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| 1 | 亚太地区慢性乙型肝炎治疗共识(2012最新版)显示文摘自2008年至今,有大量关于慢性HBV感染的自然史和治疗的最新数据不断涌现。其中包括慢性HBV感染的无症状感染者,以社区为基础的队列研究,HBV基因型的作用,非药物诱导的自然HBV变异型毒株,无创性肝纤维化评估方法的应用,HBsAg定量在临床中的应用,更有效的新治疗药物和新治疗方案等等。来自亚太地区的专家审查和评估了相关数据,并共同商讨了近年来报道的最有意义的发现,基于此,对2008年版的亚太地区慢性乙型肝炎治疗共识进行修订,同时对2008年版治疗指南定义的关键词组进行了修订。修订后的指南包括以下几方面内容:一般治疗,肝纤维化评价适应证,何时开始治疗或停药,初始抗病毒治疗药物的选择,如何监测治疗中和治疗后的患者。关于特殊人群的治疗建议中包括了对妊娠妇女,已发生耐药,合并其他病毒感染,肝功能失代偿,接受免疫抑制治疗、化疗,肝移植或肝细胞癌患者的具体治疗建议。 | 廖运范 Jia-HorngKao Teerha Piratvisuth Henry Lik Yuen Chan Rong-Nan Chien Chun-Jen Liu Ed Gane Stephen Locarnini Seng-Gee Lim Kwang-Hyub Han Deepak Amarapurkar Graham Cooksley Wasim Jafri Rosmawati Mohamed Wan-Long Chuang Laurentius A.Lesmana Jose D.Sollano Dong-Jin Suh Masao Omata 刘颖 徐莹 李芸 黄祖雄 樊蓉 李小溪 吕国涛 周彬 孙剑 侯金林 | 2012 | 临床肝胆病杂志2012，28，8： | 182 |
| 2 | Expression of heat shock proteins (HSP27, HSP60, HSP70, HSP90, GRP78, GRP94) in hepatitis B virus-related hepatocellular carcinomas and dysplastic nodules显示文摘AIM: Expression of heat shock proteins (HSPs) is frequently up-regulated in hepatocellular carcinoma (HCC), which evolves from dysplastic nodule (DN) and early HCC to advanced HCC. However, little is known about the differential expression of HSPs in multistep hepatocarcinogenesis. It was the purpose of this study to monitor the expression of HSPs in multistep hepatocarcinogenesis and to evaluate their prognostic significance in hepatitis B virus (HBV)related HCC.METHODS: Thirty-eight HCC and 19 DN samples were obtained from 52 hepatitis B surface antigen-positive Korean patients. Immunohistochemical and dot immunoblot analyses of HSP27, HSP60, HSP70, HSP90, glucoseregulated protein (GRP)78, and GRP94 were performed and their expression at different stages of HCC development was statistically analyzed.RESULTS: Expression of HSP27, HSP70, HSP90, GRP78, and GRP94 increased along with the stepwise progression of hepatocarcinogenesis. Strong correlation was found only in GRP78 (Spearman's r= 0.802). There was a positive correlation between the expressions of GRP78, GRP94, HSP90, or HSP70 and prognostic factors of HCC. Specifically, the expression of GRP78, GRP94, or HSP90 was associated significantly with vascular invasion and intrahepatic metastasis.CONCLUSION: The expressions of HSPs are commonly up-regulated in HBV-related HCCs and GRP78 might play an important role in the stepwise progression of HBVrelated hepatocarcinogenesis. GRP78, GRP94, and HSP90 may be important prognostic markers of HBV-related HCC, strongly suggesting vascular invasion and intrahepatic metastasis. | Seung Oe Lim Sung Gyoo Park Jun-Hi Yoo Young Min Park Hie-Joon Kim Kee-Taek Jang Jae Won Cho Byung Chul Yoo Gu-Hung Jung Cheol Keun Park | 2005 | World Journal of Gastroenterology2005，11，14： | 62 |
| 3 | Systematic review on the surgical treatment for T1 gallbladder cancer显示文摘AIM:To evaluate the efficacy of simple and extended cholecystectomy for mucosa(T1a) or muscularis(T1b) gallbladder(GB) cancer. METHODS:Original studies on simple and extended cholecystectomy for T1a or T1b GB cancer were searched from MEDLINE(PubMed) ,Cochrane Library,EMBase,and CancerLit using the search terms of GB,cancer/carcinoma/tumor/neoplasm. RESULTS:Twenty-nine out of the 2312 potentially relevant publications met the eligibility criteria.Of the 1266 patients with GB cancer included in the publications,706(55.8%) and 560(44.2%) had T1a and T1b