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| 1 | Inhibition of Rac1-dependent forgetting alleviates memory deficits in animal models of Alzheimer's disease显示文摘Accelerated forgetting has been identified as a feature of Alzheimer's disease(AD),but the therapeutic efficacy of the manipulation of biological mechanisms of forgetting has not been assessed in AD animal models.Ras-re-lated C3 botulinum toxin substrate 1(Rac1),a small GTPase,has been shown to regulate active forgetting in Drosophila and mice?Here,we showed that Rac1 activity is aberrantly elevated in the hippocampal tissues of AD patients and AD animal models.Moreover,amyloid-beta 42 could induce Rac1 activation in cultured cells.The elevation of Rac1 activity not only accelerated 6-hour spatial memory decay in 3-month-old APP/PS1 mice,but also significantly contributed to severe memory loss in aged APP/PS1 mice.A similar age-dependent Rac1 activity-based memory loss was also observed in an AD fly model.Moreover,inhibition of Rac1 activity could ameliorate cognitive defects and synaptic plasticity in AD animal models.Finally,two novel compounds,identified through behavioral screening of a randomly selected pool of brain permeable small molecules for their positive effect in rescuing memory loss in both fly and mouse models,were found to be capable of inhibiting Rac1 activity.Thus,multiple lines of evidence corroborate in supporting the idea that inhibition of Rac1 activity is effective for treating AD-related memory loss. | Wenjuan Wu Shuwen Du Wei Shi Yunlong Liu Ying Hu Zuolei Xie Xinsheng Yao Zhenyu Liu Weiwei Ma Lin Xu Chao Ma Yi Zhong | 2019 | Protein & Cell2019，10，10： | 10 |
| 2 | Salvianolic acid C potently inhibits SARS-CoV-2 infection by blocking the formation of six-helix bundle core of spike protein显示文摘Dear Editor,The pandemic of COVID-19 caused by SARS-CoV-2 infection has posed a serious threat to global public health and the economy.Up to now,although several potentially effective antiviral drugs are under evaluating in clinical trials around the world,1 there are still no specific antiviral countermeasures beyond supportive therapies have been established.We herein report that the hydrophilic compound Salvianolic acid C(Sal-C)from Danshen,a traditional Chinese medicine(TCM),potently inhibit SARS-CoV-2 infection by blocking the formation of six-helix bundle(6-HB)core of spike(S)protein. | Chan Yang Xiaoyan Pan Xinfeng Xu Chen Cheng Yuan Huang Lin Li Shibo Jiang Wei Xu Gengfu Xiao Shuwen Liu | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 5 |
| 3 | New Knowledge-based Genetic Algorithm for Excavator Boom Structural Optimization显示文摘Due to the insufficiency of utilizing knowledge to guide the complex optimal searching, existing genetic algorithms fail to effectively solve excavator boom structural optimization problem. To improve the optimization efficiency and quality, a new knowledge-based real-coded genetic algorithm is proposed. A dual evolution mechanism combining knowledge evolution with genetic algorithm is established to extract, handle and utilize the shallow and deep implicit constraint knowledge to guide the optimal searching of genetic algorithm circularly. Based on this dual evolution mechanism, knowledge evolution and population evolution can be connected by knowledge influence operators to improve the configurability of knowledge and genetic operators. Then, the new knowledge-based selection operator, crossover operator and mutation operator are proposed to integrate the optimal process knowledge and domain culture to guide the excavator boom structural optimization. Eight kinds of testing algorithms, which include different genetic operators, are taken as examples to solve the structural optimization of a medium-sized excavator boom. By comparing the results of optimization, it is shown that the algorithm including all the new knowledge-based genetic operators can more remarkably improve the evolutionary rate and searching ability than other testing algorithms, which demonstrates the effectiveness of knowledge for guiding optimal searching. The proposed knowledge-based genetic algorithm by combining multi-level knowledge evolution with numerical optimization provides a new effective method for solving the complex engineering optimization problem. | HUA Haiyan LIN Shuwen | 2014 | Chinese Journal of Mechanical Engineering2014，27，2： | 5 |
