|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | GL3.3, a Novel QTL Encoding a GSK3/SHAGGY- like Kinase, Epistatically Interacts with GS3 to Produce Extra-long Grains in Rice显示文摘 | Duo Xia Nao Zhou Rongjia Liu Wenhan Dan Pingbo Li Bian Wu Junxiao Chen Lingqiang Wang Guanjun Gao Qinglu Zhang Yuqing He | 2018 | Molecular Plant2018，11，5： | 41 |
| 2 | Neddylation of PTEN regulates its nuclear import and promotes tumor development显示文摘PTEN tumor suppressor opposes the PI3K/Akt signaling pathway in the cytoplasm and maintains chromosomal integrity in the nucleus.Nucleus–cytoplasm shuttling of PTEN is regulated by ubiquitylation,SUMOylation and phosphorylation,and nuclear PTEN has been proposed to exhibit tumor-suppressive functions.Here we show that PTEN is conjugated by Nedd8 under high glucose conditions,which induces PTEN nuclear import without effects on PTEN stability.PTEN neddylation is promoted by the XIAP ligase and removed by the NEDP1 deneddylase.We identify Lys197 and Lys402 as major neddylation sites on PTEN.Neddylated PTEN accumulates predominantly in the nucleus and promotes rather than suppresses cell proliferation and metabolism.The nuclear neddylated PTEN dephosphorylates the fatty acid synthase(FASN)protein,inhibits the TRIM21-mediated ubiquitylation and degradation of FASN,and then promotes de novo fatty acid synthesis.In human breast cancer tissues,neddylated PTEN correlates with tumor progression and poor prognosis.Therefore,we demonstrate a previously unidentified pool of nuclear PTEN in the Nedd8-conjugated form and an unexpected tumor-promoting role of neddylated PTEN. | Ping Xie Zhiqiang Peng Yujiao Chen Hongchang Li Mengge Du Yawen Tan Xin Zhang Zhe Lu Chun-Ping Cui Cui Hua Liu Fuchu He Lingqiang Zhang | 2021 | Cell Research2021，31，3： | 11 |
| 3 | Prognostic significance of neutrophil to lymphocyte ratio in patients with hepatocellular carcinoma after transcatheter arterial chemoembolization显示文摘 | Xu Xinsen Chen Wei Zhang Lingqiang Miao Runchen Zhou Yanyan Wan Yong Dong Yafeng Liu Chang | 2014 | Chinese Medical Journal2014，，24： | 10 |
| 4 | MiR-98 promotes chondrocyte apoptosis by decreasing Bcl-2 expression in a rat model of osteoarthritis显示文摘 | Jing Wang Lingqiang Chen Song Jin Jun Lin Hongmei Zheng Hong Zhang Hongtao Fan Fang He Sha Ma Qin Li | 2016 | Acta Biochimica et Biophysica Sinica2016，48，10： | 8 |
| 5 | CKIP-1 regulates macrophage proliferation by inhibiting TRAF6-mediated Akt activation显示文摘巨噬细胞在开发,动态平衡,织物修理和免疫起枢轴的作用。巨噬细胞增长被刺激殖民地的因素(M-CSF ) 导致了 Akt 发信号的巨噬细胞支持;然而,这个过程怎么被终止,仍然保持不清楚。这里,我们作为巨噬细胞增长的一个新奇禁止者识别酷蛋白 kinase 2-interacting protein-1 (CKIP-1 ) 。在放松巨噬细胞, CKIP-1 是在由组成地活跃的 GSK3β 的丝氨酸 342 点的 phosphorylated;, Akt 的下游的目标。这 phosphorylation 触发 CKIP-1 的 polyubiquitination 和 proteasomal 降级。在 M-CSF 刺激之上, Akt 被 CSF-1R-PI3K 激活然后使 GSK3β 失去活性;,导致 CKIP-1 和 β 的稳定; -catenin 蛋白质。β -catenin 包括 cyclin D 和 c-Myc 支持增长基因的表示。CKIP-1 与 TRAF6,为连接 K63 的 ubiquitination 要求的 ubiquitin ligase 和 Akt 的血浆膜招募交往,并且终止调停 TRAF6 的 Akt 激活。由这个工具, CKIP-1 在 M-CSF 刺激以后在迟了的阶段明确地禁止巨噬细胞增长。而且, CKIP-1 缺乏在老鼠自发地开发的 vitro 和 CKIP-1 −/− 导致增加的增长和巨噬细胞的减少的 apoptosis 巨噬细胞主导的脾大和 myeloproliferation。一起,这些数据证明 CKIP-1 由禁止调停 TRAF6 的 Akt 激活在巨噬细胞动态平衡的规定起一个关键作用。 | Luo Zhang Yiwu Wang Fengjun Xiao Shaoxia Wang Guichun Xing Yang Li Xiushan Yin Kefeng Lu Rongfei Wei Jiao Fan Yuhan Chen Tao Li Ping Xie Lin Yuan Lei Song Lanzhi Ma Lujing Ding Fuchu He Lingqiang Zhang | 2014 | Cell Research2014，24，6： | 7 |
