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| 1 | Multiple genetic alterations and behavior of cellular biology in gastric cancer and other gastric mucosal lesions:H.pylori infection,histological types and staging显示文摘AIM To investigate the expression of multiplegenes and the behavior of cellular biology ingastric cancer(GC)and other gastric mucosallesions and their relations to Helicobacter pylori(H.pylori)infection,tumor staging andhistological subtypes.METHODS Three hundred and twenty-sevenspecimens of gastric mucosa obtained viaendoscopy or surgical resection,and ABCimmunohistochemical staining were used todetect the expression of p53,p16,Bcl-2 andCOX-2 proteins.H.pylori was determined byrapid urea test combined with pathologicalstaining or14C urea breath test.Cellular image analysis was performed in 66 patients withintestinal metaplasia(IM)and/or dysplasia(Dys).In 30 of them,both cancer and theparacancerous tissues were obtained at the timeof surgery.Histological pattern,tumor staging,lymph node metastasis,grading ofdifferentiation and other clinical data werestudied in the medical records.RESULTS p16 expression of IM or Dys wassignificantly lower in positive H.pylori chronicatrophic gastritis(CAG)than those withnegative H.pylori(CAG:54.8% vs 88.0%,IM:34.4% vs 69.6%,Dys:23.8% vs 53.6%,allP<0.05),Bcl-2 or COX-2 expression of IM orDys in positive H.pylori cases was significantlyhigher than that without H.pylori(Bcl-2:68.8%vs23.9%,90.5% vs 60.7%;COX-2:50.0% vs10.8%,61.8% vs 17.8%;all P<0.05).Themean number of most parameters of cellularimage analysis in positive H.pylori group wassignificantly higher than that in negative H.pylori group(Ellipser:53±14,40±12μm,Area1:748±572,302±202 μm2,Area2:3050±1661,1681±1990 μm2,all P<0.05;Ellipseb:79±23,58±15 μm,Ratio1:22%±5%,13%±4%,Ratio2:79%±17%,53%±20%,all P<0.01).There was significant correlation between Bcl-2and histologic pattern of gastric carcinoma,andbetween COX-2 and tumor staging or lymph nodemetastasis(Bcl-2:75.0% vs 16.7%;COX-2:76.0% vs 20.0%,79.2% vs 16.7%;allP<0.05).CONCLUSION p1l6, Bcl-2, and COX-2 but not p53 gene may play a role in the early genesis/ progression of gastric carcinoma and are associated with H. pylori infection. p53 gene is relatively late event in gastric tumorigenesis and mainly relates to its progression. There is more cellular-biological behavior of malignant tumor in gastric mucosal lesions with H. pylori infection. Aberrant Bcl-2 protein expression appears to be preferentially associated with the intestinal type cancer. COX-2 seems to be related to tumor staging and lymph node metastasis. | Heng Jun Gao Lian Zhen Yu Jian Feng Bai Yan Shen Peng Gu Sun Han Lin Zhao Kun Miu Xiu Zhen Lü Xiao Yong Zhang Zhi Quan Zhao | 2000 | World Journal of Gastroenterology2000，6，6： | 52 |
| 2 | Get effective polyclonal antisera in one month显示文摘According to the traditional immunization procedure, after the first injection of the sample A (emulsion of aimed antigen and Freund's complete adjuvant) to immunize rabbit, successive injections of the sample B (emulsion of aimed antigen and Freund's incomplete adjuvant) were followed every 2-4 weeks. In general,high titer of the corresponding polyclonal antisera will be observed after 4-5 injections of sample B in 3-4months. This report presents a simply modified procedure that was able to stimulate the antisera formation in one month and achieve enough avidity to satisfy either Western blot