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| 1 | Liver expression of steroid hormones and Apolipoprotein D receptors in hepatocellular carcinoma显示文摘AIM: To evaluate the tissular expression of Androgen (A), Estrogen (E) and Progesterone (Pg) receptors, and Apolipoprotein D (ApoD), in liver tumors from resected hepatocellular carcinoma (HCC) cases in order to assess their possible relationship to prognosis. METHODS: We performed an immunohistochemical study using tissue microarrays (containing more than 260 cancer specimens, from 31 HCC patients and controls) to determine the presence of specif ic antibodies against AR, ER, PgR and ApoD, correlating their findings with several clinico-pathological and biological variables. The staining results were categorized using a semi-quantitive score based on their intensity, and the percentage of immunostained cells was measured. RESULTS: A total of 21 liver tumors (67.7%) were positive for AR; 16 (51.6%) for ER; 26 (83.9%) for PgR and 12 (38.7%) stained for ApoD. We have found a wide variability in the immunostaining score values for each protein, with a median (range) of 11.5 (11.5-229.5) for AR; 11.1 (8.5-65) for ER; 14.2 (4-61) for PgR; and 37.7 (13.8-81.1) for ApoD. A history of heavy ethanol consumption, correlated positively with AR and PgR and negatively with ER status. HCV chronic infection also correlated positively with AR and PgR status. However, the presence of ApoD immunostaining did not correlate with any of these variables. Tumors with a positive immuno-staining for PgR showed a better prognosis. CONCLUSION: Our results indicate a moderate clinical value of the steroid receptor status in HCC, emphasizing the need to perform further studies in order to evaluate the possible role of new hormonal-based therapies. | FJ Vizoso M Rodriguez A Altadill ML González-Diéguez A Linares LO González S Junquera F Fresno-Forcelledo MD Corte L Rodrigo | 2007 | World Journal of Gastroenterology2007，13，23： | 11 |
| 2 | National natural capital accounting with the ecological footprint concept显示文摘 | Mathis Wackernagel Larry Onisto Patricia Bello Alejandro Callejas Linares Ina Susana López Falfán Jesus Méndez Garc??a Ana Isabel Suárez Guerrero Ma Guadalupe Suárez Guerrero | 1999 | Ecological Economics1999，，3： | 5 |
| 3 | National natural capital accounting with the ecological footprint concept显示文摘 | Mathis Wackernagel Larry Onisto Patricia Bello Alejandro Callejas Linares Ina Susana López Falfán Jesus Méndez Garc??a Ana Isabel Suárez Guerrero Ma Guadalupe Suárez Guerrero | 1999 | Ecological Economics1999，，3： | 3 |
| 4 | Effect of Dif- ferent Gas Stunning Methods on Manchega Suckling Lamb Meat Packed under Different Modified Atmospheres 显示文摘 | BORNEZ R LINARES M B VERGARA H | 2010 | Meat Science2010，84，4： | 1 |
| 5 | Impacts of the European Emission Trading Scheme Directive and Permit Assignment Methods on the Spanish Electricity Sector显示文摘 | LINARES P SANTOS F J VENTOSA M LAPIEDRA L | 2006 | Energy Journal2006，27，1： | 1 |
| 6 | Effect of immediate or delayed loading following immediate placement of implants with a modified surface显示文摘 | Linares A Mardas N Dard M Donos N | 2010 | Clin Oral Implants Res2010，，： | 1 |
| 7 | Emulsfying and foaming properties of gluten hydrolysates with an increasing degree of hydrosis:role of soluble and insoluble fractions 显示文摘 | Linares E Larre C Lemeste M | 2000 | Cereal Chemistry2000，77，4： | 1 |
| 8 | Autoimmune thrombocytopenia associated with hepatitis C virus infection 显示文摘 | Blanquer A Linares M | 1998 | Acta Haematologica1998，99，4： | 1 |
| 9 | Chronic idiopathic thrombocytopenic purpura in the elderly显示文摘 | Linares M Cervero A Colomina P | 1995 | Acta Haematol1995，93，24： | 1 |
| 10 | Effect of Gas Composition on Rabbit Meat Quality in Modified Atmos- phere Packaging显示文摘 | VERGARA H BERRUGA M I LINARES M | 2005 | Journal of the Science of Food and Ag- riculture2005，85，12： | 1 |
| 11 | Benefits and limitations of parametric design implementation in helicopter gearbox design phase显示文摘 | Mermoz E Linares J M Bernard A | 2011 | Manufacturing Technology2011，60，1： | 1 |
| 12 | Quantitative analysis of enalapril by ^1H NMR spectroscopy in tablets 显示文摘 | Zoppi A Linares M Longhi M | 2005 | J Pharm Biomed Anal2005，37，3： | 1 |
| 13 | Study of the susceptibility of yeast isolates of clinical interest to five antifungal agents using the E- test 显示文摘 | Linares M J Manoz J F Solis F | 1998 | Rev Esp Quimioter1998，11，3： | 1 |
| 14 | Calcium-carbon interaction study:its importance in the carbongas reactions显示文摘 | Cazorla A D Linares S A Salinas M D L C | 1991 | Carbon1991，29，3： | 1 |
| 15 | Abstract Convexity and Fixed Points显示文摘 | Ben-Ei-Mechaiekh H Chebbi S Flornzano M Linares J V | | 0，，： | 1 |
| 16 | Sulfasalazine induced oxidative stress a possible mechanism of male infertility 显示文摘 | Alonso V Linares V Belles M | 2009 | Reprod Toxicol2009，27，： | 1 |
| 17 | Risk factors for pulmonary As- pergillus terreus infection in patients with positive culture for filamentous fungi显示文摘 | Cast6n JJ Linares M J Gallego C | 2007 | Chest2007，131，1： | 1 |
| 18 | Our experience with wet - wrap treatment 显示文摘 | Albarrrn - Planelles C Jimenez - Gallo D Linares - Barri- os M | 2014 | Actas Dermosifiliogr2014，105，3： | 1 |
| 19 | Music, immunity and cancer显示文摘 | Nunez M J Maria P Linares D | 2002 | Life Sci2002，71，9： | 1 |
| 20 | Fold-evolution matrices and axial-surface analysis of fault-bend folds:Application to the Medina anticline eastern Cordillera,Columbia显示文摘 | Rowan M G Linares R | 2000 | AAPG Bulletin2000，84，6： | 1 |
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