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| 1 | Tannin inhibits HIV-1 entry by targeting gp41显示文摘AIM: To investigate the mechanism by which tannin inhibits HIV-1 entry into target cells. METHODS: The inhibitory activity of tannin on HIV-1 replication and entry was detected by p24 production and HIV-1-mediated cell fusion, respectively. The inhibitory activity on the gp41 six-helix bundle formation was determined by an improved sandwich ELISA. RESULTS: Tannins from different sources showed potent inhibitory activity on HIV-1 replication, HIV-1-mediated cell fusion, and the gp41 six-helix bundle formation. CONCLUSION: Tannin inhibits HIV-1 entry into target cells by interfering with the gp41 six-helix bundle formation, thus blocking HIV-1 fusion with the target cell. | LinLUE Shu-wenLIU Shi-boJIANG Shu-guangWU | 2004 | Acta Pharmacologica Sinica2004，25，2： | 9 |
| 2 | Efficient singlet oxygen generation by excitonic energy transfer on ultrathin g-C_(3)N_(4) for selective photocatalytic oxidation of methyl-phenyl-sulfide with O_(2)显示文摘Efficient generation of singlet oxygen(1 O_(2)) by an excitonic ene rgy transfer process is highly desired on a semiconductor photocatalyst for selective oxidation of methyl phenyl sulfide(MPS).Herein,it is demonstrated that a large amount of 1 O_(2) is produced on pristine graphitic carbon nitride(CN) nanosheet compared with bismuth oxybromide(BiOBr) and comme rcial P25 titanium dioxide(TiO_(2)).This leads to a certain photoactivity of CN for MPS oxidation.The observed ~77% selectivity for CN depends on the competitive results of excitonic energy transfer for 1 O_(2) formation and charge carrier separation for superoxide radical(O_(2)·) production,which are based on the phosphorescence spectra and electron paramagnetic resonance signals,respectively.Moreover,ultrathin CN nanosheets are synthesized by thermal treatment with the cyanuric acid-melamine hydrogen bonded aggregates as precursors.It is confirmed that the amount of produced 1 O_(2) could be increased by decreasing the thickness of resultant CN nanosheets.The optimized ultrathin CN nanosheet(~4 nm) exhibits excellent photoactivity with high selectivity(~99%).It is suggested that the excitonic energy transfer for 1 O_(2) formation is close related to the intrinsic exciton binding energy and the two-dimensional quantum confinement effect.This work establishes a basic mechanistic understanding on the excitonic processes in CN,and develops a feasible route to design CN-based photocatalysts for efficient 1 O_(2) generation. | Fan Yang Xiaoyu Chu Jianhui Sun Yuhang Zhang Zhijun Li Haiyue Liu Linlu Bai Yang Qu Liqiang Jing | 2020 | Chinese Chemical Letters2020，31，10： | 3 |
| 3 | Structure-guided analysis of Arabidopsis JASMONATE-INDUCED OXYGENASE(JOX)2 reveals key residues for recognition of jasmonic acid substrate by plant JOXs显示文摘The jasmonic acid(JA)signaling pathway is used by plants to control wound responses.The persistent accumulation of JA inhibits plant growth,and the hydroxylation of JA to 12-hydroxy-JA by JASMONATE-INDUCED OXYGENASEs(JOXs,also named jasmonic acid oxidases)is therefore vital for plant growth,while structural details of JA recognition by JOXs are unknown.Here,we present the 2.65Åresolution X-ray crystal structure of Arabidopsis JOX2 in complex with its substrate JA and its co-substrates 2-oxoglutarate and Fe(Ⅱ).JOX2 contains a distorted double-stranded p helix(DSBH)core flanked by a helices and loops.JA is bound in the narrow substrate pocket by hydrogen bonds with the arginine triad R225,R350,and R354 and by hydrophobic interactions mainly with the phenylalanine triad F157,F317,and F346.The most critical residues for JA binding are F157 and R225,both from the DSBH core,which interact with the cyclopentane ring of JA.The spatial distribution of critical residues for JA binding and the shape of the substrate-binding pocket together define the substrate selectivity of the JOXs.Sequence alignment shows that these critical residues are conserved among JOXs from higher plants.Collectively,our study provides insights into the mechanism by which higher plants hydroxylate the hormone JA. | Xin Zhang Dongli Wang Joyce Elberse Linlu Qi Wei Shi You-Liang Peng Robert C.Schuurink Guido Van den Ackerveken Junfeng Liu | 2021 | Molecular Plant2021，14，5： | 2 |
