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| 1 | A continued saga of Boc5, the first non-peptidic glucagon-like peptide-1 receptor agonist with in vivo activities显示文摘象 Glucagon 一样 peptide-1 (GLP-1 ) 基于治疗为治疗类型 2 糖尿病介绍一种有希望的选择。然而,在市场上或在开发中当前相对 peptidic GLP-1 mimetics 有几限制。这颗担心为 GLP-1 受体(GLP-1R ) 为 non-peptidic 收缩筋在搜索导致了继续的兴趣。这里,我们简短为 GLP-1R 考察发现,描述和 cyclobutane-derivative-based non-peptidic 收缩筋的一个新奇的班的当前的地位,包括 Boc5 和它的最新发现的类似物 WB4-24。尽管如此的混合物的口头的 bioavailability 仍然提出大挑战,到目前为止取得的进步鼓励我们识别一真正“ druggable ”为 GLP-1R 的小分子收缩筋。 | Min HE Ni GUAN Wei-wei GAO Qing LIU Xiao-yan WU Da-wei MA Da-fang ZHONG Guang-bo GE Chuan LI Xiao-yan CHEN LingYANG Jia-yu LIAO Ming-wei WANG | 2012 | Acta Pharmacologica Sinica2012，33，2： | 5 |
| 2 | Genome wide association study identifies SNPs associated with fatty acid composition in Chinese Wagyu cattle显示文摘Background: Fatty acids are important traits that affect meat quality and nutritive values in beef cattle. Detection of genetic variants for fatty acid composition can help to elucidate the genetic mechanism underpinning these traits and promote the improvement of fatty acid profiles. In this study, we performed a genome-wide association study(GWAS) on fatty acid composition using high-density single nucleotide polymorphism(SNP) arrays in Chinese Wagyu cattle.Results: In total, we detected 15 and 8 significant genome-wide SNPs for individual fatty acids and fatty acid groups in Chinese Wagyu cattle, respectively. Also, we identified nine candidate genes based on 100 kb regions around associated SNPs. Four SNPs significantly associated with C14:1 cis-9 were embedded with stearoyl-CoA desaturase(SCD), while three SNPs in total were identified for C22:6 n-3 within Phospholipid scramblase family member 5(PLSCR5), Cytoplasmic linker associated protein 1(CLASP1), and Chymosin(CYM). Notably, we found the top candidate SNP within SCD can explain ~ 7.37% of phenotypic variance for C14:1 cis-9.Moreover, we detected several blocks with high LD in the 100 kb region around SCD. In addition, we found three significant SNPs within a 100 kb region showing pleiotropic effects related to multiple FA groups(PUFA,n-6, and PUFA/SFA), which contains BAI1 associated protein 2 like 2(BAIAP2 L2), MAF bZIP transcription factor F(MAFF),and transmembrane protein 184 B(TMEM184 B).Conclusions: Our study identified several significant SNPs and candidate genes for individual fatty acids and fatty acid groups in Chinese Wagyu cattle, and these findings will further assist the design of breeding programs for meat quality in cattle. | Zezhao Wang Bo Zhu Hong Niu Wengang Zhang Ling Xu Lei Xu Yan Chen Lupei Zhang Xue Gao Huijiang Gao Shengli Zhang Lingyang Xu Junya Li | 2019 | Journal of Animal Science and Biotechnology2019，10，2： | 4 |
| 3 | Rolling up MXene sheets into scrolls to promote their anode performance in lithium-ion batteries显示文摘Although Ti3 C2 MXene sheets have attracted extensive attention in lithium-ion storage techniques,their restacking makes against and even hinders the Li ions diffusion within them,thereby decreasing the capacity as well as rate performance of conventional MXene anode.Here,for the first time,we roll up the Ti3 C2 Tx sheets into scrolls with unclosed topological structure and the interlayer galleries to alleviate the restacking problem.Thus,Ti3 C2 Tx scrolls as anode materials in lithium-ion batteries(LIBs)have higher capacity and better rate performance than Ti3 C2 Tx sheets.On the bases of these,high-capacity silicon nanoparticles are added during the rolling process to in-situ produce Ti3 C2 Tx/Si composite scrolls.The addition of 10%silicon nanoparticles shows the best overall improvement among capacity,rate capability and cyclic stability for Ti3 C2 Tx scrolls. | Jianing Meng Fangfang Zhang Li Zhang Lingyang Liu Jiangtao Chen Bingjun Yang Xingbin Yan | 2020 | Journal of Energy Chemistry2020，29，7： | 4 |
| 4 | KLF4 is a tumor suppressor in anaplastic meningioma stem-like cells and human rneningiomas显示文摘 | Hailiang Tang Hongda Zhu Xuanchun Wang Lingyang Hua Jingrun Li Qing Xie Xiancheng Chen Tao Zhang Ye Gong | 2017 | Journal of Molecular Cell Biology2017，9，4： | 3 |
