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| 1 | Liver cancer incidence and mortality in China: Temporal trends and projections to 2030显示文摘Objective: Liver cancer is one of the most common cancers and major cause of cancer deaths in China,which accounts for over 50% of new cases and deaths worldwide.The systematic liver cancer statistics including of projection through 2030 could provide valuable information for prevention and control strategies in China,and experience for other countries.Methods: The burden of liver cancer in China in 2014 was estimated using 339 cancer registries' data selected from Chinese National Cancer Center(NCC).Incident cases of 22 cancer registries were applied for temporal trends from 2000 to 2014.The burden of liver cancer through 2030 was projected using age-period-cohort model.Results: About 364,800 new cases of liver cancer(268,900 males and 95,900 females) occurred in China,and about 318,800 liver cancer deaths(233,500 males and 85,300 females) in 2014.Western regions of China had the highest incidence and mortality rates.Incidence and mortality rates decreased by about 2.3% and 2.6% per year during the period of 2000-2014,respectively,and would decrease by more than 44% between 2014 and 2030 in China.The young generation,particularly for those aged under 40 years,showed a faster down trend.Conclusions: Based on the analysis,incidence and mortality rates of liver cancer are expected to decrease through 2030,but the burden of liver cancer is still serious in China,especially in rural and western areas.Most cases of liver cancer in China can be prevented through vaccination and more prevention efforts should be focused on high risk groups. | Rongshou Zheng Chunfeng Qu Siwei Zhang Hongmei Zeng Kexin Sun Xiuying Gu Changfa Xia Zhixun Yang He Li Wenqiang Wei Wanqing Chen Jie He | 2018 | Chinese Journal of Cancer Research2018，30，6： | 132 |
| 2 | Magnetic recording of the Cenozoic oceanic crustal accretion and evolution of the South China Sea basin显示文摘我们考察并且讨论一些在华南海(SCS ) 在磁性的数据上做的最近的科学调查结果。磁性的异例在中生代和新生代上忍受极其富有的信息构造进化。从磁性的异例计算的分析信号振幅很精确揭示的 3D 二上的中生代沉积序列的寡妇分布结合大陆人边缘,和他们也在在 SCS 海洋的外壳以内描绘以后阶段的 magmatism 和构造转变和带状配列被发现很有效。通过综合分析磁性,严肃和思考地震数据,我们在华南海大陆人边缘附近定义大陆海洋边界(圆块) ,并且发现圆块与一个转变地区与一致很好从对否定免费空气的严肃异例主要积极。COB 的这精确构画出为更好跟踪海洋的外壳导致的磁性的异例是批评的。几何上复杂的圆块和内部磁性的带状配列要求一个阵发性的洞模型,以及一个变换差错的介绍(这里作为 Zhongnan 差错制造了)在东方和西南亚盆之间在东方和西南亚盆以内,磁性的异例旁边地是相当连续的,在这些亚盆以内显示大变换差错的不存在。我们提高浅玄武岩的层经由一个通带过滤器引起的磁性的异例,并且认识到北大陆人边缘附近的多半最旧的磁性的异例根据磁性的时间规模 CK95 是 C12。在南部的大陆人边缘附近,磁性的异例是不太可认识的,异例 C12 看起来失踪。这些差别证明关于散布中心的寡妇的一种不均匀的开始式样,和北部分看起来比到南方有稍微更快传播的率。磁性的异例 C8 (M1 和 M2, 26 妈) 在海洋的盆以内代表重要磁性的边界,并且可能与在散布率和 magmatic 紧张的变化有关。为一条以前建议的山脉的磁性的证据在异例 C7 不是清楚的以后,跳。西南亚盆的年龄还得进一步被检验,最有利地与深拖引磁性的调查并且海洋钻。我们的磁性光谱最浅的居里削尖的学习表演在西南的亚盆的东方部分附近被定位,而在东方亚盆居里以内深度对传播的寡妇的北方更小,比到南方集中。居里深度的这个模式对地区性的热流动大小和以后阶段的暴烈的海底山分布一致,并且我们因此推想居里深度变化仔细与以后阶段的 magmatism,而非与外壳的年龄被联系。尽管在北大陆海洋转变地区(简易窄床) 附近定位的磁性的异例是相对安静的,自从概念上它与一个海洋的磁性的安静地区显著地不同,这个区域不是一个典型磁性的安静地区。相对安静的磁性的异例看起来在居里等温线与 shallowing 被联系并且在磁性的层,而是我们的全面观察变瘦建议保存得很好的厚中生代沉积岩石是为有磁力地安静的地区的主要原因。各种各样的低通行证的过滤水兵和在空中的磁性的异例和卫星的高类似磁性的异例清楚地证实那更深磁性的来源(在更低的外壳中并且最高披风) 有贡献到长波长的表面在区域的磁性的异例,当已经推断了从有磁力地 inversed 居里深度。近海华南磁性的异例(SCMA ) 在低通行证的过滤水兵和在空中的磁性的异例和卫星上变得更突出磁性的异例,在它下面显示很深深地埋葬的磁性的来源。 | LI ChunFeng SONG TaoRan | 2012 | Chinese Science Bulletin2012，57，24： | 40 |
| 3 | Deep crustal structures of eastern China and adjacent seas revealed by magnetic data显示文摘Through reduction to the North Pole and upward continuation of the total field magnetic anomalies, we analyze magnetic patterns and spatial distributions of different tectonic blocks and crustal faults in eastern China and adjacent seas. Depths to the Curie isotherms are further estimated from radially averaged amplitude spectra of magnetic data reduced to the pole. Data reductions effectively enhance boundaries of regional tectonic belts, such as the Dabie ultra-high metamorphic belt, the Tanlu Fault, and the Diaoyudao Uplift. Curie depths are estimated at between 19.6 and 48.9 km, with a mean of 31.7 km. The Subei