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| 1 | The altered PD-1/PD-L1 pathway delivers the ‘one-two punch’ effects to promote the Treg/Th17 imbalance in pre-eclampsia显示文摘The programmed cell death-1(PD-1)/PD-ligand 1(PD-L1)pathway is critical for normal pregnancy by promoting regulatory T(Treg)cell development and inhibiting the Th17 response.However,the relationship between the PD-1/PD-L1 pathway and the Treg/Th17 imbalance in pre-eclampsia(PE)is an enigma.In this study,decreased PD-1 and PD-L1 expression and a Treg/Th17 imbalance were observed at the maternal-fetal interface in PE.The regulatory effects of the PD-1/PD-L1 pathway on the Treg and Th17 cell quantities were determined in vitro by targeting T-cell proliferation,differentiation and transdifferentiation.First,decreased PD-1 expression might contribute to a higher Th17 cell frequency by promoting proliferation in PE.Second,the percentages of Treg but not Th17 cells differentiated from peripheral naive CD4+T cells were increased by PD-L1 Fc administration.This effect was accompanied by decreased PI3K/AKT/m-TOR and increased PTEN mRNA expression and was completely reversed by PD-1 blockade.Finally,the percentage of IL-17-producing Treg cells increased and was positively associated with the Th17 cell frequency in PE.Increased RORγt and IL-17 but not Foxp3 and IL-10 mRNA expression by Treg cells was observed with PD-1 blockade.Similar findings occurred when Treg cells were exposed to IL-6/IL-23/IL-1βand were reversed by PD-L1 Fc.Taken together,our findings indicate that the PD-1/PD-L1 pathway contributes to the Treg/Th17 imbalance via‘one-two punch’approaches:(i)promoting Th17 cell proliferation,(ii)inhibiting Treg cell differentiation and(iii)enhancing Treg cell plasticity into Th17 cells in PE.The therapeutic value of PD-L1 Fc for PE treatment will be explored in the future. | Yonghong Zhang Zhaozhao Liu Mei Tian Xiaohui Hu Liling Wang Jinlu Ji Aihua Liao | 2018 | Cellular & Molecular Immunology2018，15，7： | 21 |
| 2 | Boosting pH-Universal Hydrogen Evolution of Molybdenum Disulfide Particles by Interfacial Engineering显示文摘The design of high-efficiency non-noble and earth-abundant electrocatalysts for hydrogen evolution reaction(HER)is highly paramount for water splitting and renewable energy systems.Molybdenum disulfide(MoS_(2))with abundant edge sites can be utilized as a promising alternative,but its catalytic activity is greatly related to the pH values,especially in an alkaline environment due to the extremely high energy barriers for water adsorption and dissociation steps.Here we report an exceptionally efficient and stable electrocatalyst to improve the sluggish HER process of layered MoS_(2)particles in different pH electrolytes,especially in base.The electrocatalyst is constructed by in situ growing selenium-doped MoS_(2)(Se-MoS_(2))nanoparticles on three-dimensional cobalt nickel diselenide(mCo_(0.2)Ni_(0.8)Se_(2))nanostructured arrays.Due to the large number of active edge sites of Se-MoS_(2)particles exposed at the surface,robust electrical conductivity and large surface area of mCo_(0.2)Ni_(0.8)Se_(2)support,and strong interfacial interactions between Se-MoS_(2)and mCo_(0.2)Ni_(0.8)Se_(2),this hybrid catalyst shows very outstanding catalytic HER properties featured by low overpotentials of 30 and 122 mV at 10 and 100 mA/cm^(2)with good operational stability in base,respectively,which outperforms most of inexpensive catalysts consisting of layered MoS_(2),transition metal selenides and sulfides,and it performs as well as noble Pt catalysts.Meanwhile,this electrocatalyst is also very active in neutral and acidic electrolytes,requiring low overpotentials of 93 and 94 mV at 10 mA/cm^(2),respectively,demonstrating its superb pH universality as a HER electrocatalyst with excellent catalytic durability.This study provides a straightforward strategy to construct an efficient non-noble electrocatalyst for driving the HER kinetics in different electrolytes. | Liling Liao Lun Yang Gang Zhao Haiqing Zhou Fengming Cai Yi Li Xiuzhang Wang Fang Yu | 2021 | Chinese Journal of Chemistry2021，39，2： | 2 |
