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| 1 | TRIM35 mediates protection against influenza infection by activating TRAF3 and degrading viral PB2显示文摘Tripartite motif(TRIM)family proteins are important effectors of innate immunity against viral infections.Here we identified TRIM35 as a regulator of TRAF3 activation.Deficiency in or inhibition of TRIM35 suppressed the production of type I interferon(IFN)in response to viral infection.777m35-deficient mice were more susceptible to influenza A virus(IAV)infection than were wild-type mice.TRIM35 promoted the RIG-Imediated signaling by catalyzing Lys63-linked polyubiquitination of TRAF3 and the subsequent formation of a signaling complex with VISA and TBK1.IAV PB2 polymerase countered the innate antiviral immune response by impeding the Lys63-linked polyubiquitination and activation of TRAF3.TRIM35 mediated Lys48-linked polyubiquitination and proteasomal degradation of IAV PB2,thereby antagonizing its suppression of TRAF3 activation.Our in vitro and in vivo findings thus reveal novel roles of TRIM35,through catalyzing Lys63-or Lys48-linked polyubiquitination,in RIG-I antiviral immunity and mechanism of defense against IAV infection. | Nan Sun Li Jiang Miaomiao Ye Yihan Wang Guangwen Wang Xiaopeng Wan Yuhui Zhao Xia Wen Libin Liang Shujie Ma Liling Liu Zhigao Bu Hualan Chen Chengjun Li | 2020 | Protein & Cell2020，11，12： | 4 |
| 2 | Effects of gravity on the microstructure of Zr_(41)Ti_(14)-Cu_(12.5)Ni_(10)Be_(22.5) bulk glass forming alloy显示文摘The ZrTiCuNiBe alloy is melt and solidified by Bridgman unidirectional solidification on two gravity field orientations (the gravity field orientation is parallel and opposite to solidification direction). Effects of gravity on morphology and microstructure are investigated by scanning electron microscope (SEM) and X-ray diffraction (XRD). When gravity field orientation is parallel to solidificationdirection, less needle-like primary phase is embedded in a matrix eutectic; when gravity field orientation is opposite to solidification direction, a large amount of coarser needle-like primary phases were observed. | LI Gong, ZHAN Zaiji, WANG Limin, CAO Limin, SUN Liling, DAI Daoyang, ZHANG Jun & WANG WenkuiInstitute of Physics, Center for Condensed Matter Physics, Chinese Academy of Sciences, Beijing 100080, China Department of Materials Science and Engineering, Yanshan University, Qinhuangdao 066004, China | 2001 | Chinese Science Bulletin2001，46，11： | 3 |
| 3 | Observation of a bi-critical point between antiferromagnetic and superconducting phases in pressurized single crystal Ca0.73La0.27FeAs2显示文摘One of the most strikingly universal features of the high-temperature superconductors is that the superconducting phase emerges in the close proximity of the antiferromagnetic phase, and the interplay between these two phases poses a long-standing challenge. It is commonly believed that, as the antiferromagnetic transition temperature is continuously suppressed to zero, there appears a quantum critical point, around which the existence of antiferromagnetic fluctuation is responsible for the development of the superconductivity. In contrast to this scenario, we report the observation of a bi-critical point identified at 2.88 GPa and 26.02 K in the pressurized high-quality single crystal Ca_(0.73)La_(0.27)FeAs_2 by complementary in-situ high pressure measurements. At the critical pressure, we find that the antiferromagnetism suddenly disappears and superconductivity simultaneously emerges at almost the same temperature, and that the external magnetic field suppresses the superconducting transition temperature but hardly affects the antiferromagnetic transition temperature. | Yazhou Zhou ShanJiang Qi wu Vladimir A.Sidorov Jing Guo Wei Yi Shan Zhang Zhe Wang HonghongWang shu Cai Ke Yang Sheng Jiang Aiguo Li Ni Ni Guangming Zhang Liling Sun Zhongxian Zhao | 2017 | Science Bulletin2017，62，12： | 3 |