Basin and the south Yellow Sea Basin in the lower Yangtze block show relatively deep Curie isotherms, up to about 35 km in depth, whereas in the surrounding areas Curie depths are averaged at about 25 km. This implies that the lower Yangtze Block has experienced a unique tectonic evolution and/or has unique basement lithology and structures. From a regional perspective, sedimentary basins, such as the Subei Basin, the south Yellow Sea Basin, and the East China Sea Basin, normally show deeper Curie isotherms than surrounding uplifts such as the Diaoyudao Uplift and the Zhemin Uplifts. Curie isotherms also upwell significantly in volcanically active areas such as the Ryukyu Arc and the Cheju Island, confirming strong magmatic and geothermal activities at depth. | LI ChunFeng CHEN Bing ZHOU ZuYi | 2009 | Science China Earth Sciences2009，52，7： | 21 |
| 4 | L-3-n-butylphthalide protects against vascular dementia via activation of the Akt kinase pathway显示文摘As a neuroprotective drug for the treatment of ischemic stroke, 3-n-butylphthalide, a celery seed extract, has been approved by the State Food and Drug Administration of China as a clinical therapeutic drug for ischemic stroke patients. L-3-n-butylphthalide possesses significant efficacy in the treatment of acute ischemic stroke. The activated Akt kinase pathway can prevent the death of nerve cells and exhibit neuroprotective effects in the brain after stroke. This study provides the hypothesis that l-3-n-butylphthalide has a certain therapeutic effect on vascular dementia, and its mechanism depends on the activation of the Akt kinase pathway. A vascular dementia mouse model was established by cerebral repetitive ischemia/reperfusion, and intragastrically administered l-3-n-butylphthalide daily for 28 consecutive days after ischemia/reperfusion, or 7 consecutive days before ischemia/reperfusion. The Morris water maze test showed significant impairment of spatial learning and memory at 4 weeks after operation, but intragastric administration of l-3-n-butylphthalide, especially pretreatment with l-3-n-butylphthalide, significantly reversed these changes. Thionine staining and western blot analylsis showed that preventive and therapeutic application of l-3-n-butylphthalide can reduce loss of pyramidal neurons in the hippocampal CA1 region and alleviate nerve damage in mice with vascular demen-tia. In addition, phosphorylated Akt expression in hippocampal tissue increased significantly after l-3-n-butylphthalide treatment. Experimental findings demonstrate that l-3-n-butylphthalide has preventive and therapeutic effects on vascular dementia, and its mechanism may be mediated by upregulation of phosphorylated Akt in the hippocampus. | Yaping Huai Yanhong Dong Jing Xu Nan Meng Chunfeng Song Wenbin Li Peiyuan Lv | 2013 | Neural Regeneration Research2013，8，19： | 17 |
| 5 | Evaluation of zeolites synthesized from fly ash as potential adsorbents for wastewater containing heavy metals显示文摘The pure-form zeolites(A and X) were synthesized by applying a two-stage method during hydrothermal treatment of fly ash prepared initial Cu and Zn gel. The difference of adsorption capacity of both synthesized zeolits was assessed using Cu and Zn as target heavy metal ions. It was found that adsorption capacity of zeolite A showed much higher value than that of zeolite X. Thus,attention was focused on investigating the removal performance of heavy metal ions in aqueous solution on zeolite A,comparing with zeolite HS(hydroxyl-solidate) prepared from the residual fly ash(after synthesis of pure-form zeolite A from fly ash) and a commercial grade zeolite A. Batch method was used to study the influential parameters of the adsorption process. The equilibrium data were well fitted by the Langmuir model. The removal mechanism of metal ions followed adsorption and ion exchange processes. Attempts were also made to recover heavy metal ions and regenerate adsorbents. | WANG Chunfeng,LI Jiansheng,SUN Xia,WANG Lianjun,SUN XiuyunSchool of Chemical Engineering,Nanjing University of Science and Technology,Nanjing 210094,China. | 2009 | Journal of Environmental Sciences2009，21，1： | 12 |