| 5 | Effect of carboxylic acid groups on the supercapacitive performance of functional carbon frameworks derived from bacterial cellulose显示文摘Three-dimensional(3D) carbonaceous materials derived from bacterial cellulose(BC) has been introduced as electrode for supercapacitors in recent. Here, we report a simple strategy for the synthesis of functional carbon frameworks through 2,2,6,6-tetramethylpilperidine 1-oxyl radical(TEMPO)-mediated oxidation of bacterial cellulose(BC) followed by carbonization. TEMPO-mediated oxidation can efficiently convert the hydroxyls on the surface of BC to carboxylate groups to improve electrochemical activity. Because of its high porosity, good hydrophilicity, rich oxygen groups, and continuous ion transport in-between sheet-like porous network, the TEMPO-oxidized BC delivers a much higher gravimetric capacitance(137.3 F/g) at low annealing temperature of 500℃ than that of pyrolysis BC(31 F/g) at the same annealing temperature. The pyrolysis modified BC obtained at 900℃ shows specific capacitance(160.2 F/g), large current stability and long-term stability(84.2% of its initial capacitance retention after 10,000 cycles). | Tianyun Zhang Junwei Lang Li Liu Lingyang Liu Hongxia Li Yipeng Gu Xingbin Yan Xin Ding | 2017 | Chinese Chemical Letters2017，28，12： | 2 |
| 6 | Molecular diagnosis and treatment of meningiomas:an expert consensus(2022)显示文摘Meningiomas are the most common primary intracranial neoplasm with diverse pathological types and complicated clinical manifestations.The fifth edition of the WHO Classification of Tumors of the Central Nervous System(WHO CNS5),published in 2021,introduces major changes that advance the role of molecular diagnostics in meningiomas.To follow the revision of WHO CNS5,this expert consensus statement was formed jointly by the Group of Neuro-Oncology,Society of Neurosurgery,Chinese Medical Association together with neuropathologists and evidence-based experts.The consensus provides reference points to integrate key biomarkers into stratification and clinical decision making for meningioma patients. | Jiaojao Deng Lingyang Hua Liuguan Bian Hong Chen Ligang Chen Hongwei Cheng Changwu Dou Dangmurenjiapu Geng Tao Hong Hongming Ji Yugang Jiang Qing Lan Gang Li Zhixiong Liu Songtao Qi Yan Qu Songsheng Shi Xiaochuan Sun Hajun Wang Yongping You Hualin Yu Shuyuan Yue Jianming Zhang Xiaohua Zhang Shuo Wang Ying Mao Ping Zhong Ye Gong Group of Neuro-Oncology Society of Neurosurgery Chinese Medical Association | 2022 | Chinese Medical Journal2022，135，16： | 1 |
| 7 | Selection of an Effective Small Interference RNA to Silence Myostatin Gene Expression in Sheep Fibroblast Cells显示文摘 | Jian Lu Dan Sun Lingyang Xu Guobin Lu Fuping Zhao Caihong Wei Li Zhang Jiatong Ding Bichun Li Lixin Du | 2012 | Biochemical Genetics2012，，11： | 1 |
| 8 | Incorporating kernelized multi-omics data improves the accuracy of genomic prediction显示文摘Background:Genomic selection(GS)has revolutionized animal and plant breeding after the first implementation via early selection before measuring phenotypes.Besides genome,transcriptome and metabolome information are increasingly considered new sources for GS.Difficulties in building the model with multi-omics data for GS and the limit of specimen availability have both delayed the progress of investigating multi-omics.Results:We utilized the Cosine kernel to map genomic and transcriptomic data as n×n symmetric matrix(G matrix and T matrix),combined with the best linear unbiased prediction(BLUP)for GS.Here,we defined five kernel-based prediction models:genomic BLUP(GBLUP),transcriptome-BLUP(TBLUP),multi-omics BLUP(MBLUP,M=ratio×G+(1-ratio)×T),multi-omics single-step BLUP(mss BLUP),and weighted multi-omics single-step BLUP(wmss BLUP)to integrate transcribed individuals and genotyped resource population.The predictive accuracy evaluations in four traits of the Chinese Simmental beef cattle population showed that(1)MBLUP was far preferred to GBLUP(ratio=1.0),(2)the prediction accuracy of wmss BLUP and mss BLUP had 4.18%and 3.37%average improvement over GBLUP,(3)We also found the accuracy of wmss BLUP increased with the growing proportion of transcribed cattle in the whole resource population.Conclusions:We concluded that the inclusion of transcriptome data in GS had the potential to improve accuracy.Moreover,wmss BLUP is accepted to be a promising alternative for the present situation in which plenty of individuals are genotyped when fewer are transcribed. | Mang Liang Bingxing An Tianpeng Chang Tianyu Deng Lili Du Keanning Li Sheng Cao Yueying Du Lingyang Xu Lupei Zhang Xue Gao Junya Li Huijiang Gao | 2023 | Journal of Animal Science and Biotechnology2023，14，1： | 0 |