| 4 | Phase Diagram Prediction of the Al_2O_3-SiO_2-La_2O_3 System显示文摘Rare earth oxide systems Al2O3-La2O3 and SiO2-La2O3 were thermodynamically assessed and optimized with the substitution model. The obtained model parameters and Gibbs free energy of tine compounds and pure components were applied to the prediction of the liquidus surface and isothermal sections of Al2O3-SiO2-La2O3 | Lin LI and Zhujun TANG(Department of Materials Science & Engineering, Shanghai University, Shanghai 200072, China) To whom correspondence should be addressedE-mail: liling@public6.sta.net.cn Weiying SUN and Peiling WANG(Shanghai Institute of Ceramics, Chi | 1999 | Journal of Materials Science & Technology1999，15，5： | 3 |
| 5 | FRACTAL ANALYSES OF DIRECTIONAL SOLIDIFICATION BEHAVIOR OF A Ni-BASE SUPERALLOY显示文摘The morphology of solid/liquid interface of a directionally solidification process is describedby means of fractal analysis,and the relations among the fractal dimension of the solid/liq-uid interface,solidification rate,dendrite arm space and the phosphorus content of the test al-loys have been given.It was found that the increase of the solidification rate and the phos-phorus content of the test alloy will lead to a increase,following the regularity of exponentialfunction,in the fractal dimension of solid/liquid interface.Furthermore,by combining thefractal theory and the thermodynamic principle with the measured results,it has been provedthat the fractal dimension is not only a kind of simple geometrical parameter used in des-cribing irregular geometry,but also a state function depending the change of solidificationparameters and chemical compositions. | SUN Liling DONG Lianke ZHANG Jishan TANG Yajun ZHANG Jinghua HU Zhuangqi Institute of Metal Research,Academia Sinica,Shenyang,China SUN Liling,Institute of Metal Research,Academia Sinica,Shenyang 110015,China | 1993 | Acta Metallurgica Sinica(English Letters)1993，6，5： | 2 |
| 6 | Application of fractal theory on the study of solid-liquid interface morphology显示文摘 | LILING SUN LIANKE DONG JIHUA ZHANG ZHUANGQI HU | 1997 | Journal of Materials Science Letters1997，，6： | 1 |
| 7 | Compression behavior of Zr_(41)Ti_(14)Cu_(12.5)Ni_(10)Be_(22.5) bulk metallic glass up to 24 GPa显示文摘The compression of a Zr41Ti14Cu12.5Ni10Be22.5 bulk metallic glass (BMG) is investigated at room temperature up to 24 GPa using in-situ high pressure energy dispersive X-ray diffraction with a synchrotron radiation source. The pressure-induced structural relaxation is exhibited. It is found that below about 8 GPa, the existence of excess free volume contributes to the rapid structural relaxation, which gives rise to the rapid volumetric change, and the structural relaxation results in the structural stiffness under higher pressure. | LI Gong 1, 2 , ZHAN Zaiji 2 , LIU Jing 3 , YUN Jinku 1 , SUN Liling 2 , LIU Riping 1 , ZHANG Jun 2 & WANG Wenkui 1, 2 1. Key Laboratory of Metastable Materials Science and Technology, Yanshan University, Qinhuangdao 066004, China 2. Center for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100080, China 3. BSRF, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100039, China | 2005 | Science China(Physics,Mechanics & Astronomy)2005，48，3： | 1 |
| 8 | Containerless solidification of Zr_(41)Ti_(14)Cu_(12.5)Ni_(10)Be_(22.5) glass-forming alloy in drop tube显示文摘Droplets of Zr41Ti14Cu12.5Ni10Be22.5 glass forming alloys with different sizes are solidified in a drop tube containerless processing. Glass transition behavior, crystallization kinetics, and the phase evolution during annealing of the Zr41Ti14Cu12.5Ni10Be22.5 glassy spheres are investigated. The experimental results indicate that the apparent activation energy of the glass transition (Eg=435.5 kJ/mol), and the activation energy of the main crystallization reaction (Ep1 = 249.6 kJ/mol) are obviously different from those of bulk glass samples prepared by water quenched (Eg=559.1 kJ/mol and Ep1=192.5 kJ/mol). The difference is discussed in the view point of the atomic configuration of the liquid state of the metallic glass and nucleation mechanism. | LI Gong, SUN Liling & WANG WenkuiCollege of Material Sciences and Engineering, Yanshan University, Qinhuangdao 066004, China Center for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100080, China National Microgravit | 2002 | Chinese Science Bulletin2002，47，20： | 1 |
