|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Human umbilical cord-derived mesenchymal stem cell therapy in patients with COVID-19:a phase 1 clinical trial显示文摘No effective drug treatments are available for coronavirus disease 2019(COVID-19).Host-directed therapies targeting the underlying aberrant immune responses leading to pulmonary tissue damage,death,or long-term functional disability in survivors require clinical evaluation.We performed a parallel assigned controlled,non-randomized,phase 1 clinical trial to evaluate the safety of human umbilical cord-derived mesenchymal stem cells(UC-MSCs)infusions in the treatment of patients with moderate and severe COVID-19 pulmonary disease.The study enrolled 18 hospitalized patients with COVID-19(n=9 for each group).The treatment group received three cycles of intravenous infusion of UC-MSCs(3×107 cells per infusion)on days 0,3,and 6.Both groups received standard COVID-treatment regimens.Adverse events,duration of clinical symptoms,laboratory parameters,length of hospitalization,serial chest computed tomography(CT)images,the PaO2/FiO2 ratio,dynamics of cytokines,and IgG and IgM anti-SARS-CoV-2 antibodies were analyzed.No serious UC-MSCs infusion-associated adverse events were observed.Two patients receiving UC-MSCs developed transient facial flushing and fever,and one patient developed transient hypoxia at 12 h post UC-MSCs transfusion.Mechanical ventilation was required in one patient in the treatment group compared with four in the control group.All patients recovered and were discharged.Our data show that intravenous UC-MSCs infusion in patients with moderate and severe COVID-19 is safe and well tolerated.Phase 2/3 randomized,controlled,double-blinded trials with long-term follow-up are needed to evaluate the therapeutic use of UC-MSCs to reduce deaths and improve long-term treatment outcomes in patients with serious COVID-19. | Fanping Meng Ruonan Xu Siyu Wang Zhe Xu Chao Zhang Yuanyuan Li Tao Yang Lei Shi Junliang Fu Tianjun Jiang Lei Huang Peng Zhao Xin Yuan Xing Fan Ji-Yuan Zhang Jinwen Song Dawei Zhang Yanmei Jiao Limin Liu Chunbao Zhou Markus Maeurer Alimuddin Zumla Ming Shi Fu-Sheng Wang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 16 |
| 2 | H5N1 influenza virus-specific miRNA-like small RNA increases cytokine production and mouse mortality via targeting poly(rC)-binding protein 2显示文摘H5N1 流行性感冒病毒的感染在所有流行性感冒病毒之中引起最高的死亡。位于如此的高病毒的致病力下面的机制不完全地被理解。这里,我们报导 H5N1 流行性感冒病毒编码象 microRNA 一样小 RNA, miR-HA-3p,它从茎被处理由 Argonaute 2 的包含环的病毒的 RNA 先锋,和戏在在 H5N1 感染期间提高 cytokine 生产的一个角色。miR-HA-3p poly 指向的机械学的学习表演(rC ) 有约束力的蛋白质 2 (PCBP2 ) 并且压制它的表达式。与 PCBP2 being 一致 RIG-I/MAVS-mediated 抗病毒的天生的免疫的一个重要否定管理者,由 miR-HA-3p 的 PCBP2 表示的抑制在感染 H5N1 的人的巨噬细胞和老鼠支持 cytokine 生产病毒。我们断定 miR-HA-3p 是首先识别的流行性感冒编码病毒的象 microRNA 一样功能的 RNA 碎片和贡献导致 H5N1 的 cytokine 暴风雨和死亡的一个新奇毒力因素。 | Xihan Li Zheng Fu Hongwei Liang Yanbo Wang Xian Qi Meng Ding Xinlei Sun Zhen Zhou Ying Huang Hongwei Gu Limin Li Xi Chen Donghai Li Quan Zhao Fenyong Li Hua Wang Jin Wang Ke Zen Chen-Yu Zhang | 2018 | Cell Research2018，28，2： | 12 |
