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| 1 | Whole-genome sequencing of 508 patients identifies key molecular features associated with poor prognosis in esophageal squamous cell carcinoma显示文摘Esophageal squamous cell carcinoma(ESCC)is a poor-prognosis cancer type with limited understanding of its molecular etiology.Using 508 ESCC genomes,we identified five novel significantly mutated genes and uncovered mutational signature clusters associated with metastasis and patients’outcomes.Several functional assays implicated that NFE2L2 may act as a tumor suppressor in ESCC and that mutations in NFE2L2 probably impaired its tumor-suppressive function,or even conferred oncogenic activities.Additionally,we found that the NFE2L2 mutations were significantly associated with worse prognosis of ESCC.We also identified potential noncoding driver mutations including hotspot mutations in the promoter region of SLC35E2 that were correlated with worse survival.Approximately 5.9%and 15.2%of patients had high tumor mutation burden or actionable mutations,respectively,and may benefit from immunotherapy or targeted therapies.We found clinically relevant coding and noncoding genomic alterations and revealed three major subtypes that robustly predicted patients’outcomes.Collectively,we report the largest dataset of genomic profiling of ESCC useful for developing ESCC-specific biomarkers for diagnosis and treatment. | Yongping Cui Hongyan Chen Ruibin Xi Heyang Cui Yahui Zhao Enwei Xu Ting Yan Xiaomei Lu Furong Huang Pengzhou Kong Yang Li Xiaolin Zhu Jiawei Wang Wenjie Zhu Jie Wang Yanchun Ma Yong Zhou Shiping Guo Ling Zhang Yiqian Liu Bin Wang Yanfeng Xi Ruifang Sun Xiao Yu Yuanfang Zhai Fang Wang Jian Yang Bin Yang Caixia Cheng Jing Liu Bin Song Hongyi Li Yi Wang Yingchun Zhang Xiaolong Cheng Qimin Zhan Yanhong Li Zhihua Liu-Show | 2020 | Cell Research2020，30，10： | 19 |
| 2 | A "green pathway" different from simple diffusion in soft matter: Fast molecular transport within micro/nanoscale multiphase porous systems显示文摘 | Jiantao Feng Fang Wang Xinxiao Han Zhuo Ao Quanmei Sun Wenda Hua Peipei Chen Tianwei Jing Hongyi Li Dong Han | 2014 | Nano Research2014，7，3： | 18 |
| 3 | Discovery of biclonal origin and a novel oncogene SLC12A5 in colon cancer by single-cell sequencing显示文摘单个房间的定序是为描出的一个强大的工具为个性化的癌症管理的同种细胞的关系和识别关键司机基因。这里,我们执行了结肠癌的一个盒子的单个房间的定序的分析。人口遗传分析在肿瘤房间人口识别了二独立克隆。主要肿瘤克隆作为早 oncogenic 事件怀有 APC 和 TP53 变化,而次要的克隆包含了优势的 CDC27 和 PABPC1 变化。在这二克隆的次要的克隆支持的 APC 和 TP53 变化的缺席从二细胞的起源被导出。体的变化等位基因频率系列的检查另外 21 个整个织物的定序 exome 的盒子在结肠癌揭示了同种细胞的起源的异质。下次,我们识别了在单个房间的水平显示出变化的高频率,但是在人口水平展出了低流行的变异的基因 SLC12A5。变异的 SLC12A5 的功能的描述在结肠癌揭示了它的潜在的 oncogenic 效果。我们的学习在单个房间的水平支持提供第一条 exome 宽的证据那结肠癌能具有 biclonal 起源,并且建议在一个队的低流行的变化可以也在单个水平起重要 protumorigenic 作用。 | Chang Yu Jun Yu Xlaotlan Yao Wllham KK Wu Youyong Lu Senwel Tang Xiangchun Li Li Bao Xiaoxing Li Yong Hou Renhua Wu Min Jian Ruoyan Chen Fan Zhang Lixia Xu Fan Fan Jun He Qiaoyi Liang Hongyi Wang Xueda Hu Minghui He Xiang Zhang Hancheng Zheng Qibin Li Hanjie Wu Yan Chen Xu Yang Shida Zhu Xun Xu Huanming Yang Jian Wang Xiuqing Zhang Joseph JY Sung Yingrui Li Jun Wang | 2014 | Cell Research2014，，6： | 16 |
| 4 | Adaptive event-triggered control for a class of nonlinear systems with periodic disturbances显示文摘This paper investigates the adaptive event-triggered control problem for a class of nonlinear systems subject to periodic disturbances. To reduce the communication burden, a reliable relative threshold strategy is proposed. Fourier series expansion and radial basis function neural network are combined into a function approximator to model suitable time-varying disturbed function of known periods in strict-feedback systems. By combining the Lyapunov stability theory and the backstepping technique, the proposed adaptive control approach ensures that all the signals in the closed-loop system are bounded, and the tracking error can be regulated to a compact set around zero in finite time. Finally, simulation results are presented to verify the effectiveness of the theoretical results. | Hui MA Hongyi LI Renquan LU Tingwen HUANG | 2020 | Science China(Information Sciences)2020，63，5： | 14 |