GB cancer,respectively.Simple cholecystectomy for T1a and T1b GB cancer was performed in 590(83.6%) and 375(67.0%) patients,respectively(P<0.01) .In most series,the treatment of choice was simple cholecystectomy for T1a GB cancer patients with a 5-year survival rate of 100%.Lymph node metastasis was detected in 10.9% of the T1b GB cancer patients and in 1.8%of the T1a GB cancer patients,respectively(P<0.01) .Eight patients(1.1%) with T1a GB cancer and 52 patients(9.3%) with T1b GB cancer died of recurrent GB cancer(P<0.01) . CONCLUSION:Simple cholecystectomy represents the adequate treatment of T1a GB cancer.There is no definite evidence that extended cholecystectomy is advantageous over simple cholecystectomy for T1b GB cancer. | Seung Eun Lee Jin-Young Jang Chang-Sup Lim Mee Joo Kang Sun-Whe Kim | 2011 | World Journal of Gastroenterology2011，17，2： | 69 |
| 4 | High-dose Iodized Oil Transcatheter Arterial Chemoembolization For Patients with Large Hepatocellular Carcinoma显示文摘AIM:To conduct a randomized trial to evaluate the role ofusing high-dose iodized oil transcatheter arterialchemosmbolization(TACE)in the treatment of largehepatocellular carcinoma(HCC).METHODS:From January 1993 to June 1998,473 patientswith unresectable hepatocellular carcinoma ware divided intotwo groups:216 patients in group A received more than20mL iodized oil during the first TACE treatment;257patients in group B received 5-15mL iodized oil in the sameway.The Child's classification and ICG-R15 for evaluatingthe liver function of the patients ware done before thetreatment.During the TACE procedure the catheters wasinserted into the target artery selectively and the tumorvessels ware demonstrated with contrast medium in thehepatic angiography.The anticancar drugs mixed withiodized oil(Lipiodol)ware Epirubicin and Mitomycin.Ingroup A,112 cases received 20-29mL Lipiodol in the firstprocedure,85 cases 30-39mL,19 cases more than 40mL.The largest dose was 53 mL and the average dose was28.3mL.In group B,119 cases received 5-10mL Lipiodol,138 cases received 11-15mL,and the average dose was11.8mL.RESULTS:High-dose Lipiodol chemoembolization causedtolerable side effects and a little hurt to the liver function inthe patients with Child grade A or ICG-R15<20.But thepatients with child grade B or ICG-R15>20 had higher risk ofliver failure after high-dose TACE.More type Ⅱ and type Ⅱlipiodol accumulations in CT scan after 4 weeks of TACEware seen in the group A patients than those in the group Bpatients(P<0.01).The resection rate and complete tumornecrosis rate in group A ware higher than those of group B(P<0.05).The 1-,2-,3-year survival rates of group Apatients with Child grade A ware 79.2%,51.8% and 34.9%,respectively,better then those of group B(P<0.001).CONCLUSION:High-dose Lipiodol can result in morecomplete tumor necrosis by blocking both arteries and small portal veins of the tumor.High-dose TACE for treatment oflarge and hypervascular hepatocallular carcinoma ispractically acceptable with the better effect than the routinedose.For the patients with large and hypervascular tumor ofChild grade A liver function or ICG-R15 less than 20%,oilychemoembolization with 20-40mL Lipiodol is recommended. | Min-Shan Chen Jin-Qing Li Ya-Qi Zhang Yun-Fei Yuan Yong-Ping Guo Xiao-Jun Lin Guo-Hui Lim Department of Hepatobiliary Cancer Center of Sun Yet-sen University of Medical Sciences,Guangzhou 510060,China Li-Xia Lu Wei-Zhang Zhang Department of Radiology Cancer Center of Sun Yet-sen University of Medical Sciences,Guangzhou 510060,China | 2002 | World Journal of Gastroenterology2002，8，1： | 58 |