| 4 | S1P/S1PR1 signaling differentially regulates the allogeneic response of CD4 and CD8 T cells by modulating mitochondrial fission显示文摘Graft-versus-host disease (GVHD) significantly contributes to patient morbidity and mortality after allogeneic hematopoietic cell transplantation (allo-HSCT). Sphingosine-1-phosphate (S1P) signaling is involved in the biogenetic processes of different immune cells. In the current study, we demonstrated that recipient sphingosine kinase 1 (Sphk1), but not Sphk2, was required for optimal S1PR1-dependent donor T-cell allogeneic responses by secreting S1P. Using genetic and pharmacologic approaches, we demonstrated that inhibition of Sphk1 or S1PR1 substantially attenuated acute GVHD (aGVHD) while retaining the graft-versus-leukemia (GVL) effect. At the cellular level, the Sphk1/S1P/S1PR1 pathway differentially modulated the alloreactivity of CD4+ and CD8+ T cells;it facilitated T-cell differentiation into Th1/Th17 cells but not Tregs and promoted CD4+ T-cell infiltration into GVHD target organs but was dispensable for the CTL activity of allogeneic CD8+ T cells. At the molecular level, the Sphk1/S1P/S1PR1 pathway augmented mitochondrial fission and increased mitochondrial mass in allogeneic CD4+ but not CD8+ T cells by activating the AMPK/AKT/mTOR/Drp1 pathway, providing a mechanistic basis for GVL maintenance when S1P signaling was inhibited. For translational purposes, we detected the regulatory efficacy of pharmacologic inhibitors of Sphk1 and S1PR1 in GVHD induced by human T cells in a xenograft model. Our study provides novel mechanistic insight into how the Sphk1/S1P/S1PR1 pathway modulates T-cell alloreactivity and validates Sphk1 or S1PR1 as a therapeutic target for the prevention of GVHD and leukemia relapse. This novel strategy may be readily translated into the clinic to benefit patients with hematologic malignancies and disorders. | Linlu Tian Yongxia Wu Hee-Jin Choi Xiaohui Sui Xinlei Li M.Hanief Sofi Mohamed Faisal Kassir Xiao Chen Shikhar Mehrotra Besim Ogretmen Xue-zhong Yu | 2022 | Cellular & Molecular Immunology2022，19，11： | 2 |
| 5 | Phylogeny and biogeography of the family Cyprinidae in the Middle East inferred from cytochrome b DNA-evdutionary significance of this region显示文摘 | DURAND J D TSIGENOPOULOS C S LINLU E | 2002 | Mol Phylogenet Evol2002，22，： | 1 |
| 6 | Potential Impacts of Proposed Chenglingji Hydraulic Project on Wetlands in Dongting Lake显示文摘Water level fluctuation of is an important ecological character of lakes in monsoon climate zone.It is the key driver to seasonal change of the wetlands and associated habitats,which provide vital inhabiting conditions for different species in summer and winter,or,wet season and dry season.Due the hydrologic regime changes in the recent years after the operation of Three Gorges Dam,in 2012,the government of Hunan province proposed Chenglingji Hydraulic Project,aiming at water level control in dry season at Chenglingji,where the outlet of Dongting Lake located.Through different operations on water retreat process,five scenarios on the water level control from 21 m to 24 m were set in the plan.The potential ecological impacts of the project are under enormous public concern.To analyze potential impacts from different scenarios of water level control on the wetlands,this paper studied the topography of Dongting Lake bed and wetlands in dry season,by using Digital Elevation Model(DEM)and 15 images from HJ satellite and 1 image from Landsat TM.The wetlands at water levels of 19 m to 27 m were analyzed.The study revealed that there were 4 terrain steps on Dongting Lake bed from the West Dongting Lake to East Dongting Lake.Water level control at Chenglingji would increase area of open water in East Dongting Lake and Hengling Lake areas,while its effect on South Dongting Lake and West Dongting Lake areas due to higher terrain was weaker.Particularly,the area percentages of South Dongting Lake area did not change with water level fluctuation,due to