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| 1 | Genetic associations with adverse events from anti-tumor necrosis factor therapy in inflammatory bowel disease patients显示文摘AIM To study the type and frequency of adverse events associated with anti-tumor necrosis factor(TNF)therapy and evaluate for any serologic and genetic associations.METHODS This study was a retrospective review of patients attending the inflammatory bowel disease(IBD) centers at Cedars-Sinai IBD Center from 2005-2016. Adverse events were identified via chart review. IBD serologies were measured by ELISA. DNA samples were genotyped at Cedars-Sinai using Illumina Infinium Immunochipv1 array per manufacturer's protocol. SNPs underwent methodological review and were evaluated using several SNP statistic parameters to ensure optimal allele-calling. Standard and rigorous QC criteria were applied to the genetic data, which was generated using immunochip. Genetic association was assessed by logistic regression after correcting for population structure.RESULTS Altogether we identified 1258 IBD subjects exposed to anti-TNF agents in whom Immunochip data were available. 269/1258 patients(21%) were found to have adverse events to an anti-TNF-α agent that required the therapy to be discontinued. 25% of women compared to 17% of men experienced an adverse event. All adverse events resolved after discontinuing the antiTNF agent. In total: n = 66(5%) infusion reactions; n = 49(4%) allergic/serum sickness reactions; n = 19(1.5%) lupus-like reactions, n = 52(4%) rash, n = 18(1.4%) infections. In Crohn's disease, Ig A ASCA(P = 0.04) and Ig G-ASCA(P = 0.02) levels were also lower in patients with any adverse events, and anti-I2 level in ulcerative colitis was significantly associated with infusion reactions(P = 0.008). The logistic regression/human annotation and network analyses performed on the Immunochip data implicated the following five signaling pathways: JAK-STAT(Janus Kinase-signal transducer and activator of transcription), measles, IBD, cytokine-cytokine receptor interaction, and toxoplasmosis for any adverse event. CONCLUSION Our study shows 1 in 5 IBD patients experience an adverse event to anti-TNF therapy with novel serologic, genetic, and pathways associations. | Daniel Lew Soon Man Yoon Xiaofei Yan Lori Robbins Talin Haritunians Zhenqiu Liu Dalin Li Dermot PB McGovern | 2017 | World Journal of Gastroenterology2017，23，40： | 4 |
| 2 | Frequent amplification of a chr19q13.41 microRNA polycistron in aggressive primitive neuroectodermal brain tumors显示文摘 | Li M Lee KF Lu Y Clarke I Shih D Eberhart C Collins VP Van Meter T Picard D Zhou L Boutros PC Modena P Liang ML Scherer SW Bouffet E Rutka JT Pomeroy SL Lau CC Taylor MD Gajjar A Dirks PB Hawkins CE Huang A. | 2009 | 中国神经肿瘤杂志2009，7，4： | 3 |
| 3 | Structural and mechanistic insights into STIMl-mediated initiation of store- operated calcium entry 显示文摘 | StathopuIos PB Zheng L Li GY | 2008 | Cell2008，135，1： | 1 |
| 4 | Racial difference in blood pressure response to angiotensin-converting enzyme inhibitors in children: a meta-analysis显示文摘 | Li JS Baker-Smith CM Smith PB Hasselblad V Murphy MD Califf RM | 2008 | Clin Pharmacol Ther2008，84，3： | 1 |
| 5 | Core bioactive components Promoting blood circulation in the traditional Chinese medicine Compound Xueshuantong capsule(CXC)based on the relevance analysis between chemical HPLC fingerprint and in vivo biological effects显示文摘 | Liu H Liang JP Li PB | 2014 | PLo S ONE2014，9，11： | 1 |
| 6 | Plasma levels of soluble CD105 correlate with metastasis in patients with breast cancer 显示文摘 | Li C Guo B Wilson PB | 2000 | Int J Cancer2000，89，2： | 1 |
| 7 | Characteristic compari- son of three rat models induced by cigarette smoke or combined with LPS: to establish a suitable model for study of airway mucus hypersecretion in chronic obstructive pulmonary disease显示文摘 | Nie YC Wu H Li PB | 2012 | Pulm Pharmacol Ther2012，25，5： | 1 |
| 8 | Stored Ca^2+ depletion-induced oligomerization of stromal interaction molecule 1 (STIM1) via the EF-SAM region: An initiation mechanism for capacitive Ca^2+ entry 显示文摘 | Stathopulos PB Li GY Plevin M J | 2006 | J Biol Chem2006，281，35： | 1 |
| 9 | Tribological properties of bismaleimide composites with surface-modified SiO2 nanopartieles显示文摘 | Yan HX Li PB Ning RC Ma X Y Zhang Z P | 2008 | Journal of Applied Polymer Science2008，110，3： | 1 |
| 10 | Focal cerebral ischemia induces a multilineage cytogenic response from adult subventricular zone that is predominantly gliogenic显示文摘 | Li L Harms KM Ventura PB | | 0，，： | 1 |
| 11 | Approach to infants born at 22 to 24 weeks' gestation:relationship to outcomes of more-mature infants显示文摘 | Smith PB Ambalavanan N Li L | 2012 | Pediatrics2012，129，6： | 1 |
| 12 | Stored Ca2+depletion-induced oligomerization of STIM1 via the EF-SAM region:An ini-tiation mechanism for capacitive Ca2+ entry显示文摘 | Stathopulos PB Li G-Y Plevin MJ | | 0，，： | 1 |
| 13 | Antitussive effect of naring- in on experimentally induced cough in guinea pigs 显示文摘 | Gao S Li PB Yang HL | 2010 | Planta Med2010，77，1： | 1 |
| 14 | Immuno-enhancement effects of Shenqi Fuzheng Injection on cyclophosphamide induced immunosuppression in Balb/c mice显示文摘 | Wang JX Tong X Li PB | 2012 | J Ethnopharmacol2012，139，3： | 1 |
| 15 | Structural and mechanistic insights into STIM1-mediated initiation of store-operated calcium entry显示文摘 | Stathopulos PB Zheng L Li GY | | 0，，： | 1 |
| 16 | Normal or non-diagnostic neuroimaging studies prior to the detection of malignant primary brain tumors显示文摘 | Thater PB Black KS Li JUet Clin Nertosci M Lsakov Y Demopouios AJ | 2012 | 2012，，： | 1 |
| 17 | Bioactive components on immuno-enhancement effects in the traditional Chinese medicine Shenqi Fuzheng injection based on relevance analysis between chemical HPLC fingerprints and in vivo biological effects显示文摘 | Wang JX Tong X Li PB | 2014 | J Ethnopharmacol2014，155，1： | 1 |
| 18 | Plasma levels of soluble CD105 correlate with metastasis in patients with breast cancer显示文摘 | Li C Guo B Wilson PB | 2000 | Int J Cancer2000，89，2： | 1 |
| 19 | Biophysical characteriza-tion of the EF-hand and SAM domain containing Ca2+sensory re-gion of STIM1 and STIM2显示文摘 | Zheng L Stathopμlos PB Li GY | | 0，，： | 1 |
| 20 | Plasma levels of soluble CD105 corre- late with metastasis in patients with breast cancer 显示文摘 | Li C Guo B Wilson PB | 2000 | Int J Cancer2000，89，2： | 1 |
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