| 5 | The promoting molecular mechanism of alphafetoprotein on the growth of human hepatoma Bel7402 cell line显示文摘AIM: The goal of this study was to characterize the AlPreceptor, its possible signal transduction pathway and itsproliferative functions in human hepatoma cell line Bel 7402.METHODS: Cell proliferation enhanced by AFlP was detectedby MTT assay, 3H-thymidine incorporation and S-stsgepercentage of cell cycle analysis. With radioactive labeled 125 I-AFP for receptor binding assay; cAMP acctmuation, ProteinKinase A activity were detected by radioactive immunosorbentassay and the change of intracellular free calcium ([Ca2+ ], )was monitored by scanning fluorescence intensity under TCS-NT confocal microscope. The expression of oncxgenes N- ras,p53, and p21ras in the cultured cells in vitro were detected byNorthem blotting and Western blotting respectively.RESULTS: It was demonstrated that AFP enhanced theproliferation of human hepatoma Bel 7402 cell in a dosedependlent fashion asshown in MTT assay, 3H-thymidineincorporation and S-phase percentage up to 2-fold. Twosubtypes of AFP receptors were identified in the cells withKds of 1.3 x 10-9 mol. L-1 and 9.9 x 10-8 mol. L-1 respectively.Pretreatnent of cells with AFP resulted-in a significantincrease (625 %) in cAMP accumulation. The activity ofprotein kinase A activity were increased up to 37.5, 122.6,73.7 and 61.2 % at treatment time point 2, 6, 12 and 24hours. The level of intracellular calcium were elevated afterthe treatment of alpha-fetoprotsin and achieved to 204 % at 4min. The results also showed that AFP (20 mg. L-1 ) couldupregulate the expression of N-ras oncogenes and p53 andp21ras in Bel 7402 cells. In the later case, the alteration ware 81.1%(12 h) and 97.3 %(12 h) respectively compared with control.CONCLUSION: These results demonstrate that AFP is apotential growth factor to promote the proliferation of humanhepatoma Bel 7402 cells. Its growth-regulatory effects aremediated by its specific plasma membrane receptorscoupled with its transmembrane signaling transductionthrough the pathway of cAMP-PKA and intracellular calciumto regulate the expression of oncogenes. | LiMS LiPF 等 | 2002 | World Journal of Gastroenterology2002，8，3： | 59 |
| 6 | Helicobacter pylori associated chronic gastritis,clinical syndromes,precancerous lesions,and pathogenesis of gastric cancer development显示文摘Helicobacter pylori(H.pylori)infection is well known to be associated with the development of precancerous lesions such as chronic atrophic gastritis(AG),or gastric intestinal metaplasia(GIM),and cancer.Various molecular alterations are identified not only in gastric cancer(GC)but also in precancerous lesions.H.pylori treatment seems to improve AG and GIM,but still remains controversial.In contrast,many studies,including meta-analysis,show that H.pylori eradication reduces GC.Molecular markers detected by genetic and epigenetic alterations related to carcinogenesis reverse following H.pylori eradication.This indicates that these changes may be an important factor in the identification of high risk patients for cancer development.Patients who underwent endoscopic treatment of GC are at high risk for development of metachronous GC.A