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| 1 | Alternative splicing and expression of the insulin-like growth factor (IGF-1) gene in osteoblasts under mechanical stretch显示文摘(IGF-1 ) 像胰岛素的生长因素 1 支持造骨细胞区别和骨头形成,和它的表示被机械段导致,因此, IGF-1 被认为连接机械刺激和本地织物回答的一个受动器分子。在这研究,一台机械拉长设备被设计把生理的水平静电干扰或周期的拉长刺激用于造骨细胞。IGF-1 mRNA 的不同 isoforms 被 RT-PCR 用各自的教材从房间放大,这些放大产品被定序。产品被发现被造骨细胞有选择地在拉长刺激下面生产的拼接的 IGF-1 的 iso 形式。ThisIGF-1 isoform 与原来在肌肉细胞被识别的 mechano 生长因素(MGF ) 有相同顺序。肝类型 IGF (L.IGF-1 ) 和在在段刺激下面的造骨细胞的 MGF 的表示的规定进一步用半量的 RT-PCR 被学习。Stretchstimulation 被发现 IGF-1 (L.IGF-1 和 MGF ) 的表示到职业人员警句,并且为两 isoformsexpression,更多被周期的段有效地比静态的段刺激。MGF 仅仅在受到机械段的造骨细胞被检测,建议 MGF 是段敏感生长因素。MGF 的表示比 L.IGF-1 的早达到顶点,它类似于他们在肌肉的规定并且作为在肌肉房间在骨头建议了 MGF 和 L.IGF-1 的类似的角色。在造骨细胞的 MGF 和 L.IGF-1 的功能将被进一步试验性的研究建立。 | XIAN Chengyu WANG Yuanliang ZHANG Bingbing TANG Liling PAN Jun LUO Yanfeng JIANG Peng LI Dajun | 2006 | Chinese Science Bulletin2006，51，22： | 7 |
| 2 | Physiological responses of osteoblasts to cyclic stretching and the change of intracellular calcium concentration显示文摘The development of bone tissues is regulated by mechanical stimulation. Cyclic stretching was applied to the osteoblasts that were delivered from rat calvarie. The results showed that stretching at 500 me increased the cell prolifera-tion while loading at 1000 me and 1500 me inhabited cell growth. Loading also increased the adhesive force between cells and substrate as well as spreading areas of osteobalsts. Furthermore, the fluorescence probe Fluo-3/AM was used to investigate the effect of stretching stimulation on the intra-cellular calcium concentration of osteoblasts. The intracellu-lar calcium concentration of osteoblasts that were stretched at 500 me for 5 min was 92.9% higher than the control. After being treated with the panax ontoginseng saponins, the stretched osteoblasts still expressed 28.6% higher intracellu-lar calcium concentration than that of the control, which proved that both the influx of extracellular calcium and the release of intracellular calcium store were involved in the increase of intracellular calcium concentration when os-teoblasts responded to the cyclic stretching. And the influx of extracellular calcium through transmembrance channel played a main role. | TANG Liling, WANG Yuanliang, GU Li, CAI Shaoxi & SU Aihua Bio-engineering College, Chongqing University, Chongqing 400044, China Correspondence should be addressed to Tang Liling | 2003 | Chinese Science Bulletin2003，48，4： | 7 |
| 3 | Competing endogenous RNAs in lung cancer显示文摘Competing endogenous RNAs(ce RNAs)containing micro RNA response elements can competitively interact with micro RNA via mi RNA response elements,which can combine non-coding RNAs with protein-coding RNAs through complex ce RNA networks.Ce RNAs include non-coding RNAs(long non-coding RNAs,circular RNAs,and transcribed pseudogenes)and protein-coding RNAs(m RNAs).Molecular interactions in ce RNA networks can coordinate many biological processes;however,they may also lead to ce RNA network imbalance and thus contribute to cancer occurrence when disturbed.Recent studies indicate that many dysregulated RNAs derived from lung cancer may function as ce RNAs to regulate multitudinous biological functions for lung cancer,including tumor cell proliferation,apoptosis,growth,invasion,migration,and metastasis.This study therefore reviewed the research progress in the field of non-coding and protein-coding RNAs as ce RNAs in lung cancer,and highlighted validated ce RNAs involved in biological lung cancer functions.Furthermore,the roles of ce RNAs as novel prognostic and diagnostic biomarkers were also discussed.Interpreting the involvement of ce RNAs networks in lung cancer will provide new insight into cancer pathogenesis and treatment strategies. | Meilian Zhao Jianguo Feng Liling Tang | 2021 | Cancer Biology & Medicine2021，18，1： | 5 |
| 4 | Phase Diagram Prediction of the Al_2O_3-SiO_2-La_2O_3 System显示文摘Rare earth oxide systems Al2O3-La2O3 and SiO2-La2O3 were thermodynamically assessed and optimized with the substitution model. The obtained model parameters and Gibbs free energy of tine compounds and pure components were applied to the prediction of the liquidus surface and isothermal sections of Al2O3-SiO2-La2O3 | Lin LI and Zhujun TANG(Department of Materials Science & Engineering, Shanghai University, Shanghai 200072, China) To whom correspondence should be addressedE-mail: liling@public6.sta.net.cn Weiying SUN and Peiling WANG(Shanghai Institute of Ceramics, Chi | 1999 | Journal of Materials Science & Technology1999，15，5： | 3 |