| 9 | Quantum Phases of SrCu2(BO3)2 from High-Pressure Thermodynamics显示文摘In recent years,theoretical proposals for exotic states in quantum magnets are developing very rapidly,but many of these intriguing quantum phases and transitions have been difficult to realize experimentally.One class of such states is the valence bond solid,in which spins entangle locally and form symmetry-breaking singlet patterns.Signatures of a state with four-spin singlets were recently detected in the two-dimensional(2D)quantum magnet SrCu2(BO3)2 under high pressure. | SUN Liling Anders Sandvik | 2020 | Bulletin of the Chinese Academy of Sciences2020，34，2： | 0 |
| 10 | Preparation and characterization of methacrylated gelatin/bacterial cellulose composite hydrogels for cartilage tissue engineering显示文摘Methacrylated gelatin(GelMA)/bacterial cellulose(BC)composite hydrogels have been successfully prepared by immersing BC particles in GelMA solution followed by photo-crosslinking.The morphology of GelMA/BC hydrogel was examined by scanning electron microscopy and compared with pure GelMA.The hydrogels had very well interconnected porous network structure,and the pore size decreased from 200 to 10 mm with the increase of BC content.The composite hydrogels were also characterized by swelling experiment,X-ray diffraction,thermogravimetric analysis,rheology experiment and compressive test.The composite hydrogels showed significantly improved mechanical properties compared with pure GelMA.In addition,the biocompatility of composite hydrogels were preliminarily evaluated using human articular chondrocytes.The cells encapsulated within the composite hydrogels for 7 days proliferated and maintained the chondrocytic phenotype.Thus,the GelMA/BC composite hydrogels might be useful for cartilage tissue engineering. | Liling Gu Tao Li Xiongbo Song Xianteng Yang Senlei Li Long Chen Pingju Liu Xiaoyuan Gong Cheng Chen Li Sun | 2020 | Regenerative Biomaterials2020，7，2： | 0 |
| 11 | Conformation of Organic Chain in Phase Transition of Hybrid(C1_2H_(25)NH_3)_2MnCl_4显示文摘The structural change in phase transition of hybrid(C 12 H 25 NH 3 ) 2 MnCl 4 was investigated.The temperature and the structures of the phase transition is investigated by thermal gravimetry(TG)and differential scanning calorimetry(DSC),infrared spectrum(IR)and X-ray diffraction(XRD).The results suggest that the phase transition is reversible and the structural change arises from the conformation change of the organic chain. The interlayer distance increases when the hybrid transforms from low temperature phase to high temperature phase.This is explained by the diffusion of gauche-bond along the organic chains and they move away from each other when the phase transition occurs.Combining the experimental data with theoretical calculation, we propose that organic chain of the hybrid in high temperature phase is the conformation of gauche-bond alternating with trans bond(noted as GTG’TGTG’TGTG’T). | GUO Liling SUN Yubing MEI Ao DAI Yadong LIU Hanxing | 2008 | Journal of Wuhan University of Technology(Materials Science)2008，23，4： | 0 |
| 12 | PIP2和PIP3平衡以及Dock2的招募和活化调控B细胞抗原受体微簇体成熟显示文摘文章简介B淋巴细胞作为抗体免疫应答过程中的重要参与者,维系着人类的健康,其免疫活化是启动体液免疫反应的关键步骤。B淋巴细胞的免疫活化进程在其质膜表面的B细胞抗原受体(BCR)识别外来病原体抗原后快速启动,具有瞬时性和高度动态性特点,一直是免疫学领域的研究热点和难点。 | Jing Wang Liling Xu Samina Shaheen Sichen Liu Wenjie Zheng Xiaolin Sun Zhanguo Li 刘万里 | 2018 | 科学新闻2018，0，4： | 0 |
