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| 1 | Sulfur-containing amino acid methionine as the precursor of volatile organic sulfur compounds in algea-induced black bloom显示文摘After the application of methionine, a progressive and significant increase occurred in five volatile organic sulfur compounds (VOSCs): methanethiol (MeSH), dimethyl sulfide (DMS), dimethyl disulfide (DMDS), dimethyl trisulfide (DMTS) and dimethyl tetrasulfide (DMTeS). Even in the untreated control without a methionine addition, methionine and its catabolites (VOSCs, mainly DMDS) were found in considerable amounts that were high enough to account for the water's offensive odor. However, blackening only occurred in two methionine-amended treatments. The VOSCs production was observed to precede black color development, and the reaching of a peak value for total VOSCs was often followed by water blackening. The presence of glucose stimulated the degradation of methionine while postponing the occurrence of the black color and inhibiting the production of VOSCs. In addition, DMDS was found to be the most abundant species produced after the addition of methionine alone, and DMTeS appeared to be the most important compound produced after the addition of methionine+glucose. These results suggest that methionine acted as an important precursor of the VOSCs in lakes suffering from algea-induced black bloom. The existence of glucose may change the transformation pathway of methionine into VOSCs to form larger molecular weight compounds, such as DMTS and DMTeS. | Xin Lu Chengxin Fan Wei He Jiancai Deng Hongbin Yin | 2013 | Journal of Environmental Sciences2013，25，1： | 27 |
| 2 | Ciliary parathyroid hormone signaling activates transforming growth factor-βto maintain intervertebral disc homeostasis during aging显示文摘Degenerative disc disease(DDD) is associated with intervertebral disc degeneration of spinal instability. Here, we report that the cilia of nucleus pulposus(NP) cells mediate mechanotransduction to maintain anabolic activity in the discs. We found that mechanical stress promotes transport of parathyroid hormone 1 receptor(PTH1 R) to the cilia and enhances parathyroid hormone(PTH) signaling in NP cells. PTH induces transcription of integrin α_vβ_6 to activate the transforming growth factor(TGF)-β-connective tissue growth factor(CCN2)-matrix proteins signaling cascade. Intermittent injection of PTH(iPTH) effectively attenuates disc degeneration of aged mice by direct signaling through NP cells, specifically improving intervertebral disc height and volume by increasing levels of TGF-β activity, CCN2, and aggrecan. PTH1 R is expressed in both mouse and human NP cells. Importantly,knockout PTH1 R or cilia in the NP cells results in significant disc degeneration and blunts the effect of PTH on attenuation of aged discs. Thus, mechanical stress-induced transport of PTH1 R to the cilia enhances PTH signaling, which helps maintain intervertebral disc homeostasis, particularly during aging, indicating therapeutic potential of iPTH for DDD. | Liwei Zheng Yong Cao Shuangfei Ni Huabin Qi Zemin Ling Xin Xu Xuenong Zou Tianding Wu Ruoxian Deng Bo Hu Bo Gao Hao Chen Yusheng Li Jianxi Zhu Francis Tintani Shadpour Demehri Amit Jain Khaled M.Kebaish Shenghui Liao Cheryle A.Séguin Janet L.Crane Mei Wan Hongbin Lu Paul D.Sponseller Lee H.RileyIII Xuedong Zhou Jianzhong Hu Xu Cao | 2018 | Bone Research2018，6，3： | 13 |
| 3 | A novel partner of Scalloped regulates Hippo signaling via antagonizing Scalloped-Yorkie activity显示文摘由调整 transcriptional 激活剂 Yorkie (Yki ) 的活动的河马(Hpo ) 小径控制织物生长和机关尺寸,它在原子核与抄写因素 Scalloped (Sd ) 联系下游地支持指向基因表示。这里,我们识别新奇蛋白质 Sd-Binding-Protein (SdBP )/Tgi,它直接通过它的 TDU 域为绑定与 Yki 竞争到 Sd 并且禁止 Sd-Yki transcriptional 活动。我们也发现 SdBP 经由它的 PPXY 主题与 Yki WW 领域通过协会在原子核保留 Yki。一起,我们作为 Hpo 小径的一个新奇部件识别 SdBP,否定地调整 Sd-Yki 的 transcriptional 活动限制织物生长。 | Tong Guo Yi Lu Peixue Li Meng-Xin Yin Dekang Lv Wenjing Zhang Huizhen Wang Zhaocai Zhou Hongbin Ji Yun Zhao Lei Zhang | 2013 | Cell Research2013，23，10： | 13 |