its 2 elevation steps.The area percentages of various types of the wetlands in Dongting Lake area during the processes of water level rising and retreating were quite different,even in the relatively close water level interval.The retreating area of open water in autumn was larger than that during the spring flooding.The 23 m was the key water level,a turning point of the area change of the wetlands in Dongting Lake area.Areas of open water,mudflat,meadows and their percentages changed significantly at water levels above 23 meters,with increasing of open water area and shrinking of meadow area,their areas would decrease 30 000 ha.As the key habitats for wintering geese,the area of meadows was from near 70 000 ha to 10 000 ha.Among 5 scenarios,the impact of the scenario at 21 m elevation on wetlands was the weakest.However,water level dropping was still postponed than that of natural hydrological process in the scenarios.It resulted in longer inundation of large area of lakebed at elevation of 22-23 m,increasing habitats for aquatic biodiversity but reducing area of the meadows,where is the key habitat for wintering geese.All the other water level control scenarios would cause large area of inundation of lakebed in dry season and dramatic change of wetlands.To maintain the natural wetlands in Dongting Lake area,the Chenglingji Hydraulic Project should be considered in a more cautious way and further researches were needed on the response of aquatic biodiversity and wintering water birds. | LU Cai SHI Linlu GUAN Lei ZHOU Yan JING Lei LEI Guangchun | 2018 | 湿地科学2018，16，3： | 1 |
| 7 | Comprehensive Evaluation and Forecast Analysis of Control System Quality in ATC Operation显示文摘 | Zongping Lv Linlu Wang Zhaoning Zhang | 2012 | Journal of Convergence Information Technology2012，，7： | 1 |
| 8 | Study on the Complexes of Gallic acid-Zn(Ⅱ) and the Interaction with DNA显示文摘 | ZhangLian-ru ChenKa-lin LinLu YangXi ZouGuo-lin | 2004 | Wuhan University Journal of Natural Sciences2004，9，3： | 1 |
| 9 | Construction of Protein Nanowires through Cucurbit[8]uril‐based Highly Specific Host–Guest Interactions: An Approach to the Assembly of Functional Proteins显示文摘 | Chunxi Hou Jiaxi Li Linlu Zhao Wei Zhang Quan Luo Zeyuan Dong Jiayun Xu Junqiu Liu | 2013 | Angew Chem Int Ed2013，，21： | 1 |
| 10 | Releasing nitrogen from ammoniated lignin by white rot fungus cometabolizes environmental pollutants显示文摘The nitrogen modified lignocelluloses(NML) produced under oxic ammoniation was metabolized by white rot fungus, NH + 4 N was released, NO - 3 N concentration was decreased and total nitrogen loss was blocked within incubation period. During releasing nitrogen from the metabolism of NML, white rot fungus cometabolized recalcitrant environmental pollutants and showed higher degradation capability. Results indicated that this NML complex colonized by white rot fungus might be effective with economic feasibility when they are applied into the vast field ecosystem, it might stabilize NH + 4 nitrogen flux and bioremediate the polluted environmental sites. | LINLu ZHAODe-qing ZHOUXian-tao QIUYu-gui ZHANGGan: | 2003 | Journal of Environmental Sciences2003，15，5： | 1 |
| 11 | Quantifying the impacts of emissions and meteorology on the interannual variations of air pollutants in major Chinese cities from 2015 to 2021显示文摘Air pollutant concentration is a function of emission rates and meteorology.To accurately evaluate the effect of control measures,the meteorological covariate must be corrected from the observations.This study quantified the impacts of emission abatement and meteorological condition on the interannual variations of SO_(2),NO_(2),CO,O_(3),PM_(10) and PM_(2.5) concentrations in 31 major Chinese cities using an optimized machine learning-based meteorological normalization technique.Overall,the annual average concentrations of SO_(2),NO_(2),CO,PM_(10)and PM_(2.5)were reduced by 86%,51%,99%,86% and 88%from 2015 to 2020,respectively,in the studied cities,attributable to their emission reductions.However,the concentration of O_(3) was found with no significant decrease with the reduction of precursors.Emission abatement notably improved