| 4 | Elastic Scattering of 7Be on Pb Target显示文摘 | Yang Yanyun Wang Jiansong Wang Qi Huang Meirong Ma Junbing Ma Peng Cao Xiguang Han Jianlong Bai Zhen Jin Shilong Hu Qiang Jin Lei Chen Jiangbo Zhang Xueying Chen Ruofu Hu Zhengguo Xu Shiwei Zhen Chuan Xu Zhiguo Xu Hushan Duan Liming Sun Zhiyu Chen Zhiqiang He Jianjun Li Songlin Lei Xiangguo Fu Fen Zhang Xueheng Yuan Xiaohua Du Chengming Yan Xinshuang Hu Jun Tang Shuwen Ye Ruiping Yang Kun Shi Fudong Zhang Wei Chen Ze Li Long Xu Xing Liu Longxiang Zhang Liyong Lin Qingyun Gou Boxing Xu Ge Zhou Xionghong Zhang Yuhu Xiao Guoqing | 2011 | IMP & HIRFL Annual Report2011，，1： | 4 |
| 5 | Simulation and Improvements of Oceanic Circulation and Sea Ice by the Coupled Climate System Model FGOALS-f3-L显示文摘This study documents simulated oceanic circulations and sea ice by the coupled climate system model FGOALS-f3-L developed at the State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics,Institute of Atmospheric Physics,Chinese Academy of Sciences,under historical forcing from phase 6 of the Coupled Model Intercomparison Project(CMIP6).FGOALS-f3-L reproduces the fundamental features of global oceanic circulations,such as sea surface temperature(SST),sea surface salinity(SSS),mixed layer depth(MLD),vertical temperature and salinity,and meridional overturning circulations.There are notable improvements compared with the previous version,FGOALS-s2,such as a reduction in warm SST biases near the western and eastern boundaries of oceans and salty SSS biases in the tropical western Atlantic and eastern boundaries,and a mitigation of deep MLD biases at high latitudes.However,several obvious biases remain.The most significant biases include cold SST biases in the northwestern Pacific(over 4°C),freshwater SSS biases and deep MLD biases in the subtropics,and temperature and salinity biases in deep ocean at high latitudes.The simulated sea ice shows a reasonable distribution but stronger seasonal cycle than observed.The spatial patterns of sea ice are more realistic in FGOALS-f3-L than its previous version because the latitude–longitude grid is replaced with a tripolar grid in the ocean and sea ice model.The most significant biases are the overestimated sea ice and underestimated SSS in the Labrador Sea and Barents Sea,which are related to the shallower MLD and weaker vertical mixing. | Yuyang GUO Yongqiang YU Pengfei LIN Hailong LIU Bian HE Qing BAO Bo AN Shuwen ZHAO and Lijuan HUA | 2020 | Advances in Atmospheric Sciences2020，37，10： | 3 |
| 6 | CAS-FGOALS Datasets for the Two Interglacial Epochs of the Holocene and the Last Interglacial in PMIP4显示文摘Two versions of the Chinese Academy of Sciences Flexible Global Ocean-Atmosphere-Land System model(CASFGOALS),version f3-L and g3,are used to simulate the two interglacial epochs of the mid-Holocene and the Last Interglacial in phase 4 of the Paleoclimate Modelling Intercomparison Project(PMIP4),which aims to study the impact of changes in orbital parameters on the Earth’s climate.Following the PMIP4 experimental protocols,four simulations for the mid-Holocene and two simulations for the Last Interglacial have been completed,and all the data,including monthly and daily outputs for the atmospheric,oceanic,land and sea-ice components,have been released on the Earth System Grid Federation(ESGF)node.These datasets contribute to PMIP4 and CMIP6(phase 6 of the Coupled Model Intercomparison Project)by providing the variables necessary for the two interglacial periods.In this paper,the basic information of the CAS-FGOALS models and the protocols for the two interglacials are briefly described,and the datasets are validated using proxy records.Results suggest that the CAS-FGOALS models capture the large-scale changes in the climate system in response to changes in solar insolation during the interglacial epochs,including warming in mid-to-high latitudes,changes in the hydrological cycle,the seasonal variation in the extent of sea ice,and the damping of interannual variabilities in the tropical Pacific.Meanwhile,disagreements within and between the models and the proxy data are also presented.These datasets will help the modeling and the proxy data communities with a better understanding of model performance and biases in paleoclimate simulations. | Weipeng ZHENG Yongqiang YU Yihua LUAN Shuwen ZHAO Bian HE Li DONG Mirong SONG Pengfei LIN and Hailong LIU | 2020 | Advances in Atmospheric Sciences2020，37，10： | 2 |