| 4 | Statistics of gravity waves in the lower stratosphere over Beijing based on high vertical resolution radiosonde显示文摘The seasonal variation of inertia gravity-wave activity in the lower stratosphere (17―24 km) over Beijing is studied based on the high vertical resolution radionsonde observa- tions (from December 2001 to February 2003) of Beijing Observatory (116°28′E, 39°48′N). Some of the important gravity-wave parameters, such as intrinsic frequency, and propagation direction, are estimated according to the polarized relation among gravity-wave wind components and temperature. Time series of wave energy show that the largest wave amplitudes occur during the winter and the least during the summer, and the average of the KE:PE ratios is about 2.6. Zonal and meridional wind perturbations have almost the same roots of mean variances, which shows that the wave energy in the lower stratosphere is isotropic horizontally. The motion and tem- perature fields are dominated by waves with vertical wavelengths of 1.5―3 km, which occupy above 80% samples, with a mean value of about 2.3 km. The horizontal wavelengths are mainly distributed between 100―800 km, averaging 445 km. The ratio of the mean horizontal to vertical wavelength is about 200:1, which indicates that the wave propagates nearly horizontally, with a very small vertical angle. The intrinsic frequency is estimated by fitting a polarized ellipse to the wind perturbations after band-filtering waves with a wavelength of 1.5―3 km, and the results show that the intrinsic frequency is dominated by 1f―3.5f, with an averaging value of 2f, corre- sponding to an intrinsic time period of 9 hours. Wave energy is found to propagate mainly upward, and in the horizontal direction, there is clear azimuthal anisotropy, with predominate northwest propagation against the prevailing wind. | BIAN Jianchun CHEN Hongbin LU Daren | 2005 | Science China Earth Sciences2005，48，9： | 12 |
| 5 | Overexpressed miR-9 promotes tumor metastasis via targeting E-cadherin in serous ovarian cancer显示文摘MicroRNAs (miRNAs ) 玩在在各种各样的癌症的发展和前进的关键角色。不正常的 miR-9 表示仍然保持模糊,并且卵巢的癌症的变形前进上的一致都没被到达。在这研究,从生物信息学分析的结果证明 E-cadherin mRNA 的 3-UTR 被 miR-9 直接调整。酶记者试金结果证实 miR-9 能直接指向这 3-UTR。在卵巢的癌症织物的 miR-9 和 E-cadherin 表示被 qRT-PCR 确定。移植和侵略被在 SKOV3 和 A2780 愈合弯屈和 Transwell 系统试金检测。qRT-PCR 和西方的污点被执行检测上皮 ? 间充质的联系转变的 mRNA 和蛋白质。Immunofluorescence 技术被用来分析表示和 E-cadherin, N-cadherin,和 vimentin 的 subcellular 本地化。结果证明 miR-9 经常与配对的主要的相比是在变形浆液的卵巢的癌症织物的 upregulated。miR-9 的 Upregulation 能 downregulate E-cadherin 的表示但是 upregulate 间充质的标记(N-cadherin 和 vimentin ) 的表示。miR-9 的 Overexpression 能在卵巢的癌症支持房间移植和侵略,并且这些进程能有效地经由 miR-9 禁止者被禁止。因此,我们的学习证明 miR-9 可以经由指向 E-cadherin 和一条新奇潜在的治疗学的途径控制卵巢的癌症的转移支持卵巢的癌症转移。 | Bo Zhou Hongbin Xu Meng Xia Chaoyang Sun Na Li Ensong Guo Lili Guo Wanying Shan Hao Lu Yifan Wu Yuan Li Degui Yang Danhui Weng Li Meng Junbo Hu Ding Ma Gang Chen Kezhen Li | 2017 | Frontiers of Medicine2017，11，2： | 10 |
| 6 | A novel nonviral nanoparticle gene vector: Poly-L-lysine- silica nanoparticles显示文摘DNA delivery is a core technology for gene structure and function research as well as clinical settings. The ability to safely and efficiently targeted transfer foreign DNA into cells is a fundamental goal in biotechnology. With the development of nanobiotechnology, nanoparticle gene vectors brought about new hope to reach the goal. In our research, silica nanoparticles (SiNP) were synthesized first in a microemulsion system polyoxyethylene nonylphenyl ether (OP-10)/cyclohexane/ammonium hydroxide, at the same time the effects of SiNP size and its distribution were elucidated by orthogonal analysis; then poly-L-lysine (PLL) was linked on the surface of SiNP by nanoparticle surface energy and electrostatically binding; lastly a novel complex nanomate-rial-poly-L-lysine-silica nanoparticles (PLL-SiNP) wasprepared. The analysis of plasmid DNA binding and DNase I enzymatic degradation discovered that PLL-SiNP could bind DNA, and protect it against enzymatic degradation. Cell transfection showed that | Shiguo Zhu Hongbin Lu Juanjuan Xiang Ke Tang Bicheng Zhang Ming Zhou Chen Tan Guiyuan Li | 2002 | Chinese Science Bulletin2002，47，8： | 9 |
