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| 1 | Activation of gibberellin 2-oxidase 6 decreases active gibberellin levels and creates a dominant semi-dwarf phenotype in rice (Oryza sativa L.)显示文摘Gibberellin (GA) 2-oxidase plays a key role in the GA catabolic pathway through 2β-hydroxylation.In the present study,we isolated a CaMV 35S-enhancer activation tagged mutant,H032.This mutant exhibited a dominant dwarf and GA-deficient phenotype,with a final stature that was less than half of its wild-type counterpart.The endogenous bioactive GAs are markedly decreased in the H032 mutant,and application of bioactive GAs (GA3 or GA4) can reverse the dwarf phenotype.The integrated T-DNA was detected 12.8 kb upstream of the OsGA2ox6 in the H032 genome by TAIL-PCR.An increased level of OsGA2ox6 mRNA was detected at a high level in the H032 mutant,which might be due to the enhancer role of the CaMV 35S promoter.RNAi and ectopic expression analysis of OsGA2ox6 indicated that the dwarf trait and the decreased levels of bioactive GAs in the H032 mutant were a result of the up-regulation of the OsGA2ox6 gene.BLASTP analysis revealed that OsGA2ox6 belongs to the class III of GA 2-oxidases,which is a novel type of GA2ox that uses C20-GAs (GA12 and/or GA53) as the substrates.Interestingly,we found that a GA biosynthesis inhibitor,paclobutrazol,positively regulated the OsGA2ox6 gene.Unlike the over-expression of OsGA2ox1,which led to a high rate of seed abortion,the H032 mutant retained normal flowering and seed production.These results indicate that OsGA2ox6 mainly affects plant stature,and the dominant dwarf trait of the H032 mutant can be used as an efficient dwarf resource in rice breeding. | Jian Huang Ding Tang Yi Shen Baoxiang Qin Lilan Hong Aiqing You Ming Li Xin Wang Hengxiu Yu Minghong Gu Zhukuan Cheng | 2010 | Journal of Genetics and Genomics2010，37，1： | 36 |
| 2 | Malate transported from chloroplast to mitochondrion triggers production of ROS and PCD in Arabidopsis thaliana显示文摘规划房间死亡(PCD ) 是一个基本生物过程。在马赛克死亡 1 的缺乏(MOD1 ) ,质体局部性的 enoyl-ACP reductase,导致反应的氧种类(ROS ) 和 PCD 的累积,它能被 mitochondrial 建筑群压制我变化,从叶绿体显示一个信号到线粒体。然而,这个信号尚待被阐明。在这研究,通过克隆并且分析一系列 mod1 suppressors,我们揭示调整 mitochondrial ROS 和扳机 PCD 的产生的一条全面细胞器通讯小径。我们证明在 PLASTIDIAL NAD 依赖的 MALATE 脱氢酶(plNAD-MDH ) 的变化, chloroplastic DICARBOXYLATE TRANSPORTER 1 (DiT1 ) 并且(mMDH1 ) MITOCHONDRIAL MALATE 脱氢酶 1 能各在 mod1 救 ROS 累积和 PCD 显型,经由 malate 梭从叶绿体表明直接通讯到线粒体。进一步的研究证明这些元素在不同光周期条件下面在氧化还原作用动态平衡和植物生长起关键作用。而且,我们表明 ROS 水平和 PCD 显著地在房间,它能是戏剧性地稀释了由的对待 malate 的 HeLa 被增加人的基因 MDH2 击倒, Arabidopsis mMDH1 的 ortholog。这些结果揭开在植物和动物系统的一条保存导致 malate 的 PCD 小径,革命化我们在细胞器之间的通讯的理解。 | Yannan Zhao Lilan Luo Jiesi Xu Peiyong Xin Hongyan Guo Jian Wu Lin Bai Guodong Wang Jinfang Chu Jianru Zuo Hong Yu Xun Huang Jiayang Li | 2018 | Cell Research2018，28，4： | 24 |
| 3 | Effects of environmental factors on sulfamethoxazole photodegradation under simulated sunlight irradiation: Kinetics and mechanism显示文摘To advance the knowledge of the environmental fate of sulfamethoxazole(SMX),we systematically investigated the effects of natural water constituents and synthetic substances(i.e.,TiO2 nanoparticles(nTiO2) and Ti-doped β-Bi2O3(NTB)) on the photodegradation kinetics of SMX under xenon lamp irradiation.The photolysis of SMX in aqueous solution followed first-order kinetics.Our results showed that higher concentrations of SMX,fulvic acid,suspended sediments,NTB and higher pH value decreased the photodegradation rates of SMX,whereas H2O2 improved the SMX photodegradation.TiO2 nanoparticles had a dual effect on photodegradation due to their photocatalytic activity and photoabsorption of photons.No intermediates more toxic toward Vibrio fischeri than SMX were produced after direct photolysis and photocatalytic degradation for 3 hr.The photolysis of SMX involved three pathways:hydroxylation,cleavage of the sulfonamide bond,and fragmentation of the isoxazole ring.This study lays the groundwork for a better understanding of the environmental fate of SMX. | Junfeng Niu Lilan Zhang Yang Li Jinbo Zhao Sidan Lv Keqing Xiao | 2013 | Journal of Environmental Sciences2013，25，6： | 14 |