| 6 | Mycobacterium tuberculosis Mce2E suppresses the macrophage innate immune response and promotes epithelial cell proliferation显示文摘The intracellular pathogen Mycobacterium tuberculosis(Mtb)can survive in the host and cause disease by interfering with a variety of cellular functions.The mammalian cell entry 2(mce2)operon of Mtb has been shown to contribute to tuberculosis pathogenicity.However,little is known about the regulatory roles of Mtb Mce2 family proteins towards host cellular functions.Here we show that the Mce2 family protein Mce2E suppressed the macrophage innate immune response and promoted epithelial cell proliferation.Mce2E inhibited activation of the extracellular signal-regulated kinase(ERK)and Jun N-terminal kinase(JNK)mitogen-activated protein kinase(MAPK)signaling pathways in a non-canonical D motif(a MAPK-docking motif)-dependent manner,leading to reduced expression of TNF and IL-6 in macrophages.Furthermore,Mce2E promoted proliferation of human lung epithelium-derived lung adenoma A549 cells by inhibiting K48-linked polyubiquitination of eEF1A1 in aβstrand region-dependent manner.In summary,Mce2E is a novel multifunctional Mtb virulence factor that regulates host cellular functions in a niche-dependent manner.Our data suggest a potential novel target for TB therapy. | Lihua Qiang Jing Wang Yong Zhang Pupu Ge Qiyao Chai Bingxi Li Yi Shi Lingqiang Zhang George Fu Gao Cui Hua Liu | 2019 | Cellular & Molecular Immunology2019，16，4： | 7 |
| 7 | The function and regulation of OTU deubiquitinases显示文摘Post-translational modification of cellular proteins by ubiquitin regulates numerous cellular processes,including cell division,immune responses,and apoptosis.Ubiquitin-mediated control over these processes can be reversed by deubiquitinases(DUBs),which remove ubiquitin from target proteins and depolymerize polyubiquitin chains.Recently,much progress has been made in the DUBs.In humans,the ovarian tumor protease(OTU)subfamily of DUBs includes 16 members,most of which mediate cell signaling cascades.These OTUs show great variation in structure and function,which display a series of mechanistic features.In this review,we provide a comprehensive analysis of current progress in character,structure and function of OTUs,such as the substrate specificity and catalytic activity regulation.Then we discuss the relationship between some diseases and OTUs.Finally,we summarize the structure of viral OTUs and their function in immune escape and viral survival.Despite the challenges,OTUs might provide new therapeutic targets,due to their involvement in key regulatory processes. | Jiansen Du Lin Fu Yingli Sui Lingqiang Zhang | 2020 | Frontiers of Medicine2020，14，5： | 4 |
| 8 | Exploring the diagnosis markers for gallbladder cancer based on clinical data显示文摘一会儿,没有有效标记是可得到的便于胆囊癌症(GBC ) 诊断。这研究试图为 GBC 诊断探索可得到的标记。144 GBC 和 116 个胆石病病人的临床的数据回顾地被考察。逻辑回归分析被执行评估 GBC 风险因素。操作特征(巨鸟) 曲线的接收装置被用来估计风险因素的诊断价值。由比较 GBC 和胆石病病人的特征,下列因素展出了统计差别:年龄,性,胆石,全部的 bilirubin (TB ) ,碱的磷酸酶(高山) , aspartate aminotransferase (著名计算机生产厂商) ,丙氨酸 aminotransferase (中高音) ,血小板计数(PLT ) , CA125 (carcinoembryonic 抗原 125 ) ,和 CA199 (糖类抗原 199 ) 。逻辑回归分析显示了那年龄[机会比率(或) , 1.032;95%confidence 间隔(95% CI ) , 1.004 ~ 1.061;P = 0.024 ] ,性(或, 0.346;95% CI, 0.167 ~ 0.716;P = 0.004 ) ,胆石(或, 0.027;95% CI, 0.007 ~ 0.095;P < 0.001 ) ,高山(或, 1.003;95% CI, 1.000 ~ 1.006;P = 0.032 ) , TB (或, 1.004;95% CI, 1.000 ~ 1.009;P = 0.042 ) ,并且 CA125 (或, 1.007;95% CI, 1.002 ~ 1.013;P = 0.011 ) 是为 GBC 的独立风险因素。根据巨鸟曲线, CA125 [在曲线(AUC ) 下面的区域, 0.720 ] ,高山(AUC, 0.713 ) , TB (AUC, 0.636 ) ,并且年龄(AUC, 0.573 ) 是珍贵诊断标记。基于独立风险因素,另外, GBC 诊断模型被建立。年龄, TB,高山,和 CA125 能被用作 GBC 的辅助诊断因素。当包括地考虑各种各样的风险因素时,诊断模型为 GBC 诊断提供一个量的工具。 | Lingqiang Zhang Runchen Miao Xiude Zhang Wei Chen Yanyan Zhou Ruitao Wang Ruiyao Zhang Qing Pang Xinsen Xu Chang Liu | 2015 | Frontiers of Medicine2015，9，3： | 4 |
