwei Fu | 2009 | Chemosphere2009，，7： | 2 |
| 4 | Injectable self-healing hydrogel with siRNA delivery property for sustained STING silencing and enhanced therapy of intervertebral disc degeneration显示文摘Inflammatory responses of nucleus pulposus(NP)can induce imbalanced anabolism and catabolism of extracellular matrix,and the cytosolic dsDNA accumulation and STING-NF-κB pathway activation found in NP inflammation are considered as fairly important cause of intervertebral disc(IVD)degeneration.Herein,we constructed a siSTING delivery hydrogel of aldehyde hyaluronic acid(HA-CHO)and poly(amidoamine)PAMAM/siRNA complex to intervene the abnormal STING signal for IVD degeneration treatment,where the formation of dynamic Schiff base bonds in the system(siSTING@HPgel)was able to overcome the shortcomings such as low cellular uptake,short half-life,and rapid degradation of siRNA-based strategy.PAMAM not only formed complexes with siRNA to promote siRNA transfection,but also served as dynamic crosslinker to construct hydrogel,and the injectable and self-healing hydrogel efficiently and steadily silenced STING expression in NP cells.Finally,the siSTING@HPgel significantly eased IVD inflammation and slowed IVD degeneration by prolonging STING knockdown in puncture-induced IVD degeneration rat model,revealing that STING pathway was a therapeutic target for IVD degeneration and such novel hydrogel had great potential for being applied to many other diseases for gene delivery. | Jiaxin Chen Haifeng Zhu Yutao Zhu Chenchen Zhao Shengyu Wang Yixin Zheng Ziang Xie Yang Jin Honghai Song Linjun Yang Jin Zhang Jiayong Dai Zhijun Hu Huaiyu Wang | 2022 | Bioactive Materials2022，7，3： | 2 |
| 5 | Fractal Uniform Circular Arrays Based Multi-Orbital-Angular-Momentum-Mode Multiplexing Vortex Radio MIMO显示文摘A radio wave driven by Orbital angular momentum(OAM) is called a vortex radio and has a helical wavefront. The differential helical wavefronts of several vortex radios are closely related to their topological charges or mode numbers. In physics, two or more radio waves with different mode numbers are orthogonal to their azimuth angles. With the development of radio communication technologies, some researchers have been exploring the OAM-based multi-mode multiplexing(multi-OAM-mode multiplexing) technologies in order to enhance the channel spectrum efficiency(SE) of a radio communication system by using the orthogonal properties of vortex radios. After reviewing the reported researches of OAM-based radio communication, we find that some breakthroughs have been made in the combination of OAM and traditional Multi-Input-Multi-Output(MIMO). However, the existing technology is not sufficient to support OAM-based MIMO system to achieve maximum the channel SE. To maximize the spectrum efficiency of OAM-based MIMO system, we present a reused multi-OAM-mode multiplexing vortex radio(RMMVR) MIMO system, which is based on fractal uniform cir-cular arrays(UCAs). The scheme described in this study can effectively combine multiOAM-mode multiplexing with MIMO spatial multiplexing. First, we present the generation of RMMVR MIMO signals. Second, under line-of-sight(LOS) propagation conditions, we derive the channels of the RMMVR MIMO system. Third, we separate the RMMVR MIMO signals using an orthogonal separation method based on full azimuth sampling. Finally, we introduce the method for calculating the channel capacity of the RMMVR MIMO system. Theoretical analysis shows that the scheme proposed in this study is feasible. Moreover, the simulation results show that spatial and mode diversity are obtained by exploiting fractal UCAs. However, to enhance the channel SE of RMMVR MIMO system, an interference cancellation method needs to be introduced for zero-mode vortex radios, and some methods of multi-OAM-mode beams convergence and mode power optimization strategy should be introduced in the future. | Linjun Zhao Hailin Zhang Wenchi Cheng | 2018 | China Communications2018，15，9： | 2 |