| 5 | Cerebral small vessel disease or intracranial large vessel atherosclerosis may carry different risk for future strokes显示文摘Background The effect of cerebral small vessel disease(CSVD)and intracranial arterial stenosis(ICAS)on stroke outcomes remains unclear.Methods Data of 1045 patients with minor stroke or transient ischaemic attack(TIA)were obtained from 45 sites of the Clopidogrel in High-Risk Patients with Acute Non-disabling Cerebrovascular Events(CHANCE)trial.We assessed the associations of burdens of CSVD and ICAS with new strokes and bleeding events using multivariate Cox regression models and those with modified Rankin Scale(mRS)scores using ordinal logistic regression models.Results Among the 1045 patients,CSVD was present in 830 cases(79.4%)and ICAS in 460(44.0%).Patients with>1 ICAS segment showed the highest risk of new strokes(HR 2.03,95%CI 1.15 to 3.56,p=0.01).No association between CSVD and the occurrence of new strokes was found.The presence of severe CSVD(common OR(cOR)2.01,95%CI 1.40 to 2.89,p<0.001)and>1 ICAS segment(cOR 2.15,95%CI 1.57 to 2.93,p<0.001)was associated with higher mRS scores.Severe CSVD(HR 10.70,95%CI 1.16 to 99.04,p=0.04),but not ICAS,was associated with a higher risk of bleeding events.Six-point modified CSVD score improved the predictive power for bleeding events and disability.Interpretation CSVD is associated with more disability and bleeding events,and ICAS is associated with an increased risk of stroke and disability in patients with minor stroke and TIA at 3 months.CSVD and ICAS may represent different vascular pathologies and play distinct roles in stroke outcomes. | Huimin Chen Yuesong Pan Lixia Zong Jing Jing Xia Meng Yuyuan Xu Hongyi Yan Xingquan Zhao Liping Liu Hao Li S Claiborne Johnston Yongjun Wang Yilong Wang | 2020 | Stroke & Vascular Neurology2020，5，2： | 13 |
| 6 | High lake levels on Alxa Plateau during the Late Quaternary显示文摘Field investigations including lake shoreline measurement and 14 C chronology have been carried out on the Alxa Plateau to better understand the formation and evolution of the high lake levels in northwest China during the late Pleistocene.Comprehensive field investigations show that there are at least ten shorelines at different elevations at Juyan Lake,at least four on the northwest side of the Jilantai Salt Lake,and nine shorelines and one terrace on the northeast margin of Zhuye Lake.Stratigraphic correlations and chronological evidence indicate that the paleo-lakes have the highest lake levels in Marine Isotope Stage (MIS) 3.Though the optically stimulated luminescence (OSL) results which have been reported by some scholars do not support this view,the fact that the paleo-lakes have the highest lake levels in MIS 3 can not be denied.Differences between OSL and 14 C results from this work might indicate that high lake levels existed on the Alxa Plateau during two different periods.It also suggests that the high lake levels may exist in both MIS 5 and early MIS 3.This paper also provides the basic hydrological information for further water resources research in this arid region. | WANG NaiAng LI ZhuoLun CHENG HongYi LI Yu HUANG YinZhou | 2011 | Chinese Science Bulletin2011，56，17： | 12 |