| 13 | Discovery of Quantum Phase Transition in Pressurized Cuprate Superconductors显示文摘The discovery of cuprate high-temperature superconductors in 1986 impacted science and technology considerably and continues to fascinate the communities of condensed matter physics and material sciences because they host the highest ambient-pressure superconducting transition temperature and unconventional electronic behavior.However,the underlying mechanism of the superconductivity is yet an unsolved mystery.Searching for the universal links between the superconducting state and its neighboring quantum states is believed to be an effective approach to elucidate the high-temperature superconducting mechanism. | SUN Liling | 2022 | Bulletin of the Chinese Academy of Sciences2022，36，1： | 0 |
| 14 | Thermosensitive injectable hydrogel loaded with hypoxia-induced exosomes maintains chondrocyte phenotype through NDRG3-mediated hypoxic response显示文摘Current clinical treatments cannot effectively delay the progression of osteoarthritis(OA).Consequently,joint replacement surgery is required for late-stage OA when patients cannot tolerate pain and joint dysfunction.Therefore,the prevention of OA progression in the early and middle stages is an urgent clinical problem.In a previous study,we demonstrated that NDRG3-mediated hypoxic response might be closely related to the development and progression of OA.In this study,an injectable thermosensitive hydrogel was established by cross-linking Pluronic F-127 and hyaluronic acid(HA)for the sustained release of hypoxia-induced exosomes(HExos)derived from adipose-derived mesenchymal stem cells.We demonstrated that for OA at the early and middle stages,the HExos-loaded HP hydrogel could maintain the chondrocyte phenotype by enhancing chondrocyte autophagy,reducing chondrocyte apoptosis,and promoting chondrocyte activity and proliferation through the NDRG3-mediated hypoxic response.This novel composite hydrogel,which could activate the NDRG3-mediated hypoxic response,may provide new ideas and a theoretical basis for the treatment of early-and mid-stage OA. | Xiongbo Song Liling Gu Qiming Yang Jiarui Wu Junrong Chen Xiaobin Tian Li Sun Long Chen | 2023 | Chinese Chemical Letters2023，34，8： | 0 |
| 15 | Transitions of amorphous-crystalline-amorphous in bulk metallic glass under HP and HT显示文摘In-situ SR-XRD measurements revealed that the crystallization process in Zr41.2Ti13.8Cu12.5Ni10Be22.5 bulk metallic glass is significantly different from that in tradi-tional glasses. Subsequent heating at 10 GPa converts the sample from amorphous phase into the metastable fcc phase and then leads to the fcc phase back to the amorphous phase, indicating that there exists ’reversible’ phase transition phe-nomena in the material under high pressure and high tem-perature. | SUN Liling TKikegawa WANG Wenkui | 2002 | Chinese Science Bulletin2002，47，2： | 0 |
| 16 | Monolithic integration of nanorod arrays on microfluidic chips for fast and sensitive one-step immunoassays显示文摘Here,we present integrated nanorod arrays on microfluidic chips for fast and sensitive flow-through immunoassays of physiologically relevant macromolecules.Dense arrays of Au nanorods are easily fabricated through one-step oblique angle deposition,which eliminates the requirement of advanced lithography methods.We report the utility of this plasmonic structure to improve the detection limit of the cardiac troponin I(cTnI)assay by over 6x 105-fold,reaching down to 33.9fg mL^(-1)(-1.4fM) compared with an identical assay on glass substrates.Through monolithic integration with microfluidic elements,the device enables a flow-through assay for quantitative detection of cTnI in the serum with a detection sensitivity of 6.9 pg mL^(-1)(-0.3 pM)in<6 min,which was 4000 times lower than conventional glass devices.This ultrasensitive detection arises from the large surface area for antibody conjugation and metal-enhanced fluorescent signals through plasmonic