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| 1 | Successful Applications of Generic Atmospheric Correction Online Service for InSAR (GACOS) to the Reduction of Atmospheric Effects on InSAR Observations显示文摘The tremendous development of Synthetic Aperture Radar(SAR)missions in recent years facilitates the study of smaller amplitude ground deformation over greater spatial scales using longer time series.However,this poses greater challenges for correcting atmospheric effects due to the wider coverage of SAR imagery than ever.Previous attempts have used observations from Global Positioning System(GPS)and Numerical Weather Models(NWMs)to separate atmospheric delays,but they are limited by(1)The availability(and distribution)of GPS stations;(2)The low spatial resolution of NWM;And(3)The difficulties in quantifying their performance.To overcome these limitations,we have developed the Generic Atmospheric Correction Online Service for InSAR(GACOS)which utilizes the high-resolution European Centre for Medium-Range Weather Forecasts(ECMWF)products using an Iterative Tropospheric Decomposition(ITD)model.This enables the reduction of the coupling effects of the troposphere turbulence and stratification and hence achieves equivalent performances over flat and mountainous terrains.GACOS comprises a range of notable features:(1)Global coverage;(2)All-weather,all-time usability;(3)Available with a maximum of two-day latency;And(4)Indicators available to assess the model’s performance and feasibility.In this paper,we demonstrate some successful applications of the GACOS online service to a variety of geophysical studies. | Chen YU Zhenhong LI Lin BAI Jan-Peter MULLER Jingfa ZHANG Qiming ZENG | 2021 | Journal of Geodesy and Geoinformation Science2021，4，1： | 8 |
| 2 | Inactivation of SACE_3446, a TetR family transcriptional regulator, stimulates erythromycin production in Saccharopolyspora erythraea显示文摘Erythromycin A is a widely used antibiotic produced by Saccharopolyspora erythraea;however,its biosynthetic cluster lacks a regulatory gene,limiting the yield enhancement via regulation engineering of S.erythraea.Herein,six TetR family transcriptional regulators(TFRs)belonging to three genomic context types were individually inactivated in S.erythraea A226,and one of them,SACE_3446,was proved to play a negative role in regulating erythromycin biosynthesis.EMSA and qRT-PCR analysis revealed that SACE_3446 covering intact N-terminal DNA binding domain specifically bound to the promoter regions of erythromycin biosynthetic gene eryAI,the resistant gene ermE and the adjacent gene SACE_3447(encoding a longchain fatty-acid CoA ligase),and repressed their transcription.Furthermore,we explored the interaction relationships of SACE_3446 and previously identified TFRs(SACE_3986 and SACE_7301)associated with erythromycin production.Given demonstrated relatively independent regulation mode of SACE_3446 and SACE_3986 in erythromycin biosynthesis,we individually and concomitantly inactivated them in an industrial S.erythraea WB.Compared with WB,the WBΔ3446 and WBΔ3446Δ3986 mutants respectively displayed 36%and 65%yield enhancement of erythromycin A,following significantly elevated transcription of eryAI and ermE.When cultured in a 5 L fermentor,erythromycin A ofWBΔ3446 and WBΔ3446Δ3986 successively reached 4095 mg/L and 4670 mg/L with 23%and 41%production improvement relative to WB.The strategy reported here will be useful to improve antibiotics production in other industrial actinomycete. | Hang Wu Yansheng Wang Li Yuan Yongrong Mao Weiwei Wang Lin Zhu Panpan Wu Chengzhang Fu Rolf Muller David T.Weaver Lixin Zhang Buchang Zhang | 2016 | Synthetic and Systems Biotechnology2016，1，1： | 7 |
| 3 | ReaChR: A red-shifted variant of channelrhodopsin enables deep transcranial optogenet- ic excitation显示文摘 | Lin JY Knutsen PM Muller A | 2013 | Nat Neurosei2013，16，10： | 1 |