randomized controlled trial from Japan concluded that prophylactic eradication of H.pylori after endoscopic resection should be used to prevent the development of metachronous GC,but recent retrospective studies did not show the tendency.Patients with precancerous lesions(molecular alterations)that do not reverse after H.pylori treatment,represent the'point of no return'and may be at high risk for the development of GC.Therefore,earlier H.pylori eradication should be considered for preventing GC development prior to the appearance of precancerous lesions. | Jiro Watari Nancy Chen Peter S Amenta Hirokazu Fukui Tadayuki Oshima Toshihiko Tomita Hiroto Miwa Kheng-Jim Lim Kiron M Das | 2014 | World Journal of Gastroenterology2014，20，18： | 60 |
| 7 | 经桡动脉穿刺的冠状动脉介入治疗显示文摘目的 探讨经桡动脉穿刺行冠状动脉介入治疗的可行性和安全性。方法 116例冠心病患者 (男 96例 ,女 2 0例 ,平均年龄 5 7 44± 9 40岁 )经桡动脉穿刺行冠状动脉介入治疗。结果 5例桡动脉穿刺失败改行股动脉穿刺 ,2例桡动脉穿刺虽成功但试行球囊扩张失败 ,其余患者均取得穿刺和介入治疗成功。共扩张病变血管 135支 (前降支 6 9支 ,回旋支 2 6支 ,右冠状动脉 39支 ,静脉桥血管1支 ) ,治疗病变 148处 (A型 15处 ,B型 10 6处 ,C型 2 7处 )。 98例患者的 10 5支血管植入支架共 110个 ,1例行旋磨术 ,1例行冠状动脉内超声检查。 2 5例患者术中须更换导引导管。术后穿刺局部大量出血需输血者 1例 ,局部较大血肿 2例 ,肘动脉分支穿孔 1例。结论 经桡动脉穿刺行冠状动脉介入治疗在临床上可行 ,但穿刺较困难 ,导引导管支撑力较差 ,应警惕局部血管损伤的可能。 | 洪涛 Koh Tian Hai Charles Chan Lim Yean-Leng | 2002 | 中国介入心脏病学杂志2002，10，3： | 39 |
| 8 | Nat Genet:单细胞分析解开结直肠癌细胞的神秘面纱显示文摘结合单细胞基因组学和计算机技术,一个研究团队(包括来自杰克逊实验室(JAx)单细胞生物学主任Paul Robson博士在内)鉴定出了11种结直肠癌肿瘤的癌细胞组成及邻近的非癌细胞。这对于更好的肿瘤靶向诊断和治疗很重要。”使用单细胞测序。”JAX科学家、这篇发表在Nature Genetics上的文章共同第一作者Elise Courtois说道。”我们可以根据肿瘤中的细胞组成将结直肠癌进一步分类。因为每种亚型的肿瘤病人生存率存在差别,我们的方法将为肿瘤医生提供更多的关于肿瘤预后和治疗的信息。” | Huipeng Li, Elise T Courtois, Debarka Sengupta, Yuliana Tan Shyam Prabhakar Elise T Courtois, Yuliana Tan Paul Robson Debarka Sengupta Kok Hao Chen, Jolene Jie Lin Goh Paul Jongjoon Choi Say Li Kong, Axel M Hillmer Iain Beehuat Tan Clarinda Chua Iain Beehuat Tan Lim Kiat Hon Wah Siew Tan Mark Wong Lawrence J K Wee Iain Beehuat Tan Paul Robson Paul Robson Paul Robson | 2017 | 现代生物医学进展2017，17，15： | 37 |
| 9 | Analysis of demographic characteristics in 3242 young age gastric cancer patients in Korea显示文摘AIM:To evaluate the epidemiologic features of young age gastric cancer(GC). METHODS:Retrospectively,a total of 3242 patients with GC between 18 and 45 years of age and 3000 sex-and age-matched controls were reviewed.All subjects were stratified into 3 groups based on age (A,18-30 years;B,31-40 years;C,41-45 years). Epidemiologic characteristics and risk factors were investigated with reference to their age and gender. RESULTS:Compared to controls,more frequent intake of high risk diet(P=0.00075),history of heavy smoking(P=0.00087),intake of heavy alcohol(P= 0.00091),lower social economic status(P=0.00083), body mass index>30(P=0.00097),urban residence(P=0.00065),and more frequent exposure to harmful occupational environments(P=0.00072)were observed in all age groups and both genders in young age GC.These relationships were weaker in females compared to males of the same age,and were stronger as the age of patients increased.However,in group C of young age GC patients,environmental factors played important roles in females and males with a similar body weight.In females,older age at first delivery(> 35 years),lack of lactation history,nulliparity,and poor nutritional status during pregnancy were significantly associated with an increased risk of GC(P=0.00034). In this study,252 patients(7.8%)had a family history of GC with high odds ratio(OR)(3.22-4.21).In particular, family history was more closely associated with GC in males(OR,4.21 in male vs 3.46 in female)and more advanced cases(P=0.00051). CONCLUSION:Hormonal associated factors were more commonly associated with females whereas environmental factors were more commonly associated with males in young age GC patients. | Hye Won Chung Sung Hoon Noh Jong-Baeck Lim | 2010 | World Journal of Gastroenterology2010，16，2： | 26 |