| 6 | Precollisional tectonics and terrain amalgamation offshore southern Taiwan:Characterizations from reflection seismic and potential field data显示文摘Sponsored by the Chinese National Fundamental Research and Development Program in 2001,Guang-zhou Marine Geological Survey launched out a long geophysical survey from the northeastern part of the South China Sea (SCS),through the Luzon Arc,to the Huatung Basin and the Gagua Ridge. Based on high-resolution seismic data from this survey,combined with gravimetric and magnetic modeling,a systematic effort is made to the study of the regional geodynamics offshore southern Taiwan. By focusing particularly on precollisional tectonic interactions between adjacent geological units and their tectonic affiliations,this study can help reveal early arc-continent collisional processes that formed the Taiwan orogen. The construction of the Manila accretionary prism and its eastward progressive deformation indicate that the subduction of SCS have experienced multiple phases of increased activity. Active precollisional crustal shortening within the Northern Luzon Trough resulted in tilting of sedimentary layers at angles between 6° and 13°. But the shortening induced by tilting accounts for only a tiny part of regional total crustal compression. The eastern flank of the Luzon Arc appears to be more active than the rest,evidenced by active faulting and folding in the intra-arc basins on the eastern flank. Magnetic modeling/inversion shows that the Luzon Arc may have experienced multiple phases of magmatic activities,causing lateral magnetic inhomogeneity. Bouguer gravity anomalies and gravity modeling indicate that the Huatung Basin has anomalously higher crustal and upper mantle densities than those of SCS and the Luzon Arc. In addition,there is a large bathymetric difference between the Huatung Basin and the northeastern part of SCS basin. These observations argue against early hypothesis that the Huatung Basin and the northeastern part of SCS basin may once have belonged to one single oceanic crust,in part or in whole. The Gagua Ridge,as a sliver of uplifted oceanic crust,may be related to a transient northwestward subduction of the western Philippine plate. All evidences point to the argument that the region offshore southern Taiwan is experiencing multiple terrain amalgamation,which is a classical model for continental growth. | LI ChunFeng ZHOU ZuYi LI JiaBiao CHEN HuanJiang GENG JianHua LI Hui | 2007 | Science China Earth Sciences2007，50，6： | 8 |
| 7 | Development of an Amphibious Turtle-Inspired Spherical Mother Robot显示文摘 | Liwei Shi Shuxiang Guo Shilian Mao Chunfeng Yue Maoxun Li Kinji Asaka | 2013 | Journal of Bionic Engineering2013，10，4： | 7 |
| 8 | No expenditure difference among patients with liver cancer at stageⅠ-ⅣV:Findings from a multicenter cross-sectional study in China显示文摘Objective:The number of liver cancer patients in China accounts for more than half of the world.However,China currently lacks national,multicenter economic burden data,and meanwhile,measuring the differences among different subgroups will be informative to formulate corresponding policies in liver cancer control.Thus,the aim of the study was to measure the economic burden of liver cancer by various subgroups.Methods:A hospital-based,multicenter and cross-sectional survey was conducted during 2012・2014,covering 39 hospitals and 21 project sites in 13 provinces across China.The questionnaire covers clinical information,sociology,expenditure,and related variables.All expenditure data were reported in Chinese Yuan(CNY)using 2014 values.Results:A total of 2,223 liver cancer patients were enrolled,of whom 59.61%were late-stage cases(III-IV),and 53.8%were hepatocellular carcinoma.The average total expenditure per liver cancer patient was estimated as 53,220 CNY,including 48,612 