air quality between 2015 and 2018.Such a decline in emissions tended to progressively slow down since 2018.Overall,the meteorological conditions in 2016–2017 and 2018–2019 were unfavorable for a better air quality,while it became favorable in 2020–2021.Specifically,emission abatement in 2021 further lowered the concentrations of SO_(2),NO_(2),CO,and PM_(2.5),while the emission of PM_(10) increased.And changes in precursors emissions worsened O_(3) air quality.To meet the demand of improving air quality,more aggressive abatement measures need to be formulated to synergistically reduce NOx,volatile organic compounds,and coarse particles. | Qili DAI Tianjiao DAI Linlu HOU Linxuan LI Xiaohui BI Yufen ZHANG Yinchang FENG | 2023 | Science China Earth Sciences2023，66，8： | 0 |
| 12 | Protein self-assembly: technology and strategy显示文摘Proteins, as the premier building blocks in nature, exhibit extraordinary ability in life activities during which process proteins mostly self-assemble into large complexes to exert prominent functions. Inspired by this, recent chemical and biological studies mainly focus on supramolecular self-assembly of proteins into high ordered architectures, especially the assembly strategy to unravel the formation and function of protein nanostructures. In this review, we summarize the progress made in the engineering of supramolecular protein architectures according to the strategies used to control the orientation and the order of the assembly process. Furthermore, potential applications in biomedical areas of the supramolecular protein nanostructures will also be reviewed. | Linlu Zhao Shanpeng Qiao Junqiu Liu | 2016 | Science China Chemistry2016，59，12： | 0 |
| 13 | STING negatively regulates allogeneic T-cell responses by constraining antigen-presenting cell function显示文摘Stimulator of interferon genes(STING)-mediated innate immune activation plays a key role in tumor-and self-DNA-elicited antitumor immunity and autoimmunity.However,STING can also suppress tumor immunity and autoimmunity.STING signaling In host nonhematopoietic cells was reported to either protect against or promote graft-versus-host disease(GVHD),a major complication of allogeneic hematopoietic cell transplantation(allo-HCT).Host hematopoietic antigen-presenting cells(APCs)play key roles in donor T-cell priming during GVHD initiation.However,how STING regulates host hematopoietic APCs after allo-HCT remains unknown.We utilized murine models of allo-HCT to assess the role of STING in hematopoietic APCs.STING-deficient recipients developed more severe GVHD after major histocompatibility complex-mismatched allo-HCT.Using bone marrow chimeras,we found that STING deficiency in host hematopoietic cells was primarily responsible for exacerbating the disease.Furthermore,STING on host CD11c+cells played a dominant role in suppressing allogeneic T-cell responses.Mechanistically,STING deficiency resulted in increased survival,activation,and function of APCs,including macrophages and dendritic cells.Consistently,constitutive activation of STING attenuated the survival,activation,and function of APCs isolated from STING V154M knock-in mice.STING-deficient APCs augmented donor T-cell expansion,chemokine receptor expression,and migration into intestinal tissues,resulting in accelerated/exacerbated GVHD.Using pharmacologic approaches,we demonstrated that systemic administration of a STING agonist(bis-(3'-5')-cyclic dimeric guanosine monophosphate)to recipient mice before transplantation significantly reduced GVHD mortality.In conclusion,we revealed a novel role of STING in APC activity that dictates T-cell allogeneic responses and validated STING as a potential therapeutic target for controlling GVHD after allo-HCT. | Hee-Jin ChoiTaylor Ticer Yongxia Wu Chih-Hang Anthony Tang Corey Mealer David Bastian M.Hanief Sofi Linlu Tian Steven Schutt Hee-Jin Choi Taylor Ticer Mengmeng Zhang Xiaohui Sui Lei Huang Andrew L.Mellor Chih-Chi Andrew Hu Xue-Zhong Yu | 2021 | Cellular & Molecular Immunology2021，18，3： | 0 |