or immunohistochemistry analysis.It just applied an additional injection of the sample A to the rabbit at the 3rd day after the primary immunization injection. You could gain the high titer of the antisera right after the first sample B injection in one month. This method has produced the desired results in three different recombinant antigens with different molecular weight (5.9 KD-55 KD) expressed from prokaryotic or eukaryotic cells. | YUAN XIN HU, Ju YUAN QUO, Lu SHEN, YAN CHEN, Zu CHUAN ZHANG, YONG LIAN ZHANGState Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, | 2002 | Cell Research2002，12，2： | 45 |
| 3 | Circulation anomalies associated with interannual variation of early- and late-summer precipitation in Northeast China显示文摘Summer rainfall is vital for crops in Northeast China. In this study, we investigated large-scale circulation anomalies related to monthly summer rainfall in Northeast China using European Center for Medium-Range Weather Forecast ERA-40 reanalysis data and monthly rainfall data from 79 stations in Northeast China. The results show that the interannual variation in rainfall over Northeast China is mainly dominated by a cold vortex in early summer (May-June) and by the East Asian summer monsoon in late summer (July-August). In early summer, corresponding to increased rainfall in Northeast China, an anomalous cyclonic anomaly tilted westward with height appears to the northwest and cold vortices occur frequently. In late summer, the rainfall anomaly is mainly controlled by a northward shift of the local East Asian jet stream in the upper troposphere and the northwest extension of the western Pacific subtropical high (WPSH) in the lower troposphere. The enhanced southwesterly anomaly in the west of the WPSH transports more moisture into Northeast China and results in more rainfall. In addition, compared with that in July, the rainfall in Northeast China in August is also influenced by a mid- and high-latitude blocking high over Northeast Asia. | SHEN BaiZhu LIN ZhongDa LU RiYu LIAN Yi | 2011 | Science China Earth Sciences2011，54，7： | 24 |
| 4 | NGX6 inhibits cell invasion and adhesion through suppression of Wnt/β-catenin signal pathway in colon cancer显示文摘结肠癌是与增加的病态和死亡被联系的一个普通恶意的肿瘤。鼻咽的联系癌的基因(NGX6 ) 6 是肿瘤转移的新奇候选人 suppressor 基因,它在结肠癌是下面调整的。这研究被设计在人的结肠癌房间线的生长和侵略上调查 NGX6 的角色,并且阐明, HT-29 他们的行动的分子的机制。结果证明 NGX6 能禁止侵略和 HT-29 房间的细胞外的矩阵粘附并且恢复差距 junctional 房间的细胞间的通讯。而且, NGX6 能从原子核和细胞质压制 -catenin 的 translocation 到血浆膜,禁止 TCF4 抄本因素,和下面调整的活动 Wnt-direct-targeted 基因 c-myc, cyclin D1 和 COX-2 的表示。我们建议 NGX6 在结肠癌通过 Wnt 信号小径的抑制禁止房间侵略和粘附。 | Qin Guo Shourong Shen Mantian Liao Ping Lian Xiaoyan Wang | 2010 | Acta Biochimica et Biophysica Sinica2010，42，7： | 13 |
| 5 | Correlation of Epworth Sleepiness Scale with multiple sleep latency test and its diagnostic accuracy in assessing excessive daytime sleepiness in patients with obstructive sleep apnea hypopnea syndrome显示文摘 | CAI Si-jie CHEN Rui ZHANG Yan-lin XIONG Kang-ping LIAN Yi-xin LI Jie SHEN Jiu-cheng LIU Chun-feng | 2013 | Chinese Medical Journal2013，，17： | 12 |