| 6 | Emerging phagocytosis checkpoints in cancer immunotherapy显示文摘Cancer immunotherapy,mainly including immune checkpoints-targeted therapy and the adoptive transfer of engineered immune cells,has revolutionized the oncology landscape as it utilizes patients’own immune systems in combating the cancer cells.Cancer cells escape immune surveillance by hijacking the corresponding inhibitory pathways via overexpressing checkpoint genes.Phagocytosis checkpoints,such as CD47,CD24,MHC-I,PD-L1,STC-1 and GD2,have emerged as essential checkpoints for cancer immunotherapy by functioning as“don’t eat me”signals or interacting with“eat me”signals to suppress immune responses.Phagocytosis checkpoints link innate immunity and adaptive immunity in cancer immunotherapy.Genetic ablation of these phagocytosis checkpoints,as well as blockade of their signaling pathways,robustly augments phagocytosis and reduces tumor size.Among all phagocytosis checkpoints,CD47 is the most thoroughly studied and has emerged as a rising star among targets for cancer treatment.CD47-targeting antibodies and inhibitors have been investigated in various preclinical and clinical trials.However,anemia and thrombocytopenia appear to be formidable challenges since CD47 is ubiquitously expressed on erythrocytes.Here,we review the reported phagocytosis checkpoints by discussing their mechanisms and functions in cancer immunotherapy,highlight clinical progress in targeting these checkpoints and discuss challenges and potential solutions to smooth the way for combination immunotherapeutic strategies that involve both innate and adaptive immune responses. | Yu’e Liu Yanjin Wang Yanrong Yang Linjun Weng Qi Wu Jin Zhang Pengcheng Zhao Lan Fang Yufeng Shi Ping Wang | 2023 | Signal Transduction and Targeted Therapy2023，8，4： | 1 |
| 7 | CVD diamond devices for charged particle detection显示文摘 | Zhang Minglong Xia Yiben Wang Linjun | 2005 | Semicond Sci Technol2005，20，： | 1 |
| 8 | X-ray Detectors Based on (100)-Textured CVD Diamond Films显示文摘 | Zhang Minglong Gu Beibei Wang Linjun | 2004 | Physics Letters A2004，332，： | 1 |
| 9 | Identification of Glutaminyl Cyclase isoenzyme isoQC as a regulator of SIRPα-CD47 axis显示文摘Dear Editor,Cancer cells often upregulate the expression of ligands for the inhibitory immune checkpoints receptor to escape anti-tumor immunity1. Targeting inhibitory immune checkpoints has become one of the most promising anticancer therapeutic inventions. Infiltration of myeloid cells, especially phagocytic cells, to tumors is often associated with chemotherapy resistance and progression of various cancer types. Phagocytosis of cancer cells is the major mechanism for these myeloid cells-mediated antitumor activity. However, many types of cancer cells express high level of ‘don’t eat me’ signals on the cell surface to escape the phagocytic cells-mediated antitumor immunity. | Zhiqiang Wu Linjun Weng Tengbo Zhang Hongling Tian Lan Fang Hongqi Teng Wen Zhang Jing Gao Yun Hao Yaxu Li Hu Zhou Ping Wang | 2019 | Cell Research2019，29，6： | 1 |
| 10 | Oxidative stress response and gene expression with atrazine exposure in adult female zebrafish ( Danio rerio )显示文摘 | Yuanxiang Jin Xiangxiang Zhang Linjun Shu Lifang Chen Liwei Sun Haifeng Qian Weiping Liu Zhengwei Fu | 2009 | Chemosphere2009，，7： | 1 |