| 3 | Life prediction of high-cycle fatigue in aluminum bonding wires under power cycling test显示文摘 | Hung Tuanyu Liao Liling Wang C C | 2014 | IEEE Transactions on Device and Materials Reliability2014，14，1： | 1 |
| 4 | The dynamic profile and potential function of B-cell subsets during pregnancy显示文摘As the main antibody-producing and antigen-presenting cells,B cells play critical roles in autoimmune diseases,tumors,and transplantation.Recently,the immunoregulatory functions of B cells have attracted attention and have been extensively studied in these fields. | Liling Wang Panpan Jiang Sijia Zhao Hong Liu Liping Liu Gil Mor Chaohong Liu Aihua Liao | 2021 | Cellular & Molecular Immunology2021，18，4： | 1 |
| 5 | Revealing the nucleation event of Mg-Al alloy induced by Fe impurity显示文摘This study revealed the nucleation event and grain refinement mechanism of Mg-Al alloy induced by Fe impurity.The following orientation relationship was observed between Al-Fe particle andα-Mg matrix in the Mg-3Al alloy containing Fe impurity using a focused ion beam aided transmission electron microscope technique:(1^(-)011)[011^(-)1]_(Mg)//(011^(-))[011]_(Al_(2)Fe).Mg-3Al alloy was inoculated by adding 0.02wt%Fe to verify the nucleating potency of the Al_(2)Fe phase forα-Mg grain.The results indicated that Mg-3Al alloy was effectively refined with an average grain size declining from 1135 to 540μm.Among the potential Al-Fe phases of Mg-3Al-0.02Fe alloy,only the precipitation of the Al_(2)Fe phase occurs earlier than that ofα-Mg grain,and the Al_(2)Fe phase is stable in the nucleation stage ofα-Mg grain.Therefore,the Al_(2)Fe particle is the only available nucleating site for Mg-Al alloy with Fe impurity.The heterogeneous nucleation event ofα-Mg grain on the Al_(2)Fe particle is responsible for the grain refinement of Mg-3Al alloy inoculated by Fe. | Hengbin Liao Liling Mo Xiong Zhou Zhizhong Yuan Jun Du | 2022 | International Journal of Minerals,Metallurgy and Materials2022，29，7： | 1 |
| 6 | Development prospects of metal-based two-dimensional nanomaterials in lithium-sulfur batteries显示文摘A lithium-sulfur(Li-S)system is an important candidate for future lithium-ion system due to its low cost and high specific theoretical capacity(1675 m Ah/g,2600 Wh/kg),which is greatly hindered by the poor conductivity of sulfur,large volume change and dissolution of lithium polysulfides.Two-dimensional(2D)materials with monolayers or few-layers usually have peculiar structures and physical/chemical properties,which can resolve the critical issues in Li-S batteries.Especially,the metal-based 2D nanomaterials,including ferrum,cobalt or other metal-based composites with various anions,can provide high conductivity,large surface area and abundant reaction sites for restraining the diffusion for lithium polysulfides.In this mini-review,we will present an overview of recent developments on metal-based 2D nanomaterials with various anions as the electrode materials for Li-S batteries.Since the main bottleneck for the Li-S system is the shuttle of polysulfides,emphasis is placed on the structure and components,physical/chemical interaction and interaction mechanisms of the 2D materials.Finally,the challenges and prospects of metal-based 2D nanomaterials for Li-S batteries are discussed and proposed. | Yuxue Mo Liling Liao Dongyang Li Rongwu Pan Yanhong Deng Yanliang Tan Haiqing Zhou | 2023 | Chinese Chemical Letters2023，34，1： | 1 |