| 10 | 全球慢性非传染病负担急剧增长及中国的现状(英文)显示文摘慢性非传染病(简称慢病)是全球致死的重要原因,每年因慢病死亡的人数超过其他所有疾病导致死亡人数的总和。据估计,全球有63%的死亡源于慢病。在慢病死亡的人中,约有80%来自于低收入和中等收入国家。中国作为最大的发展中国家,拥有数量庞大的慢病患者和死于慢病的病例。在过去的20年里,中国和许多其他国家的慢病负担以惊人的速度增长。人群干预可以帮助减轻慢病负担,并具有较高的性价比,另外,改善医疗质量、早期诊断和及时治疗也可以减少慢病的影响。政府的坚定承诺和充足投入、各大社会体系和医疗系统的密切配合对减轻所有国家、特别是低收入和中等收入国家的慢病负担来说都非常重要。 | 王友发 LIM Hyunjung 吴杨 | 2012 | 北京大学学报(医学版)2012，44，5： | 26 |
| 11 | Restoration of common bile duct diameter within 2 weeks after endoscopic stone retraction is a preventive factor for stone recurrence显示文摘Background: Little information is available about the relationship between restoration of common bile duct(CBD) diameter after endoscopic stone retraction and recurrence of CBD stones in elderly patients.The present study was to determine whether restoration of CBD diameter is a preventive factor for CBD stone recurrence in elderly patients who underwent endoscopic retrograde cholangiopancreatography(ERCP).Methods: From January 2006 to December 2010, 238 patients underwent the first and the second session of ERCP for the removal of CBD stones. Among them, 173 were over 65 years old. These patients were divided into recurrent group and non-recurrent group. Restoration of CBD diameter and patients' characteristics were compared.Results: There was no statistical difference in patients' characteristics, associated diseases, or ERCP-related complications between the two groups. Reduction of CBD diameter was significantly larger in the nonrecurrent group(2.7 ± 1.7 mm) compared to that in the recurrent group(1.4 ± 2.3 mm, P = 0.002). The proportion of patients with restoration of CBD diameter were significantly lower in the recurrent group(6/42, 14.3%) compared with that in the non-recurrent group(67/131, 51.1%)(P < 0.01).Conclusions: There is an inverse relationship between restoration of CBD diameter and CBD stone recurrence. Therefore, patients without restoration of CBD diameter within 2 weeks after endoscopic stone removal should be monitored more frequently. | Jin Jeon Sung Uk Lim Chang-Hwan Park Chung-Hwan Jun Seon-Young Park Jong-Sun Rew | 2018 | Hepatobiliary & Pancreatic Diseases International2018，17，3： | 25 |
| 12 | PTEN-L is a novel protein phosphatase for ubiquitin dephosphorylation to inhibit PINK1-Parkin-mediated mitophagy显示文摘Mitophagy 是为损坏线粒体的特定的消除的选择 autophagy 的一种重要类型。(PINK1 )导致 PTEN 的通常认为的 kinase 蛋白质 1 催化 ubiquitin (Ub ) 的 phosphorylation 在 PINK1-Parkin-mediated mitophagy 的发作起一个关键作用。(PTEN-L ) 磷酸酶和 tensin 相当或相同的事物(PTEN ) 长是 PTEN 的最新识别的 isoform,与到它的 N 终点的 173 氨基酸的增加。这里,我们报导 PTEN-L 是经由它对 phosphorylated ubiquitin 的蛋白质磷酸酶活动的 mitophagy 的一个新奇否定管理者。我们发现 PTEN-L 在外部 mitochondrial 膜(OMM ) 本地化,而 PTEN-L 的删除支持, PTEN-L 的 overexpression 禁止, mitophagy 由各种各样的损坏线粒体的代理人导致了。机械学地, PTEN-L 能够有效地阻止 Parkin mitochondrial translocation,减少 Parkin phosphorylation,维持它的关上的不活跃的符合构造,并且禁止它的 E3 ligase 活动。更重要地, PTEN-L 在 vivo 减少 phosphorylated ubiquitin (pSer65-Ub ) 的水平,并且在 vitro,磷酸酶试金经由它的蛋白质磷酸酶活动证实那 PTEN-L dephosphorylates pSer65-Ub,独立于它的类脂化合物磷酸酶功能。