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| 1 | Community structure of ammonia-oxidizing bacteria under long-term application of mineral fertilizer and organic manure in a sandy loam soil显示文摘 | Chu HY Fujii T Morimoto S Lin XG Yagi K Hu JL Zhang JB | 2007 | 中国生物学文摘2007，21，6： | 77 |
| 2 | Viral and host causes of fatty liver in chronic hepatitis B显示文摘AIM: To investigate the viral and host causes of fatty liver in chronic hepatitis B patients and the role of fat deposits in liver damage.METHODS: A total of 164 patients (113 males and 51 females, average age 35±11.3 years, and range 10-62 years) with previously untreated chronic hepatitis B were included in the study. The patients were divided into two groups depending on the result of liver biopsy: group without steatosis (100 patients with <5% hepatosteatosis) and group with steatosis (64 patients with >5% hepatosteatosis). The groups were compared in terms of gender, body mass index (BMI), liver enzymes (ALT, AST, ALP, GGT), cholesterol, triglyceride, HBeAg, viral load, and histological findings. In the group with steatosis, the patients were subdivided depending on the degree of steatosis into mild group (45 patients with 5-24% steatosis), and severe group (19 patients with >25% steatosis). RESULTS: In the group of chronic hepatitis B with steatosis, the mean age, BMI, cholesterol, and triglyceride levels were significantly higher than those in the group without steatosis (P<0.05). Steatosis was found in 53 (46.9%) of male patients and 11 (22%) of female patients (P<0.05). No significant difference was found in the positivity of ALT, AST, ALP, GGT, HBeAg, viral load, histological activity index (HAI) and stage between the two groups (P>0.05). In the group with severe steatosis, the BMI was significantly higher than that in the group with mild steatosis (P<0.05). No significant difference was found in the other parameters between the groups (P>0.05). CONCLUSION: Steatosis in chronic hepatitis B appears to be a result of metabolic factors of the host rather than the effect of viruses. Steatosis is unrelated to the HAI and degree of fibrosis, which are considered as the histological indicators of liver damage. | Emin Altiparmak Seyfettin K(o|¨)klü Mesut Yalinkilic Osman Yüksel Bahattin Cicek Ertugrul Kayacetin Tülin Sahin | 2005 | World Journal of Gastroenterology2005，11，20： | 52 |
| 3 | Nat Genet:单细胞分析解开结直肠癌细胞的神秘面纱显示文摘结合单细胞基因组学和计算机技术,一个研究团队(包括来自杰克逊实验室(JAx)单细胞生物学主任Paul Robson博士在内)鉴定出了11种结直肠癌肿瘤的癌细胞组成及邻近的非癌细胞。这对于更好的肿瘤靶向诊断和治疗很重要。”使用单细胞测序。”JAX科学家、这篇发表在Nature Genetics上的文章共同第一作者Elise Courtois说道。”我们可以根据肿瘤中的细胞组成将结直肠癌进一步分类。因为每种亚型的肿瘤病人生存率存在差别,我们的方法将为肿瘤医生提供更多的关于肿瘤预后和治疗的信息。” | Huipeng Li, Elise T Courtois, Debarka Sengupta, Yuliana Tan Shyam Prabhakar Elise T Courtois, Yuliana Tan Paul Robson Debarka Sengupta Kok Hao Chen, Jolene Jie Lin Goh Paul Jongjoon Choi Say Li Kong, Axel M Hillmer Iain Beehuat Tan Clarinda Chua Iain Beehuat Tan Lim Kiat Hon Wah Siew Tan Mark Wong Lawrence J K Wee Iain Beehuat Tan Paul Robson Paul Robson Paul Robson | 2017 | 现代生物医学进展2017，17，15： | 37 |
| 4 | 新辅助放化疗联合全直肠系膜切除术后接受辅助化疗不能改善Ⅱ/Ⅲ期直肠癌患者的无复发生存率显示文摘目的:目前,NCCN指南建议对局部进展期Ⅱ/Ⅲ期直肠癌先行新辅助放化疗(nCRT),然后行全直肠系膜切除术(TME)和辅助化疗。辅助化疗的肿瘤学获益尚未得到进一步证实。本研究的目的是评估nCRT+TME手术后接受辅助化疗的直肠癌患者肿瘤复发和生存情况。方法:本研究是在南加州的14家医院和相关诊所完成的回顾性研究,研究对象为2005年1月1日至2016年12月31日接受手术治疗的862例Ⅱ/Ⅲ期直肠癌患者,无论是否行辅助化疗,纳入研究的患者均接受了新辅助化疗以及全直肠系膜切除术。主要终点是无复发生存率。 | 李来元 VOSS R K LIN J C ROPER M T | 2020 | 结直肠肛门外科2020，26，2： | 5 |
| 5 | Procedural complexity independent of P2Y12 reaction unit(PRU)values is associated with acute in situ thrombosis in Pipeline flow diversion of cerebral aneurysms显示文摘background Acute in situ thrombosis is an ischaemic phenomenon during Pipeline embolisation device(PED)procedures with potentially high morbidity and mortality.There is controversy regarding the role of platelet function testing with P2Y12 assay as a predictor of intraprocedural thromboembolic events.There is limited knowledge on whether procedural complexity influences these events.Methods Data were collected retrospectively on 742 consecutive PED cases at a single institution.Patients with intraprocedural acute thrombosis were compared with patients without these events.results A cohort of 37 PED cases with acute in situ thrombosis(mean age 53.8 years,mean aneurysm size 8.4 mm)was matched with a cohort of 705 