| 7 | Geo- metric error compensation for multi-axis CNC ma- chines based on differential transformation显示文摘 | CHEN Jiangxiong LIN Shuwen HE Bingwei | 2014 | The International Journal of Advanced ManufacturingTechnology2014，71，1： | 1 |
| 8 | Sound Source Localization Based on SRP-PHAT Spatial Spectrum and Deep Neural Network显示文摘Microphone array-based sound source localization(SSL)is a challenging task in adverse acoustic scenarios.To address this,a novel SSL algorithm based on deep neural network(DNN)using steered response power-phase transform(SRP-PHAT)spatial spectrum as input feature is presented in this paper.Since the SRP-PHAT spatial power spectrum contains spatial location information,it is adopted as the input feature for sound source localization.DNN is exploited to extract the efficient location information from SRP-PHAT spatial power spectrum due to its advantage on extracting high-level features.SRP-PHAT at each steering position within a frame is arranged into a vector,which is treated as DNN input.A DNN model which can map the SRP-PHAT spatial spectrum to the azimuth of sound source is learned from the training signals.The azimuth of sound source is estimated through trained DNN model from the testing signals.Experiment results demonstrate that the proposed algorithm significantly improves localization performance whether the training and testing condition setup are the same or not,and is more robust to noise and reverberation. | Xiaoyan Zhao Shuwen Chen Lin Zhou Ying Chen | 2020 | Computers, Materials & Continua2020，，7： | 1 |
| 9 | A new method of the constraints expression and handling for excavator boom structural optimization显示文摘 | HUA Haiyan LIN Shuwen SHEN Zhenhui | 2012 | Advanced Materials Research2012，，： | 1 |
| 10 | Crosstalk between adipose-derived stem cells and chondrocytes:when growth factors matter显示文摘Adipose-derived stem cells(ASCs)and mesenchymal stem cells are promising for tissue repair because of their multilineage differentiation capacity.Our previous data confirmed that the implantation of mixed ASCs and chondrocytes into cartilage defects induced desirable in vivo healing outcomes.However,the paracrine action of ASCs on chondrocytes needs to be further elucidated.In this study,we established a co-culture system to achieve cell-to-cell and cell-to-tissue crosstalk and explored the soluble growth factors in both ASCs and chondrocytes supplemented with 1%fetal bovine serum to mimic the physiological microenvironment.In ASCs,we screened for growth factors by semi-quantitative PCR and quantitative real-time PCR and found that the expression of bone morphogenetic protein 2(BMP-2),vascular endothelial growth factor B(VEGFB),hypoxia inducible factor-1α(HIF-1α),fibroblast growth factor-2(FGF-2),and transforming growth factor-β1 significantly increased after co-culture in comparison with mono-culture.In chondrocytes,VEGFA was significantly enhanced after co-culture.Unexpectedly,the expression of collagen II and aggrecan was significantly down-regulated in the co-culture group compared with the mono-culture group.Meanwhile,among all the growth factors screened,we found that the BMP family members BMP-2,BMP-4,and BMP-5 were down-regulated and that VEGFB,HIF-1α,FGF-2,and PDGF were significantly decreased after co-culture.These results suggest that crosstalk between ASCs and chondrocytes is a pathway through the regulated growth factors that might have potential in cartilage repair and regeneration and could be useful for tissue engineering. | Juan Zhong Bin Guo Jing Xie Shuwen Deng Na Fu Shiyu Lin Guo Li Yunfeng Lin Xiaoxiao Cai | 2015 | Bone Research2015，3，4： | 1 |
| 11 | Repurposing of a clinically used anti-HPV agent to prevent and treat SARS-CoV-2 infection as an intranasal formulation显示文摘Dear Editor,Fan et al.have shown that whey protein,such as that found in human,bovine,and goat milk,could effectively inhibit SARS-CoV-2 infection,but they did not identify the components in whey protein having this activity.1 Since p-lactoglobulin(P-LG)is the main component of whey protein,we herein tested the anti-SARS-CoV-2 activity of p-LG and 3-hydroxyphthalic anhydride(3HP)-modified P-LG(3HP-P-LG),an active component in anti-human papillomavirus(HPV)biological dressing(JB01-BD)that has been used in clinics since 2013 to block cervical infection of HPV. | Chen Hua Qinhai Ma Yun Zhu Shuai Xia Zezhong Liu Lin Li Lu Lu Nanshan Zhong Shuwen Liu Zifeng Yang Shibo Jiang | 2021 | Signal Transduction and Targeted Therapy2021，6，9： | 1 |