| 9 | CKIP-1 suppresses the adipogenesis of mesenchymal stem cells by enhancing HDACl-associated repression of C/EBPα显示文摘 | Dahu Li HengZhu Chao Liang Wenbo Li Guichun Xing Lanzhi Ma Lujing Ding Yi Zhang Fuchu He Lingqiang Zhang | 2014 | Journal of Molecular Cell Biology2014，8，5： | 4 |
| 10 | Gravity variations before the Menyuan Ms6.4 earthquake显示文摘In order to study the relationship between gravity variation and Menyuan Ms6.4 earthquake, gravity variation characteristics in mid-eastern of Qilian Mountain were analyzed based on the 2012-2015 relative gravity datasets. The results indicated that the gravity changes in mid-eastern of Qilian Mountain increased gradually, while gravity changes around Menyuan remarkably. Besides, great positive-negative gravity changing gradients appeared along the Lenglongling Fault which was located at the north of Menyuan, and the 2016 Menyuan Ms6.4 earthquake occurred near the junction of positive and negative gravity changes. | Weifeng Liang Guoqing Zhang Yiqing Zhu Yunma Xu Shusong Guo Yunfeng Zhao Fang Liu Lingqiang Zhao | 2016 | Geodesy and Geodynamics2016，7，4： | 3 |
| 11 | The deubiquitinase OTUD1 inhibits colonic inflammation by suppressing RIPK1-mediated NF-κB signaling显示文摘The E3 ubiquitin ligase(E3)-mediated ubiquitination and deubiquitinase(DUB)-mediated deubiquitination processes are closely associated with the occurrence and development of colonic inflammation.Ovarian tumor deubiquitinase 1(OTUD1)is involved in immunoregulatory functions linked to infectious diseases.However,the effect of OTUD1 on intestinal immune responses during colonic inflammatory disorders such as inflammatory bowel disease(IBD)remains unclear.Here,we show that loss of OTUD1 in mice contributes to the pathogenesis of dextran sulfate sodium(DSS)-induced colitis via excessive release of proinflammatory cytokines.In addition,bone marrow transplantation experiments revealed that OTUD1 in hematopoietic cells plays a dominant role in protection against colitis.Mechanistically,OTUD1 physically interacts with receptor-interacting serine/threonine-protein kinase 1(RIPK1)and selectively cleaves K63-linked polyubiquitin chains from RIPK1 to inhibit the recruitment of NF-κB essential modulator(NEMO).Moreover,the expression of OTUD1 in mucosa samples from ulcerative colitis(UC)patients was lower than that in mucosa samples from healthy controls.Furthermore,we demonstrate that the UC-associated OTUD1 G430V mutation abolishes the ability of OTUD1 to inhibit RIPK1-mediated NF-κB activation and intestinal inflammation.Taken together,our study unveils a previously unexplored role of OTUD1 in moderating intestinal inflammation by inhibiting RIPK1-mediated NF-κB activation,suggesting that the OTUD1-RIPK1 axis could be a potential target for the treatment of IBD. | Bo Wu Lihua Qiang Yong Zhang Yesheng Fu Mengyuan Zhao Zehui Lei Zhe Lu Yan-Ge Wei Hongmiao Dai Yingwei Ge Mingqiu Liu Xuemei Zhou Zhiqiang Peng Hongchang Li Chun-Ping Cui Jing Wang Hui Zheng Cui Hua Liu Lingqiang Zhang | 2022 | Cellular & Molecular Immunology2022，19，2： | 3 |