| 7 | Association of elevated hs-CRP and multiple infarctions with outcomes of minor stroke or TIA: subgroup analysis of CHANCE randomised clinical trial显示文摘Background and purpose The relationship of high-sensitive C-reactive protein(hs-CRP)levels and infarction numbers with the prognosis of stroke is uncertain.This study evaluated the association of different hs-CRP levels and infarction numbers with the prognosis of acute minor ischaemic stroke or transient ischaemic attack(TIA).Methods A subset of 807 patients with both hs-CRP measurement and baseline MRI was included from the Clopidogrel in High-risk Patients with Acute Non-disabling Cerebrovascular Events trial.The primary efficacy outcome was the occurrence of an ischaemic stroke at the 1-year follow-up.Infarction numbers were classified as multiple acute infarctions(MAIs),single acute infarction and no acute infarction(NAI).The association between different hs-CRP levels with different infarction numbers and the risk of any outcome was analysed using multivariable Cox regression models.Results Among the 807 patients,84(10.4%)patients had a recurrent ischaemic stroke within 1 year.After adjustment for conventional confounding factors,patients with both elevated hs-CRP levels and MAIs were associated with approximately 4.7-fold of risk of ischaemic stroke within 1 year(16.7% vs 3.5%,HR 4.68,95% CI 1.54 to 14.23,p=0.007),compared with those with non-elevated hs-CRP levels and NAI.Similar results were observed for the composite events.Conclusions Combined elevated hs-CRP levels and MAIs may increase 1-year stroke risk stratification efficiency in patients with minor ischaemic stroke or TIA compared with using those markers alone,which indicated that the combination of inflammatory and imaging markers might improve the effectiveness of risk stratification concerning minor ischaemic stroke or TIA. | Guangyao Wang Jing Jing Jiejie Li Yuesong Pan Hongyi Yan Xia Meng Xingquan Zhao Liping Liu Hao Li David Z Wang Yongjun Wang Yilong Wang | 2021 | Stroke & Vascular Neurology2021，6，1： | 11 |
| 8 | Observer-based adaptive consensus control for nonlinear multi-agent systems with time-delay显示文摘In this paper, we consider the observer-based adaptive consensus tracking problem for a class of nonlinear time-delay multi-agent systems in the presence of input saturation. Under the assumption that the communication topology is directed and connected, a distributed adaptive consensus controller is developed based on the dynamic surface control technique. By constructing the nonlinear observer, the unmeasurable agents dynamics can be estimated. Input saturation problem is solved by a smooth function combined with an auxiliary variable. With the help of prescribed performance functions, the synchronization errors converge to the prescribed sets, which are characterized as a neighborhood of zero. According to Lyapunov stability theory, it is shown that with the proposed distributed consensus tracking approach, the consensus errors are cooperatively semi-globally uniformly ultimately bounded. Finally, a simulation example is provided to show the effectiveness of the proposed algorithm. | Wenbin XIAO Liang CAO Hongyi LI Renquan LU | 2020 | Science China(Information Sciences)2020，63，3： | 10 |
| 9 | Longitudinal non-vascular transport pathways originating from acupuncture points in extremities visualised in human body显示文摘A subcutaneous transport pathway in humans has been previously visualised by injection of a paramagnetic tracer into the specific region of skin.In the current study,we further investigated the behaviours of imaging tracers in the transport pathways using imaging techniques.Three types of imaging tracers,including Gd-DTPA,iodised oil,and fluorescein sodium,were hypodermically injected into different acupuncture points of healthy volunteers to visualise the transport pathways by magnetic resonance imaging(MRI),X-ray,CT,and a digital fluorescein camera.Several longitudinal transport pathways in the arms and feet,which represent venous vessels and subcutaneous transport