| 4 | Deficient plastidic fatty acid synthesis triggers cell death by modulating mitochondrial reactive oxygen species显示文摘 | Jian Wu Yuefeng Sun Yannan Zhao Jian Zhang Lilan Luo Meng Li Jinlong Wang Hong Yu Guifu Liu Liusha Yang Guosheng Xiong Jian-Min Zhou Jianru Zuo Yonghong Wang Jiayang Li | 2015 | Cell Research2015，25，5： | 13 |
| 5 | ELE restrains empty glumes from developing into lemmas显示文摘Although there is evident homology among reproductive organs when comparing Poaceae (grass) and eudicots, the identity of grass specific organs, such as lodicules, palea, lemma, and glumes has been the subject of a vast and largely inconclusive discussion. Here we provide some direct evidence to support the idea that the empty glumes of rice (Oryza sativa) are counterparts of lemmas. We show that the development of empty glumes is regulated by ELE (elongated empty glume), which belongs to a plant specific novel gene family. Mutations at the ELE locus cause elongated empty glumes, which mimic the lemmas and have the epidermal morphology of lemmas with four or five vascular bundles. As a nuclear-localized gene, ELE is specifically expressed at the empty glumes of immature spikelets, and its ectopic expression causes many floral development defects, including lemma-like palea, extra palea-like structures, elongated lodicules, extra stamens and stigmas. Our result suggests that empty glumes are lemmas of the sterile florets located at the lateral side of the rice spikelet, and ELE acts as a regulator restraining its growth to maintain its small size in wild-type plants. | Lilan Hong Qian Qian Keming Zhu Ding Tang Zejun Huang Ling Gao Ming Li Minghong Gu Zhukuan Cheng | 2010 | Journal of Genetics and Genomics2010，37，2： | 11 |
| 6 | Effects of low-frequency repetitive transcranial magnetic stimulation on electroencephalogram and seizure frequency in 15 patients with temporal lobe epilepsy following dipole source localization显示文摘BACKGROUND:Low-frequency repetitive transcranial magnetic stimulation (rTMS) has been shown to significantly reduce epileptiform discharges and control clinical seizures in intractable epilepsy patients. The location of epileptic foci and magnetic stimulation sites remain uncertain. The effects of rTMS on electroencephalogram and seizure remain unclear in epileptic patients following dipole source localization. OBJECTIVE: To investigate the effects of low-frequency rTMS on electroencephalogram and seizure in temporal lobe epilepsy patients after dipole source localization. DESIGN,TIME AND SETTING: The randomized,controlled study was performed at the outpatient clinic,Department of Neurology,Hospital Affiliated to North Sichuan Medical College from December 2003 to February 2007. PARTICIPANTS: A total of 30 temporal lobe epilepsy patients,comprising 19 males and 11 females,aged 17-49 years,presented with epileptiform discharges and were enrolled for this study. Disease course ranged between 1-6 years,with 1-5 seizures per month. Imaging examinations revealed 11 patients with structural changes in the brain. The patients were randomly and equally assigned into drug treatment and transcranial magnetic stimulation (TMS) groups. METHODS: Patients in the drug treatment group were orally treated with carbamazepine. Patients in the TMS group received oral carbamazepine treatment of and TMS. A Maglite-r25 magnetic stimulator (Dantec Dynamics,Denmark) was used to stimulate epileptic foci in the temporal lobe following electroencephalogram dipole localization (1 Hz,90% threshold intensity,at a stimulation frequency of 500 times,once a day,for 7 days). MAIN OUTCOME MEASURES: At 30 days after TMS,seizure frequency and rate of epileptiform discharges were observed in patients from both groups. Therapeutic safety was investigated during treatment. RESULTS: Within 