CNY of medical expenditures(91.3%)and 4,608 CNY of non-medical expenditures(8.7%).The average total expenditures in stage I,H,m and stage IV were 52,817 CNY,50,877 CNY,50,678 CNY and 54,089 CNY(P>0.05),respectively.Non-medical expenditures including additional meals,additional nutrition care,transportation,accommodation and hired informal nursing were 1,453 CNY,839 CNY,946 CNY,679 CNY and 200 CNY,respectively.The one-year out-of-pocket expenditure of a newly diagnosed patient was 24,953 CNY,and 77.2%of the patients suffered an unmanageable financial burden.Multivariate analysis showed that overall expenditure differed in almost all subgroups(P<0.05),except for sex,clinical stage,and pathologic type.Conclusions:There was no difference in treatment expenditure for liver cancer patients at different clinical stages,which suggests that maintaining efforts on treatment efficacy improvement is important but not enough.To fiirtherly reduce the overall economic burden from liver cancer,more effort should be given to primary and secondary prevention strategies. | Haike Lei Lin Lei Jufang Shi Yongzhong Wu Ling Liang Huiyao Huang Mei He Fangzhou Bai Maomao Cao Hui Qiu Yuting Wang Chengcheng Liu Jia Du Hong Wang Yan Zhang Mengdi Cao Ji Peng Ni Li Chunfeng Qu Min Dai Wanqing Chen Jie He | 2020 | Chinese Journal of Cancer Research2020，32，4： | 7 |
| 9 | SIMUUTION OF ELECTROMAGNETIC TUBE BULGING BASED ON LOOSE COUPLING METHOD显示文摘一个松开的联合方法被使用,到解决电磁的试管bulging.ANSYS/ EMAG 被用来为改变电磁的地,分泌物水流用作刺激的时间建模,以便获得光线、轴的磁性的压力作用于试管,磁性的压力然后被用作边界条件与 DYNAFORM 为试管的高速度变丑建模。试管上的光线的磁性的压力从中心减少到试管目的,轴的磁性的压力在另外的区域在到卷高度和忽视的地点平等者附近是更大的。使变形的细工品的光线的排水量从中心在试管中心和减少附近一致地是分布式的到目的;到到试管目的卷高度的从地点平等者的变丑是很少。这分布与光线的压力的分发一致;变丑上的轴的磁性的压力的效果能被忽略。计算结果与试验性的结果显示出协议很好。 | LI Zhong LI Chunfeng | 2006 | Chinese Journal of Mechanical Engineering2006，19，4： | 6 |
| 10 | Characterization of nanoscale iron and its degradation of 2,4-dichlorophenol显示文摘Nanoscale iron was detected by TEM, X-ray diffraction and X-ray photoelectron spectroscopy. It was found that the size of the nanoscale iron particles is in the range of 30?40 nm according to TEM image, and it contains abundant Fe3O4 as passivating layers on the surface of the core-shell structure. To improve its performance, dilute HCl was used for the removal of the passivating layers, and the degradation of 2,4-dichlorophenol (2,4-DCP) was measured for the nanoscale iron samples treated and untreated. Experimental results demonstrated that the removal of 2,4-DCP by untreated nanoscale iron is mainly due to the adsorption of 2, 4-DCP by nanoscale iron, and there are no degradation products detected by HPLC in the process. However, excellent dechlorination of 2,4-DCP was gained by HCl-treated nanoscale iron, and 2-chlorophenol, 4-chlorophenol and phenol were detected during the process. It was concluded that dechlorination is the key reaction pathway for the degradation of 2,4-DCP by activated nanoscale iron, and phenol is found to be the main product. | HOU ChunFeng GE XiaoPeng ZHOU YanMei LI Yi WANG DongSheng TANG HongXiaoI | 2010 | Chinese Science Bulletin2010，55，4： | 6 |
| 11 | Construction of plasmid vector pAFP-HSVtk-IRES2-EGFP and its effect on the cytotoxicity of ganciclovir to hepatocellular carcinoma显示文摘 | Lai Zhiyong Qin Qin Yu Baofeng Xie Jun Gao Ranpeng Zhang Tiantian Li Chunfeng Niu Kai Xu Jun | 2014 | Chinese Medical Journal2014，，12： | 6 |
| 12 | Real-time pressure mapping smart insole system based on a controllable vertical pore dielectric layer显示文摘Real-time monitoring of plantar pressure has significant applications in wearable biosensors,sports injury detection,and early diagnostics.Herein,an all-in-one insole composed of 24 capacitive pressure sensors(CPSs)with vertical pores in an elastic dielectric layer is fabricated by laser cutting.Optimized CPSs with a hexagonal configuration and a pore size of 600μm possess good linearity over a wide detection range of 0–200 kPa with a sensitivity of 12×10^(–3) kPa−1.Then,a smart system including the all-in-one