| 7 | Hierarchical Manganese Oxide/Carbon Nanocomposites for Supercapacitor Electrodes显示文摘有装载的层次毛孔结构和可控制的 MnO2 的 MnO2/carbon nanocomposites 用一个自我限制的生长方法被综合了。这被 KMnO4 的氧化还原作用反应与包含层次毛孔的牺牲的碳底层完成。唯一的毛孔结构允许 nanocomposites 的合成,悦耳的 MnO2 装载直到 83 wt.% 。nanocomposites 的特定的电容增加了, MnO2 装载;在另一方面,电气化学的阻抗光谱学测量的传导性与增加装载的 MnO2 减少了。装载的 MnO2 的优化与高特定的电容和优秀的率能力导致了 nanocomposites。这个工作提供将为应用的一个大变化便于高效的 supercapacitor 材料的设计和制造的重要基本理解。 | Yiting Peng Zheng Chen Jing Wen Qiangfeng Xiao Ding Weng Shiyu He Hongbin Geng Yunfeng Lu | 2011 | Nano Research2011，4，2： | 8 |
| 8 | Pool boiling on the superhydrophilic surface with TiO_2 nanotube arrays显示文摘Surface with TiO2 nanotube arrays(TNTAs)is superhydrophilic and of great specific area.This paper investigates the pool boiling characteristics at the thermal interface with TNTAs.The results show that the TNTAs interface can enhance the pool boiling heat transfer compared to the pure Ti metal plate.The bubbles formed at the initial nucleation state are very small and released in higher frequency.The pool boiling heat transfer enhancement at the TNTAs interface may be attributed to the high density of nucleate site,high intrinsic heating area of nanotubes layer,superhydrophilicity and the vertically oriented nanotube structure. | CHEN Yue,MO DongChuan,ZHAO HongBin,DING Nan & LU ShuShen School of Chemistry and Chemical Engineering,Sun Yat-sen University,Guangzhou 510275,China | 2009 | Science China(Technological Sciences)2009，52，6： | 7 |
| 9 | Advances in the Researches in Middle and Upper Atmosphere in 2006—2008显示文摘This paper summarizes the research results obtained by Chinese scientists and/or through international collaborations in 2006—2008.Specifically,this paper focus on the research fields in the middle and upper atmosphere,including developments in facilities and instruments,and the advancements in scientific issues. | CHEN Zeyu CHEN Hongbin CHEN Wen LU Daren | 2008 | 空间科学学报2008，28，5： | 6 |
| 10 | Advances in the Studies of the Middle and Upper Atmosphere in 2004 - 2006显示文摘This paper summarizes the research results obtained by Chinese scientists and/or through international collaborations during 2004 to 2006. Within the context of COSPAR, the progresses in the studies of the middle and upper atmosphere in China in the past two years are introduced with focusing the developments in facilities and instruments, and the advancements in scientific issues, e.g., dynamics related processes, atmospheric constituents, and the coupling with the lower atmosphere. | CHEN Zeyu LIU Renqiang CHEN Hongbin CHEN Wen LU Daren XU Jiyao HU Xiong | 2006 | 空间科学学报2006，26，z1： | 6 |
| 11 | Rational synthesis of carbon shell coated polyaniline/ MoS2 monolayer composites for high-performance supercapacitors显示文摘进行的聚合物通常显示出高特定的电容,但是受不了差的率能力和快速的电容腐烂,它极大地在 supercapacitor 电极限制他们的实际应用。到这个目的,许多研究在由综合改进全面电容的表演上集中了进行聚合物的 nanostructured 或由扔涂层的一个范围增加,活跃表面区域暴露了到电解质并且提高费用运输效率和结构的稳定性。尽管有这,同时完成高特定的电容,好率表演,和长周期生活仍然是可观的挑战。在之中各种各样二维(2D ) 分层的材料,八面(1T ) 分阶段执行铝二硫化物(瞬间 2) nanosheets 有高电的电导率,大特定的表面区域,和唯一的表面化学药品特征,为进行聚合物的 nanostructured 的控制生长使他们成为有趣的底层。这份报纸报导碳的合理合成在 1T 瞬间 2 单层上种的壳涂的 polyaniline (PANI )( 瞬间 2/PANI@C) 。合成电极与 3 nm 碳壳展出了的 ~ 瞬间包括了 2/PANI@C 多达 678 F 耶尙洜暗囊桓鱿灾囟ǖ牡缛萋穑浚? | Chao Yang Zhongxin Chen Imran Shakir Yuxi Xu Hongbin Lu | 2016 | Nano Research2016，9，4： | 5 |
| 12 | Discovery and Analysis of Shale Gas in a Carboniferous Reservoir and its Enrichment Characteristics in the Northern Nanpanjiang Depression, Guizhou Province, China显示文摘Shale gas resources are considered to be extremely abundant in southern China,which has dedicated considerable attention to shale gas exploration in recent years.Exploration of shale gas has considerably progressed and several breakthroughs have been made in China.However,shale gas explorations are still scarce.Summary and detailed analysis studies on black shale reservoirs are still to be performed for many areas.This lack of information slows the progress of shale gas explorations and results in low quantities of stored black shale.The Carboniferous Dawuba Formation,which is widely distributed and considerably thick,is one of the