| 6 | First proof-of-principle experiment with the post-accelerated isotope separator on-line beam at BRIF:measurement of the angular distribution of ^(23)Na+^(40)Ca elastic scattering显示文摘The reaction dynamics of exotic nuclei near the drip line is one of the main research topics of current interest.Elastic scattering is a useful probe for investigating the size and surface diffuseness of exotic nuclei.The development of rare isotope accelerators offers opportunities for such studies.To date,many relevant measurements have been performed at accelerators using the projectile fragmentation technique,while the measurements at accelerators using isotope separator on-line(ISOL)systems are still quite scarce.In this work,we present the first proof-of-principle experiment with a post-accelerated ISOL beam at the Beijing Radioactive Ion Beam Facility(BRIF)by measuring the angular distribution of elastic scattering for the stable nucleus^(23)Na from the doubly magic nucleus^(40)Ca at energies above the Coulomb barrier.The angular distribution measured by a silicon strip detector array in a scattering chamber using the ISOL beam at BRIF is in good agreement with that measured by the high-precision Q3 D magnetic spectrograph using the nonISOL beam at nearly the same energy.This work provides useful background for making BRIF a powerful tool for the investigation of the reaction dynamics of exotic nuclei. | Wei Nan Bing Guo Cheng-Jian Lin Lei Yang Dong-Xi Wang Yang-Ping Shen Bing Tang Bao-Qun Cui Tao Ge Yin-Long Lyu Hui-Ming Jia Yun-Ju Li Chen Chen Li-Hua Chen Qi-Wen Fan Xin-Yue Li Gang Lian Jian-Cheng Liu Tian-Peng Luo Nan-Ru Ma Rui-Gang Ma Xie Ma Ying-Jun Ma Wei-Ke Nan Dan-Yang Pang You-Bao Wang Pei-Wei Wen Feng Yang Yong-Jin Yao Sheng Zeng Hao Zhang Fu-Peng Zhong Shan-Hao Zhong Zhi-Hong Li Tian-Jue Zhang Wei-Ping Liu BRIF Collaboration | 2021 | Nuclear Science and Techniques2021，32，5： | 9 |
| 7 | Short term effect of choroid thickness in the horizontal meridian detected by spectral domain optical coherence tomography in myopic children after orthokeratology显示文摘AIM: To investigate choroidal thickness changes in the horizontal meridian after orthokeratology.METHODS: This is a prospective cross-sectional observed study. Subjects(n=30; 11.3±1.7 y) with low-to-moderate myopia(-1.0 to-6.0 diopters), wore orthokeratology(Ortho-K)lenses for 3 mo. Before and after Ortho-K, OCT scans were made through the fovea in the horizontal meridian.Choroid thickness around the fovea was acquired by custom software. The analyzed regions along the horizontal meridian were divided into 7 equal zones. Ocular parameters were measured by Lenstar LS 900 non-contact biometry.RESULTS: Only the right eye ocular parameters were analyzed in this study. Before Ortho-K, choroidal thickness along the horizontal meridian was 273.7±31.8 μm in the temporal zone, 253.1±38.6 μm in the macula zone,and 194.8±52.2 μm in the nasal zone. After Ortho-K, the choroid was thicker in each horizontal zone(P<0.05). The increased thickness was greatest in the temporal zone(13.5±22.5 μm) and least in the nasal zone(8.4±14.2 μm).The axial length(AL) increased 0.02 mm(P>0.05). The choroid thickness change in each horizontal zone was negatively correlated with AL(r,-0.3 to-0.4; P<0.05) except one of the nasal zones.CONCLUSION: In myopic children, the thickness of the choroid is greatest in the temporal zone and thinnest in the nasal zone. After nightly Ortho-K for 3 mo, the thickness increase along the horizontal meridian. The choroid thickness changes are negatively correlated with the change of AL. | Wan-Qing Jin Sheng-Hai Huang Jun Jiang Xin-Jie Mao Mei-Xiao Shen Yan Lian | 2018 | International Journal of Ophthalmology(English edition)2018，11，6： | 9 |