30 days of treatment,there were no significant differences in seizure frequency between the TMS group (1.5 ± 0.3) seizures and the drug treatment group [(1.9 ± 0.4) seizures] (P > 0.05). The rate of epileptiform discharges [27% (4/15)] was significantly less in the TMS group than in the drug treatment group [73% (11/15)] (P<0.05). During TMS,five patients suffered from transient mild headache,but were completely relieved within 2 hours. CONCLUSION: Low-frequency rTMS exhibited inhibitory effects on epileptiform discharges over a short period of time,and decreased seizure frequency to some degree. Results from the present study suggested that low-frequency rTMS is safe. | Xiaoming Wang Deben Yang Shunxian Wang Xiaoqiong Zhao Lilan Zhang Zhiqiong Chen Xiangrong Sun | 2008 | Neural Regeneration Research2008，3，11： | 8 |
| 7 | Optimal Operation of Integrated Energy Systems Subject to Coupled Demand Constraints of Electricity and Natural Gas显示文摘This paper proposes a hybrid multi-objective optimization and game-theoretic approach(HMOGTA)to achieve the optimal operation of integrated energy systems(IESs)consisting of electricity and natural gas(E&G)utility networks,multiple distributed energy stations(DESs),and multiple energy users(EUs).The HMOGTA aims to solve the coordinated operation strategy of the electricity and natural gas networks considering the demand characteristics of DESs and EUs.In the HMOGTA,a hierarchical Stackelberg game model is developed for generating equilibrium strategies of DESs and EUs in each district energy network(DEN).Based on the game results,we obtain the coupling demand constraints of electricity and natural gas(CDCENs)which reflect the relationship between the amounts and prices of electricity and cooling(E&C)that DESs purchase from utility networks.Furthermore,the minimization of conflicting costs of E&G networks considering the CDCENs are solved by a multi-objective optimization method.A case study is conducted on a test IES composed of a 20-node natural gas network,a modified IEEE 30-bus system,and 3 DENs,which verifies the effectiveness of the proposed HMOGTA to realize fair treatment for all participants in the IES. | Yingjie Qin Lilan Wu Jiehui Zheng Mengshi Li Zhaoxia Jing Q.H.Wu Xiaoxin Zhou Feng Wei | 2020 | CSEE Journal of Power and Energy Systems2020，6，2： | 7 |
| 8 | A CRISPR evolutionary arms race: structural insights into viral anti-CRISPR/Cas responses显示文摘 | Jiuyu Wang Jun Ma Zhi Cheng Xu Meng Lilan You Min Wang Xinzheng Zhang Yanli Wang | 2016 | Cell Research2016，26，10： | 6 |
| 9 | Effects of combined chemical design(Cu addition) and topographical modification(SLA) of Ti-Cu/SLA for promoting osteogenic, angiogenic and antibacterial activities显示文摘Cu has been proved to possess various beneficial biological activities, while sandblasting and acid etching(SLA) is widely used to modify the commercial dental implant in order to improve osseointegration. Based on the above, a novel antimicrobial dental implant material, Ti-Cu alloy, was treated with SLA, to combine chemical design(Cu addition) and topographical modification(SLA). In this work, the effects of SLA treated Ti-Cu alloys(Ti-Cu/SLA) on osteogenesis, angiogenesis and antibacterial properties were evaluated from both in vitro and in vivo tests, and Ti/SLA and Ti-Cu(without SLA) were served as control groups. Benefiting by the combined effects of chemical design(Cu addition) and micro-submicron hybrid structures(SLA),Ti-Cu/SLA had significantly improved inhibitory effects on oral anaerobic bacteria(P. gingivalis and S.mutans) and could induce upregulation of osteogenic-related and angiogenic-related genes expression in vitro. More importantly, in vivo studies also demonstrated that Ti-Cu/SLA implants had wonderful biological performance. In the osseointegration model, Ti-Cu/SLA implant promoted osseointegration via increasing peri-implant bone formation and presenting good bone-binding, compared to Ti/SLA and Ti-Cu implants. Additionally, in the peri-implantitis model, Ti-Cu/SLA effectively resisted the bone resorption resulted from bacterial infection and meanwhile promoted osseointegration. All these results suggest that the novel multiple functional Ti-Cu/SLA implant with rapid osseointegration and bone resorption inhibition abilities has the potential application in the future dental implantation. | Rui Liu Yulong Tang Hui Liu Lilan Zeng Zheng Ma Jun Li Ying Zhao Ling Ren Ke Yang | 2020 | Journal of Materials Science & Technology2020，47，12： | 6 |