| 11 | Effects of the deposition conditions and annealing process on the electric properties of hot - filament CVD diamond films显示文摘 | Minglong Zhang Yiben Xia Linjun Wang | 2005 | Journal of Crystal Growth2005，274，： | 1 |
| 12 | FGF8-mediated signaling regulates tooth developmental pace during odontogenesis显示文摘The developing human and mouse teeth constitute an ideal model system to study the regulatory mechanism underlying organ growth control since their teeth share highly conserved and well-characterized developmental processes, and their developmental tempo varies notably. In the current study, we manipulated heterogenous recombination between human and mouse dental tissues and demonstrated that the dental mesenchyme dominates the tooth developmental tempo and FGF8 could be a critical player during this developmental process. Forced activation of FGF8 signaling in the dental mesenchyme of mice promoted cell proliferation, prevented cell apoptosis via p38 and perhaps PI3 K-Akt intracellular signaling,and impelled the transition of the cell cycle from G1-to S-phase in the tooth germ, resulting in the slowdown of the tooth developmental pace. Our results provide compelling evidence that extrinsic signals can profoundly affect tooth developmental tempo, and the dental mesenchymal FGF8 could be a pivotal factor in controlling the developmental pace in a non-cell-autonomous manner during mammalian odontogenesis. | Chensheng Lin Ningsheng Ruan Linjun Li Yibin Chen Xiaoxiao Hu YiPing Chen Xuefeng Hu Yanding Zhang | 2022 | Journal of Genetics and Genomics2022，49，1： | 1 |
| 13 | A convenient preparation of 5-iodo-1,4-disubstituted-1,2,3-triazole:Multicomponent one-pot reaction of azido and alkyne mediated by Cul and NBS显示文摘 | Linjun Li Guisheng Zhang Anlian Zhu | 2008 | J Org Chem2008，73，： | 1 |
| 14 | Dual isotope simultaneous imaging to evaluate the effects of intracoronarybone marrow-derived mesenchymal stem cells on perfusion and metabolism in canineswith acute myocardial infarction显示文摘 | Linjun Hao Jin Hao Wei Fang Chunlei Han Kaixiu Zhang Xuemei Wang | 2015 | Biomedical Reports2015，，： | 1 |
| 15 | Preparation and characterization of (100)-textured diamond films obtained by hot-filament CVD显示文摘 | Minglong Zhang Beibei Gu Linjun Wang | 2005 | Vacuum2005，，： | 1 |
| 16 | Transforming growth factor-β1 polymorphisms and breast cancer risk: a meta-analysis based on 27 case–control studies显示文摘 | Xiaowei Qi Fan Zhang Xinhua Yang Linjun Fan Yi Zhang Li Chen Yan Zhou Xianchun Chen Ling Zhong Jun Jiang | 2010 | Breast Cancer Research and Treatment2010，，1： | 1 |
| 17 | Effects of Ti additive on the structure and electrochemical performance of LiMnPO 4 cathode material显示文摘 | Laifen Qin Yonggao Xia Hailiang Cao Linjun Luo Qian Zhang Lipeng Chen Zhaoping Liu | 2014 | Electrochimica Acta2014，，： | 1 |
| 18 | The electrical properties of diamond - like carbon film/ D263 glass composite for the substrate of micro - Strip gas chamber显示文摘 | Yiben Xia Linjun Wang | 2003 | Diamond and Related Materials2003，，： | 1 |
| 19 | Removal of fine particles from combustion by condensation scrubbing显示文摘 | Sun Lujuan(孙露娟) Yang Linjun(杨林军) Zhang Xia(张霞) Yan Jinpei(颜金培) Zhang Yu(张字) Shen Xianglin(沈湘林) | 2008 | Journal of Chemical Industry and Engineering(China)(化工学报)2008，59，6： | 1 |
| 20 | Experimental study on separation of inhalable particles from coal combustion by heterogeneous condensation enlargement显示文摘 | Yan Jinpei(颜金培) Yang Linjun(杨林军) Zhang Xia(张霞) Sun Lujuan(孙露娟) Zhang Yu(张宇) Shen Xianglin(沈湘林) | 2007 | Proceedings of the CSEE(中国电机工程学报)2007，27，35： | 1 |
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