| 3 | Adsorption of VOCs on reduced graphene oxide显示文摘A modified Hummer's method was adopted for the synthesis of graphene oxide(GO) and reduced graphene oxide(rGO). It was revealed that the modified method is effective for the production of GO and rGO from graphite. Transmission electron microscopy(TEM) images of GO and rGO showed a sheet-like morphology. Because of the presence of oxygenated functional groups on the carbon surface, the interlayer spacing of the prepared GO was higher than that of rGO. The presence of \OH and C_O groups in the Fourier transform infrared spectra(FTIR) spectrum and G-mode and 2D-mode in Raman spectra confirmed the synthesis of GO and rGO. rGO(292.6 m^2/g) showed higher surface area than that of GO(236.4 m^2/g). The prepared rGO was used as an adsorbent for benzene and toluene(model pollutants of volatile organic compounds(VOCs)) under dynamic adsorption/desorption conditions. rGO showed higher adsorption capacity and breakthrough times than GO. The adsorption capacity of rGO for benzene and toluene was 276.4 and 304.4 mg/g, respectively.Desorption experiments showed that the spent rGO can be successfully regenerated by heating at 150.0°C. Its excellent adsorption/desorption performance for benzene and toluene makes rGO a potential adsorbent for VOC adsorption. | Lian Yu Long Wang Weicheng Xu Limin Chen Mingli Fu Junliang Wu Daiqi Ye | 2018 | Journal of Environmental Sciences2018，30，5： | 10 |
| 4 | High-performance silicon−graphene hybrid plasmonic waveguide photodetectors beyond 1.55μm显示文摘Graphene has attracted much attention for the realization of high-speed photodetection for silicon photonics over a wide wavelength range.However,the reported fast graphene photodetectors mainly operate in the 1.55μm wavelength band.In this work,we propose and realize high-performance waveguide photodetectors based on bolometric/photoconductive effects by introducing an ultrathin wide silicon−graphene hybrid plasmonic waveguide,which enables efficient light absorption in graphene at 1.55μm and beyond.When operating at 2μm,the present photodetector has a responsivity of ~70 mA/W and a setup-limited 3 dB bandwidth of >20 GHz.When operating at 1.55μm,the present photodetector also works very well with a broad 3 dB bandwidth of >40 GHz(setup-limited)and a high responsivity of ~0.4 A/W even with a low bias voltage of−0.3 V.This work paves the way for achieving highresponsivity and high-speed silicon-graphene waveguide photodetection in the near/mid-infrared ranges,which has applications in optical communications,nonlinear photonics,and on-chip sensing. | Jingshu Guo Jiang Li Chaoyue Liu Yanlong Yin Wenhui Wang Zhenhua Ni Zhilei Fu Hui Yu Yang Xu Yaocheng Shi Yungui Ma Shiming Gao Limin Tong Daoxin Dai | 2020 | Light(Science & Applications)2020，9，1： | 10 |
| 5 | Highly efficient Cu/anatase TiO2 {001}-nanosheets catalysts for methanol synthesis from CO2显示文摘Anatase TiO_2 nanosheets(-ns-) with dominant exposed {001} facets were used as support to load copper,and the synthesized Cu/TiO_2-ns catalysts were evaluated for CO_2 hydrogenation to methanol. Under the reaction conditions, P = 3.0 MPa, T = 260 ℃, V(N_2):V(H_2):V(CO_2) = 8:69:23 and gas hourly space velocity(GHSV) = 3600 mL g^(-1)h^(-1), the methanol yield reached an appealing high value, 5.6%. Copper-loading amount, calcination temperature and reduction atmosphere have been investigated in this work, which significantly influence the particle sizes of copper and/or the defect concentration in TiO_2, then leading to different catalytic performance. Characterizations of XRD, EPR, CO_2-TPD and FTIR demonstrate that higher specific surface area of Cu is good for the hydrogenation of CO_2 and adequate amount of Ti^(3+) plays important roles in CO_2 activation. Both of them facilitate high turnover frequency(TOF) of methanol formation. | Yunfeng Bao Chunlei Huang Limin Chen Yu dong Zhang Long Liang Jinjun Wen Mingli Fu Junliang Wu Daiqi Ye | 2018 | Journal of Energy Chemistry2018，27，2： | 7 |