black shale formations targeted for shale gas exploration in southern China in the recent years.The acquisition and analysis of total organic carbon,vitrinite reflectance,types of organic matter,mineral composition,porosity,and permeability are basic but important processes.In addition,we analyzed the microscopic pores present in the shale.This study also showesd the good gas content of the Dawuba Formation,as well as the geological factors affecting its gas content and other characteristics.To understand the prospect of exploration,we compared this with other shale reservoirs which have been already successfully explored for gas.Our comparison showesd that those shale reservoirs have similar but not identical geological characteristics. | LU Shufan LUO Xiangjian DU Shengjiang HE Ben FU Hongbin LIU Kuiyong | 2019 | Acta Geologica Sinica(English Edition)2019，93，3： | 5 |
| 13 | Origin of strong solid solution strengthening in the CrCoNi-W medium entropy alloy显示文摘Solid solution strengthening is one of the most conventional strategies for optimizing alloys strength,while the corresponding mechanisms can be more complicated than we traditionally thought specifically as heterogeneity of microstructure is involved.In this work,by comparing the change of chemical distribution,dislocation behaviors and mechanical properties after doping equivalent amount of tungsten(W)atoms in CrCoNi alloy and pure Ni,respectively,it is found that the alloying element W in CrCoNi alloy resulted in much stronger strengthening effect due to the significant increase of heterogeneity in chemical distribution after doping trace amount of W.The large atomic scale concentration fluctuation of all elements in CrCoNi-3W causes dislocation motion via strong nanoscale segment detrapping and severe dislocation pile up which is not the case in Ni-3W.The results revealed the high sensitivity of elements distribution in multi-principle element alloys to composition and the significant consequent influence in tuning the mechanical properties,giving insight for complex alloy design. | Yujie Chen Yan Fang Xiaoqian Fu Yiping Lu Sijing Chen Hongbin Bei Qian Yu | 2021 | Journal of Materials Science & Technology2021，，14： | 5 |
| 14 | Biofilm from a clinical strain of Cryptococcus neoformans activates the NLRP3 inflammasome显示文摘 | Guowei Lei Mingkuan Chen Hua Li Jun-Ling Niu Shuxian Wu Liming Mao Ailing Lu Hongbin Wang Wei Chen Bin Xu Qibin-Leng Cunshuan Xu Guiwen Yang Liguo An Li-Ping Zhu Guangxun Meng | 2013 | Cell Research2013，23，7： | 5 |
| 15 | Tubeimoside-1 induces TFEB-dependent lysosomal degradation of PD-L1 and promotes antitumor immunity by targeting mTOR显示文摘Programmed cell death ligand 1(PD-L1)/programmed cell death protein 1(PD-1)cascade is an effective therapeutic target for immune checkpoint blockade(ICB)therapy.Targeting PD-L1/PD-1 axis by small-molecule drug is an attractive approach to enhance antitumor immunity.Using flow cytometry-based assay,we identify tubeimoside-1(TBM-1)as a promising antitumor immune modulator that negatively regulates PD-L1 level.TBM-1 disrupts PD-1/PD-L1 interaction and enhances the cytotoxicity of T cells toward cancer cells through decreasing the abundance of PD-L1.Furthermore,TBM-1 exerts its antitumor effect in mice bearing Lewis lung carcinoma(LLC)and B16 melanoma tumor xenograft via activating tumor-infiltrating T-cell immunity.Mechanistically,TBM-1 triggers PD-L1 lysosomal degradation in a TFEB-dependent,autophagy-independent pathway.TBM-1 selectively binds to the mammalian target of rapamycin(m TOR)kinase and suppresses the activation of m TORC1,leading to the nuclear translocation of TFEB and lysosome biogenesis.Moreover,the combination of TBM-1 and anti-CTLA-4 effectively enhances antitumor T-cell immunity and reduces immunosuppressive infiltration of myeloid-derived suppressor cells(MDSCs)and regulatory T(Treg)cells.Our findings reveal a previously unrecognized antitumor mechanism of TBM-1 and represent an alternative ICB therapeutic strategy to enhance the efficacy of cancer immunotherapy. | Xiaojia Liu Mingxiao Yin Jingwen Dong Genxiang Mao Wenjian Min Zean Kuang Peng Yang Lu Liu Na Zhang Hongbin Deng | 2021 | Acta Pharmaceutica Sinica B2021，11，10： | 5 |