| 12 | OTUD5 promotes innate antiviral and antitumor immunity through deubiquitinating and stabilizing STING显示文摘Stimulator of interferon genes(STING)is an adaptor protein that is critical for effective innate antiviral and antitumor immunity.The activity of STING is heavily regulated by protein ubiquitination,which is fine-tuned by both E3 ubiquitin ligases and deubiquitinases.Here,we report that the deubiquitinase OTUD5 interacts with STING,cleaves its K48-linked polyubiquitin chains,and promotes its stability.Consistently,knockout of OTUD5 resulted in faster turnover of STING and subsequently impaired type I IFN signaling following cytosolic DNA stimulation.More importantly,Lyz2-Cre Otud5^(fl/Y) mice and CD11-Cre Otud5^(fl/Y) mice showed more susceptibility to herpes simplex virus type 1(HSV-1)infection and faster development of melanomas than their corresponding control littermates,indicating that OTUD5 is indispensable for STING-mediated antiviral and antitumor immunity.Our data suggest that OTUD5 is a novel checkpoint in the cGAS-STING cytosolic DNA sensing pathway. | Yunyun Guo Fei Jiang Lingli Kong Haifeng Wu Honghai Zhang Xiaorong Chen Jian Zhao Baoshan Cai Yanqi Li Chunhong Ma Fan Yi Lei Zhang Bingyu Liu Yi Zheng Lingqiang Zhang Chengjiang Gao | 2021 | Cellular & Molecular Immunology2021，18，8： | 2 |
| 13 | DNA damage stress induces the dissociation of Smurf1/2 from MDM2 in a slow manner显示文摘The tumor suppressor p53 locates at the key point of cell growth or apoptosis balance, and the expression level of p53 is tightly controlled by ubiquitin ligases including MDM2. Upon DNA damage stresses, p53 was accumulated and activated, leading to cell cycle arrest or apoptosis. We previously showed that Smad ubiquitylation regulatory factor 1/2 (Smurf1/2) promotes p53 degradation by interacting with and stabilizing MDM2, and consequently enhancing MDM2-mediated ubiquitylation of p53. However, it is unclear how the Smurf1-MDM2 interaction is regulated in response to DNA damage stress. Here, we show that in response to etoposide treatment Smurf1 dissociates from MDM2, resulting in MDM2 destabilization and p53 accumulation. The negative regulation of Smurf1 on apoptosis is released. Notably, this dissociation is a slow process rather than a rapid response, implicating high expression of Smurf1 might confer the resistance against p53 activation. Consistent with this notion, we observed that Smurf1/2 ligases are highly expressed in colon cancer, esophageal squamous cell carcinoma and pancreatic cancer tissues, suggesting the oncogenic tendency of Smurf1/2. | NIE Jing LIU Lin ZHAO XiaoHang XIE Ping ZHOU PingKun XING GuiChun LIU XiangJun HE FuChu HAN WeiDong ZHANG LingQiang | 2011 | Chinese Science Bulletin2011，56，30： | 2 |