| 6 | Systematic Identification of the Light-quality Responding Anthocyanin Synthesis-related Transcripts in Petunia Petals显示文摘Previous studies have shown that high light intensity can induce anthocyanin synthesis(AS)in petunia plants.To identifywhich kind of light quality plays a role in inducing such metabolic process,and what transcripts participate in controlling it,we carried out whole-transcriptome sequencing and analysis of petunia petals treated with different light-quality conditions.Among the red and white light treatments,a total of 2205 differentially expressed genes and 15,22,and 20 differentially expressed circRNAs,miRNAs,and lncRNAs,were identified respectively.The AS-related genes,including the structural genes CHSj,F3H,F35H,DFR,and ANS,and the regulatory genes AN4,DPL,PHZ and MYBx were found to be downregulated under red light condition compared with their levels under white light condition.Furthermore,the light photoreceptor Cryptochrome 3(CRY3)and a series of light-dependent genes,such as PIF,HY5,andBBXs,were also determined to respond to the light treatments.The anthocyanin contents in early petunia petals under red light were significantly lower than that under white and blue light.The results of qRT-PCR further confirmed the expression pattern of some AS-related and light-response genes in response to different light quality.Yeast two-hybrid results showed that the key elements in the light signal pathway,HY5 can interact with BBX19,BBX24 and BBX25.And PHZ,the important AS regulator can induce anthocyanin synthesis in response to blue light quality fromtransient expression analysis in petunia petals.These findings presented here not only deepen our understanding of how light quality controls anthocyanin synthesis,but also allow us to explore potential target genes for improving pigment production in petunia flower petals. | Zhenzhu Fu Hongquan Shang Hui Jiang Jie Gao Xiaoyu Dong Huijuan Wang Yanmin Li Limin Wang Jing Zhang Qingyan Shu Yacong Chao Menglan Xu Rui Wang Liangsheng Wang Hechen Zhang | 2020 | Horticultural Plant Journal2020，6，6： | 7 |
| 7 | A Multicenter Study of Viral Aetiology of Community-Acquired Pneumonia in Hospitalized Children in Chinese Mainland显示文摘Community-acquired pneumonia(CAP) is one of the leading causes of morbidity and mortality in children worldwide.In this study,we aimed to describe the aetiology of viral infection of pediatric CAP in Chinese mainland.During November2014 to June 2016,the prospective study was conducted in 13 hospitals.The hospitalized children under 18 years old who met the criteria for CAP were enrolled.The throat swabs or nasopharyngeal aspirates(NPAs) were collected which were then screened 18 respiratory viruses using multiplex PCR assay.Viral pathogens were present in 56.6%(1539/2721) of the enrolled cases,with the detection rate of single virus in 39.8% of the cases and multiple viruses in 16.8% of the cases.The most frequently detected virus was respiratory syncytial virus(RSV)(15.2%,414/2721).The highest detection rate of virus was in <6-month-age group(70.7%,292/413).RSV,human metapneumovirus(HMPV),human parainfluenza viruses(HPIVs) and influenza B virus(Flu B) showed the similar prevalence patterns both in north and south China,but HPIVs,Flu A,human bocavirus(HBoV),human adenovirus(HAdV) and human coronaviruses(HCoVs) showed the distinct circulating patterns in north and south China.Human enterovirus/human rhinovirus(HEV/HRV)(27.6%,27/98),HBoV(18.4%,18/98),RSV(16.3%,16/98) and