一起拿,我们的调查结果为 ubiquitin 作为蛋白质磷酸酶表明 PTEN-L 的新奇功能,它抵抗在 mitophagy 正式就职和 mitophagy 的最终的抑制导致前馈控制机制的阻塞的调停 PINK1 的 ubiquitin phosphorylation。因此,理解 PTEN-L 的这新奇功能在控制 mitophagy 的分子的难题提供一关键错过片,在包括象 Parkinsons 那样的 neurodegenerative 混乱的许多重要人的疾病的一个批评过程疾病。 | Liming Wang Yik-Lam Cho Yancheng Tang Jigang Wang Jung-Eun Park Yajun Wu Chunxin Wang Yan Tong Ritu Chawla Jianbin Zhang Yin Shi Shuo Deng Guang Lu Yihua Wu Hayden Weng-Siong Tan Pornteera Pawijit Grace Gui-Yin Lim Hui-Ying Chan Jingzi Zhang Lei Fang Hanry Yu Yih-Cherng Liou Mallilankaraman Karthik Boon-Huat Bay Kah-Leong Lim Siu-Kwan Sze Celestial T. Yap Han-Ming Shen | 2018 | Cell Research2018，28，8： | 25 |
| 13 | Epidemiology of clinical benign prostatic hyperplasia显示文摘Clinical benign prostatic hyperplasia(BPH)is one of the most common diseases in ageing men and the most common cause of lower urinary tract symptoms(LUTS).The prevalence of BPH increases after the age of 40 years,with a prevalence of 8%-60% at age 90 years.Some data have suggested that there is decreased risk among the Asians compared to the western white population.Genetics,diet and life style may play a role here.Recent reports suggest the strong relationship of clinical BPH with metabolic syndrome and erectile dysfunction,as well as the possible role of inflammation as a cause of the prostatic hyperplasia.Lifestyle changes including exercise and diet are important strategies in controlling this common ailment. | Kok Bin Lim | 2017 | Asian Journal of Urology2017，4，3： | 26 |
| 14 | Common bile duct stones on multidetector computed tomography:Attenuation patterns and detectability显示文摘AIM:To investigate the attenuation patterns and detectability of common bile duct(CBD) stones by multidetector computed tomography(MDCT).METHODS:Between March 2010 and February 2012,191 patients with suspicion of CBD stones undergoing both MDCT and endoscopic retrograde cholangiopancreatography(ERCP) were enrolled and reviewed retrospectively.The attenuation patterns of CBD stones on MDCT were classified as heavily calcified,radiopaque,less radiopaque,or undetectable.The association between the attenuation patterns of CBD stones on MDCT and stone type consisting of pure cholesterol,mixed cholesterol,brown pigment,and black pigment and the factors related to the detectability of CBD stones by MDCT were evaluated.RESULTS:MDCT showed CBD stones in 111 of 130 patients in whom the CBD stones were demonstrated by ERCP with 85.4% sensitivity.The attenuation patterns of CBD stones on MDCT were heavily calcified 34(26%),radiopaque 31(24%),less radiopaque 46(35%),and undetectable 19(15%).The radiopacity of CBD stones differed significantly according to stone type(P < 0.001).From the receiver operating characteristic curve,stone size was useful for the determination of CBD stone by MDCT(area under curve 0.779,P < 0.001) and appropriate cut-off stone size on MDCT was 5 mm.The factors related to detectability of CBD stones on MDCT were age,stone type,and stone size on multivariate analysis(P < 0.05).CONCLUSION:The radiopacity of CBD stones on MDCT differed according to stone type.Stone type and stone size were related to the detectability by MDCT,and appropriate cut-off stone size was 5 mm. | Chang Whan Kim Jae Hyuck Chang Yeon Soo Lim Tae Ho Kim In Seok Lee Sok Won Han | 2013 | World Journal of Gastroenterology2013，19，11： | 24 |