| 5 | FRACTAL ANALYSES OF DIRECTIONAL SOLIDIFICATION BEHAVIOR OF A Ni-BASE SUPERALLOY显示文摘The morphology of solid/liquid interface of a directionally solidification process is describedby means of fractal analysis,and the relations among the fractal dimension of the solid/liq-uid interface,solidification rate,dendrite arm space and the phosphorus content of the test al-loys have been given.It was found that the increase of the solidification rate and the phos-phorus content of the test alloy will lead to a increase,following the regularity of exponentialfunction,in the fractal dimension of solid/liquid interface.Furthermore,by combining thefractal theory and the thermodynamic principle with the measured results,it has been provedthat the fractal dimension is not only a kind of simple geometrical parameter used in des-cribing irregular geometry,but also a state function depending the change of solidificationparameters and chemical compositions. | SUN Liling DONG Lianke ZHANG Jishan TANG Yajun ZHANG Jinghua HU Zhuangqi Institute of Metal Research,Academia Sinica,Shenyang,China SUN Liling,Institute of Metal Research,Academia Sinica,Shenyang 110015,China | 1993 | Acta Metallurgica Sinica(English Letters)1993，6，5： | 2 |
| 6 | Plasma miR-126 Is a Potential Biomarker for Early Prediction of Type 2 Diabetes Mellitus in Susceptible Individuals显示文摘 | Tao Zhang Chunfang Lv Liling Li Sihan Chen Shenglin Liu Changyi Wang Bing Su Thean Hock Tang | 2013 | BioMed Research International2013，，： | 1 |
| 7 | Investigation on mechanism of antishock effect in anisodamine 显示文摘 | Tang Chaoshu Wu Liling Suingy | 1982 | Kexue Tongbao1982，27，： | 1 |
| 8 | The Cell-Type Specificity and Endosomal Escape of Cell-Penetrating Peptides显示文摘 | Jing Feng Liling Tang | 2015 | Current Pharmaceutical Design2015，，： | 1 |
| 9 | AF9YEATS结构域在分子层面偶联组蛋白巴豆酰化和活跃转录显示文摘染色质结合蛋白质模块(“阅读器”)识别组蛋白共价修饰构成表观遗传调控的主要方式之一,例如溴域识别乙酰化赖氨酸修饰。除乙酰化之外,近来研究发现组蛋白赖氨酸还能发生巴豆酰化、丁酰化、丙酰化等酰基化修饰.但能够偏好识别这些新型酰基化修饰的阅读器尚未见报道。 | Yuanyuan Li Benjamin R.Sabari Tatyana Panchenko Hong Wen Dan Zhao Haipeng Guan Liling Wan He Huang Zhanyun Tang Yingming Zhao Robert G.Roeder Xiaobing Shi C.David Allis 李海涛 | 2017 | 科学新闻2017，19，4： | 0 |
| 10 | The Effect of Cyclic Stretching on Matrix Production, Mineralization and Differentiation of Osteoblasts显示文摘A four-point bending apparatus is used to investigate the effects of stretching on collagen synthesis, mineralization and differentiation of osteoblasts. Cells are stretched at 1500 με for 24 hours. The responses of osteoblasts to mechanical signal of physiological stretching are evaluated from three aspects: collagen production, extracellular inorganic calcium secretion and ALP activity. The results show that osteoblasts decrease the collagen synthesis, calcium secretion and ALP activity compared to the control cells (65.82%,73.51%,48.10% respectively), confirming that cyclic stretching at 1500 με inhabits the physiological activity of osteoblasts. | 秦建 TANG LILING Wang Yuanliang Gu Li | 2003 | High Technology Letters2003，9，3： | 0 |
| 11 | In situ electrochemical dehydrogenation of ultrathin Co(OH)_(2) nanosheets for enhanced hydrogen evolution显示文摘Transition metal hydroxides/oxyhydroxides have recently emerged as highly active electrocatalysts for oxygen evolution reaction in alkaline water electrolysis,while have not yet been widely investigated for hydrogen evolution electrocatalysts owing to their unfavorable H*-adsorption,making it difficult to construct an overall-water-splitting cell for hydrogen production.In this work,we proposed a straightforward and effective approach to develop an efficient in-plane heterostructured CoOOH/Co(OH)_(2) catalyst via in-situ electrochemical dehydrogenation method,in which the dehydrogenated–CoOOH and Co(OH)_(2) at the surface synergistically boost the hydrogen evolution reaction(HER)kinetics in base as confirmed by high-resolution transmission electron microscope,synchrotron X-ray absorption spectroscopy,and electron energy loss spectroscopy.Due to the in-situ dehydrogenation of ultrathin Co(OH)_(2) nanosheets,the catalytic activity of the CoOOH/Co(OH)_(2) heterostructures is progressively improved,which exhibit outstanding hydrogen-evolving activity in base requiring a low overpotential of 132 m V to afford 10 m A/cm^(2)with very fast reaction kinetics after 60 h dehydrogenation.The gradually improved catalytic performance for the CoOOH/Co(OH)2is probably due to the enhanced H*-adsorption induced by the synergistic effect of heterostructures and better conductivity of Co OOH relative to electrically insulating Co(OH)_(2).This work will open the opportunity for a new family of transition metal hydroxides/oxyhydroxides as active HER catalysts,and also highlight the importance of using in situ techniques to construct precious metal-free efficient catalysts for alkaline hydrogen evolution. | Qian Zhou Qihang Bian Liling Liao Fang Yu Dongyang Li Dongsheng Tang Haiqing Zhou | 2023 | Chinese Chemical Letters2023，34，1： | 0 |
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