HMPV(14.3%,14/98) were the most commonly detected viruses in severe pneumonia cases with single virus infection.In conclusion,viral pathogens are frequently detected in pediatric CAP cases and may therefore play a vital role in the aetiology of CAP.RSV was the most important virus in hospitalized children with CAP in Chinese mainland. | Yun Zhu Baoping Xu Changchong Li Zhimin Chen Ling Cao Zhou Fu Yunxiao Shang Aihuan Chen Li Deng Yixiao Bao Yun Sun Limin Ning Shuilian Yu Fang Gu Chunyan Liu Ju Yin Adong Shen Zhengde Xie Kunling Shen | 2021 | Virologica Sinica2021，36，6： | 7 |
| 8 | Effect of focal adhesion kinase on cytoskeletal arrangement of HepG2 cells induced by hypoxia显示文摘对在 hypoxic HepG2 房间和 HepG2 房间的细胞骨架安排上的 FAK siRNA 的效果的焦点的粘附 kinase (FAK ) 表示由组织缺氧导致了的学习客观。方法 HepG2 房间在 21% O 2 和 1% O 2 是有教养的。词法变化在组织缺氧处理以后被观察。西方的污点被用来测量 FAK 表示。指向 FAK 和向量 pGensil-2 的 mRNA 的 siRNA 表示向量 pshRNA-FAK (作为控制) 被构造,然后 transfected 进 HepG2 房间。西方的污点被用来检测 FAK。有组织缺氧导致的 pshRNA-FAK 的 HepG2 房间 transfected 的细胞骨架安排被 phalloidin 分析。有组织缺氧导致的 pshRNA-FAK 的 HepG2 房间 transfected 的迁移的能力被房间迁居试金分析。结果对待组织缺氧的房间与房间分开的大度显示了更多的伸长的形状。FAK 表示在 hypoxic HepG2 房间增加了。FAK 蛋白质水平被 75.64% ±减少 3.12%(P <
0.01 ) 在 pshRNA-FAK transfection 以后。组织缺氧导致了 HepG2 房间的细胞骨架安排。然而,有组织缺氧导致的 pshRNA-FAK 的 HepG2 房间 transfected 的细胞骨架安排在 1% O 2 被禁止。当房间移植试金出现了,有 pshRNA-FAK 的 HepG 房间 transfected 的移居的数字比控制的显著地低(P <
0.05 ) 。在 hypoxic HCC 的 FAK 的表示可能有一种靠近的关系到 HepG2 房间的细胞骨架安排的结论由组织缺氧导致了。FAK 表示的起来规定可以是细胞骨架安排的机制和组织缺氧导致的 hepatocellular 癌的侵略之一。 | Wei Yan Yu Fu Jiazhi Liao Limin Xia Min Luo Qian Zhu Dean Tian | 2009 | The Chinese-German Journal of Clinical Oncology2009，8，3： | 4 |
| 9 | Macroporous Ni foam-supported Co_3O_4 nanobrush and nanomace hybrid arrays for high-efficiency CO oxidation显示文摘Herein, we reported the synthesis of well-defined Co_3O_4 nanoarrays(NAs) supported on a monolithic three-dimensional macroporous nickel(Ni) foam substrate for use in highefficiency CO oxidation. The monolithic Co_3O_4 NAs catalysts were obtained through a generic hydrothermal synthesis route with subsequent calcination. By controlling the reaction time,solvent polarity and deposition agent, these Co_3O_4 NAs catalysts exhibited various novel morphologies(single or hybrid arrays), whose physicochemical properties were further characterized by using several analytical techniques. Based on the catalytic and characterization analyses, it was found that the Co_3O_4 NAs-6 catalyst with nanobrush and nanomace arrays displayed enhanced catalytic activity for CO oxidation, achieving an efficient 100% CO oxidation conversion at a gas hourly space velocity(GHSV) 10,000 hr^(-1) and 150°C with longterm stability. Compared with the other Co_3O_4 NAs catalysts, it had the highest abundance of surface-adsorbed oxygen species, excellent low-temperature reducibility and was rich in surface-active sites(Co^(3+)/Co^(2+)= 1.26). | Shengpeng Mo Hui He Quanming Ren Shuangde Li Weixia Zhang Mingli Fu Limin Chen Junliang Wu Yunfa Chen Daiqi Ye | 2019 | Journal of Environmental Sciences2019，31，1： | 4 |
