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| 1 | 常规脂蛋白检测和载脂蛋白在心血管病预测中的比较显示文摘总胆固醇和高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)测量值对于心血管病风险评估至关重要,但对于其他脂质用于风险预测的效用一直存在争议。该研究纳入来自英国生物银行(Biobank)的无基线心血管病、未服用他汀类药物、有相关的脂质指标(n=346 686)的受试者。 | Welsh C Celis-Morales CA Brown R Mackay DF Lewsey J Mark PB Gray SR Ferguson LD Anderson JJ Lyall DM Cleland JG Jhund PS Gill J MR Pell JP Sattar N Welsh P 刘青(译) 叶鹏(摘、审校) | 2019 | 中华高血压杂志2019，27，7： | 10 |
| 2 | 消化内镜检查的安全问题与对策显示文摘我们使用消化内镜诊治患者应该最大限度地发挥检查的好处,同时将危险性减至最低限度。要达到这一目的,需要由专家操作,使用合适的镜型及附件,受检指征明确,术前准备充分,保护措施得力,助手技术熟练。应该认识到,复杂的治疗与急诊检查危险性更大,准备(病人与器械... | Cott.,PB 廖宁逊 | 1998 | 中华消化内镜杂志1998，15，3： | 9 |
| 3 | 铅神经毒作用的机制显示文摘铅对人中枢神经系统有毒性作用,其作用机制可能模拟或动员钙以及激活蛋白激酶,并破坏血脑屏障。由于儿童脑组织发育不完善,所以铅更易导致儿童的学习障碍和行为缺陷。 | Joseph PB 李莹 | 1992 | 国外医学(卫生学分册)1992，19，4： | 6 |
| 4 | Genetic associations with adverse events from anti-tumor necrosis factor therapy in inflammatory bowel disease patients显示文摘AIM To study the type and frequency of adverse events associated with anti-tumor necrosis factor(TNF)therapy and evaluate for any serologic and genetic associations.METHODS This study was a retrospective review of patients attending the inflammatory bowel disease(IBD) centers at Cedars-Sinai IBD Center from 2005-2016. Adverse events were identified via chart review. IBD serologies were measured by ELISA. DNA samples were genotyped at Cedars-Sinai using Illumina Infinium Immunochipv1 array per manufacturer's protocol. SNPs underwent methodological review and were evaluated using several SNP statistic parameters to ensure optimal allele-calling. Standard and rigorous QC criteria were applied to the genetic data, which was generated using immunochip. Genetic association was assessed by logistic regression after correcting for population structure.RESULTS Altogether we identified 1258 IBD subjects exposed to anti-TNF agents in whom Immunochip data were available. 269/1258 patients(21%) were found to have adverse events to an anti-TNF-α agent that required the therapy to be discontinued. 25% of women compared to 17% of men experienced an adverse event. All adverse events resolved after discontinuing the antiTNF agent. In total: n = 66(5%) infusion reactions; n = 49(4%) allergic/serum sickness reactions; n = 19(1.5%) lupus-like reactions, n = 52(4%) rash, n = 18(1.4%) infections. In Crohn's disease, Ig A ASCA(P = 0.04) and Ig G-ASCA(P = 0.02) levels were also lower in patients with any adverse events, and anti-I2 level in ulcerative colitis was significantly associated with infusion reactions(P = 0.008). The logistic regression/human annotation and network analyses performed on the Immunochip data implicated the following five signaling pathways: JAK-STAT(Janus