| 8 | Paleo-productivity evolution across the Permian-Triassic boundary and quantitative calculation of primary productivity of black rock series from the Dalong Formation, South China显示文摘The change of the primary productivity across the Permian-Triassic boundary(PTB)remains controversial.In this study,records from two deep-water sections in South China(Xiakou and Xinmin sections)show the primary productivity decreased gradually from the latest Permian to the earliest Triassic,and five evolutionary stages Increase-Decrease-Recovery-RecessionStagnation)can be observed from Clarkina changxingensis-C.deflecta to Hindeodus parvus-Isarcicella isarcica zones.Primary productivity decreased abruptly from the base of C.meishanensis zone.Besides,for adjusting to the deterioration of the oceanic environment,the primary producers in the oceanic surface had changed to acritarch and cyanobacteria,which were more tolerant of stressful environment.Then the producers were under huge stagnation in the H.parvus-I.isarcica zone.The values of quantitative calculation of the primary productivity from the black rock series in the Dalong Formation were very high,corresponding to that of an upwelling area in modern ocean,which shows that the strata of the Dalong Formation in the study region are potential hydrocarbon source-rocks.This result may come from the fact that South China craton was located at the equatorial upwelling area during the Permian-Triassic transitions.But organic matter contents were different in various sections because they could be affected by redox conditions and diagenesis process after burial. | SHEN Jun ZHOU Lian FENG QingLai ZHANG MuHui LEI Yong ZHANG Ning YU JianXin GU SongZhu | 2014 | Science China Earth Sciences2014，57，7： | 8 |
| 9 | Molecular epidemiology of serotype 19A Streptococcus pneumoniae isolated from children in Beijing, 1997-2006显示文摘尽管有链球菌 pneumoniae serotype 19A 的流行的背景,这 serotype 的分子的特征充分还有待于被阐明。学习因此是在打字的 China.Methods 脉搏地胶化电气泳动和 multilocus 顺序决定 serotype 19A 的相同的这的目的被做到这 49 serotype 19A 孤立调查在在北京和另外的区域流行的紧张之间的关系。从 1997 ~ 2006 的结果, serotype 19A 的百分比孤立增加。到青霉素和 amoxicillin 的危险性率减少了,到 cefuroxime 的抵抗率增加了。ST320 是最流行的圣,由 ST3546 列在后面。有六新圣,在我们的学习识别。serotype 19A 种类被分类进六不同脉搏地胶化电气泳动(PFGE ) 模式。 ST320 ,与二个不同 PFGE 模式( A 和 D )被联系,说明了因为 32 孤立,并且 ST3546 ,与二个 PFGE 模式( B 和 E )被联系,向前从 2003 说明了 eightConclusions , ST320 是最普通的圣和到显著地增加的 cefuroxime 的抵抗的率。链球菌 pneumoniae serotype 19A 的进一步长期的调查被要求在这重要人的病原体监视圣流行和抗菌剂抵抗。 | XUE Lian YAO Kai-hu YU Sang-jie LIU Zun-jie QIAN Jing SHEN Xu-zhuang YANG Yong-hong | 2011 | Chinese Medical Journal2011，，12： | 6 |
| 10 | Eradication of H pylori infection in a rural population: One-day quadruple therapy versus 7-day triple therapy显示文摘瞄准:比较有标准 7-d 的四倍的治疗增加两倍的一天为在中国的一张农村人口的 H pylori 根除的治疗。方法:396 个病人与的一个总数(13 ) pylori 被分配进二的为 H 阳性的 C 脲呼吸测试组织:239 个病人收到了一天四倍的治疗(amoxicillin 2000 mg qid;灭滴灵 500 mg qid;枸橼酸铋 900 mg qid 和 lansoprazole 60 mg 从前每日) 并且 157 个病人收到了 7-d 标准三元组治疗(amoxicillin 1000 mg 出价;clarithromycin 500 mg 出价和 lansoprazole 30 mg 出价) 。所有病人经历了一(13 ) 六个星期估计 H pylori 感染的根除的 C-UBT 术后疗法。结果:229 个病人完成了一天治疗(95.8%) , 148 个病人完成了 7-d 治疗(94.2%) 。一天治疗根除了在 64 个病人(27.95%) 的 H pylori 感染。相反, 103 个病人(69.59%) 是在 7-d 治疗以后否定的 H pylori (P <
0.01 ) 。结论:这个预研项目建议与 7-d 标准治疗相比没有在 H pylori 感染的治疗的一天治疗的有益的效果。 | Lian Zhang Lin Shen Jun-Ling Ma Kai-Feng Pan Wei-Dong Liu Jie Li Shu-Dong Xiao San-Ren Lin Meinhard Classen Wei-Cheng You | 2006 | World Journal of Gastroenterology2006，12，24： | 6 |