pathways(STPs) without well-defined boundaries,were visualised by MRI.Among the visualised veins,the partial walls of a few veins were enhanced by Gd-DTPA.The fluorescent images further indicated that STPs likely represent boundless pathways.The findings in this study suggested that specific anatomical structures within the subcutaneous tissues or the partial walls of certain veins werenot vascular conduits but rather represented unique transport pathways in humans that warrant extensive future studies. | Hongyi Li Jiabin Tong Weiguo Cao Min Chen Hua Li Hong Dai Liang Xu Xiaoliang Chen | 2014 | Chinese Science Bulletin2014，59，35： | 10 |
| 10 | Allele-aware chromosome-level genome assembly of Artemisia annua reveals the correlation between ADS expansion and artemisinin yield显示文摘Artemisia annua is the major natural source of artemisinin,an anti-malarial medicine commonly used worldwide.Here,we present chromosome-level haploid maps for two A.annua strains with different artemisinin contents to explore the relationships between genomic organization and artemisinin production.High-fidelity sequencing,optical mapping,and chromatin conformation capture sequencing were used to assemble the heterogeneous and repetitive genome and resolve the haplotypes of A.annua.Approximately 5o,ooo genes were annotated for each haplotype genome,and a triplication event that occurred approximately 58.12million years ago was examined for the first time in this species.A total of 3,903,467-5,193,414 variants(SNPs,indels,and structural variants)were identified in the 1.5-Gb genome during pairwise comparison between haplotypes,consistent with the high heterozygosity of this species.Genomic analyses revealed a correlation between artemisinin concents and the copy number of amorpha-4,11-dienes ynthasegenes.This correlation was further confirmed by resequencing of 36A.annua samples with varied artemisinin contents.Circular consensus sequencing of transcripts facilitated the detection of paralog expression.Collectively,our study provides chromosome-level allele-aware genome assemblies for two A.annua strains and new insights into the biosynthesis of artemisinin and its regulation,which will contribute to conquering malaria worldwide. | Baosheng Liao Xiaofeng Shen Li Xiang Shuai Guo Shiyu Chen Ying Meng Yu Liang Dandan Ding Junqi Bai Dong Zhang Tomasz Czechowski Yi Li Hui Yao Tingyu Mai Caroline Howard Chao Sun Haitao Liu Jiushi Liu Jin Pei Jihai Gao Jigang Wang Xiaohui Qiu Zhihai Huang Hongyi Li Ling Yuan Jianhe Wei lan Graham Jiang Xu Boli Zhang Shilin Chen | 2022 | Molecular Plant2022，15，8： | 9 |
| 11 | Changes of Precipitation and Extremes and the Possible Effect of Urbanization in the Beijing Metropolitan Region during 1960–2012 Based on Homogenized Observations显示文摘Daily precipitation series at 15 stations in the Beijing metropolitan region(BMR) during 1960–2012 were homogenized using the multiple analysis of series for homogenization method,with additional adjustments based on analysis of empirical cumulative density function(ECDF) regarding climate extremes.The cumulative density functions of daily precipitation series,the trends of annual and seasonal precipitation,and summer extreme events during 1960–2012 in the original and final adjusted series at Beijing station were comparatively analyzed to show the necessity and efficiency of the new method.Results indicate that the ECDF adjustments can improve the homogeneity of high-order moments of daily series and the estimation of climate trends in extremes.The linear trends of the regional-mean annual and seasonal(spring,summer,autumn,and winter)precipitation series are-10.16,4.97,-20.04,5.02,and-0.11 mm(10 yr)-1,respectively.The trends over the BMR increase consistently for spring/autumn and decrease for the whole year/summer; however,the