| 10 | Effects of centrifugal and Coriolis forces on the mold-filling behavior of titanium melts in vertically rotating molds显示文摘The vertical centrifugal-casting technique is widely used in the manufacture of various irregularly-shaped castings of advanced structural alloys with thin walls,complex shapes and/or large sizes.These castings are used in the increasing applications in aero-space/aviation industries,human teeth/bone repairs with near-net shaped components,etc.In a vertically rotating casting system,the mold-filling processes of alloy melts,coupled with solidification-heat transfer,may be much more complicated,because they are driven simultaneously by gravity,centrifugal and Coriolis forces.In the present work,an N-S/VOF-equations-based model,solved using a SOLA-VOF algorithm,under a rotating coordinate system was applied to numerically investigate the impacts of centrifugal and Coriolis forces on metallic melt mold-filling processes in different vertical centrifugal-casting configurations with different mold-rotation rates using an authors'computer-codes system.The computational results show that the Coriolis force may cause remarkable variations in the flow patterns in the casting-part-cavities of a large horizontal-section area and directly connected to the sprue via a short ingate in a vertical centrifugal-casting process.A'turn-back'mold-filling technique,which only takes advantage of the centrifugal force in a transient rotating melt system,has been confirmed to be a rational centrifugal-casting process in order to achieve smooth and layer-by-layer casting-cavities-filling control.The simulated mold-filling processes of Ti-6Al-4V alloy melt,in a vertical centrifugal-casting system with horizontally-connected plate-casting cavities,show reasonable agreement with experimental results from the literature. | Xu Daming Jia Limin Fu Hengzhi | 2008 | China Foundry2008，5，4： | 4 |
| 11 | Development of agricultural bionic mechanisms:Investigation of the effects of joint angle and pressure on the stability of goats moving on sloping lands显示文摘The use of small-scale agricultural machinery becomes prevalent as it provides the stability of agricultural machinery research ideas.To lay the theoretical foundation for the research and design of agriculture walking mechanism,the Phantom Camera Control software was used to measure the anterior and posterior joint angle of a goat walking on different slopes.Foot pressure was measured by the film pressure sensor.The result of joint motion sequence,range of motion,and change of range showed that the fitting degree of the measured value was accurate.As the goat walking speed increased,the level of the hind limb angle changed to ensure itself stability.When the goat is walking,the forelimbs bear more weight than the hind limbs due to the different static and physiological structures of the front and rear legs.The key parameters of gait on different slopes were analyzed.The curve of angle change of legs was measured and analyzed when the goat is walking in slope.The results showed that,with the increase of the slope gradient,the anterior hip angle ranges from 83.3°to 117.1°,the posterior hip angle ranges at 120.3°-173.1°,the left knee angle ranges from 91.3°to 170.1°,the right knee angle is roughly the same as its range of variation.When the slope increased,the pressure change of left hind foot was consistent with that of the right anterior foot,and the pressure change of right hind foot was consistent with that of the left anterior foot.This demonstrated the theory of diagonal gait.Meanwhile,with the change of the slope,the plantar pressure of the limbs changes periodically.The research results verified the rationality of the four-legged bionic mechanism under various parameters,which can provide a theoretical basis for the design of agricultural walking mechanism to adapt different slopes in the hilly and mountainous areas. | Fu Zhang Limin Zheng Wei Wang Yafei Wang Jiajia Wang | 2018 | International Journal of Agricultural and Biological Engineering2018，11，3： | 3 |