nanostructures.Moreover,due to the parallel arrangement of flow paths,simultaneous detection of multiple cancer biomarkers,including prostate-specific antigen and carcinoembryonic antigen,has been fulfilled with increased signal-to-background ratios.Given the high performance of this assay,together with its simple fabrication process that is compatible with standard mass manufacturing techniques,we expect that the prepared integrated nanorod device can bring on-site point-of-care diagnosis closer to reality. | Ye Wang Jiongdong Zhao Yu Zhu Shurong Dong Yang Liu Yijun Sun Liling Qian Wenting Yang Zhen Cao | 2021 | Microsystems & Nanoengineering2021，7，4： | 0 |
| 17 | Weakly complex Einstein-Finsler vector bundle Dedicated to Professor Tongde Zhong for His 90th Birthday显示文摘Let(E, F) be a complex Finsler vector bundle over a compact Khler manifold(M, g) with Khler form Φ. We prove that if(E, F) is a weakly complex Einstein-Finsler vector bundle in the sense of Aikou(1997),then it is modeled on a complex Minkowski space. Consequently, a complex Einstein-Finsler vector bundle(E, F) over a compact Khler manifold(M, g) is necessarily Φ-semistable and(E, F) =(E_1, F_1)⊕…⊕(E_k, F_k),where Fj := F |Ej, and each(Ej, Fj) is modeled on a complex Minkowski space whose associated Hermitian vector bundle is a Φ-stable Einstein-Hermitian vector bundle with the same factor c as(E, F). | Liling Sun Chunping Zhong | 2018 | Science China Mathematics2018，61，6： | 0 |
| 18 | Establishment of cervical model of squamous cell cavity lymph node metastasis carcinoma in the oral显示文摘 | Rui Sun Liling Wu Jiangang Zhang Chuanbin Guo | 2008 | 中国口腔颌面外科杂志2008，6，B05： | 0 |
| 19 | No evidence of superconductivity in a compressed sample prepared from lutetium foil and H_(2)/N_(2) gas mixture显示文摘A material described as lutetium–hydrogen–nitrogen(Lu-H-N in short)was recently claimed to have“near-ambient superconductivity”[Dasenbrock-Gammon et al.,Nature 615,244–250(2023)].If this result could be reproduced by other teams,it would be a major scientific breakthrough.Here,we report our results of transport and structure measurements on a material prepared using the same method as reported by Dasenbrock-Gammon et al.Our x-ray diffraction measurements indicate that the obtained sample contains three substances:the facecentered-cubic(FCC)-1 phase(Fm-3m)with lattice parameter a=5.03Å,the FCC-2 phase(Fm-3m)with a lattice parameter a=4.755Å,and Lu metal.The two FCC phases are identical to the those reported in the so-called near-ambient superconductor.However,we find from our resistance measurements in the temperature range from 300 K down to 4 K and the pressure range 0.9–3.4 GPa and our magnetic susceptibility measurements in the pressure range 0.8–3.3 GPa and the temperature range down to 100 K that the samples show no evidence of superconductivity.We also use a laser heating technique to heat a sample to 1800 XC and find no superconductivity in the produced dark blue material below 6.5 GPa.In addition,both samples remain dark blue in color in the pressure range investigated. | Shu Cai Jing Guo Haiyun Shu Liuxiang Yang Pengyu Wang Yazhou Zhou Jinyu Zhao Jinyu Han Qi Wu Wenge Yang Tao Xiang Ho-kwang Mao Liling Sun | 2023 | Matter and Radiation at Extremes2023，8，4： | 0 |
| 20 | On the projective Ricci curvature显示文摘The notion of the Ricci curvature is defined for sprays on a manifold.With a volume form on a manifold,every spray can be deformed to a projective spray.The Ricci curvature of a projective spray is called the projective Ricci curvature.In this paper,we introduce the notion of projectively Ricci-flat sprays.We establish a global rigidity result for projectively Ricci-flat sprays with nonnegative Ricci curvature.Then we study and characterize projectively Ricci-flat Randers metrics. | Zhongmin Shen Liling Sun | 2021 | Science China Mathematics2021，64，7： | 0 |
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