| 11 | Prenatal nicotine exposure enhances the susceptibility to metabolic syndrome in adult offspring rats fed high-fat diet via alteration of HPA axis-associated neuroendocrine metabolic programming显示文摘 | Dan XU Li-ping XIA Ben-jian ZHANG Lang SHEN You-ying LEI Lian LIU Li ZHANG Jacques MAGDALOU Hui WANG | 2013 | Acta Pharmacologica Sinica2013，34，12： | 5 |
| 12 | 基于沉浸边界法的轴流泵内鱼体运动数值模拟显示文摘为精细分析鱼类在水力机械流道中的运动特性,本文以轴流泵为例,采用沉浸边界(immersed boundary,IB)与流固耦合(fluid-structure interaction,FSI)及大涡模拟(large eddy simulation,LES)相结合的方法,对泵内流场及鱼体通过泵流道的运动过程进行了数值模拟。结果表明,在相同雷诺数下计算得到的设计工况扬程系数与实验值误差仅为2.7%,验证了IB-FSI-LES方法适合于模拟轴流泵内部流动。与将鱼体视为流体示踪粒子的常规计算相比,采用IB-FSI-LES方法可以得到鱼体在泵内的复杂运动轨迹,捕捉鱼体与叶片发生碰撞时的运动突变以及叶轮内鱼体周围流场中涡结构的形成和脱落。研究结果可为水利水电工程中鱼类过机损伤精确评估及鱼类友好型水力机械优化设计提供科学依据。 | 杨丹丹 赵明翔 叶维祥 SHEN Lian 罗先武 | 2021 | 水力发电学报2021，40，7： | 5 |
| 13 | Design and efficient synthesis of novel haptens and complete antigens for the AOZ,a toxic metabolite of furazolidone显示文摘好策略为设计有效幸运向前被带十并且为 3-amino-2-oxazolidinone (AOZ ) 的完全的抗原。最新设计的 Haptens 被使用 LiCl N (et ) 在好产量轻易地完成 3 同样新的催化作用系统,其结构被光谱学分析阐明,。为 AOZ 的新奇抗原被方便活跃酉旨方法成功地准备。3 和 4 作为 41:1 (5a ) 分别地被证明到搬运人蛋白质的幸运十的比率, 39:1 (6a ) , 11:1 (5b ) 和由 trinitrobenzene 的 9:1 (6b ) 酸性硫酸基的酸(TNBS ) 方法。抗血清的间接竞争 ELISA (ic-ELISA ) 的结果显示十与一个短不饱和的方面锁住的幸运能有效地唤起特定的有免疫力的反应。 | Yu Dong Shen Yu Wang Shi Wei Zhang Zhi LiXiao Yuan Ming Sun Xian Zhang Bu Lian Quan Gu | 2007 | Chinese Chemical Letters2007，18，12： | 5 |
| 14 | Measurement of γ detector backgrounds in the energy range of 3-8 MeV at Jinping underground laboratory for nuclear astrophysics显示文摘The astrophysical reaction rate of the charged-particleinduced reaction is dominated by the cross section within the Gamow window.The total cross section σ(E)of a chargedparticle-induced reaction is known to drops steeply with decreasing energy owing to the Coulomb barrier in the entrance channel: | YangPing Shen Jun Su WeiPing Liu Gang Lian Lin Gan LvHua Qiao ShengQuan Yan Yong Zhou Qian Yue Zhi Zeng QingDong Hu YuHao Mi Wei Zhao | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，10： | 5 |
| 15 | Postoperative chemotherapy with S-1 plus oxaliplatin versus S-1alone in locally advanced gastric cancer(RESCUE-GC study): a protocol for a phase Ⅲ randomized controlled trial显示文摘Background:The ACTS-GC study had shown postoperative adjuvant therapy with S-1 improved survival of patients with locally advanced gastric cancer.Addition of oxaliplatin to S-1 is considered to be acceptable as one of the treatment options for gastric cancer patients after radical gastrectomy with D2 lymph node excision.Methods:We have commenced a randomized phase III trial in December 2016 to evaluate S-1 plus oxaliplatin compared with S-1 alone in the adjuvant setting for locally advanced gastric cancer.A total of 564 patients will be accrued from 13 Chinese institutions in two years.The primary endpoint is 3-year relapse-free survival.The secondary endpoints are 5-year overall survival,proportion of patients who complete the postoperative chemotherapy and incidence of adverse events.Ethic and dissemination:The trial has been approved by the institutional review board of each participating institution and it was activated on December,2016.The enrollment will be finished in December,2018.Patient’s follow-up will be ended until December,2023.Trial registration:Clinical Trials.gov,identifier:NCT02867839.Registered on August 4,2016. | Xiang Hu Lin Chen Yian Du Biao Fan Zhaode Bu Xin Wang Yingjiang Ye Zhongtao Zhang Gang Xiao Fei Li Qingsi He Guoli Li Xian Shen Bin Xiong Liming Zhu Jiwei Liui Lian Liu Tao Wu Jing Zhou Jun Zhang Gang Zhao Xulin Wang Pin Liang Xinxin Wang Yan Zhang Xiaojiang Wu Ji Zhang Xin Ji Xianglong Zong Tao Fu Ziyu Jia Jiafu Ji | 2017 | Chinese Journal of Cancer Research2017，29，2： | 5 |
