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| 1 | OSBPL2-disrupted pigs recapitulate dual features of human hearing loss and hypercholesterolaemia显示文摘Oxysterol binding protein like 2(OSBPL2), an important regulator in cellular lipid metabolism and transport, was identified as a novel deafness-causal gene in our previous work. To resemble the phenotypic features of OSBPL2 mutation in animal models and elucidate the potential genotypephenotype associations, the OSBPL2-disrupted Bama miniature(BM) pig model was constructed using CRISPR/Cas9-mediated gene editing, somatic cell nuclear transfer(SCNT) and embryo transplantation approaches, and then subjected to phenotypic characterization of auditory function and serum lipid profiles. The OSBPL2-disrupted pigs displayed progressive hearing loss(HL) with degeneration/apoptosis of cochlea hair cells(HCs) and morphological abnormalities in HC stereocilia, as well as hypercholesterolaemia. High-fat diet(HFD) feeding aggravated the development of HL and led to more severe hypercholesterolaemia. The dual phenotypes of progressive HL and hypercholesterolaemia resembled in OSBPL2-disrupted pigs confirmed the implication of OSBPL2 mutation in nonsydromic hearing loss(NSHL) and contributed to the potential linkage between auditory dysfunction and dyslipidaemia/hypercholesterolaemia. | Jun Yao Huasha Zeng Min Zhang Qinjun Wei Ying Wang Haiyuan Yang Yajie Lu Rongfeng Li Qiang Xiong Lining Zhang Zhibin Chen Guangqian Xing Xin Cao Yifan Dai | 2019 | Journal of Genetics and Genomics2019，46，8： | 7 |
| 2 | Design of task priority model and algorithm for imaging observation problem显示文摘In the imaging observation system, imaging task scheduling is an important topic. Most scholars study the imaging task scheduling from the perspective of static priority, and only a few from the perspective of dynamic priority. However,the priority of the imaging task is dynamic in actual engineering. To supplement the research on imaging observation, this paper proposes the task priority model, dynamic scheduling strategy and Heuristic algorithm. At first, this paper analyzes the relevant theoretical basis of imaging observation, decomposes the task priority into four parts, including target priority, imaging task priority, track, telemetry & control(TT&C)requirement priority and data transmission requirement priority, summarizes the attribute factors that affect the above four types of priority in detail, and designs the corresponding priority model. Then, this paper takes the emergency tasks scheduling problem as the background, proposes the dynamic scheduling strategy and heuristic algorithm. Finally, the task priority model,dynamic scheduling strategy and heuristic algorithm are verified by experiments. | WU Jian LU Fang ZHANG Jiawei YANG Jinghui XING Lining | 2020 | Journal of Systems Engineering and Electronics2020，31，2： | 1 |
| 3 | Bond-graph model of a piezostack driven jetting dispenser显示文摘 | Shizhou Lu Yaxin Liu Yufeng Yao Lining Sun Ming Zhong | 2014 | Simulation Modelling Practice and Theory2014，，： | 1 |
| 4 | Deep desulfurization of fuels catalyzed by surfactant-type decatungstates using H 2 O 2 as oxidant显示文摘 | Xue Jiang Huaming Li Wenshuai Zhu Lining He Huoming Shu Jidong Lu | 2008 | Fuel2008，，3： | 1 |
| 5 | Analysis of higher-order finite-difference schemes in 3 D reverse-time migration显示文摘 | Wu W Lines L R Lu H | 1996 | Geophysics1996，61，3： | 1 |
| 6 | Analysis of higher-order finite-difference schemes in 3-D reverse-time migration显示文摘 | Wu W J Lines L R Lu H X | 1996 | Geophysics1996，61，3： | 1 |
| 7 | PAPR reduction based on improved Nyquist pulse shaping technology in OFDM-RoF systems 显示文摘 | LIU Jianfei LINing LU Jia | 2013 | OptoelectronicsLetters(S1673-1905)2013，9，： | 1 |
| 8 | Deep oxidative desulfurization of fuels catalyzed by phosphotungstic acid in ionic liquids at room temperature显示文摘 | LI Huaming HE Lining LU Jidong | 2009 | Energy and Fuels2009，23，： | 1 |
| 9 | Analysis of higher-order,finite-difference schemes in 3-D reverse-time migration显示文摘 | Wu W Lines L R Lu H | 1996 | Geophysics1996，61，3： | 1 |
| 10 | Deep oxidative desulfurization of fuels catalyzed by phosphotungstic acid in ionic liquids at room temperature显示文摘 | LI Huaming HE Lining LU Jidong | 2009 | Energy & Fuels2009，23，3： | 1 |
| 11 | Analysis of higher-order, finite difference schemes in a-D reverse-time migration 显示文摘 | Wu W Lines L R Lu H | 1996 | Geophysics1996，61，3： | 1 |
| 12 | Genetic algorithms in resource optimization of construction project 显示文摘 | Zhang Lianying Luo Gang Lu Lining | 2001 | J of Tianjin University2001，34，2： | 1 |