| 9 | Deep Reinforcement Learning Based Charging Scheduling for Household Electric Vehicles in Active Distribution Network显示文摘With the booming of electric vehicles(EVs) across the world, their increasing charging demands pose challenges to urban distribution networks. Particularly, due to the further implementation of time-of-use prices, the charging behaviors of household EVs are concentrated on low-cost periods, thus generating new load peaks and affecting the secure operation of the medium-and low-voltage grids. This problem is particularly acute in many old communities with relatively poor electricity infrastructure. In this paper, a novel two-stage charging scheduling scheme based on deep reinforcement learning is proposed to improve the power quality and achieve optimal charging scheduling of household EVs simultaneously in active distribution network(ADN) during valley period. In the first stage, the optimal charging profiles of charging stations are determined by solving the optimal power flow with the objective of eliminating peak-valley load differences. In the second stage, an intelligent agent based on proximal policy optimization algorithm is developed to dispatch the household EVs sequentially within the low-cost period considering their discrete nature of arrival. Through powerful approximation of neural network, the challenge of imperfect knowledge is tackled effectively during the charging scheduling process. Finally, numerical results demonstrate that the proposed scheme exhibits great improvement in relieving peak-valley differences as well as improving voltage quality in the ADN. | Taoyi Qi Chengjin Ye Yuming Zhao Lingyang Li Yi Ding | 2023 | Journal of Modern Power Systems and Clean Energy2023，11，6： | 0 |
| 10 | Achieving grain refinement ofα-Al and Si modification simultaneously by La-B-Sr addition in Al-10Si alloys显示文摘As-cast Al-Si alloys always face low ductility because of coarseα-Al grains and large lamellar eutectic Si.Although B-containing refiners and Sr modifiers could refine theα-Al grains and eutectic Si respec-tively,simultaneous addition leads to an invalid effect of Sr because B-containing refiner has a poison-ing effect(PE)on Sr modifier in the Al-10Si-B-Sr alloys.The present work achieves both refinement ofα-Al grains and modification of Si merely by the addition of 500 ppm La in Al-10Si-0.02B-0.015Sr alloy,which greatly enhances the ductility and tensile strength.Sr-B interaction in the Al-10Si-0.02B-0.015Sr melt results in a consumption of Sr by forming Sr-B intermetallic compound.CALPHAD-type calculations reveal that Sr concentration in liquid before eutectic reaction becomes a key parameter to estimate the alloying modification effect.The addition of La forms LaB 6 and thereby releases Sr to protect the Sr modification effect.First-principles calculations illustrate that both Sr and La are benefi-cial to the formation of twin boundaries in Si particles due to their negative formation energy of twin boundaries.The formed LaB 6 has a semicoherent interface withα-Al with the orientation relationship of[110]_(LaB6)//[110]_(Al) and(111)_(LaB6)//(111)_(Al),demonstrating that LaB 6 is an efficient nucleation site forα-Al,which contributes to the refinement ofα-Al in the Al-10Si-0.05La-0.02B-0.015Sr alloy.Our findings re-veal the micro-mechanism of refinement during the solidification process and develop an effective and simple way to obtain high-performance Al alloys. | Qun Luo Xingrui Li Qian Li Lingyang Yuan Liming Peng Fusheng Pan Wenjiang Ding | 2023 | Journal of Materials Science & Technology2023，，4： | 0 |