trends for winter decrease in southern parts and increase in northern parts.Urbanization affects local trends of precipitation amount,frequency,and intensity and their geographical patterns.For the urban-influenced sites,urbanization tends to slow down the magnitude of decrease in the precipitation and extreme amount series by approximately-10.4% and-6.0%,respectively; enhance the magnitude of decrease in precipitation frequency series by approximately 5.7%; reduce that of extremes by approximately-8.9%; and promote the decreasing trends in the summer intensity series of both precipitation and extremes by approximately 6.8% and51.5%,respectively. | LI Zhen YAN Zhongwei TU Kai WU Hongyi | 2015 | Advances in Atmospheric Sciences2015，32，9： | 9 |
| 12 | Single-trial decoding of imagined grip force parameters involving the right or left hand based on movement-related cortical potentials显示文摘Time–domain feature representation for imagined grip force movement-related cortical potentials(MRCP)of the right or left hand and the decoding of imagined grip force parameters based on electroencephalogram(EEG)activity recorded during a single trial were here investigated.EEG signals were acquired from eleven healthy subjects during four different imagined tasks performed with the right or left hand.Subjects were instructed to execute imagined grip movement at two different levels of force.Each task was executed 60 times in random order.The imagined grip force MRCP of the right or left hand was analyzed by superposition and averaging technology,a single-trial extraction method,analysis of variance(ANOVA),and multiple comparisons.Significantly different features were observed among different imagined grip force tasks.These differences were used to decode imagined grip force parameters using Fisher linear discrimination analysis based on kernel function(k-FLDA)and support vector machine(SVM).Under the proposed experimental paradigm,the study showed that MRCP may characterize the dynamic processing that takes place in the brain during the planning,execution,and precision of a given imagined grip force task.This means that features related to MRCP can be used to decode imagined grip force parameters based on EEG.ANOVA and multiple comparisons of time–domain features for MRCP showed that movement-monitoring potentials(MMP)and specific interval(0–150 ms)average potentials to be significantly different among 4 different imagined grip force tasks.The minimum peak negativity differed significantly between high and low amplitude grip force.Identification of the 4different imagined grip force tasks based on MMP was performed using k-FLDA and SVM,and the average misclassification rates of 27%±5%and 24%±4%across 11 subjects were achieved respectively.The minimum misclassification rate was 15%,and the average minimum misclassification rate across 11 subjects was24%±4.5%.This investigation indicates that imagined grip force MRCP may encode imagined grip force parameters.Single-trial decoding of imagined grip force parameters based on MRCP may be feasible.The study may provide some additional and fine control instructions for brain–computer interfaces. | Yunfa Fu Baolei Xu Yongcheng Li Yuechao Wang Zhengtao Yu Hongyi Li | 2014 | Chinese Science Bulletin2014，59，16： | 8 |
| 13 | An in vivo study of the biodistribution of gold nanoparticles after intervaginal space injection in the tarsal tunnel显示文摘金 nanoparticles (AuNPs ) 的 biodistribution 是仔细与毒物学的效果有关并且因为他们的潜在的申请,担心大。与为液体运输的新奇解剖、组织学的结构的发现,然而,内在的机制包含了在在里面 AuNPs 的 vivo 运输和 biodistribution 要求进一步深入的调查。在当前的学习,在腱,容器,和神经纤维的一个焦点的点可以最佳地与另外的遥远的结缔组织连接的地方,我们在跗骨的隧道在 intervaginal 空间注射(ISI ) 以后在老鼠调查了 10-nm AuNPs 的 biodistribution。AuNPs 的静脉内的注射(IVI ) 用作控制。血和机关与诱导地联合的血浆团 spectrometry (ICPMS ) 为 Au 分发的定量分析在注射以后在 5, 15,和 30 min 并且在 1, 4, 12,和 24 h 被收集。IVI 和 ISI 产出显著地不同的结果:在在 ISI 以后的血的 AuNP 内容在 IVI 以后是比那低得多的;在肺,心,和肠是类似的;并且在皮和肌肉是更高的。这些调查结果被 AuNP 内容和相对机关 AuNP 分发比例的比率支持。我们表明的结果一快,直接并且发行量无关的 AuNP 器官运输小径,它可以改进我们生理、病理学的 biodistribution 的理解在生物系统处理。而且,这些结果提供新奇卓见进在里面 vivo 运输和 AuNPs 的 biodistribution,它可以导致新奇、有效治疗学并且管理策略。 | Xiaoli Shi Yuting Zhu Wenda Hua Yinglu Ji Qing Ha Xinxiao Han Yang Liu Jingwei Gao Qiang Zhang Sidi Liu Keli Ren Xiaochun Wu Hongyi Li Dong Han | 2016 | Nano Research2016，9，7： | 7 |