| 12 | Temperature modulation of concentration quenching in lanthanide-doped nanoparticles for enhanced upconversion luminescence显示文摘lanthanide 离子的做的集中为操作 upconversion nanoparticles (UCNP ) 的光性质是重要的。然而,在高度做的 UCNP 熄灭的严肃的集中为进一步提高的 upconversion 光(UCL ) 仍然是重要限制。此处,我们在熄灭的集中上检验了温度的效果稀土元素的 UCNP,被俯看的一个问题,和我们证明它为 UCNP 的生物医学或光的应用是重要的。在这个工作,我们由做准备了一系列 UCNP 嗯 3+ 在在一个 NaLuF 4:Yb3+ 矩阵的不同集中的光中心。在房间温度(298 K ) ,不变的光致发光(PL ) 光谱学显示出与增加做集中 Er 3+ 排放熄灭的实质的集中。然而,熄灭效果的集中在更低的温度不再是有效的。进一步从解决时间的 PL 光谱学获得的运动曲线证明熄灭动力学的集中极其在低温实验法的温度区域被改变,即,在 160 K 下面。我们熄灭机制的温度可切换的集中上的工作可以使改善 UCL 性质清楚些,支持他们的实际应用。 | Luoyuan Li Ningjiu Zhao Limin Fu Jing Zhou Xicheng Ai Jianping Zhang | 2018 | Nano Research2018，11，4： | 3 |
| 13 | Effects of Dietary Concentrate to Forage Ratios on Production Performance and Serum Biochemical Indicators in Post-fattening Hainan Yellow Cattle显示文摘[Objective]The paper was to investigate the effects of dietary concentrate to forage ratios on production performance and serum bio-chemical indicators of post-fattening Hainan Yellow Cattle.[Method]Sixteen Hainan Yellow Cattles with the same genetic backgrounds and similar initial weight of(242.22 ±0.71 kg) were randomly divided into four treatments.Cattles were fed with diets of different concentrate to forage ratios(20:80, group Ⅰ;30:70, Group Ⅱ;40:60, group Ⅲ;50:50, group Ⅳ).The trial lasted 62 d.[Result]The daily gain in experimental group Ⅳ was significantly higher than that in experimental group Ⅱ(P<0.05), but the feed gain ratio in experimental group Ⅳ was lower than those in other ex-perimental groups(P>0.05).The feed intake in experimental group Ⅳ was also markedly higher than those in experimental groups Ⅰ and Ⅱ(P<0.05).Compared with the experimental group Ⅱ, the gross profit of experimental group Ⅳ was significantly promoted(P<0.05).The alanine aminotransferase and aspartate aminotransferase activities in experimental group Ⅱ were markedly higher than those in experimental groups Ⅰ, Ⅲ and Ⅳ.[Conclusion]When the dietary concentrate to forage ratios was 50∶50, the production performance of post-fattening Hainan Yellow Cattle was better. | Wang Feng Wei Limin Zheng Xinli Liu Hailong Sun Ruiping Chao Zhe Huang Lili Fu Liang Liu Quanwei | 2020 | Animal Husbandry and Feed Science2020，12，1： | 3 |
| 14 | Formation and Optical Properties of ZnO:ZnFe_(2)O_(4) Superlattice Microwires显示文摘Pure ZnO hexagonal microwires and Fe(Ⅲ)-doped ZnO microwires(MWs)with a novel rectangular cross section were synthesized in a confined chamber by a convenient one-step thermal evaporation method.An oriented attachment mechanism is consistent with a vapor-solid growth process.Photoluminescence(PL)and Raman spectroscopy of the Fe(Ⅲ)-doped ZnO MWs and in situ spectral mappings indicate a quasi-periodic distribution of Fe(Ⅲ)along a one-dimensional(1-D)superlattice ZnO:ZnFe_(2)O_(4) wire,while PL mapping shows the presence of optical multicavities and related multimodes.The PL spectra at room temperature show weak near-edge doublets(376 nm and 383 nm)and a broad band(450-650 nm)composed of strong discrete lines,due to a 1-D photonic crystal structure.Such a 1-D coupled optical cavity material may find many applications in future photonic and spintronic devices. | Yun Li Guozhang Dai Chunjiao Zhou Qinglin Zhang Qiang Wan Limin Fu Jianping Zhang Ruibin Liu Chuanbao Cao Anlian Pan Yunhong Zhang Bingsuo Zou | 2010 | Nano Research2010，3，5： | 2 |