| 7 | Stabilization of MYC G-quadruplex DNA by ruthenium(II)complex overcomes imatinib resistance in chronic myeloid leukemia cells harboring T315I mutation显示文摘The key pathogenesis of chronic myeloid leukemia(CML)is the formation of BCR-ABL fusion gene,encoding a 210 kDa Bcr-Abl tyrosine kinase,which is crucial for the occurrence and development of CML.Imatinib(IM)is the first targeted anticancer drug approved by FDA for the treatment of CML;however,some patients,especially those in accelerated phase and blastic phase,develop primary or secondary drug resistance to IM.Particularly,the most challenging resistance is caused by T315I mutation of Bcr-Abl,which represents approximately 15%–20%of all acquired mutations and renders cell resistant to a variety of tyrosine kinase inhibitors.1,2 Thus,there is an urgent need to develop novel strategies to overcome Bcr-Abl T315I-meidated IM resistance. | Yuening Sun Xin Chen Siyan Liao Aochu Liu Huan Zhou Liling Jiang Wa Ding Wenjie Mei Jinbao Liu Xianping Shi | 2023 | Genes & Diseases2023，10，2： | 0 |
| 8 | In situ electrochemical dehydrogenation of ultrathin Co(OH)_(2) nanosheets for enhanced hydrogen evolution显示文摘Transition metal hydroxides/oxyhydroxides have recently emerged as highly active electrocatalysts for oxygen evolution reaction in alkaline water electrolysis,while have not yet been widely investigated for hydrogen evolution electrocatalysts owing to their unfavorable H*-adsorption,making it difficult to construct an overall-water-splitting cell for hydrogen production.In this work,we proposed a straightforward and effective approach to develop an efficient in-plane heterostructured CoOOH/Co(OH)_(2) catalyst via in-situ electrochemical dehydrogenation method,in which the dehydrogenated–CoOOH and Co(OH)_(2) at the surface synergistically boost the hydrogen evolution reaction(HER)kinetics in base as confirmed by high-resolution transmission electron microscope,synchrotron X-ray absorption spectroscopy,and electron energy loss spectroscopy.Due to the in-situ dehydrogenation of ultrathin Co(OH)_(2) nanosheets,the catalytic activity of the CoOOH/Co(OH)_(2) heterostructures is progressively improved,which exhibit outstanding hydrogen-evolving activity in base requiring a low overpotential of 132 m V to afford 10 m A/cm^(2)with very fast reaction kinetics after 60 h dehydrogenation.The gradually improved catalytic performance for the CoOOH/Co(OH)2is probably due to the enhanced H*-adsorption induced by the synergistic effect of heterostructures and better conductivity of Co OOH relative to electrically insulating Co(OH)_(2).This work will open the opportunity for a new family of transition metal hydroxides/oxyhydroxides as active HER catalysts,and also highlight the importance of using in situ techniques to construct precious metal-free efficient catalysts for alkaline hydrogen evolution. | Qian Zhou Qihang Bian Liling Liao Fang Yu Dongyang Li Dongsheng Tang Haiqing Zhou | 2023 | Chinese Chemical Letters2023，34，1： | 0 |
| 9 | Effect of solute atom adsorption on heterogeneous nucleation by in-situ MgO particles:Experimental and theoretical studies显示文摘The introduction of oxide inclusions during the smelting process has a clear promising heterogeneous nucleation potency on Mg-based alloys, but the mechanism has not been explored clearly yet. In the present work, the grain refinement mechanism of MgO in pure Mg,Mg-3Al and AZ31(Mg-2.9Al-0.9Zn-0.3Mn) alloys is investigated by combing first-principles calculations and experiments. The theoretical results show that solute atoms adsorption will affect the nucleation and the subsequent growth process, which is an important factor affecting the refinement efficiency. A contradiction between the experimental results and the grain growth restriction factor(GRF) theory is observed,that is the refinement ratio of AZ31 is worse than Mg-3Al alloy. This is explained by an adsorption model which reveals that Al promotes the adsorption of Mg on MgO surface so as to stimulate more particles available as nucleating sites. Meanwhile, Fe and Mn also have favorable effects on the adsorption of Mg, Zn may play the opposite role compared to Al. The theoretical analyzes provide a strong support to the experiments that Al benefits the initial nucleation of α-Mg on MgO to promote the grain refining effect of Mg-3Al prior to AZ31 alloy. | Liling Mo Hengbin Liao Xiong Zhou Yu-Jun Zhao Jun Du | 2023 | Journal of Magnesium and Alloys2023，11，10： | 0 |
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