| 16 | Spiral Field Generation in Smith-Purcell Radiation by Helical Metagratings显示文摘Moving electrons interacting with media can give rise to electromagnetic radiations and has been emerged as a promising platform for particle detection,spectroscopies,and free-electron lasers.In this letter,we investigate the Smith-Purcell radiation from helical metagratings,chiral structures similar to deoxyribonucleic acid(DNA),in order to understand the interplay between electrons,photons,and object chirality.Spiral feld patterns can be generated while introducing a gradient azimuthal phase distribution to the induced electric dipole array at the cylindrical interface.Experimental measurements show efcient control over angular momentum of the radiated feld at microwave regime,utilizing a phased electromagnetic dipole array to mimic moving charged particles.Te angular momentum of the radiated wave is determined solely by the handedness of the helical structure,and it thus serves as a potential candidate for the detection of chiral objects.Our fndings not only pave a way for design of orbital angular momentum free-electron lasers but also provide a platform to study the interplay between swif electrons with chiral objects. | Liqiao Jing Zuojia Wang Xiao Lin Bin Zheng Su Xu Lian Shen Yihao Yang Fei Gao Min Chen Hongsheng Chen | 2019 | Research2019，，1： | 4 |
| 17 | Involvement of Plasma Membrane H+-ATPase in Adaption of Rice to Ammonium Nutrient显示文摘The preference of paddy rice for NH4+ rather than NO3ˉ is associated with its tolerance to low pH since a rhizosphere acidification occurs during NH4+ absorption.However,the adaptation of rice root to low pH has not been fully elucidated.The plasma membrane H+-ATPase is a universal electronic H+ pump,which uses ATP as energy source to pump H+ across the plasma membranes into the apoplast.The key function of this enzyme is to keep pH homeostasis of plant cells and generate a H+ electrochemical gradient,thereby providing the driving force for the active influx and efflux of ions and metabolites across the plasma membrane.This study investigated the acclimation of plasma membrane H+-ATPase of rice root to low pH.This mechanism might be partly responsible for the preference of rice plants to NH4+ nutrition. | Yi-yong ZHU Juan LIAN Hou-qing ZENG Liu GAN Ting-jun DI Qi-rong SHEN Guo-hua XU | 2011 | Rice science2011，18，4： | 4 |
| 18 | Porous Si/C composite as anode materials for high-performance rechargeable lithium-ion battery显示文摘A novel porous silicon was synthesized through a magnesiothermic reduction method of molecular sieve for the first time, Si/C composite was synthesized by using pitch as carbon source. The porous Si/C composite shows a high initial specific capacity of 2018.5 mAh/g with current density of 0.1 A/g. When the current density increases to 2 A/g, it still exhibits high average specific capacity of 640.3 mAh/g. The porous structure can remit the Si particle pulverization during the lithiation/delithiation process. This article can provide a reference for the research of the porous Si anode for the high performance rechargeable lithium-ion battery. | Bingbing Deng Lian Shen Yangai Liu Tao Yang Manshu Zhang Renjie Liu Zhaohui Huang Minghao Fang Xiaowen Wu | 2017 | Chinese Chemical Letters2017，28，12： | 4 |