| 14 | Comparative Secretome Analysis of Magnaporthe oryzae Identified Proteins Involved in Virulence and Cell Wall Integrity显示文摘Plant fungal pathogens secrete numerous proteins into the apoplast at the plant–fungus contact sites to facilitate colonization.However,only a few secretory proteins were functionally characterized in Magnaporthe oryzae,the fungal pathogen causing rice blast disease worldwide.Asparagine-linked glycosylation 3(Alg3)is an a-1,3-mannosyltransferase functioning in the Nglycan synthesis of N-glycosylated secretory proteins.Fungal pathogenicity and cell wall integrity are impaired inΔalg3 mutants,but the secreted proteins affected inΔalg3 mutants are largely unknown.In this study,we compared the secretomes of the wild-type strain and theΔalg3 mutant and identified 51 proteins that require Alg3 for proper secretion.These proteins were predicted to be involved in metabolic processes,interspecies interactions,cell wall organization,and response to chemicals.Nine proteins were selected for further validation.We found that these proteins were localized at the apoplastic region surrounding the fungal infection hyphae.Moreover,the Nglycosylation of these proteins was significantly changed in theΔalg3 mutant,leading to the decreased protein secretion and abnormal protein localization.Furthermore,we tested the biological functions of two genes,INV1(encoding invertase 1,a secreted invertase)and AMCase(encoding acid mammalian chinitase,a secreted chitinase).The fungal virulence was significantly reduced,and the cell wall integrity was altered in theΔinv1 andΔamcase mutant strains.Moreover,the N-glycosylation was essential for the function and secretion of AMCase.Taken together,our study provides new insight into the role of N-glycosylated secretory proteins in fungal virulence and cell wall integrity. | Ning Liu Linlu Qi Manna Huang Deng Chen Changfa Yin Yiying Zhang Xingbin Wang Guixin Yuan Rui-Jin Wang Jun Yang You-Liang Peng Xunli Lu | 2022 | Genomics, Proteomics & Bioinformatics2022，20，4： | 0 |
| 15 | ITERATIVE QUASI-LIKELIHOOD FOR SEEMINGLY UNRELATED REGRESSION SYSTEMS显示文摘In the seemingly unrelated regression systems, the existing quasi-likelihood is always involved in the difficult problem of calculating inverse of a high order matrix specially for large systems. To avoid this problem, the new quasi-likelihood proposed in this paper is based mainly on a linearly iterative process of some unbiased estimating functions.Some finite sample properties and asymptotic behaviours for this new quasi-likelihood are investigated. These results show that the new quasi-likelihood for parameter of interest is E-sufficient, iteratively efficient and approximately efficient. Some examples are given to illustrate the theoretical results. | LINLU FANYUNZHENG DUJUN YUANYUAN | 2005 | Chinese Annals of Mathematics,Series B2005，26，3： | 0 |
| 16 | Improving the band alignment at PtSe_(2)grain boundaries with selective adsorption of TCNQ显示文摘Grain boundaries in two-dimensional(2D)semiconductors generally induce distorted band alignment and interfacial charge,which impair their electronic properties for device applications.Here,we report the improvement of band alignment at the grain boundaries of PtSe_(2),a 2D semiconductor,with selective adsorption of a presentative organic acceptor,tetracyanoquinodimethane(TCNQ).TCNQ molecules show selective adsorption at the PtSe_(2)grain boundary with strong interfacial charge.The adsorption of TCNQ distinctly improves the band alignment at the PtSe_(2)grain boundaries.With the charge transfer between the grain boundary and TCNQ,the local charge is inhibited,and the band bending at the grain boundary is suppressed,as revealed by the scanning tunneling microscopy and spectroscopy(STM/S)results.Our finding provides an effective method for the advancement of the band alignment at the grain boundary by functional molecules,improving the electronic properties of 2D semiconductors for their future applications. | Yanhui Hou Ziqiang Xu Yan Shao Linlu Wu Zhongliu Liu Genyu Hu Wei Ji Jingsi Qiao Xu Wu Hong-Jun Gao Yeliang Wang | 2023 | Nano Research2023，16，2： | 0 |