| 14 | Origination and Establishment of a Trigenic Reproductive Isolation System in Rice显示文摘 | Yidan Ouyang Guangwei Li Jiaming Mi Conghao Xu Hongyi Du Chengjun Zhang Weibo Xie Xianghua Li Jinghua Xiao Huazhi Song Qifa Zhang | 2016 | Molecular Plant2016，9，11： | 7 |
| 15 | Genetics and Molecular Marker Identification of a Resistance to Glomerella Leaf Spot in Apple显示文摘Apple Glomerella leaf spot(GLS) is a destructive fungal disease that damages apple leaves during the summer in China.Breeding new diseaseresistant varieties is considered to be the best way of controlling GLS.A genetic study of resistance to Glomerella leaf spot(GLS) in apple was conducted by using four F_1 hybrid groups(‘Fuji' בGolden Delicious',‘Golden Delicious' בFuji',‘Gala' בFuji',and ‘Fuji' בQF-2') generated from two highly resistant varieties or selections,‘Fuji' and ‘QF-2',and two highly susceptible varieties,‘Golden Delicious' and ‘Gala'.The results showed that the separation ratios of resistant plants to the susceptible ones in the four F_1 hybrid groups were statistically consistent with the theoretical ratios of 1:1,1:1,0:1,and 1:0.Comprehensive analysis enabled us to generate the following conclusions:GLS resistance in apple may be controlled by a single recessive gene.The genotype of the resistant plants was rr,whereas the genotypes of the susceptible ones were RR and Rr.By using ‘Golden Delicious' בFuji' F_1 hybrid groups and the bulked segregation analysis(BSA) method,the marker S0506206-243 bp associated with disease resistance character to GLS was identified through screening 500 SSR primers encompassing the entire apple genome with even coverage,and the genetic distance between the marker and the GLS resistance gene was 9.8 cM. | LIU Yuanxia LI Baohua WANG Caihong LIU Chunxiao KONG Xianghua ZHU Jun DAI Hongyi | 2016 | Horticultural Plant Journal2016，2，3： | 6 |
| 16 | Design of Environmental Monitoring and Control System for Large-scale Pig House with Fermentation Bed显示文摘The design and assembly of environmental monitoring and control system for large-scale pig house with fermentation bed helped to solve the problem of environmental automatic control in piggery.The sensors would monitor the temperature,humidity,light,wind direction,wind speed,CO2,NH3and other parameters.On-line real-time data collection was achieved.The expert system was constructed to control the temperature in piggery below 30℃,to control the air and mattress humidities higher than 65%.Under the conditions of different season or different wind speed,even in day and night,the control actuators were different.The actuators included fanning wet curtain,lighting,micro spraying,spraying,propeller fan,electric aluminum alloy shutter and spraying systems on the roof.The actuators were integrated,and they control the piggery environment simultaneously.The system also designed the remote video monitor interface,parameter-monitoring curved interface and operation interface,which provided a good man-machine interface. | Bo LIU Huiyong ZHENG Yingzhi LIN Shengbing LIU Hongyi ZHENG Chunzhong YOU Huai SHI Jianglin LAN Zhaolong LI Jianyang TANG Qinlou HUANG | 2015 | Agricultural Science & Technology2015，16，2： | 6 |