Kinase-signal transducer and activator of transcription), measles, IBD, cytokine-cytokine receptor interaction, and toxoplasmosis for any adverse event. CONCLUSION Our study shows 1 in 5 IBD patients experience an adverse event to anti-TNF therapy with novel serologic, genetic, and pathways associations. | Daniel Lew Soon Man Yoon Xiaofei Yan Lori Robbins Talin Haritunians Zhenqiu Liu Dalin Li Dermot PB McGovern | 2017 | World Journal of Gastroenterology2017，23，40： | 4 |
| 5 | Frequent amplification of a chr19q13.41 microRNA polycistron in aggressive primitive neuroectodermal brain tumors显示文摘 | Li M Lee KF Lu Y Clarke I Shih D Eberhart C Collins VP Van Meter T Picard D Zhou L Boutros PC Modena P Liang ML Scherer SW Bouffet E Rutka JT Pomeroy SL Lau CC Taylor MD Gajjar A Dirks PB Hawkins CE Huang A. | 2009 | 中国神经肿瘤杂志2009，7，4： | 3 |
| 6 | 右心室超声心动图指标预测患新生儿持续性肺动脉高压婴儿的不良预后显示文摘患新生儿持续性肺动脉高压(persistent pulmonary hypertension of the newborn,PPHN)的婴儿肺血管阻力增高可导致右心衰竭和死亡。临床医师必须准确判断常规治疗可能无效的、需要进行体外膜肺氧合(extra corporeal membrane oxygenation,ECMO)治疗的婴儿, | Malowitz JR Forsha DE Smith PB Cotten CM Barker PC Tatum GH 刘莉 叶鹏 | 2015 | 中华高血压杂志2015，23，4： | 3 |
| 7 | ABSOLUTE STABLE HOMOTOPY FINITE ELEMENT METHODS FOR CIRCULAR ARCH PROBLEM AND ASYMPTOTIC EXACTNESS POSTERIORI ERROR ESTIMATE显示文摘In this paper, HFEM is proposed to investigate the circular arch problem. Optimal error estimates are derived, some superconvergence results are established, and an asymptotic exactness posteriori error estimator is presented. In contrast with the classical displacement variational method, the optimal convergence rate for displacement is uniform to the small parameter. In contrast with classical mixed finite element methods, our results are free of the strict restriction on h(the mesh size) which is preserved by all the previous papers. Furtheremore we introduce an asymptotic exactness posteriori error estimator based on a global superconvergence result which is discovered in this kind of problem for the first time. | Feng, MF Ming, PB Yang, RK | 2002 | Journal of Computational Mathematics2002，20，6： | 2 |
| 8 | Bilateral symmetric inflammatory reaction to hylan G-F 20 injection显示文摘 | Martens PB | | Arthritis and Rheumatism0，，： | 2 |
| 9 | Vemurafenib改善伴BRAF V600E突变的黑色素瘤患者的生存率显示文摘背景 BRAF激酶抑制剂vemurafenib(PLX4032)的1期和2期临床试验已证实其对伴BRAFV600E突变的转移性黑色素瘤患者的反应率超过50%。方法我们在675例既往未经治疗、伴BRAFV600E突变的转移性黑色素瘤患者中,实施了一项Ⅲ期随机化临床试验以比较vemurafenib和Dacarbazine(氮烯唑胺)。患者通过随机分配,分别接受vemurafenib(每次口服960mg,每天两次)或氮烯唑胺(每3周静脉注射1000mg·m-2体表面积)。本研究主要终点是比较总体生存率及无进展期生存率。次要终点包括反应率、反应持续时间以及安全性。计划在死亡98例患者时进行中期分析、死亡196例时进行最终分析。结果在治疗6个月后,vemurafenib组总体生存率为84%(95%置信区间[CI],78-89),而氮烯唑胺组为64%(95%CI,56-73)。在对总体生存率的中期分析及无进展期生存率的最终分析中,与氮烯唑胺相比,vemurafenib能相对减低63%的死亡风险,以及减低74%的死亡或者疾病进展风险(两种比较P<0.001)。通过数据及安全监督委员会进行独立中期分析审查后,建议氮烯唑胺组患者也转而服用vemurafenib。对Vemurafenib反应率是48%而氮烯唑胺只有5%。伴Vemurafenib常见不良反应为关节痛、皮疹、疲劳、脱发、角化棘皮瘤或鳞状细胞癌、光过敏、恶心和腹泻;38%的患者因为毒副作用要求调整剂量。结论 Vemurafenib能改善既往未经治疗、伴有BRAFV600E突变的黑色素瘤患者的总体及无进展期生存率。(本研究由瑞士罗氏制药有限公司资助;BRIM-3临床试验编号:NCT01006980) | 涂超 Chapman PB Hauschild A Robert C | 2011 | 肿瘤药学2011，1，5： | 2 |