| 19 | Celecoxib-related gastroduodenal ulcer and cardiovascular events in a randomized trial for gastric cancer prevention显示文摘AIM: To evaluate the long-term risk of gastroduodenal ulcer and cardiovascular events induced by celecoxib in a population-based, randomized, double-blind, placebo-controlled study.METHODS: From 2004 to 2006, a total of 1024 Chinese patients (aged 35 to 64 years) with severe chronic atrophic gastritis, intestinal metaplasia or dysplasia were randomly assigned to receive 200 mg of celecoxib twice daily or placebo in Linqu County (Shandong Province, China), a high-risk area of gastric cancer. All gastroduodenal ulcer and cardiovascular events occurred were recorded and the patients were followed up for 1.5 years after treatment. At the end of the trial, a systematic interview survey about other adverse events was conducted. RESULTS: Gastroduodenal ulcer was detected in 19 of 463 (3.72%) patients who received celecoxib and 17 of 473 (3.31%) patients who received placebo, respectively (odds ratio = 1.13, 95% CI = 0.58-2.19). Cardiovascular (CV) events occurred in 4 patients who received celecoxib and in 5 patients who received placebo, respectively. Compared with those who received placebo, patients who received celecoxib had no signif icant increase in occurrence of CV events (hazard ratio = 0.84, 95% CI = 0.23-3.15). Among the adverse events acquired by interview survey, only the frequency of bloating was signif icantly higher in patients treated with celecoxib than in those treated with placebo. CONCLUSION: Treatment of gastric cancer with celecoxib is not associated with increased risk of gastroduodenal ulcer and cardiovascular events. | Guo-Shuang Feng Jun-Ling Ma Benjamin CY Wong Lian Zhang Wei-Dong Liu Kai-Feng Pan Lin Shen Xiao-Dong Zhang Jie Li Harry HX Xia Ji-You Li Shiu Kum Lam Wei-Cheng You | 2008 | World Journal of Gastroenterology2008，14，28： | 4 |
| 20 | Numerical Experiments on the Impact of Spring North Pacific SSTA on NPO and Unusually Cool Summers in Northeast China显示文摘A set of numerical experiments designed to analyze the oceanic forcing in spring show that the combined forcing of cold(warm) El Nino(La Nina) phases in the Nino4 region and sea surface temperature anomalies(SSTA) in the westerly drifts region would result in abnormally enhanced NorthEast Cold Vortex(NECV) activities in early summer. In spring, the central equatorial Pacific El Nino phase and westerly drift SSTA forcing would lead to the retreat of non-adiabatic waves,inducing elliptic low-frequency anomalies of tropical air flows. This would enhance the anomalous cyclone–anticyclone–cyclone–anticyclone low-frequency wave train that propagates from the tropics to the extratropics and further to the mid-high latitudes, constituting a major physical mechanism that contributes to the early summer circulation anomalies in the subtropics and in the North Pacific mid-high latitudes. The central equatorial Pacific La Nina forcing in the spring would, on the one hand, induce teleconnection anomalies of high pressure from the Sea of Okhotsk to the Sea of Japan in early summer, and on the other hand indirectly trigger a positive low-frequency East Asia–Pacific teleconnection(EAP) wave train in the lower troposphere. | LIAN Yi ZHAO Bin SHEN Baizhu LI Shangfeng LIU Gang | 2014 | Advances in Atmospheric Sciences2014，31，6： | 4 |
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