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| 1 | Features of extrahepatic metastasis after radiofrequency ablation for hepatocellular carcinoma显示文摘BACKGROUND Extrahepatic metastasis(EHM)of hepatocellular carcinoma(HCC)is associated with poor outcomes.However,the clinical features and risk factors of EHM of HCC after radiofrequency ablation(RFA)remain unclear.AIM To elucidate the characteristics and risk factors of EHM after RFA for HCC.METHODS From January 2008 to December 2017,we retrospectively enrolled 661 patients who underwent RFA as first-line treatment for HCC at 2 tertiary hospitals.The inclusion criteria were age≥18 years,a diagnosis of HCC,and treatment-naivety.Abdominal computed tomography(CT)or magnetic resonance imaging(MRI)and alpha-fetoprotein measurements were routinely performed at 1 mo after RFA and followed-up at intervals of 3-6 mo.Univariate analyses were performed using the chi-squared test or Student’s t-test,and univariate and multivariate analyses were performed via logistic regression,as appropriate.RESULTS EHM was diagnosed in 44 patients(6.7%)during a median follow-up period of 1204 days.The 10-year cumulative rate of HCC recurrence and EHM was 92.7%and 33.7%,respectively.Initial recurrence was most often intrahepatic,and the rate of extrahepatic recurrence at initial recurrence was only 1.2%.The median time to the diagnosis of EHM was 2.68 years,and 68.2%of patients developed EHM within 2 years of the first recurrence,regardless of recurrence-free survival and 75.0%of patients developed EHM within 5 years after first recurrence.EHM was mostly diagnosed via abdominal CT/MRI in 33(75.0%)and 38 of 44 patients(86.4%)with EHM had either positive abdominal CT scan results or serum AFP level elevation.In multivariate analysis,recurrence-free survival<2 years,ablation zone/tumor size<2,and alpha-fetoprotein level>400 IU/mL were associated with a high EHM risk.CONCLUSION EHM occurs following multiple intrahepatic recurrences after RFA and combined contrast-enhanced abdominal CT and serum AFP were useful for surveillance.Patients especially with high-risk factors require close follow-up for EHM. | Jae H Yoon Young J Goo Chae-Jun Lim Sung K Choi Sung B Cho Sang S Shin Chung H Jun | 2020 | World Journal of Gastroenterology2020，26，32： | 3 |
| 2 | A GA paradigm for learning fuzzy rules 显示文摘 | Lim M H Rahardja S Gwee B H | 1996 | Fuzzy Sets and Systems1996，72，2： | 2 |
| 3 | Hydrodynamics of spouted and spout-fluidized beds at high temperature 显示文摘 | Ye B Lim C J Grace J R | 1992 | The Canadian Journal of Chemical Engineering1992，70，5： | 2 |
| 4 | Prediction of plant microRNA targets 显示文摘 | Rhoades M W Reinhart B J Lim L P | 2002 | Cell2002，110，4： | 1 |
| 5 | Homoeologous recombination in 2n-ganetes producing interspecific hybrids of Lilium(Liliaceae)studied by genomic in stiu hybridization (GISH)显示文摘 | KARLOV G KHRUSTALEVA L L LIM K B | 1999 | Genome1999，42，： | 1 |
| 6 | Coordination of differential effects of primary estrogen and catecholestrogen on two distinct targets mediates embryo implantation in the mouse显示文摘 | PARIA B C LIM H WANG X N | 1998 | Endocrinology1998，139，12： | 1 |
| 7 | Flowdfield around ogive/elliptic-tip cylinder at high angle of attack显示文摘 | LIM T T LUA K B | 1998 | AIAA Journal1998，36，10： | 1 |
| 8 | Transpalatal advancement pharyngoplasty outcomes compared with uvulopalatopharygoplasty显示文摘 | WOODSON B T ROBINSON S LIM H J | 2005 | Otolaryngol Head NeckSurg2005，133，： | 1 |
| 9 | Crane scheduling with spatial constraints显示文摘 | Lim A Rodrigues B Xiao F | 2004 | Naval Research Logistics2004，51，： | 1 |
| 10 | Cl-channel blockers inhibit cell proliferation and arrest the cell cycle of human ovarian cancer cells显示文摘 | LiM Wang B Lin W | 2008 | Eur J Gynaecol Oncol2008，29，3： | 1 |
| 11 | A GA paradigm for learning fuzzy rules显示文摘 | Lim M N Rahardjm S Gwee B H | 1996 | Fuzzy Systems1996，82，2： | 1 |
| 12 | Physical properties of gelidium corneum-gelatin blend films containing grapefruit seed extract or green tea extract and its application in the packaging of pork loins显示文摘 | HONG Y H LIM G O SONG K B | 2009 | Food Science2009，74，1： | 1 |
| 13 | Preparation of Ru thin film layer on Si and TaN/Si as diffusion barrier by plasma enhanced atomic layer deposition 显示文摘 | Choi B H Lim Y H Lee J H0 | 2010 | Microelec- tronie Engineering2010，87，： | 1 |
| 14 | Curcumin down -regulates the muhidrug- resistance mdrl b genc by inhibiting the PI3K/Akt/ NF kappa B pathway显示文摘 | CHOI B H KIM C G LIM Y | 2008 | Cancer Lett2008，259，： | 1 |
| 15 | BMP-2 modulates beta-catenin signaling through stimulation of Lrp5 expression and inhibition of beta-TrCP expression in osteoblasts显示文摘 | ZHANG M YAN Y LIM Y B | 2009 | J Cell Biochem2009，108，4： | 1 |
| 16 | Deconjugation of bile salts by Lactobacillus acidophilus isolates显示文摘 | AHN Y T KIM G B LIM K S | | 0，，： | 1 |
| 17 | Forward kinematics solution of stewartplatform using neural networks 显示文摘 | YEE C S LIM K B | 1997 | Neurocomputing1997，16，3： | 1 |
| 18 | Prediction of inverse covariance matrix( PICM ) sequences for STAP 显示文摘 | Lim C H Mulgrew B | 2006 | IEEE Signal Process Letters2006，15，4： | 1 |
| 19 | Environmentally friendly preparation of pec- fins from agricultural byproducts and their strnctural/rheological char- acterization 显示文摘 | Min B Lim J Ko S | 2011 | Bioresource Technology2011，102，4： | 1 |
| 20 | Gene induction by glycyrol to apoptosis through endonuclease G in tumor cells and prediction of oncogene function by microarray analysis显示文摘 | Lee S 0h H M Lim W B | 2008 | Anticancer Drugs2008，19，5： | 1 |
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