| 4 | The comparative RNA web (CRW) site:An online database of comparative sequence and structure information for ribosomal,intron,and other RNAs显示文摘 | Cannone J.J Subramanian S Schnare M.N Collett J.R D'Souza L.M Du Y Feng B Lin N Madabusi L.V Muller K.M Pande N Shang Z Yu N Gutell R.R | | 0，，： | 1 |
| 5 | Total synthesis of a functional designer eukaryotic chromosome 显示文摘 | Annaluru N Muller H Mitchell L A Ramalingam S Stracquadanio G Richardson S M Dymond J S Kuang Z Scheifele L Z Cooper E M Cai Y Z Zeller K Agmon N Han J S Hadjithomas M Tullman J Caravelli K Cirelli K Guo Z Y London V Yeluru A Murugan S Kandavelou K Agier N Fischer G Yang K Martin J A Bilgel M Bohutski P Boulier K M Capaldo B J Chang J Charoen K Choi W J Deng P Dicarlo J E Doong J Dunn J Feinberg J I Fernandez C Floria C E Gladowski D Hadidi P Ishizuka I Jabbari J Lau C Y L Lee P A Li S Lin D Linder M E Ling J Liu J Liu J London M Ma H Mao J Mcdade J E Mcmillan A Moore A M Oh W C Ouyang Y Patel R Paul M Paulsen L C Qiu J Rhee A Rubashkin M G Soh I Y Sotuyo N E Srinivas V Suarez A Wong A Wong R Xie W R Xu Y J Yu A T Koszul R Bader J S Boeke J D Chandrasegaran S | 2014 | Science2014，344，6179： | 1 |
| 6 | ReaChR: a red-shifted vari- ant of channelrhodopsin enables deep transcranialoptogenetic exci- tation显示文摘 | Lin JY Knutsen PM Muller A | 2013 | Nat Neurosci2013，16，10： | 1 |
| 7 | Confined crystallization and morphology of melt segregated PL- LA,b-PE and PLDA-b-PE dibloek copolymers 显示文摘 | CASTILLO R V MULLER A J LIN M C | 2008 | Macromolecules2008，41，16： | 1 |
| 8 | Influence of maeromolecular architecture on the crystallization of (PCL2) -b- (PS2) 4-miktoarm star block eopolymers in comparison to linear PCL-b-PS diblock copolymer analogues 显示文摘 | LORENZO A T MULLER A J LIN M C | 2009 | Macromolecules2009，42，21： | 1 |
| 9 | Grassland responses to grazing:effects of grazing intensity and management system in an Inner Mongolian steppe ecosystem显示文摘 | Sch(o)nbach P Wan HW Gierus M Bai YF Muller K Lin LJ Susenbeth A Taube F | | 0，，： | 1 |
| 10 | The Membrane-Associated Sec1/Munc18 KEULE is Required for Phragmoplast Microtubule Reorganization During Cytokinesis in Arabidopsis显示文摘胞质分裂,划分跟随原子分割的细胞质,要求在膜 trafficking 和细胞骨架动力学之间的广泛的协作。在植物,胞质分裂的发作被一个双极的微导管数组的汇编描绘, phragmoplast,并且短暂的膜分隔空间,房间板。很少在房间板和 phragmoplast 微导管的动力学对在膜免职之间的协作被知道。在这研究,我们在整个胞质分裂监视微导管和膜标记的本地化动力学。我们的空间与时间的分辨率与一般看法一致微导管动力学开车膜运动。尽管如此,我们为在这是的房间板和表演的活跃排序提供证据,至少部分地,由拴住的 TRAPPII 调停了复杂。我们也在胞质分裂有缺陷者异种的一间套房描绘 phragmoplast 微导管组织和房间板形成。有在 phragmoplast 微导管组织的缺点的四根变异的线,仅仅 mor1 联系微导管的异种展出了异常房间盘子。相反地,有在 phragmoplast 微导管重组的最强壮的缺陷的异种是 keule 等位基因,它在膜熔化有一个主要缺点。我们的调查结果在植物胞质分裂期间在膜和微导管动力学的协作作为一个中央规章的节点识别 SEC1/Munc18 蛋白质 KEULE。 | Alexander Steiner Lin Muller Katarzyna Rybak Vera Vodermaier Eva Facher Martha Thellmann Raksha Ravikumar Gerhard Wanner Marie-Theres Hauser Farhah F. Assaad | 2016 | Molecular Plant2016，9，4： | 1 |
| 11 | Chromosome 4 Deletions Are Frequent in Invasive Cervical Cancer and Differ between Histologic Variants显示文摘 | Jennifer B. Sherwood Narayan Shivapurkar W.Michael Lin Raheela Ashfaq David S. Miller Adi F. Gazdar Carolyn Y. Muller | 2000 | Gynecologic Oncology2000，，1： | 1 |
| 12 | Detection of the SiNC radical in IRC+10216显示文摘 | Guélin M Muller S Cernicharo J | 2004 | A&A2004，426，： | 1 |
| 13 | Altered PTEN expression as a diagnostic marker for the earliest endometrial precancers显示文摘 | MUller GL Lin MC Fitzgerald JT | 2000 | J Natl Cancer Inst2000，92，11： | 1 |
| 14 | STEAM创客指导师显示文摘让脑海里的世界成为现实STEAM教育是将五大学科——科学(Science)、技术(Technology)、工程(Engineering)、艺术(Arts)、数学(Maths)融合起来的综合教育模式,是传统STEM教育的升级版。在对多技能人才需求越来越大的今天,仅仅具备理工科视野已不足够,还需要艺术与人文的视角,作为观察、探究世界的补充。 | Muller Lin | 2020 | 大学(高考金刊)2020，，3： | 0 |
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