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| 1 | Risk factors and natural history of breast cancer in younger Chinese women显示文摘AIM: To investigate the age differences in the risk factors, clinicopathological characteristics and patterns of treatment of female breast cancer patients. METHODS: Seven thousand one hundred and fiftytwo women with primary breast cancer from the Hong Kong Breast Cancer Registry were recruited after receiving patients' consent, they were asked to complete standardized questionnaires which captured their sociodemographic characteristics and risk factors associated with breast cancer development. Among them, clinicopathological data and patterns of treatment were further collected from medical records of 5523 patients with invasive breast cancers. Patients were divided into two groups according to the age at diagnosis: younger(< 40 years old) vs older patients(≥ 40 years old) for subsequent analyses.RESULTS: Analysis on the sociodemographic characteristics and exposure to risk factors were performed on 7152 women with primary breast cancer and the results revealed that younger patients were more likely to have unhealthy lifestyles; these include a lack of exercise(85.4% vs 73.2%, P < 0.001), having high stress in life(46.1% vs 35.5%, P < 0.001), having dairy/meat-rich diets(20.2% vs 12.9%, P < 0.001),having alcohol drinking habit(7.7% vs 5.2%, P = 0.002). Younger patients were also more likely to have hormone-related risk factors including nulliparity(43.3% vs 17.8%, P < 0.001) and an early age at menarche(20.7% vs 13.2%, P < 0.001). Analyses on clinicopathological characteristics and patterns of treatment were performed on 5523 women diagnosed with invasive breast cancer. The invasive tumours in younger patients showed more aggressive pathological features such as having a higher percentage of grade 3 histology(45.7% vs 36.5%, P < 0.001), having a higher proportion of tumours with lymphovascular invasion(39.6% vs 33.2%, P = 0.003), and having multifocal disease(15.7% vs 10.3%, P < 0.001); they received different patterns of treatment than their older counterparts.CONCLUSION: Younger patients in Hong Kong are more likely to encounter risk factors associated with breast cancer development and have more aggressive tumours than their older counterparts. | Winnie Yeo Hang-Mei Lee Amy Chan Emily YY Chan Miranda CM Chan Keeng-Wai Chan Sharon WW Chan Foon-Yiu Cheung Polly SY Cheung Peter HK Choi Josette SY Chor William WL Foo Wing-Hong Kwan Stephen CK Law Lawrence PK Li Janice WH Tsang Yuk Tung Lorna LS Wong Ting-Ting Wong Chun-Chung Yau Tsz-Kok Yau Benny CY Zee | 2014 | World Journal of Clinical Oncology2014，5，5： | 4 |
| 2 | Gsh-4 encodes an LIM-type homeodomain, is expressed in the developing central nervous system and is required for early postnatal survival显示文摘 | Witte DP Branford WW | 1994 | The EMBO J1994，13，： | 1 |
| 3 | The role of therapeutic angiogenesis in tissue repair and regeneration显示文摘 | Li WW Talcott KE Zhai AW | 2005 | J Adv Skin Wound Care2005，18，9： | 1 |
| 4 | Percutaneous transluminal sptal myocardial ablation for hypertrophic obstructive cardiomyopathy: The Chinese experience in 119 patients from a single center显示文摘 | Li ZQ Cheng TO Zhang WW | 2004 | International Journal of Cardiology2004，93，23： | 1 |
| 5 | Tumor angiogenesis as a target for dietary cancer prevention显示文摘 | Li WW Li VW Hutnik M | | 0，，： | 1 |
| 6 | Reclassification of aggres sive adenomatous mastoid neoplasms as endolymphatic sac tumors显示文摘 | Li JC Brackmann DE Lo WW | 1993 | Laryngoscope1993，103，12： | 1 |
| 7 | Updated morphology, histopathology and molecular phylogeny of Myxobolus hearti , cardiac myxosporea in gibel carp, Carassius gibelio (Bloch)显示文摘 | LT Ye WX Li WW Wang SG Wu GT Wang | 2014 | J Fish Dis2014，，1： | 1 |
| 8 | Interpreting differences in pat- terns of supportive care needs between patients with breast cancer and patients with colorectal cancer 显示文摘 | Li WW Lain WW Angl HY | 2013 | Psychooncology2013，22，4： | 1 |
| 9 | RANKL, OPG and CTRmRNA expression in ihe temporomandibular joint in rheuma-toid arthritis显示文摘 | Liu WW Xu ZM Li ZQ | 2015 | Exp Ther Med2015，10，3： | 1 |
| 10 | Factors controlling ocular angiogenesis 显示文摘 | Casey R Li WW | 1997 | Am J Ophthalmol1997，124，4： | 1 |
| 11 | Tumor angiogenesis as a target for dietary cancer prevention显示文摘 | Li WW Li VW Hutnik M | 2012 | J Oncol2012，，87： | 1 |
| 12 | Multiple roles of COX-2 in tumor angiogenesis: a target for antiangiogenic therapy 显示文摘 | Gately S Li WW | 2004 | Semin Oncol2004，，27： | 1 |
| 13 | IL-2 and IL-4 double knockout mice reject islet allografts:a role for novel T cell growth factors in allograft rejection显示文摘 | Li XC Roy-Chaudhury P Hancock WW | 1998 | J Immunol1998，161，2： | 1 |
| 14 | Establishment,characterizationand drug sensitivity of fouRnew human soft tissue sarcoma cell lines显示文摘 | Li WW Cordon-Cardo C Chen Q | | 0，，： | 1 |
| 15 | Discrepancy between radio- graphic shoulder balance and cosmetic shoulder balance in adolescent idiopathic scoliosis patients with double thoracic curve显示文摘 | Qiu XS Ma WW Li WG | 2009 | Eur Spine J2009，18，1： | 1 |
| 16 | The role of therapeutic angiogenesis in tissue repair and regeneration显示文摘 | Li WW Talcott KE Zhai AW | 2005 | Adv Skin Wound Care2005，18，9： | 1 |
| 17 | Localization of alpha-synuclein to mitochondfia within midbrain of mice显示文摘 | Li WW Yang R Guo JC | 2007 | Neuroreport2007，18，15： | 1 |
| 18 | Improved algorithm of muscle fatigue detection using linear regression analysis 显示文摘 | WW Hu YC Huang CP Li | 2013 | Electronics Letters (S0013-5194)2013，49，2： | 1 |
| 19 | Haemolytic anaemia following rituximab treatment in a patient with pemphigus vulgaris显示文摘 | Li WW Chen XX Yu J | 2009 | Br J Dermatol2009，161，1： | 1 |
| 20 | Neuroprotection of hy-pothermia against neuronal death in rat hippocam-pus through inhibiting the increased assembly ofGluR6-PSD95-MLK3 signaling module induced bycerebral ischemia/reperfusion 显示文摘 | Hu WW Du Y Li C | 2008 | Hippocampus2008，18，4： | 1 |
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