insole with the 24 CPS array,a data acquisition system with a wireless transmitter and a PC terminal with a wireless receiver is established for real-time monitoring to realize static and dynamic plantar pressure mapping.Based on this smart insole system,various standing and yoga postures can be distinguished,and variations in the center of gravity during walking can be recognized.This intelligent insole system provides great feasible supervision for health surveillance,injury prevention,and athlete training. | Juan Tao Ming Dong Li Li Chunfeng Wang Jing Li Yue Liu Rongrong Bao Caofeng Pan | 2020 | Microsystems & Nanoengineering2020，6，1： | 6 |
| 13 | Submarine slide evidence for late Miocene strike-slip reversal of the Red River Fault显示文摘During the late Miocene(~5.5 Ma), a large-scale submarine slide with an area of approximately 18000 km^2 and a maximum thickness of 930 m formed in the deep-water region of the Qiongdongnan Basin. The large-scale submarine slide has obvious features in seismic profile, with normal faults in the proximal region, escarpments at the lateral boundary, and a pronounced shear surface at the base. The internal seismic reflections are chaotic and enclosed by parallel and sub-parallel seismic events.The main direction of sediment transport was from south to north and the main sediment source was the southern region of the Qiongdongnan Basin, which is located in the east of the Indo-China Peninsula and the north of the Guangle uplift. In this region,late Miocene strike-slip reversal of the Red River Fault, uplift and increased erosion of the Indo-China Peninsula, and an abrupt rise in the rate of deposition in the western part of the South China Sea provided the basic conditions and triggering mechanism for the large-scale submarine slide. The discovery of the large-scale submarine slide provides sedimentological evidence for the tectonic event of late Miocene strike-slip reversal of the Red River Fault. It can also be inferred that the greatest tectonic activity during the process of the Red River Fault reversal occurred at ~5.5 Ma from the age of top surface of the submarine slide. | WANG DaWei WU ShiGuo LI ChunFeng YAO GenShun | 2016 | Science China Earth Sciences2016，59，11： | 6 |
| 14 | Inhibitory effect of high phenol concentration in treating coal gasification wastewater in anaerobic biofilter显示文摘In this paper, the inhibition of methanogens by phenol in coal gasification wastewater(CGW)was investigated by both anaerobic toxicity tests and a lab-scale anaerobic biofilter reactor(AF). The anaerobic toxicity tests indicated that keeping the phenol concentration in the influent under 280 mg/L could maintain the methanogenic activity. In the AF treating CGW,the result showed that adding glucose solution as co-substrate could be beneficial for the quick start-up of the reactor. The effluent chemical oxygen demand(COD) and total phenol reached1200 and 100 mg/L, respectively, and the methane production rate was 175 m L CH4/g COD/day.However, if the concentration of phenol was increased, the inhibition of anaerobic micro-organisms was irreversible. The threshold of total phenol for AF operation was 200–250 mg/L. The extracellular polymeric substances(EPS) and particle size distribution of anaerobic granular sludge in the different stages were also examined, and the results indicated that the influence of toxicity in the system was more serious than its effect on flocculation of EPS. Moreover, the proportion of small size anaerobic granular sludge gradually increased from10.2% to 34.6%. The results of high through-put sequencing indicated that the abundance of the Chloroflexi and Planctomycetes was inhibited by the toxicity of the CGW, and some shifts in the microbial community were observed at different stages. | Yajie Li Salma Tabassum Chunfeng Chu Zhenjia Zhang | 2018 | Journal of Environmental Sciences2018，30，2： | 6 |