PED cases without intraprocedural thromboembolic events(mean age 56.4 years,mean aneurysm size 6.9 mm).All patients with in situ thrombosis received intra-arterial and/or intravenous abciximab.The two groups were evenly matched in patient demographics,previous treatment/subarachnoid hemorrhage(SAH)and aneurysm location.There was no statistical difference in postprocedural P2Y12 reaction unit(PRU)values between the two groups,with a mean of 156 in the in situ thrombosis group vs 148 in the control group(p=0.5894).Presence of cervical carotid tortuosity,high cavernous internal carotid artery grade,need for multiple PED and vasospasm were not significantly different between the two groups.The in situ thrombosis group had statistically significant longer fluoroscopy time(60.4 vs 38.4 min,p<0.0001),higher radiation exposure(3476 vs 2160 mGy,p<0.0001),higher rates of adjunctive coiling(24.3% vs 8.37%,p=0.0010)and higher utilisation of balloon angioplasty(37.8% vs 12.2%,p<0.0001).Clinically,the in situ thrombosis cohort had higher incidence of major and minor stroke,intracerebral haemorrhage and length of stay.Conclusions Predictors of procedural complexity(higher radiation exposure,longer fluoroscopy time,adjunctive coiling and need for balloon angioplasty)are associated with acute thrombotic events during PED placement,independent of PRU values. | Bowen Jiang Matthew T Bender Erick M Westbroek Jessica K Campos Li-Mei Lin Risheng Xu Rafael J Tamargo Judy Huang Geoffrey P Colby Alexander L Coon | 2018 | Stroke & Vascular Neurology2018，3，3： | 2 |
| 6 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 7 | Preparation and structural determination of siloxane - modified sulfone - containing epoxy resins 显示文摘 | LIN S T HUANG S K | 1996 | Journal of Polymer Science : Part A : Polymer Chemistry1996，34，： | 1 |
| 8 | Synthesis and impact properties of siloxane- DCEBA epoxy copolymers 显示文摘 | Lin S T Huang S K | 1996 | Journal of Polymer Science : Part A : Polymer Chemistry1996，34，： | 1 |
| 9 | Screw Dislocation Dipole Near an Internal Crack显示文摘 | Lin K M Hu C T Lee S B | 1993 | Engineering Fracture Mechanics1993，45，： | 1 |
| 10 | Suppression of lipopolysaccharide- induced nuclear factor- kappaB activity by theaflavin-3,3'-digallate from black tea and other polyphenols through down-regulation of IkappaB kinase activity in macrophages 显示文摘 | Pan M H Lin-shiau S Y Ho C T Lin J H Lin J K | 2000 | Biochem Pharm2000，59，： | 1 |
| 11 | B-cell receptor signaling in chronic lymphocytic leukemia cells is regulated by overexpressed active protein kinase CbetalI 显示文摘 | Abrams ST Lakum T Lin K | 2007 | Blood2007，109，： | 1 |
| 12 | Multivariate analysis of soil heavy metal pollution and landscape pattern in Changhua County in Taiwan 显示文摘 | LIN Y P TENG T P CHANG T K | 2002 | Landscape and Urban Planning2002，62，1： | 1 |
| 13 | Integrity of complex shape product by powder injection molding 显示文摘 | HENS K F LEE D LIN S T | 1991 | Powder Metallurgy International1991，23，1： | 1 |
| 14 | 显示文摘 | Wong K T Hung T S Lin Y | 2002 | Org Lett2002，4，： | 1 |
| 15 | Tectonic Implications of Damage Zone-Related Fault-Fracture Networks Revealed in Drill Core Through the Nojima Fault,Japan显示文摘 | Lin A Maryyama T Kobayshi K | 2007 | Tectonophysics2007，443，： | 1 |
| 16 | Modelling of springback in creepforming thick aluminum sheets 显示文摘 | Ho K C Lin J Dean T A | 2004 | International Journal ofPlasticity2004，20，： | 1 |
| 17 | Information hiding based on binary encoding methods and pixel scrambling techniques显示文摘 | Lin K T | 2012 | Applied Optics2012，49，2： | 1 |
| 18 | Family Ownership and the Interna- tional Involvement of Taiwan's High -technology Firms: The Moder- ating Effect of High - discretion Organizational Slack 显示文摘 | Liu Y S Lin W T Cheng K Y | 2011 | Manage- ment and Organization Review2011，7，2： | 1 |
| 19 | Preparation and properties of nano-silica modified nega- tive acrylate photoresist 显示文摘 | Lee C K Don T M Lai W C Chert C C Lin D J Cheng L P | 2008 | Thin Solid Films2008，516，23： | 1 |
| 20 | Multinational, double-blind,randomised, placebo-controlled, prospective study of esomeprazole inthe prevention of recurrent peptic ulcer in low-dose acetylsalicylicacid users: the LAVENDER study显示文摘 | Sugano K Choi M G Lin J T | 2014 | Gut2014，63，7： | 1 |
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