| 10 | Malignant gastrointestinal melanomas of unknown origin: Should it be considered primary?显示文摘TO THE EDITOR We read with interest the article entitled: ‘Jejuno-jejunal invagination due to intestinal melanoma’ by Resta G, et al[1]. They reported a rare clinical case of a young woman with a bleeding jejunal melanoma, whose early | A Manouras M Genetzakis E Lagoudianakis H Markogiannakis A Papadima G Kafiri K Filis PB Kekis V Katergiannakis | 2007 | World Journal of Gastroenterology2007，13，29： | 2 |
| 11 | Cryptdins: endogenous antibiotic peptides of small intestinal Paneth cells显示文摘 | Harwig SS Eisenhauer PB Chen NP | 1995 | Adv Exp Med Biol1995，371，： | 2 |
| 12 | 无心血管病者尿钠排泄、血压与未来心血管病及死亡风险显示文摘高血压是心血管病的危险因素。代表膳食钠摄入的尿钠排泄增加与血压相关。但在一些观察性研究中,低钠摄入与死亡率增加相关。进一步研究应评估混杂相关性是否能解释钠摄入与预后的关系。研究者分析英国生物银行参加者(n=457484,平均年龄56.3岁,44.7%为男性)尿电解质与血压的数据。采用Kawasaki公式估算每日尿钠排泄量。研究者分析基线无心血管病、治疗的高血压或糖尿病者(n=322624)钠排泄与血压的关系,并评估钠排泄与致死性及非致死性心血管病、心力衰竭及死亡发生率的关系。 | Welsh CE Welsh P Jhund P Delles C Celis-Morales C Lewsey JD Gray S Lyall D Iliodromiti S Gill JMR Sattar N Mark PB 赵狄 练桂丽 | 2019 | 中华高血压杂志2019，27，6： | 2 |
| 13 | The Oswestry Disability Index显示文摘 | Fairbank JCT Pynsent PB | 2000 | Spine2000，25，： | 2 |
| 14 | BRCA1 functions as a differential modulator of chemotherapy-induced apoptosis显示文摘 | Quinn JE Kennedy RD Mullan PB | | 0，，19： | 2 |
| 15 | 显示文摘 | Pandak WM Hylemon PB Ren S | 2002 | Hepatology2002，35，6： | 1 |
| 16 | Rhabdomyolysis after taking atorvastatin with gemfibrozil显示文摘 | DUELL PB CONNOR WE LLINGWORTH DR | 1998 | Am J Cardiol1998，81，3： | 1 |
| 17 | Caspase-3 and p27 as predictors of invasive bladder cancer显示文摘 | Burton PB Anderson CJ | 2000 | N Engl J Med2000，343，19： | 1 |
| 18 | NCEP-defined metabolic syndrome, diabetes mellitus and prevalence of coronary heart disease among NHANES Ⅲ articipants age 50 years and older显示文摘 | Alexander CM Landsman PB Teultsch SM | 2003 | Diabetes2003，52，： | 1 |
| 19 | A contributory role for activated hepatic stellate cells in the dynamics of Schistosoma japonicum egg-induced fibrosis显示文摘 | Bartley PB Ramm GA Jones MK | 2006 | Int J Parasitol2006，36，9： | 1 |
| 20 | Prospective study on late renal toxicity following postoperative chemoradiotherapy in gastric cancer显示文摘 | Ria PB Cats A Stroom J | 2007 | Int J Radiat Oncol Biol Phys2007，67，3： | 1 |
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