| 15 | Engineering an enthesis-like graft for rotator cuff repair:An approach to fabricate highly biomimetic scaffold capable of zone-specifically releasing stem cell differentiation inducers显示文摘Rotator cuff(RC)attaches to humerus across a triphasic yet continuous tissue zones(bone-fibrocartilage-tendon),termed“enthesis”.Regrettably,rapid and functional enthesis regeneration is challenging after RC tear.The existing grafts bioengineered for RC repair are insufficient,as they were engineered by a scaffold that did not mimic normal enthesis in morphology,composition,and tensile property,meanwhile cannot simultaneously stimulate the formation of bone-fibrocartilage-tendon tissues.Herein,an optimized decellularization approach based on a vacuum aspiration device(VAD)was developed to fabricate a book-shaped decellularized enthesis matrix(O-BDEM).Then,three recombinant growth factors(CBP-GFs)capable of binding collagen were synthesized by fusing a collagen-binding peptide(CBP)into the N-terminal of BMP-2,TGF-β3,or GDF-7,and zone-specifically tethered to the collagen of O-BDEM to fabricate a novel scaffold(CBP-GFs/O-BDEM)satisfying the above-mentioned requirements.After ensuring the low immunogenicity of CBP-GFs/O-BDEM by a novel single-cell mass cytometry in a mouse model,we interleaved urine-derived stem cell-sheets into this CBP-GFs/O-BDEM to bioengineer an enthesis-like graft.Its high-performance on regenerating enthesis was determined in a canine model.These findings indicate this CBP-GFs/O-BDEM may be an excellent scaffold for constructing enthesis-like graft to patch large/massive RC tears,and provide breakthroughs in fabricating graded interfacial tissue. | Can Chen Qiang Shi Muzhi Li Yang Chen Tao Zhang Yan Xu Yunjie Liao Shulin Ding Zhanwen Wang Xing Li Chunfeng Zhao Lunquan Sun Jianzhong Hu Hongbin Lu | 2022 | Bioactive Materials2022，7，10： | 4 |
| 16 | Efficacy and safety of rasagiline in Chinese patients with early Parkinson’s disease:a randomized, double-blind,parallel,placebo-controlled,fixed-dose study显示文摘Background:Rasagiline is a monoamine oxidase-B inhibitor used for Parkinson’s disease(PD)treatment,but its effectiveness on Chinese patients is unclear.This study aimed to evaluate the efficacy and safety of rasagiline monotherapy in Chinese patients with early PD.Methods:A 26-weeks,randomized,double-blind,placebo-controlled study has been performed at 15 sites in China and enrolled outpatients(≥35 years old)with idiopathic PD without a history of using any dopaminergic drugs.Participants were randomized 1:1 to receive rasagiline 1 mg once daily or placebo.The primary endpoint was the change of the Unified Parkinson’s Disease Rating Scale(UPDRS)total score from baseline to 26 weeks treatment.Secondary endpoints included changes in UPDRS subscale scores from part Ⅰ to Ⅲ.Health status was assessed with the PD Questionnaire(PDQ)-39 and EuroQol-Five-Dimension(EQ-5D)questionnaire.Safety profile was collected until 30 weeks after randomization.Results:A total of 130 patients(n=65/group)were recruited,and 127(rasagiline,n=64;placebo,n=63)were included in the full analysis set.Baseline characteristics were comparable between the two groups.The decrease in the mean UPDRS total score was greater in the rasagiline group than in the placebo group(−3.18±0.95 vs.−0.18±0.98,P=0.025),and the mean UPDRS part I non-motor symptoms score(−0.54±0.15 vs.-0.08±0.15,P=0.003)were significantly decreased in the rasagiline group compared with placebo treated patients.An improvement trend was observed in the active treatment group for the subscales evaluation with parts Ⅱ and Ⅲ,while the difference to placebo was not statistically significant.Life quality assessed by the EQ-5D visual analog scale improved in the rasagiline group but worsened in placebo treated patients.The overall incidence of treatment-emergent adverse events(AEs)was slightly lower in the rasagiline group(41.5%)than in the placebo group(46.2%).Conclusions:Rasagiline is effective,safe,and well tolerated as monotherapy for the treatment of Chinese PD patients. | Zhenxin Zhang Jian Wang Shengdi Chen Chunfeng Liu Baorong Zhang Rong Peng Shenggang Sun Xiangru Sun Gang Zhao Qiumin Qu Yansheng Li Suiqiang Zhu Xiaoping Pan Ming Shao Yanping Wang | 2018 | Translational Neurodegeneration2018，7，1： | 3 |