| 17 | An Overview of Finite/Fixed-Time Control and Its Application in Engineering Systems显示文摘The finite/fixed-time stabilization and tracking control is currently a hot field in various systems since the faster convergence can be obtained. By contrast to the asymptotic stability,the finite-time stability possesses the better control performance and disturbance rejection property. Different from the finite-time stability, the fixed-time stability has a faster convergence speed and the upper bound of the settling time can be estimated. Moreover, the convergent time does not rely on the initial information.This work aims at presenting an overview of the finite/fixed-time stabilization and tracking control and its applications in engineering systems. Firstly, several fundamental definitions on the finite/fixed-time stability are recalled. Then, the research results on the finite/fixed-time stabilization and tracking control are reviewed in detail and categorized via diverse input signal structures and engineering applications. Finally, some challenging problems needed to be solved are presented. | Yang Liu Hongyi Li Zongyu Zuo Xiaodi Li Renquan Lu | 2022 | IEEE/CAA Journal of Automatica Sinica2022，9，12： | 6 |
| 18 | Combination of biodiesel-ethanol-diesel fuel blend and SCR catalyst assembly to reduce emissions from a heavy-duty diesel engine显示文摘在这研究,减少 NOx 和微粒的努力有关系(下午) 从两个都使用 NOx overanAg/Al2O3 催化剂和 biodiesel-ethanol-diesel 燃料的乙醇选择的催化减小(SCR ) 的一个柴油发动机的排出物相配(柴油机) 在一张引擎凳子上,测试被讨论。与柴油相比,柴油机的使用由于下午的可溶的器官的部分(SOF ) 的增加增加了下午排出物 14% ,但是它极大地减少了 Bosch 烟数字由 60%80% 根据从欧洲静止周期(转换字符) 的 13 模式测试的结果测试。SCR 催化剂在由乙醇的 NOx 减小是有效的,并且 NOx 变换是约 73% 。全部的烃(THC ) 和公司排出物在 NOx 过程的 SCR 期间显著地增加了。二个柴油机氧化催化剂(文档) 集会在 Ag/Al2O3 变换器以后被使用移开公司和 HC。不同氧化催化剂在下午排放上出现在效果对面。下午作文分析表明在彻底的下午的氧化催化剂的网效果是 SOF 减小和下午的硫酸盐形成上的综合效果。引擎凳子测试结果显示甚至没有使用柴油机粒子过滤器(DPF ) ,柴油机和一个 SCR 催化剂集会的联合能为 NOx 和下午排出物控制提供好处。 | SHI Xiaoyan YU Yunbo HE Hong SHUAI Shijin DONG Hongyi LI Rulong | 2008 | Journal of Environmental Sciences2008，20，2： | 6 |
| 19 | Applications of genome editing technology in the targeted therapy of human diseases:mechanisms,advances and prospects显示文摘Based on engineered or bacterial nucleases,the development of genome editing technologies has opened up the possibility of directly targeting and modifying genomic sequences in almost all eukaryotic cells.Genome editing has extended our ability to elucidate the contribution of genetics to disease by promoting the creation of more accurate cellular and animal models of pathological processes and has begun to show extraordinary potential in a variety of fields,ranging from basic research to applied biotechnology and biomedical research.Recent progress in developing programmable nucleases,such as zinc-finger nucleases(ZFNs),transcription activator-like effector nucleases(TALENs)and clustered regularly interspaced short palindromic repeat(CRISPR)–Cas-associated nucleases,has greatly expedited the progress of gene editing from concept to clinical practice.Here,we review recent advances of the three major genome editing technologies(ZFNs,TALENs,and CRISPR/Cas9)and discuss the applications of their derivative reagents as gene editing tools in various human diseases and potential future therapies,focusing on eukaryotic cells and animal models.Finally,we provide an overview of the clinical trials applying genome editing platforms for disease treatment and some of the challenges in the implementation of this technology. | Hongyi Li Yang Yang Weiqi Hong Mengyuan Huang Min Wu Xia Zhao | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 5 |
| 20 | A nanoporous oxide interlayer makes a better Pt catalyst on a metallic substrate: Nanoflowers on a nanotube bed显示文摘改进在铂催化剂和钛底层之间的接触, TiO 的层 < 潜水艇 class= “ a-plus-plus ” > 2 个 nanotube 数组在由脉搏电极淀积扔磅 nanoflowers 前被综合了。在 electrocatalytic 活动的戏剧的改进(3 ????????????? | Hongyi Li Jinshu Wang Man Liu Hong Wang Penglei Su JunshuWu Ju Li | 2014 | Nano Research2014，7，7： | 5 |
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