| 10 | Improving the Corrosion Resistance of ZEK100 Magnesium Alloy by Combining High-Pressure Torsion Technology with Hydroxyapatite Coating显示文摘Recently,magnesium and its alloys have attracted more and more attention as promising implant materials due to their excellent properties such as good biocompatibility,biodegradation,non-toxicity and comparable mechanical properties with natural bone.They can be gradually degraded and absorbed so as to avoid the second surgery for implants removal after the tissues are healed completely.In addition,they are also able to prevent the stress shielding effect in human body environment because of the density,elastic modulus and yield strength of magnesium closer to the bone.Unfortunately,the high corrosion rate which causes early mechanical failure of the implants in physiological environment limits the widespread use of magnesium alloys for clinical application in biology.And the high corrosion process usually causes huge hydrogen evolution and alkalinization,resulting in problems against the implants as well as the surrounding tissues.In order to enhance the corrosion resistance of magnesium alloys,in this study,the ZEK100 magnesium alloy was pre-deformed with a highpressure torsion(HPT)process and then fabricated hydroxyapatite(HA)coatings with different contents of Mg(OH)2 nanopowder via hydrothermal method.The specimens were characterized by scanning electron microscope(SEM)and X-ray diffraction(XRD).At the same time,prior and after the HPT procedure,the metallography,microhardness and tensile tests of specimens were characterized.Meanwhile,the corrosion behavior of the specimens was evaluated by electrochemical impedance spectroscopy(EIS)and hydrogen evolution tests.And the interface bonding strength of the HA coating on the magnesium alloy substrate was evaluated by a tape adhesion test/scratch test.Results showed that HPT processing refined the grain size and introduced a great number of twins,resulting in the enhancement of microhardness and Young’s modulus of ZEK100 magnesium alloy,but hardness values at the edge were higher than those at the center due to the uneven shear strain.At the same conditions,the HA coating on HPT-ZEK was denser,thicker than that on ZEK sample and the crystal sizes of HA were smaller on HPT-ZEK.These were attributed to fine,uniform distributed secondary phases and lots of fine grains,twins,grain boundaries in HPT-ZEK substrates which can provide more nucleation sites for the HA crystal.In terms of the amount of Mg(OH)2 nanopowder,Mg(OH)2 nanopowder significantly influenced the microstructure and thickness of the HA coating.And at a 0.3 mg/mL content of Mg(OH)2 nanopowder,there was the densest,thickest HA coating on magnesium alloys,and the crystal size of HA was minimum.Specifically,the HA coating thickness on ZEK-03(0.3 mg/mL Mg(OH)2 nanopowder)was 1.8 times of that on ZEK-00(0 mg/mL Mg(OH)2 nanopowder),while the HA coating thickness on HPT-03 was 2.6 times of that on ZEK-00.And the adhesion strength of HA coating on HPT-03 substrate was better than that on ZEK-03.In addition,HPT technology and surface modification by HA coating simultaneously increased the corrosion resistance of ZEK100 magnesium alloy and the corrosion of HPT-ZEK samples occurred in a more uniform manner,while it was pitting on the surface of ZEK100 magnesium alloy.Therefore,there was the best corrosion resistance on HPT-03 sample,which could promote the application of magnesium alloys in biomedical fields. | Qite Li Wenbo Ye Hong Gao Lilan Gao | 2019 | 医用生物力学2019，34，A01： | 5 |
