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| 1 | Liver expression of steroid hormones and Apolipoprotein D receptors in hepatocellular carcinoma显示文摘AIM: To evaluate the tissular expression of Androgen (A), Estrogen (E) and Progesterone (Pg) receptors, and Apolipoprotein D (ApoD), in liver tumors from resected hepatocellular carcinoma (HCC) cases in order to assess their possible relationship to prognosis. METHODS: We performed an immunohistochemical study using tissue microarrays (containing more than 260 cancer specimens, from 31 HCC patients and controls) to determine the presence of specif ic antibodies against AR, ER, PgR and ApoD, correlating their findings with several clinico-pathological and biological variables. The staining results were categorized using a semi-quantitive score based on their intensity, and the percentage of immunostained cells was measured. RESULTS: A total of 21 liver tumors (67.7%) were positive for AR; 16 (51.6%) for ER; 26 (83.9%) for PgR and 12 (38.7%) stained for ApoD. We have found a wide variability in the immunostaining score values for each protein, with a median (range) of 11.5 (11.5-229.5) for AR; 11.1 (8.5-65) for ER; 14.2 (4-61) for PgR; and 37.7 (13.8-81.1) for ApoD. A history of heavy ethanol consumption, correlated positively with AR and PgR and negatively with ER status. HCV chronic infection also correlated positively with AR and PgR status. However, the presence of ApoD immunostaining did not correlate with any of these variables. Tumors with a positive immuno-staining for PgR showed a better prognosis. CONCLUSION: Our results indicate a moderate clinical value of the steroid receptor status in HCC, emphasizing the need to perform further studies in order to evaluate the possible role of new hormonal-based therapies. | FJ Vizoso M Rodriguez A Altadill ML González-Diéguez A Linares LO González S Junquera F Fresno-Forcelledo MD Corte L Rodrigo | 2007 | World Journal of Gastroenterology2007，13，23： | 11 |
| 2 | National natural capital accounting with the ecological footprint concept显示文摘 | Mathis Wackernagel Larry Onisto Patricia Bello Alejandro Callejas Linares Ina Susana López Falfán Jesus Méndez Garc??a Ana Isabel Suárez Guerrero Ma Guadalupe Suárez Guerrero | 1999 | Ecological Economics1999，，3： | 5 |
| 3 | National natural capital accounting with the ecological footprint concept显示文摘 | Mathis Wackernagel Larry Onisto Patricia Bello Alejandro Callejas Linares Ina Susana López Falfán Jesus Méndez Garc??a Ana Isabel Suárez Guerrero Ma Guadalupe Suárez Guerrero | 1999 | Ecological Economics1999，，3： | 3 |
| 4 | HPLC-DAD法测定血满草中熊果酸和齐墩果酸的含量(英文)显示文摘建立了HPLC-DAD法测定血满草中熊果酸和齐墩果酸含量,并进行方法学考察。采用HPLC-DAD进行分析,fusion-RP C18柱(4.6 mm×250 mm,4μm),甲醇-0.2%磷酸水溶液(90∶10)为流动相,检测波长210 nm,体积流量1.0 mL/min。同时采用微波辅助提取、回流提取、索氏提取、冷浸提取、超声提取五种方法对血满草中熊果酸和齐墩果酸含量进行测定并比较不同方法所得结果的差异,还比较了血满草不同部位中熊果酸和齐墩果酸的含量差异。测定结果表明熊果酸进样量在3.6~8.4μg范围内,齐墩果酸进样量在3.2~16μg范围内,呈良好线性关系。血满草中熊果酸和齐墩果酸平均回收率分别为98.3%和101.4%(n=5),相对标准偏差分别为1.13%和0.72%(n=5)。五种方法比较得出索氏提取得熊果酸和齐墩果酸含量最高;血满草花中熊果酸和齐墩果酸含量最高,而根中含量最低。该方法使血满草中熊果酸和齐墩果酸达到基线分离,操作简便,结果稳定可靠。 | 罗智敏 Elisa linares Navarro 陶燕铎 邵赟 梅丽娟 | 2011 | 天然产物研究与开发2011，23，6： | 2 |