| 14 | TRIM27 maintains gut homeostasis by promoting intestinal stem cell self-renewal显示文摘Dysregulation of gut homeostasis is associated with irritable bowel syndrome(IBS),a chronic functional gastrointestinal disorder affecting approximately 11.2%of the global population.The poorly understood pathogenesis of IBS has impeded its treatment.Here,we report that the E3 ubiquitin ligase tripartite motif-containing 27(TRIM27)is weakly expressed in IBS but highly expressed in inflammatory bowel disease(IBD),a frequent chronic organic gastrointestinal disorder.Accordingly,knockout of Trim27 in mice causes spontaneously occurring IBS-like symptoms,including increased visceral hyperalgesia and abnormal stool features,as observed in IBS patients.Mechanistically,TRIM27 stabilizesβ-catenin and thus activates Wnt/β-catenin signaling to promote intestinal stem cell(ISC)self-renewal.Consistent with these findings,Trim27 deficiency disrupts organoid formation,which is rescued by reintroducing TRIM27 orβ-catenin.Furthermore,Wnt/β-catenin signaling activator treatment ameliorates IBS symptoms by promoting ISC self-renewal.Taken together,these data indicate that TRIM27 is critical for maintaining gut homeostasis,suggesting that targeting the TRIM27/Wnt/β-catenin axis could be a potential treatment strategy for IBS.Our study also indicates that TRIM27 might serve as a potential biomarker for differentiating IBS from IBD. | Jing Wang Dongdong Zhao Zehui Lei Pupu Ge Zhe Lu Qiyao Chai Yong Zhang Lihua Qiang Yang Yu Xinwen Zhang Bingxi Li Shu Zhu Lingqiang Zhang Cui Hua Liu | 2023 | Cellular & Molecular Immunology2023，20，2： | 2 |
| 15 | On adjunctions between Lim,SLTop,and SL-Lim显示文摘 | Li Lingqiang Jin Qiu | | 0，，182： | 1 |
| 16 | On stratified L-convergence spaces:Pretopological axioms and diagonal axioms显示文摘 | Li Lingqiang Jin Qiu | | 0，，204： | 1 |
| 17 | Multimodal Sentiment Analysis Using BiGRU and Attention-Based Hybrid Fusion Strategy显示文摘Recently,multimodal sentiment analysis has increasingly attracted attention with the popularity of complementary data streams,which has great potential to surpass unimodal sentiment analysis.One challenge of multimodal sentiment analysis is how to design an efficient multimodal feature fusion strategy.Unfortunately,existing work always considers feature-level fusion or decision-level fusion,and few research works focus on hybrid fusion strategies that contain feature-level fusion and decision-level fusion.To improve the performance of multimodal sentiment analysis,we present a novel multimodal sentiment analysis model using BiGRU and attention-based hybrid fusion strategy(BAHFS).Firstly,we apply BiGRU to learn the unimodal features of text,audio and video.Then we fuse the unimodal features into bimodal features using the bimodal attention fusion module.Next,BAHFS feeds the unimodal features and bimodal features into the trimodal attention fusion module and the trimodal concatenation fusion module simultaneously to get two sets of trimodal features.Finally,BAHFS makes a classification with the two sets of trimodal features respectively and gets the final analysis results with decision-level fusion.Based on the CMU-MOSI and CMU-MOSEI datasets,extensive experiments have been carried out to verify BAHFS’s superiority. | Zhizhong Liu Bin Zhou Lingqiang Meng Guangyu Huang | 2023 | Intelligent Automation & Soft Computing2023，37，8： | 1 |
| 18 | Differential regulation of Apak by various DNA damage signals显示文摘 | Shan Wang Chunyan Tian Tingtiang Xiao Guichun Xing Fuchu He Lingqiang Zhang Hong Chen | 2010 | Molecular and Cellular Biochemistry (-)2010，，1： | 1 |
| 19 | On adjunctions between Lim,SL-Top,and SL-Lim显示文摘 | Lingqiang Li Qiu Jin | | 0，，182： | 1 |
| 20 | On stratified L-convergence spaces:Pretopological axioms and diagonal axioms显示文摘 | Lingqiang Li Qiu Jin | | 0，，204： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员