| 11 | Regulation of mitochondrial NAD pool via NAD^+ transporter 2 is essential for matrix NADH homeostasis and ROS production in Arabidopsis显示文摘Reactive oxygen species(ROS) play a crucial role in numerous biological processes in plants, including development, responses to environmental stimuli, and programmed cell death(PCD). Deficiency in MOSAIC DEATH 1(MOD1), a plastid-localized enoyl-ACP reductase essential for de novo fatty acid biosynthesis in Arabidopsis thaliana, leads to the increased malate export from chloroplasts to mitochondria, and the subsequent accumulation of mitochondria-generated ROS and PCD. In this study, we report the identification and characterization of a mod1 suppressor, som592. SOM592 encodes mitochondrion-localized NAD^+ transporter 2(NDT2). We show that the mitochondrial NAD pool is elevated in the mod1 mutant. The som592 mutation fully suppressed mitochondrial NADH hyper-accumulation, ROS production, and PCD in the mod1 mutant, indicating a causal relationship between mitochondrial NAD accumulation and ROS/PCD phenotypes. We also show that in wild-type plants, the mitochondrial NAD+uptake is involved in the regulation of ROS production in response to continuous photoperiod. Elevation of the alternative respiration pathway can suppress ROS accumulation and PCD in mod1, but leads to growth restriction. These findings uncover a regulatory mechanism for mitochondrial ROS production via NADH homeostasis in Arabidopsis thaliana that is likely important for growth regulation in response to altered photoperiod. | Lilan Luo Yajun He Yannan Zhao Qian Xu Jian Wu Haiyan Ma Hongyan Guo Lin Bai Jianru Zuo Jian-Min Zhou Hong Yu Jiayang Li | 2019 | Science China(Life Sciences)2019，62，8： | 5 |
| 12 | Determination of Total Flavonoids in Leaves of Paliurus ramosissimus and Orthogonal Experiment Optimization Process显示文摘[Objectives] To screen the optimal extraction conditions of flavonoids from leaves of Paliurus ramosissimus( Lour.) Poir.,measure the content of flavonoids in leaves of P. ramosissimus. using the Microplate Reader,and provide experimental basis for the development of medicinal resources of P. ramosissimus. [Methods] The ultrasonic extraction method was adopted and orthogonal design was carried out to study the effects of ethanol concentration( A),ultrasonic time( B),the solid-to-liquid ratio( C) on the extraction of flavonoids from leaves of P. ramosissimus. The Microplate Reader was used to measure the content of flavonoids in leaves of P. ramosissimus. in different extraction conditions,P. ramosissimus. and the optimal extraction conditions were used to measure the content of flavonoids from leaves of P. ramosissimus.[Results]Effects of the ultrasonic extraction method on the extraction rate of flavonoids from leaves of P. ramosissimus: extraction times >ethanol concentration > Ultrasound time > solid-liquid ratio. The screened optimal extraction process was: ethanol concentration of 65%,the solid-to-liquid ratio of 1∶ 25,ultrasonic time of 2 h and extraction times Under this condition,the extraction rate of total flavonoids in leaves of P. ramosissimus. was 2. 56%. [Conclusions] This method is simple and feasibility,reliable,and suitable for rapid measurement with large samples. | Yuanchun ZHUANG Chun ZHANG Lilan OU Pixian SHUI | 2018 | Medicinal Plant2018，9，2： | 5 |
| 13 | Determination of Aromatic Components of Rosa davurica Pall. by Headspace Solid Phase Microextraction Combined with GC-MS显示文摘[Objectives] To determine the aromatic components of Rosa davurica Pall. [Methods] 42 kinds of aromatic components were identified from the flowers of R. davurica by headspace solid phase microextraction( HS-SPME) combined with gas chromatography-mass spectrometry( GC-MS). The main compounds were alcohols( 54. 88%) and aldehydes( 19. 55%). [Results] The top five components with the highest relative content were phenylethyl alcohol( 12. 69%),geraniol( 9. 85%),citronellol( 8. 80%),nerol( 7. 84%) and 2-n-pentylfuran( 7. 45%). [Conclusions] Headspace solid phase microextraction( HS-SPME) combined with gas chromatography-mass spectrometry( GC-MS) can provide basis for further development and utilization of R. davurica. | Yuan NIU Qiong XU Jian ZHUANG Yude WANG Lilan DAI Dengfei LI Yalan ZHAO | 2018 | Medicinal Plant2018，9，5： | 5 |