| 5 | Oxydation expérimentale de Fe-tourmalines et corrélation avec une déprotonation des groupes hydroxyle显示文摘 | Yves Fuchs Martine Lagache Jorge Linares | 2002 | Comptes rendus - Géoscience2002，，4： | 2 |
| 6 | Characterization and clinical impact of antinuclear antibodies in primary biliary cirrhosis显示文摘 | Paolo Muratori Luigi Muratori Rodolfo Ferrari Fabio Cassani Giampaolo Bianchi Marco Lenzi Luis Rodrigo Antonio Linares Dolores Fuentes Francesco B Bianchi | 2003 | The American Journal of Gastroenterology2003，，2： | 2 |
| 7 | Effect of Dif- ferent Gas Stunning Methods on Manchega Suckling Lamb Meat Packed under Different Modified Atmospheres 显示文摘 | BORNEZ R LINARES M B VERGARA H | 2010 | Meat Science2010，84，4： | 1 |
| 8 | Impacts of the European Emission Trading Scheme Directive and Permit Assignment Methods on the Spanish Electricity Sector显示文摘 | LINARES P SANTOS F J VENTOSA M LAPIEDRA L | 2006 | Energy Journal2006，27，1： | 1 |
| 9 | Effect of immediate or delayed loading following immediate placement of implants with a modified surface显示文摘 | Linares A Mardas N Dard M Donos N | 2010 | Clin Oral Implants Res2010，，： | 1 |
| 10 | Emulsfying and foaming properties of gluten hydrolysates with an increasing degree of hydrosis:role of soluble and insoluble fractions 显示文摘 | Linares E Larre C Lemeste M | 2000 | Cereal Chemistry2000，77，4： | 1 |
| 11 | NOM and TEP fouling of a forward osmosis (FO) membrane: Foulant identification and cleaning 显示文摘 | Valladares Linares R Yangali-Quintanilla V Li Z | 2012 | Journal of Membrane Science2012，，0： | 1 |
| 12 | Forward osmosis niches in seawater desalination and wastewater reuse 显示文摘 | LINARES R V LI Z SARP S | 2014 | Water Research2014，66，： | 1 |
| 13 | Lessons learned from the international renal cell carcino- ma-venous thrombus consortium (IRCC-VTC)显示文摘 | MARTfNEZ-SALAMANCA JI LINARES E GONZ~LEZ J | 2014 | Curr Urol Rep2014，15，5： | 1 |
| 14 | Infection-related mortality in a large cohort of renal transplant recipients显示文摘 | Linares L Cofdn F Cervera C | 2007 | Transplant Proc2007，39，7： | 1 |
| 15 | An evaluation of genetic distances for use with microsatelliteloci显示文摘 | Goldstein D B Linares A R Cavalli-Sforza L L | 1995 | Genetics1995，139，1： | 1 |
| 16 | Real-time EMTP-based transients simulation 显示文摘 | Marti J R Linares L R | 1994 | IEEE Trans on Power Systems1994，9，3： | 1 |
| 17 | Autoimmune thrombocytopenia associated with hepatitis C virus infection 显示文摘 | Blanquer A Linares M | 1998 | Acta Haematologica1998，99，4： | 1 |
| 18 | From wound to scar显示文摘 | Linares HA | 1996 | Burns1996，22，5： | 1 |
| 19 | Chronic idiopathic thrombocytopenic purpura in the elderly显示文摘 | Linares M Cervero A Colomina P | 1995 | Acta Haematol1995，93，24： | 1 |
| 20 | Effect of Gas Composition on Rabbit Meat Quality in Modified Atmos- phere Packaging显示文摘 | VERGARA H BERRUGA M I LINARES M | 2005 | Journal of the Science of Food and Ag- riculture2005，85，12： | 1 |
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