| 15 | Synthesis of Porous NiO Nanocrystals with Controllable Surface Area and Their Application as Supercapacitor Electrodes显示文摘We report a facile way to grow various porous NiO nanostructures including nanoslices,nanoplates,and nanocolumns,which show a structure-dependence in their specific charge capacitances.The formation of controllable porosity is due to the dehydration and re-crystallization of β-Ni(OH)_(2) nanoplates synthesized by a hydrothermal process.Thermogravimetric analysis shows that the decomposition temperature of the β-Ni(OH)_(2) nanostructures is related to their morphology.In electrochemical tests,the porous NiO nanostructures show stable cycling performance with retention of specific capacitance over 1000 cycles.Interestingly,the formation of nanocolumns by the stacking of β-Ni(OH)_(2) nanoslices/plates favors the creation of small pores in the NiO nanocrystals obtained after annealing,and the surface area is over five times larger than that of NiO nanoslices and nanoplates.Consequently,the specific capacitance of the porous NiO nanocolumns(390 F/g)is significantly higher than that of the nanoslices(176 F/g)or nanoplates(285 F/g)at a discharge current of 5 A/g.This approach provides a clear illustration of the process-structure-property relationship in nanocrystal synthesis and potentially offers strategies to enhance the performance of supercapacitor electrodes. | Xiaojun Zhang Wenhui Shi Jixin Zhu Weiyun Zhao Jan Ma Subodh Mhaisalkar Tuti Lim Maria Yanhui Yang Hua Zhang Huey Hoon Hng Qingyu Yan | 2010 | Nano Research2010，3，9： | 24 |
| 16 | 超声乳化联合小梁切除术及术中应用5-氟尿嘧啶治疗青光眼合并白内障的长期疗效观察显示文摘目的探讨超声乳化联合小梁切除术及术中应用5氟尿嘧啶(5fluorouracil,5Fu)治疗青光眼合并白内障的疗效。方法对1996年1月至1998年12月,在新加坡国立眼科中心行超声乳化联合小梁切除术及术中应用5Fu治疗的71例(71只眼)原发性开角型青光眼(POAG)和原发性闭角型青光眼(PACG)患者的临床资料进行回顾性分析。除外随访时间<6个月的患者。结果术后患者平均眼压和平均用药种数均较术前明显降低,差异有统计学意义(P<001)。术后随访1~5年的患者眼压与术前比较均明显下降,差异有统计学意义(P<001)。手术完全成功率1、3及5年分别为842%、627%及553%。在手术完全成功的条件下,POAG与PACG(P=0281)、同一切口与不同切口(P=0487)手术疗效比较(采用Cox模型进行多因素生存分析),手术成功率差异无统计学意义(P>005)。但POAG与PACG术后平均眼压比较,差异有统计学意义(P=002)。术后较术前平均视力提高差异有统计学意义(P<001)。术后与术前平均视野缺损(MD)值(P=055)和模式标准差(PSD)值(P=064)比较,差异无统计学意义,表明患者术后视野保持稳定。术后4d发生眼内炎1例,术后晚期由于脉络膜渗漏和伤口漏引起低眼压2例。结论超声乳化联合小梁切除术及术中应用5Fu治疗POAG和PACG的成功率高,手术安全,长期观察疗效稳定。 | 才瑜 Zena LIM Boon Ang LIM Francis OEN 晏晓明 李美玉 Steve SEAH | 2005 | 中华眼科杂志2005，41，2： | 22 |
| 17 | 在Cu/ZnO/Al_2O_3催化剂上进行甲醇蒸气重整的动力学研究显示文摘采用平推流反应器 ,在三种不同的Cu ZnO Al2 O3催化剂上对甲醇的蒸气重整制备氢气反应进行了研究。在常压 ,温度 180℃~ 2 4 0℃的条件下 ,在三种不同催化剂上对反应的动力学进行了测定 ,所获结果符合反应速率幂数模型 ,不同的催化剂相对于甲醇和水的反应级数分别均为 0 60及 0 4 5 ,对于ICI5 2 1,ICI5 3 1以及MDK 2 0催化剂所获得的活化能分别为 :92 8kJ mol、96 2kJ mol及 87 9kJ mol,与文献值吻合较好。所获动力学模型为甲醇重整反应条件优化以及反应器的数学模拟提供了一定的基础。 | 蒋元力 黄强 王福安 Kim Dong Hyun Lim Mee Sook | 2001 | 燃料化学学报2001，29，4： | 22 |
| 18 | Role of the tumor microenvironment in the pathogenesis of gastric carcinoma显示文摘Gastric carcinoma(GC)is the 4thmost prevalent cancer and has the 2ndhighest cancer-related mortality rate worldwide.Despite the incidence of GC has decreased over the past few decades,it is still a serious health problem.Chronic inflammatory status of the stomach,caused by the infection of Helicobacter pylori(H.pylori)and through the production of inflammatory mediators within the parenchyma is suspected to play an important role in the initiation and progression of GC.In this review,the correlation between chronic inflammation and H.pylori infection as an important factor for the development of GC will be discussed.Major components,including tumor-associated macrophages,lymphocytes,cancer-associated fibroblasts,angiogenic factors,cytokines,and chemokines of GC microenvironment and their mechanism of action on signaling pathways will also be discussed.Increasing our understanding of how the components of the tumor microenviroment interact with GC cells and the signaling pathways involved could help identify new therapeutic and chemopreventive targets. | Hye Won Chung Jong-Baeck Lim | 2014 | World Journal of Gastroenterology2014，20，7： | 23 |