| 12 | Mathematic Modeling and Characteristic Analysis for Dynamic System with Ssymmetrical Hysteresis in Vibratory Corn paction显示文摘 | Shen Peihui Lin Shuwen | 2008 | Meceanica2008，43，： | 1 |
| 13 | Overview of the CMIP6 Historical Experiment Datasets with the Climate System Model CAS FGOALS-f3-L显示文摘The three-member historical simulations by the Chinese Academy of Sciences Flexible Global Ocean–Atmosphere–Land System model,version f3-L(CAS FGOALS-f3-L),which is contributing to phase 6 of the Coupled Model Intercomparison Project(CMIP6),are described in this study.The details of the CAS FGOALS-f3-L model,experiment settings and output datasets are briefly introduced.The datasets include monthly and daily outputs from the atmospheric,oceanic,land and sea-ice component models of CAS FGOALS-f3-L,and all these data have been published online in the Earth System Grid Federation(ESGF,http://gffzzcb5b41580d7f4a25suk69x95kx50x6xpx.ffgz.tsg.suse.edu.cn/projects/cmip6/).The three ensembles are initialized from the 600th,650th and 700th model year of the preindustrial experiment(piControl)and forced by the same historical forcing provided by CMIP6 from 1850 to 2014.The performance of the coupled model is validated in comparison with some recent observed atmospheric and oceanic datasets.It is shown that CAS FGOALS-f3-L is able to reproduce the main features of the modern climate,including the climatology of air surface temperature and precipitation,the long-term changes in global mean surface air temperature,ocean heat content and sea surface steric height,and the horizontal and vertical distribution of temperature in the ocean and atmosphere.Meanwhile,like other state-of-the-art coupled GCMs,there are still some obvious biases in the historical simulations,which are also illustrated.This paper can help users to better understand the advantages and biases of the model and the datasets。 | Yuyang GUO Yongqiang YU Pengfei LIN Hailong LIU Bian HE Qing BAO Shuwen ZHAO and Xiaowei WANG | 2020 | Advances in Atmospheric Sciences2020，37，10： | 1 |
| 14 | Mathematic modeling and characteristic analysis for dynamic system with asym- metrical hysteresis in vibratory compaction显示文摘 | Shen Peihui Lin Shuwen | 2008 | Mec- canica2008，43，： | 1 |
| 15 | Research on the nonlinear hysteretic response characteristics of intelligent vibra- tory roller under horizontal excitation mode显示文摘 | Lin Shuwen Zheng Shuhe | 2013 | Ad- vanced Materials Research2013，694，： | 1 |
| 16 | hnpact of government and industrial agglomeration on industrial land prices: A Taiwanese case study 显示文摘 | Lin Shuwen Ben Taiming | 2009 | Habitat International2009，，33： | 1 |
| 17 | CAS FGOALS-f3-L参加CMIP6 DECK试验数据介绍显示文摘本文介绍了CAS FGOALS-f3-L参加CMIP6 DECK耦合试验数据。主要包括piControl,abrupt-4×CO2和1pctC02的试验设计,模式设置以及初步结果评估。piControl提供了561年的模拟结果,abrupt-4×CO2和1pctCO2分别提供了三组集合成员,每个成员包括160年的积分。初步评估结果表明,piControl试验中,耦合模式可以保证长期稳定积分。在气候态降水模拟上,piControl试验可以合理的再现全球海表温度和降水的基本分布型,相比上一代耦合模式,在ITCZ地区的降水有所改进。另一方面耦合模式的气候敏感度约为3.0℃,相比上一代的耦合模式更为合理。 | HE Bian YU Yongqiang BAO Qing LIN Pengfei LIU Hailong LI Jinxiao WANG Lei LIU Yimin WU Guoxiong CHEN Kangjun GUO Yuyang ZHAO Shuwen ZHANG Xiaoqi SONG Mirong XIE Jinbo | 2020 | Atmospheric and Oceanic Science Letters2020，13，6： | 0 |
| 18 | Four kinds of capping materials for controlling phosphorus and nitrogen release from contaminated sediment using a static simulation experiment显示文摘We determined the effects of quartz sand(QS),water treatment plant sludge(WTPS),aluminum-based P-inactivation agent(Al-PIA),and lanthanum-modified bentonite(LMB)thin-layer capping on controlling phosphorus and nitrogen release from the sediment,using a static simulation experiment.The sediment in the experiment was sampled from Yundang Lagoon(Xiamen,Fujian Province,China),which is a eutrophic waterbody.The total phosphorus(TP),ammonium nitrogen(NH4+-N),and total organic carbon(TOC)levels in the overlying water were measured at regular intervals,and the changes of different P forms in WTPS,Al-PIA,and sediment of each system were analyzed before and after the test.The average TP reduction rates of LMB,Al-PIA,WTPS,and QS were 94.82,92.14,86.88,and 10.68%,respectively,when the release strength of sediment TP was 2.26–9.19 mg/(m^(2)·d)and the capping strength of the materials was 2 kg/m^(2).Thin-layer capping of LMB,WTPS,and Al-PIA could effectively control P release from the sediment(P<0.05).However,thin-layer capping of LMB,Al-PIA,and QS did not significantly reduce the release of ammonium N and organic matter(P>0.05).Based on our results,LMB,Al-PIA,and WTPS thin-layer capping promoted the migration and transformation of easily released P in sediment.The P adsorbed by WTPS and Al-PIA mainly occurred in the form of NAIP. | Zhenming Zhou Canyang Lin Shuwen Li Shupo Liu Fei Li Baoling Yuan | 2022 | Frontiers of Environmental Science & Engineering2022，16，3： | 0 |