| 13 | Sartorymensin, a new indole alkaloid, and new analogues of tryptoquivaline and fiscalins produced by Neosartorya siamensis (KUFC 6349)显示文摘 | Suradet Buttachon Angsumarn Chandrapatya Leka Manoch Artur Silva Luís Gales Céline Bruyère Robert Kiss Anake Kijjoa | 2012 | Tetrahedron2012，，15： | 1 |
| 14 | Prevention of Diabetic Complications by Activation of Nrf2: Diabetic Cardiomyopathy and Nephropathy显示文摘 | Bing Li Shujun Liu Lining Miao Lu Cai Pietro Galassetti | 2012 | Experimental Diabetes Research2012，，： | 1 |
| 15 | In Vitro 显示文摘 | Lu Y Lannan C N Rohovec J S Fish cell lines: Establishment and characterization of three new cell lines from grass carp (Ctenopharyngodon idellus ) | 1990 | Cell Dev Biol1990，26，： | 1 |
| 16 | Inactivity of YGL082W in vitro due to impairment of conformational change in the catalytic center loop显示文摘MINDY-1 is a recently discovered new family of deubiquitinating enzymes(DUB),but one of its yeast homologs,YGL082 W,does not show any DUB activity in vitro.Sequence alignment shows that YGL082 W possesses the correct catalytic triad,and yet did not catalyze either the hydrolysis of di-ubiquitin,crosslinking with C-terminally propargylated ubiquitin,or hydrolysis of ubiquitin-7-amino-4-methylcoumarin.After obtaining a crystal structure of the catalytic domain of YGL082 W,we identified an interesting difference between the catalytic center loop of YGL082 W and that of its human homolog MINDY-1.Because the conformation of the catalytic center loop was previously reported to be important for the deubiquitination activity of MINDY-1,we hypothesized that Glu27(instead of the corresponding Pro136 in MINDY-1) of the catalytic center loop of YGL082 W may impair the conformational change and account for the lack of activity.This hypothesis was supported by homology modeling and molecular dynamics simulations,which showed that the Pro-to-Glu mutation(P136 E mutation for MINDY-1) creates a hydrogen bond that inhibits the conformation change of the catalytic center loop of MINDY-1.Further experiments through site-directed mutation validated this hypothesis,showing that the P27 E mutation caused MIY1(a homologous active DUB from yeast) to lose activity. | Lining Lu Yu Guo Tian Wang Lujun Liang Suwen Zhao Feng Wang Lei Liu | 2020 | Science China Chemistry2020，63，2： | 1 |
| 17 | Bone morphogenetic protein 2 stimulates endochondral ossification by regulating periosteal cell fate during bone repair显示文摘 | Yan Yiu Yu Shirley Lieu Chuanyong Lu Céline Colnot | 2010 | Bone2010，，1： | 1 |
| 18 | Deep oxida-tive desulfurization of fuels catalyzed by phosphotungstic acid in ionic liquids at room temperature显示文摘 | Li Huaming He Lining Lu Jingdong | 2009 | Energy & Fu- els2009，23，3： | 1 |
| 19 | Background progenitor activation is associated with recurrence after hepatectomy of combined hepatocellular‐cholangiocarcinoma显示文摘 | Xiong Cai Jian Zhai David E. Kaplan Yijun Zhang Lining Zhou Xutao Chen Guangyang Qian Qiudong Zhao Yonghai Li Lu Gao Wenming Cong Minghua Zhu Zhenlin Yan Lehua Shi Dong Wu Lixin Wei Feng Shen Mengchao Wu | 2012 | Hepatology2012，，5： | 1 |
| 20 | Zinc homeostasis in the metabolic syndrome and diabetes显示文摘Zinc(Zn)is an essential mineral that is required for various cellular functions.Zn dyshomeostasis always is related to certain disorders such as metabolic syndrome,diabetes and diabetic complications.The associations of Zn with metabolic syndrome,diabetes and diabetic complications,thus,stem from the multiple roles of Zn:(1)a constructive component of many important enzymes or proteins,(2)a requirement for insulin storage and secretion,(3)a direct or indirect antioxidant action,and(4)an insulin-like action.However,whether there is a clear cause-and-effect relationship of Zn with metabolic syndrome,diabetes,or diabetic complications remains unclear.In fact,it is known that Zn deficiency is a common phenomenon in diabetic patients.Chronic low intake of Zn was associated with the increased risk of diabetes and diabetes also impairs Zn metabolism.Theoretically Zn supplementation should prevent the metabolic syndrome,diabetes,and diabetic complications;however,limited available data are not always supportive of the above notion.Therefore,this review has tried to summarize these pieces of available information,possible mechanisms by which Zn prevents the metabolic syndrome,diabetes,and diabetic complications.In the final part,what are the current issues for Zn supplementation were also discussed. | Xiao Miao Weixia Sun Yaowen Fu Lining Miao Lu Cai | 2013 | Frontiers of Medicine2013，7，1： | 1 |
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