| 11 | Dependence of lithium metal battery performances on inherent separator porous structure regulation显示文摘Boosting of rechargeable lithium metal batteries(LMBs) holds challenges because of lithium dendrites germination and high-reactive surface feature.Separators may experience structure-determined chemical deterioration and worsen Li plating-stripping behaviors when smoothly shifting from lithium-ion batteries(LIBs) to LMBs.This study precisely regulations the crystal structure of β-polypropylene and separator porous construction to investigate the intrinsic porous structure and mechanical properties determined electrochemical performances and cycling durability of LMBs.Crystal structure characterizations,porous structure analyses,and electrochemical cycling tests uncover appropriate annealing thermal stimulation concentrates β-lamellae thickness and enhances lamellae thermal stability by rearranging molecular chain in inferior β-lamellae,maximally homogenizing biaxial tensile deformation and resultant porous constructions.These even pores with high connectivity lower ion migration barriers,alleviate heterogeneous Li^(+) flux dispersion,stabilize reversible Li plating-stripping behaviors,and hinder coursing and branching of Li dendrites,endowing steady cell cycling durability,especially at higher currents due to the highlighted uncontrollable cumulation of dead Li,which offers new insights for the current pursuit of high-power density battery and fast charging technology.The suggested separator structure-chemical nature functions in ensuring cyclic cell stability and builds reliable relationships between separator structure design and practical LMBs applications. | Lei Ding Dandan Li Lingyang Liu Pengfang Zhang Fanghui Du Chao Wang Daoxin Zhang Shuo Zhang Sihang Zhang Feng Yang | 2023 | Journal of Energy Chemistry2023，，9： | 0 |
| 12 | The eQTL colocalization and transcriptome‑wide association study identify potentially causal genes responsible for economic traits in Simmental beef cattle显示文摘Background A detailed understanding of genetic variants that affect beef merit helps maximize the efficiency of breeding for improved production merit in beef cattle.To prioritize the putative variants and genes,we ran a com-prehensive genome-wide association studies(GWAS)analysis for 21 agronomic traits using imputed whole-genome variants in Simmental beef cattle.Then,we applied expression quantitative trait loci(eQTL)mapping between the genotype variants and transcriptome of three tissues(longissimus dorsi muscle,backfat,and liver)in 120 cattle.Results We identified 1,580 association signals for 21 beef agronomic traits using GWAS.We then illuminated 854,498 cis-eQTLs for 6,017 genes and 46,970 trans-eQTLs for 1,903 genes in three tissues and built a synergistic network by integrating transcriptomics with agronomic traits.These cis-eQTLs were preferentially close to the transcription start site and enriched in functional regulatory regions.We observed an average of 43.5%improvement in cis-eQTL discovery using multi-tissue eQTL mapping.Fine-mapping analysis revealed that 111,192,and 194 variants were most likely to be causative to regulate gene expression in backfat,liver,and muscle,respectively.The transcriptome-wide association studies identified 722 genes significantly associated with 11 agronomic traits.Via the colocalization and Mendelian randomization analyses,we found that eQTLs of several genes were associated with the GWAS signals of agronomic traits in three tissues,which included genes,such as NADSYN1,NDUFS3,LTF and KIFC2 in liver,GRAMD1C,TMTC2 and ZNF613 in backfat,as well as TIGAR,NDUFS3 and L3HYPDH in muscle that could serve as the candidate genes for economic traits.Conclusions The extensive atlas of GWAS,eQTL,fine-mapping,and transcriptome-wide association studies aid in the suggestion of potentially functional variants and genes in cattle agronomic traits and will be an invaluable source for genomics and breeding in beef cattle. | Wentao Cai Yapeng Zhang Tianpeng Chang Zezhao Wang Bo Zhu Yan Chen Xue Gao Lingyang Xu Lupei Zhang Huijiang Gao Jiuzhou Song Junya Li | 2023 | Journal of Animal Science and Biotechnology2023，14，5： | 0 |
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