| 17 | Touchable cell biophysics property recognition platforms enable multifunctional blood smart health care显示文摘As a crucial biophysical property,red blood cell(RBC)deformability is pathologically altered in numerous disease states,and biochemical and structural changes occur over time in stored samples of otherwise normal RBCs.However,there is still a gap in applying it further to point-of-care blood devices due to the large external equipment(high-resolution microscope and microfluidic pump),associated operational difficulties,and professional analysis.Herein,we revolutionarily propose a smart optofluidic system to provide a differential diagnosis for blood testing via precise cell biophysics property recognition both mechanically and morphologically.Deformation of the RBC population is caused by pressing the hydrogel via an integrated mechanical transfer device.The biophysical properties of the cell population are obtained by the designed smartphone algorithm.Artificial intelligence-based modeling of cell biophysics properties related to blood diseases and quality was developed for online testing.We currently achieve 100%diagnostic accuracy for five typical clinical blood diseases(90 megaloblastic anemia,78 myelofibrosis,84 iron deficiency anemia,48 thrombotic thrombocytopenic purpura,and 48 thalassemias)via real-world prospective implementation;furthermore,personalized blood quality(for transfusion in cardiac surgery)monitoring is achieved with an accuracy of 96.9%.This work suggests a potential basis for next-generation blood smart health care devices. | Longfei Chen Yantong Liu Hongshan Xu Linlu Ma Yifan Wang Le Yu Fang Wang Jiaomeng Zhu Xuejia Hu Kezhen Yi Yi Yang Hui Shen Fuling Zhou Xiaoqi Gao Yanxiang Cheng Long Bai Yongwei Duan Fubing Wang Yimin Zhu | 2021 | Microsystems & Nanoengineering2021，7，6： | 0 |
| 18 | High temperature strength and ductility of the(C+N)strengthening Fe-Cr-Mn(W,V)steels显示文摘Fe-Cr-Mn(W, V) austenite steels used as low radioactive structural materials in fusion reactor have been investigated. The resultsshow that the high temperature strength and the creep fracture life of Fe-Cr-Mn(W, V) steels can be effectively improved through (C+N) complex-strengthening, so can be the high temperature ductility. The strength and ductility of the steels are superior to that of SUS316 steels and JPCAS below 673K. The relationship between strength, ductility andthe formation temperature is related to the evolution of deformation microstructure. The fracture and microstructure observation above 673Kindicates that the main way to further improve ductility at high temperature is the control of carbide coarsening at the grain boundaries. | BenfuHu QuanmaoYu LinLu ChengchangJia HiroshiKinoshita HeishichiroTakahashi | 2002 | Journal of University of Science and Technology Beijing2002，9，4： | 0 |
| 19 | Band alignment and interlayer hybridization in monolayer organic/WSe_(2) heterojunction显示文摘Semiconducting heterojunctions(HJs),comprised of atomically thin transition metal dichalcogenides(TMDs),have shown great potentials in electronic and optoelectronic applications.Organic/TMD hybrid bilayers hold enhanced pumping efficiency of interfacial excitons,tunable electronic structures and optical properties,and other superior advantages to these inorganic HJs.Here,we report a direct probe of the interfacial electronic structures of a crystalline monolayer(ML)perylene-3,4,9,10-tetracarboxylic-dianhydride(PTCDA)/ML-WSe_(2) HJ using scanning tunneling microscopy,photoluminescence,and first-principle calculations.Strong PTCDAAA/Se_(2) interfacial interactions lead to appreciable hybridization of the WSe_(2) conduction band with PTCDA unoccupied states,accompanying with a significant amount of PTCDA-to-WSe_(2) charge transfer(by 0.06 e/PTCDA).A type-ll band alignment was directly determined with a valence band offset of-1.69 eV,and an apparent conduction band offset of-1.57 eV.Moreover,we found that the local stacking geometry at the HJ interface differentiates the hybridized interfacial states. | Yanping Guo Linlu Wu Jinghao Deng Linwei Zhou Wei Jiang Shuangzan Lu Da Huo Jiamin Ji Yusong Bai Xiaoyu Lin Shunping Zhang Hongxing Xu Wei Ji Chendong Zhang | 2022 | Nano Research2022，15，2： | 0 |
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