| 17 | A male-ABCD algorithm for hepatocellular carcinoma risk prediction in HBs Ag carriers显示文摘Objective: Hepatocellular carcinoma(HCC) development among hepatitis B surface antigen(HBs Ag) carriers shows gender disparity, influenced by underlying liver diseases that display variations in laboratory tests. We aimed to construct a risk-stratified HCC prediction model for HBs Ag-positive male adults.Methods: HBs Ag-positive males of 35-69 years old(N=6,153) were included from a multi-center populationbased liver cancer screening study. Randomly, three centers were set as training, the other three centers as validation. Within 2 years since initiation, we administrated at least two rounds of HCC screening using Bultrasonography and α-fetoprotein(AFP). We used logistic regression models to determine potential risk factors,built and examined the operating characteristics of a point-based algorithm for HCC risk prediction.Results: With 2 years of follow-up, 302 HCC cases were diagnosed. A male-ABCD algorithm was constructed including participant's age, blood levels of GGT(γ-glutamyl-transpeptidase), counts of platelets, white cells,concentration of DCP(des-γ-carboxy-prothrombin) and AFP, with scores ranging from 0 to 18.3. The area under receiver operating characteristic was 0.91(0.90-0.93), larger than existing models. At 1.5 points of risk score,26.10% of the participants in training cohort and 14.94% in validation cohort were recognized at low risk, with sensitivity of identifying HCC remained 100%. At 2.5 points, 46.51% of the participants in training cohort and 33.68% in validation cohort were recognized at low risk with 99.06% and 97.78% of sensitivity, respectively. At 4.5 points, only 20.86% of participants in training cohort and 23.73% in validation cohort were recognized at high risk,with positive prediction value of 22.85% and 12.35%, respectively.Conclusions: Male-ABCD algorithm identified individual's risk for HCC occurrence within short term for their HCC precision surveillance. | Yuting Wang Minjie Wang He Li Kun Chen Hongmei Zeng Xinyu Bi Zheng Zhu Yuchen Jiao Yong Wang Jian Zhu Hui Zhao Xiang Liu Chunyun Dai Chunsun Fan Can Zhao Deyin Guo Hong Zhao Jianguo Zhou Dongmei Wang Zhiyuan Wu Xinming Zhao Wei Cui Xuehong Zhang Jianqiang Cai Wanqing Chen Chunfeng Qu | 2021 | Chinese Journal of Cancer Research2021，33，3： | 3 |
| 18 | Effects of temperature on the mechanical properties of Ti6Al4V powder compacts prepared by magnetic pulse compaction显示文摘The effects of temperature (0-500°C) on the compressive strength,hardness,average relative density,and microstructure of Ti6Al4V powder green compacts prepared by magnetic pulse compaction were investigated.The results show that with increasing heating temperature,the compressive strength first increases and then decreases with the maximum value of 976.74 MPa at 400°C.The average relative density and hardness constantly increase,and their values reach 96.11% and HRA 69.8 at 500°C,respectively.The increase of partial welding is found among the junctions of particles inside the compacts;there is no obvious grain growth inside the compacts within the temperature range. | LI Mini YU Haiping LI Chunfeng | 2010 | Rare Metals2010，29，3： | 3 |