| 19 | Current research and treatment for gastrointestinal stromal tumors显示文摘Gastrointestinal stromal tumors(GISTs) are the most common mesenchymal tumors of the gastrointestinal tract and have gained considerable research and treatment interest,especially in the last two decades. GISTs are driven by mutations commonly found in the KIT gene and less commonly in the platelet-derived growth factor receptor alpha gene,BRAF gene and succinate dehydrogenase gene. GISTs behave in a spectrum of malignant potential,and both the tumor size and mitotic index are the most commonly used prognostic criteria. Whilst surgical resection can offer the best cure,targeted therapy in the form of tyrosine kinase inhibitors(TKIs) has revolutionized the management options. As the first-line TKI,imatinib offers treatment for advanced and metastatic GISTs,adjuvant therapy in high-risk GISTs and as a neoadjuvant agent to downsize large tumors prior to resection. The emergence of drug resistance has altered some treatment options,including prolonging the first-line TKI from 1 to 3 years,increasing the dose of TKI or switching to second-line TKI. Other newer TKIs,such as sunitinib and regorafenib,may offer some treatment options for imatinib-resistant GISTs. New molecular targeted therapies are being evaluated,such as inhibitors of BRAF,heat shock protein 90,glutamine and mitogenactivated protein kinase signaling,as well as inhibitors of apoptosis proteins antagonist and even immunotherapy. This editorial review summarizes the recent research trials and potential treatment targets that may influence our future patient-specific management of GISTs. The current guidelines in GIST management from Europe,North America and Asia are highlighted. | Kheng Tian Lim Kok Yang Tan | 2017 | World Journal of Gastroenterology2017，23，27： | 23 |
| 20 | Fruit quality,anthocyanin and total phenolic contents,and antioxidant activities of 45 blueberry cultivars grown in Suwon,Korea显示文摘Blueberry fruits from 45 commercial cultivars (39 northern highbush and 6 half highbush blueberry) grown in Suwon,Korea were analyzed for fruit size,soluble solids content,titratable acidity,total anthocyanin content,total phenolic content,and antioxidant activity.Fruit characteristics varied widely among the 45 blueberry cultivars.Fruit weight ranged from 0.9 to 3.6 g,soluble solids content from 8.3 to 14.3 °Brix,and titratable acidity from 0.8% to 3.6%.Antioxidant activity ranged from 0.7 to 2.1 mg of quercetin equivalents per gram of fresh berries in different blueberry cultivars.Among the 45 blueberry cultivars,high amounts of anthocyanins and polyphenols,and high antioxidant activity were observed in 'Elliott','Rubel','Rancocas',and 'Friendship'. | Jin Gook KIM Hong Lim KIM Su Jin KIM Kyo-Sun PARK | 2013 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2013，14，9： | 20 |
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