| 14 | Finite-Time Consensus of a Leader-Following Multi-Agent Network with Non-Identical Nonlinear Dynamics and Time-Varying Topologies显示文摘In this paper, the finite-time consensus of a leader-following multi-agent network with non-identical nonlinear dynamics and time-varying topologies is investigated. All the agents, especially the leaders, have non-identical and nonlinear dynamics. According to the algebraic graph theory, Lyapunov stability theory and Kronecker product, a control strategy strategy is established to guarantee the finite-time consensus of multi-agent network with multiple leaders. Furthermore, several numerical simulations illustrate the effectiveness and feasibility of the proposed method. | YU Le TU Lilan HUANG Yifan | 2016 | Wuhan University Journal of Natural Sciences2016，21，5： | 4 |
| 15 | Luminescent research of Sr5(PO4)3Cl:Eu^2+ blue phosphor used for electron beam excitation显示文摘Eu2+-activated strontium choloro-phosphate has been used for lamp phosphor traditionally with high efficiency. In this paper, the cathodoluminescent properties of Sr5(PO4)3Cl:Eu2+ have been investigated for application in field emission display. The influence of Ba2+, Ca2+ impurities on the cathodoluminescent spectrum of Sr5(PO4)3Cl:Eu2+ has also been measured. When operate voltage varied from mid- to low-voltage, the relative brightness and saturation behavior of phosphor was observed at different current density. | LILan YANGRuixia DUZhong ZOUKaishun ZHANGXiaosong | 2003 | Chinese Science Bulletin2003，48，15： | 3 |
| 16 | Effect of IL-1βand TNF-αon the Expression of MonocyteChem otactic Protein-1 in Endom etriotic Cells显示文摘To investigate the clinical significance of monocyte chemotactic protein 1 (MCP 1) produced by endometriotic tissues, the endometriotic tissues were taken from 15 patients with endometriosis. MCP 1 mRNA and MCP 1 protein were determined by dot blot analysis and enzyme linked immunosorbent assay (ELISA) in endometriotic cells cultured with or without interleukin 1β (IL 1β, 2 μg/L), tumor necrosis factor α (TNF α, 20 g/L). After exposure to IL 1β or TNF α, the expression of MCP 1 mRNA in the endometriotic cells (8.635± 0.826, 7.031±0.970, respectively) were significantly higher than that in the control group (4.482±0.435, P <0.05); The expression of MCP 1 protein in IL 1β and TNF α group was 4.52±0.09 μg/L,2.87±0.27 μg/L, respectively, which were significantly higher than 1.74±0.16 μg/L in control ( P <0.01). The results suggested that IL 1β and TNF α could up regulate the expression of MCP 1 in endometriotic cells, which might be related to the development of endometriosis. | GAO Ying LUO Lilan HE Fuxian Department of Obstetrics and Gynecology, Xiehe Hospital, Tongji Medical University, Wuhan 430022 | 1999 | Journal of Huazhong University of Science and Technology(Medical Sciences)1999，19，3： | 3 |
| 17 | Engineering a High-Selectivity PVDF Hollow-Fiber Membrane for Cesium Removal显示文摘In this study,a copper ferrocyanide/silica/polyvinylidene fluoride(CuFC/SiO2/PVDF)hollow-fiber composite membrane was successfully synthesized through a facile and effective crosslinking strategy.The PVDF hollow-fiber membrane with embedded SiO2 was used to fix the dispersion of CuFC nanoparticles for cesium(Cs)removal.The surface morphology and chemical composition of the composite membrane were analyzed using scanning electron microscopy and X-ray photoelectron spectroscopy(XPS).The composite membrane showed a high Cs rejection rate and membrane flux