| 15 | Source profiles of volatile organic compounds (VOCs) measured in China: Part I显示文摘 | Ying Liu Min Shao Linlin Fu Sihua Lu Limin Zeng Dagang Tang | 2008 | Atmospheric Environment2008，，25： | 2 |
| 16 | Analysis of uterine CD49a^(+) NK cell subsets in menstrual blood reflects endometrial status and association with recurrent spontaneous abortion显示文摘Maternal uterine immune cells,especially natural killer(NK)cells,are important for successful pregnancy,and an abnormal number or function of uterine NK cells is closely correlated with an impaired endometrial environment and miscarriage.However,there are currently no noninvasive testing methods using reliable indicators that accurately predict uterine changes leading to miscarriage.Here,we confirmed that before implantation,menstrual blood(MB)from healthy donors had 70%CD49a^(+)tissue-resident NK(trNK)cells,the majority of which were CD49a^(+)Eomes+NK cells.Importantly,MB from patients with recurrent spontaneous abortion(RSA)had many fewer CD49a^(+)trNK cells than MB from controls.Analysis of uNK cell populations in MB may better predict an abnormal endometrial environment associated with miscarriage than peripheral blood(PB)analysis.Therefore,we suggest using MB-and CD49a-related markers as a promising noninvasive way to evaluate endometrial status. | Xianhong Tong Min Gao Xianghui Du Fangting Lu Limin Wu Haiming Wei Binqing Fu | 2021 | Cellular & Molecular Immunology2021，18，7： | 2 |
| 17 | Source profiles of volatile organic compounds (VOCs) measured in China: Part I显示文摘 | Ying Liu Min Shao Linlin Fu Sihua Lu Limin Zeng Dagang Tang | 2008 | Atmospheric Environment2008，，25： | 2 |
| 18 | Rule generation from neural networks显示文摘 | FU Limin | 1994 | IEEE Transaction on System Man and Cybernetics1994，24，8： | 1 |
| 19 | Treatment planning optimization by quasi Newton and simulated annealig methods for gammma unit treatment system显示文摘 | SHU Huazhong YAN Yulong BAO Xudong FU Yao LUO Limin | 1998 | Physics on Medical Biology1998，43，10： | 1 |
| 20 | PD-L1 is increased in the spinal cord and infiltrating lymphocytes in experimental allergic encephalomyelitis显示文摘Experimental allergic encephalomyelitis is a mouse model of human multiple sclerosis with similar pathology and pathogenesis.Th1 cells play an important role in the pathogenesis of experimental allergic encephalomyelitis.This study determined the potential effect of programmed cell death 1ligand 1 in the pathogenesis of experimental allergic encephalomyelitis induced by injecting myelin oligodendrocyte glycoprotein,complete Freund’s adjuvant and Bordetella pertussis toxin into C57BL/6J mice.Experimental allergic encephalomyelitis mice developed disease and showed inflammatory changes in the central nervous system by hematoxylin-eosin staining of spinal cord pathological sections,demyelination by Luxol fast-blue staining and clinical manifestations.The expression of programmed cell death 1 ligand 1 in mice was detected by immunohistochemistry,flow cytometry and western blot analysis.The expression of programmed cell death 1 ligand 1 in the spinal cord and splenocytes of mice was significantly increased compared with normal mice.Our findings suggest the involvement of programmed cell death 1 ligand 1 in the pathogenesis of experimental allergic encephalomyelitis and suggest this should be studied in multiple sclerosis. | Min Li Jiandong Jiang Bing Fu Jiechun Chen Qun Xue Wanli Dong Yanzheng Gu Lingtao Tang Limin Xue Qi Fang Mingyuan Wang Xueguang Zhang | 2013 | Neural Regeneration Research2013，8，35： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员