| 19 | High Elevation Energy and Water Balance:the Roles of Surface Albedo and Temperature显示文摘Observation and modeling of the coupled energy and water balance is the key to understand hydrospheric and cryospheric processes at high elevation.The paper summarizes the progress to address this aspect in relation with different earth system elements,from glaciers to wetlands.The energy budget of two glaciers,i.e.Xiao Dongkemadi and Parlung No.4,was studied by means of extended field measurements and a distributed model of the coupled energy and mass balance was developed and evaluated.The need for accurate characterization of surface albedo was further documented for the entire Qinghai Tibet Plateau by numerical experiments with Weather Research and Forecast(WRF)on the sensitivity of the atmospheric boundary layer to the parameterization of land surface processes.A new approach to the calibration of a coupled distributed watershed model of the energy and water balance was demonstrated by a case study on the Heihe River Basin in northwestern China.The assimilation of land surface temperature did lead to the retrieval of critical soil and vegetation properties as the soil permeability and the canopy resistance to the exchange of vapour and carbon dioxide.The retrievals of actual Evapo-Transpiration(ET)were generated by the ETMonitor system and evaluated against eddy covariance measurements at sites spread throughout Asia.As regards glacier response to climate variability,the combined findings based on satellite data and model experiments showed that the spatial variability of surface albedo and temperature is significant and controls both glacier mass balance and flow.Experiments with both atmospheric and hydrosphere-cryosphere models documented the need and advantages of using accurate retrievals of land surface albedo to capture lan-atmosphere interactions at high elevation. | Massimo MENENTI Li JIA Marco MANCINI Xin LI Francesca PELLICCIOTTI Kun YANG Jiancheng SHI Maria Jose ESCORIHUELA Chiara CORBARI Shaoting REN Chunfeng MA Chaolei ZHENG Lian LIU Thomas SHAW Baohong DING Wei YANG | 2020 | Journal of Geodesy and Geoinformation Science2020，3，4： | 3 |
| 20 | Effects ofβ-alanine on intestinal development and immune performance of weaned piglets显示文摘Beta-alanine is an important amino acid involved in several metabolic reactions in the body.The study aimed to investigate the effect ofβ-alanine supplementation on intestinal development and the immune performance of weaned piglets.Thirty-two 21-day-old healthy weaned piglets(half female and half male;Duroc×Landrace×Yorkshire)with an initial body weight of 8.11±0.21 kg were randomly divided into 4 groups with 8 replicates of 1 pig each.The control group was fed a basal diet and the three experimental treatment groups were fed diets supplemented with 300,600 and 1,200 mg/kgβ-alanine,respectively.The trial lasted 28 days and the diets fed were divided into 2 phases:the late lactation period(day 1 to 14)and the nursery period(day 15 to 28),during which the weaned piglets had free access to food and water.The regulatory effects ofβ-alanine were further investigated in vitro using organoids obtained from the jejunum of piglets.In vivo,the addition ofβ-alanine to the diet had no significant effect on the growth performance of weaned piglets(P>0.05),but significantly reduced serum levels of immunoglobulin G(IgG)(P<0.01),immunoglobulin M(IgM)(P=0.005),and complement 3(C3)(P=0.017).The serum interleukin-6(IL-6)levels(P<0.01)were significantly reduced in the 1,200 mg/kg treatment group.The addition ofβ-alanine increased ileal villus height,with the most significant effect at a concentration of 300 mg/kg(P=0.041).The addition of 600 mg/kgβ-alanine significantly up-regulated the expression of superoxide dismutase(SOD)activity(P=0.020)and the zonula occludens-1(ZO-1)gene(P=0.049)in the jejunum.Diets supplemented with 300 mg/kgβ-alanine significantly increased the number of Ki67 positive cells in the jejunal crypts(P<0.01).In vitro,β-alanine increased the organoid budding rates(P=0.001)and the budding height of the crypt significantly(P=0.004).In conclusion,β-alanine can improve intestinal morphology and barrier function,reduce inflammatory responses and alleviate the adverse effects of weaning stress on piglet intestinal health. | Linlin Chen Yan Zhong Xiangqin Ouyang Chunfeng Wang Lanmei Yin Jing Huang Yali Li Qiye Wang Junyan Xie Pengfei Huang Huansheng Yang Yulong Yin | 2023 | Animal Nutrition2023，，1： | 2 |
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