at the three layers of CuFC and 0.5%SiO2,and its Cs rejection rate was not affected by variation in the pH(pH=4–10).The modified membrane could be effectively regenerated many times using ammonium nitrate(NH4NO3).The Cs selectivity performance was verified by an efficient Cs rejection rate(76.25%and 88.67%in 8 h)in a solution of 100 lg L 1 of Cs with 1 mmol L 1 of competing cations(K+and Na+).The CuFC/SiO2/PVDF hollowfiber composite membrane showed a particularly superior removal performance(greater than 90%)in natural surface water and simulated water with a low Cs concentration.Therefore,the CuFC/SiO2/PVDF hollow-fiber composite membrane can be used directly in engineering applications for the remediation of radioactive Cs-contaminated water. | Shiyuan Ding Lilan Zhang Yang Li Li’an Hou | 2019 | Engineering2019，5，5： | 3 |
| 18 | Life History Recorded in the Vagino-cervical Microbiome Along with Multi-omes显示文摘The vagina contains at least a billion microbial cells,dominated by lactobacilli.Here we perform metagenomic shotgun sequencing on cervical and fecal samples from a cohort of 516 Chinese women of reproductive age,as well as cervical,fecal,and salivary samples from a second cohort of 632 women.Factors such as pregnancy history,delivery history,cesarean section,and breastfeeding were all more important than menstrual cycle in shaping the microbiome,and such information would be necessary before trying to interpret differences between vagino-cervical microbiome data.Greater proportion of Bifidobacterium breve was seen with older age at sexual debut.The relative abundance of lactobacilli especially Lactobacillus crispatus was negatively associated with pregnancy history.Potential markers for lack of menstrual regularity,heavy flow,dysmenorrhea,and contraceptives were also identified.Lactobacilli were rare during breastfeeding or post-menopause.Other features such as mood fluctuations and facial speckles could potentially be predicted from the vagino-cervical microbiome.Gut and salivary microbiomes,plasma vitamins,metals,amino acids,and hormones showed associations with the vagino-cervical microbiome.Our results offer an unprecedented glimpse into the microbiota of the female reproductive tract and call for international collaborations to better understand its long-term health impact other than in the settings of infection or pre-term birth. | Zhuye Jie Chen Chen Lilan Hao Fei Li Liju Song Xiaowei Zhang Jie Zhu Liu Tian Xin Tong Kaiye Cai Zhe Zhang Yanmei Ju Xinlei Yu Ying Li Hongcheng Zhou Haorong Lu Xuemei Qiu Qiang Li Yunli Liao Dongsheng Zhou Heng Lian Yong Zuo Xiaomin Chen Weiqiao Rao Yan Ren Yuan Wang Jin Zi Rong Wang Na Liu Jinghua Wu Wei Zhang Xiao Liu Yang Zong Weibin Liu Liang Xiao Yong Hou Xun Xu Huanming Yang Jian Wang Karsten Kristiansen Huijue Jia | 2022 | Genomics, Proteomics & Bioinformatics2022，20，2： | 2 |
| 19 | Electrochemical degradation of perfluorooctanoic acid (PFOA) by Ti/SnO 2 –Sb, Ti/SnO 2 –Sb/PbO 2 and Ti/SnO 2 –Sb/MnO 2 anodes显示文摘 | Hui Lin Junfeng Niu Shiyuan Ding Lilan Zhang | 2012 | Water Research2012，，7： | 2 |
| 20 | Research into Development Dilemmas of MOOC in China' s Higher Education and Its Countermeasures显示文摘The Massive Open Online Courses( MOOC) originated in Europe and America has been a new channel obtaining know ledge and an important learning mode in the age of big data. The development of MOOC brings about far- reaching impact on sharing and constructing the high quality education resources in the w orld,w hich may present great challenges to traditional teaching mode. Considering China's higher education environment and MOOC 's particular characteristics,this paper summarizes the development dilemmas of MOOC in China's higher educational environment and discusses the countermeasures as w ell as finds a suitable w ay for the development of informatization education. | Zhai Xuesong Lin Lilan | 2014 | 学术界2014，，3： | 2 |
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