| 19 | Datasets for the CMIP6 Scenario Model Intercomparison Project (ScenarioMIP) Simulations with the Coupled Model CAS FGOALS-f3-L显示文摘The datasets for the tier-1 Scenario Model Intercomparison Project(ScenarioMIP)experiments from the Chinese Academy of Sciences(CAS)Flexible Global Ocean-Atmosphere-Land System model,finite-volume version 3(CAS FGOALS-f3-L)are described in this study.ScenarioMIP is one of the core MIP experiments in phase 6 of the Coupled Model Intercomparison Project(CMIP6).Considering future CO2,CH4,N2O and other gases’concentrations,as well as land use,the design of ScenarioMIP involves eight pathways,including two tiers(tier-1 and tier-2)of priority.Tier-1 includes four combined Shared Socioeconomic Pathways(SSPs)with radiative forcing,i.e.,SSP1-2.6,SSP2-4.5,SSP3-7.0 and SSP5-8.5,in which the globally averaged radiative forcing at the top of the atmosphere around the year 2100 is approximately 2.6,4.5,7.0 and 8.5 W m−2,respectively.This study provides an introduction to the ScenarioMIP datasets of this model,such as their storage location,sizes,variables,etc.Preliminary analysis indicates that surface air temperatures will increase by about 1.89℃,3.07℃,4.06℃ and 5.17℃ by around 2100 under these four scenarios,respectively.Meanwhile,some other key climate variables,such as sea-ice extension,precipitation,heat content,and sea level rise,also show significant long-term trends associated with the radiative forcing increases.These datasets will help us understand how the climate will change under different anthropogenic and radiative forcings. | Shuwen ZHAO Yongqiang YU Pengfei LIN Hailong LIU Bian HE Qing BAO Yuyang GUO Lijuan HUA Kangjun CHEN Xiaowei WANG | 2021 | Advances in Atmospheric Sciences2021，38，2： | 0 |
| 20 | Identification and validation of key biomarkers and potential therapeutic targets for primary open-angle glaucoma显示文摘Primary open-angle glaucoma(POAG)is a prevalent cause of blindness worldwide,resulting in degeneration of retinal ganglion cells and permanent damage to the optic nerve.However,the underlying pathogenetic mechanisms of POAG are currently indistinct,and there has been no effective nonsurgical treatment regimen.The objective of this study is to identify novel biomarkers and potential therapeutic targets for POAG.The mRNA expression microarray datasets GSE27276 and GSE138125,as well as the single-cell high-throughput RNA sequencing(sc RNA-seq)dataset GSE148371 were utilized to screen POAGrelated differentially expressed genes(DEGs).Functional enrichment analyses,protein-protein interaction(PPI)analysis,and weighted gene co-expression network analysis(WGCNA)of the DEGs were performed.Subsequently,the hub genes were validated at a single-cell level,where trabecular cells were annotated,and the mRNA expression levels of target genes in different cell clusters were analyzed.Immunofluorescence and quantitative real-time PCR(q PCR)were performed for further validation.DEGs analysis identified 43 downregulated and 32 upregulated genes in POAG,which were mainly enriched in immune-related pathways,oxidative stress,and endoplasmic reticulum(ER)stress.PPI networks showed that FN1 and DUSP1 were the central hub nodes,while GPX3 and VAV3 were screened out as hub genes through WGCNA and subsequently validated by q PCR.Finally,FN1,GPX3,and VAV3 were determined to be pivotal core genes via single-cell validation.The relevant biomarkers involved in the pathogenesis of POAG,may serve as potential therapeutic targets.Further studies are necessary to unveil the mechanisms underlying the expression variations of these genes in POAG. | Jian Wu Caixia Lin Chenlong Yang Lijie Pan Hongyi Liu Sirui Zhu Shuwen Wei Xu Jia Qi Zhang Ziyu Yu Xiaofang Zhao Weihai Liu Yehong Zhuo Ningli Wang | 2023 | Science China(Life Sciences)2023，66，12： | 0 |
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