| 16 | Engineering an enthesis-like graft for rotator cuff repair:An approach to fabricate highly biomimetic scaffold capable of zone-specifically releasing stem cell differentiation inducers显示文摘Rotator cuff(RC)attaches to humerus across a triphasic yet continuous tissue zones(bone-fibrocartilage-tendon),termed“enthesis”.Regrettably,rapid and functional enthesis regeneration is challenging after RC tear.The existing grafts bioengineered for RC repair are insufficient,as they were engineered by a scaffold that did not mimic normal enthesis in morphology,composition,and tensile property,meanwhile cannot simultaneously stimulate the formation of bone-fibrocartilage-tendon tissues.Herein,an optimized decellularization approach based on a vacuum aspiration device(VAD)was developed to fabricate a book-shaped decellularized enthesis matrix(O-BDEM).Then,three recombinant growth factors(CBP-GFs)capable of binding collagen were synthesized by fusing a collagen-binding peptide(CBP)into the N-terminal of BMP-2,TGF-β3,or GDF-7,and zone-specifically tethered to the collagen of O-BDEM to fabricate a novel scaffold(CBP-GFs/O-BDEM)satisfying the above-mentioned requirements.After ensuring the low immunogenicity of CBP-GFs/O-BDEM by a novel single-cell mass cytometry in a mouse model,we interleaved urine-derived stem cell-sheets into this CBP-GFs/O-BDEM to bioengineer an enthesis-like graft.Its high-performance on regenerating enthesis was determined in a canine model.These findings indicate this CBP-GFs/O-BDEM may be an excellent scaffold for constructing enthesis-like graft to patch large/massive RC tears,and provide breakthroughs in fabricating graded interfacial tissue. | Can Chen Qiang Shi Muzhi Li Yang Chen Tao Zhang Yan Xu Yunjie Liao Shulin Ding Zhanwen Wang Xing Li Chunfeng Zhao Lunquan Sun Jianzhong Hu Hongbin Lu | 2022 | Bioactive Materials2022，7，10： | 4 |
| 17 | Facile one-step synthesis of Cu_2O@Cu sub-microspheres composites as anode materials for lithium ion batteries显示文摘Cu_2O@Cu sub-microspheres composites with a narrow particle size distribution from 300 to 500 nm was successfully fabricated by one-step synthesis through the direct thermal decomposition of copper nitrate(Cu(NO_3)_2) in octadecylamine(ODA) solvent. As anode materials for lithium ion batteries, the Cu_2 O@Cu composites obviously possess high specific capacity, excellent cyclic stability and rate capability. The coulombic efficiency is about 84% in the 1 st cycle and increases significantly up to 97.8% during successive cycles at various current densities. Even under a high current density of 500 m A g^(-1), the discharge capacity of Cu_2 O@Cu composites remains up to 200 m Ah g^(-1). The excellent electrochemical properties are ascribed to the synergistic effect between high electronic conductivity and volume-buffering capacity of metallic copper composited with Cu_2 O. | Huijie Zhou Hongbin Zhao Xuan Zhang Hongwei Cheng Xionggang Lu Qian Xu | 2018 | Journal of Materials Science & Technology2018，34，7： | 3 |
| 18 | Expert consensus on the establishment and maintenance of native arteriovenous fistula显示文摘Vascular access is the lifeline of hemodialysis patients.There are great differences in the establishment and use of vascular access in different countries and regions around the world.We believe that on the basis of good evaluation and planning,it is recommended that hemodialysis patients choose native arteriovenous fistula first.In view of the new progress of vascular access views domestic and international at home and abroad in recent years,we organized experts to recommend the establishment and maintenance of arteriovenous fistula(AVF)for the Chinese population,including preoperative evaluation and planning of the establishment of AVF,AVF surgery,perioperative drug intervention measures and postoperative maintenance,and put forward suggestions for future research directions.The recommendations in this consensus are general and clinicians need to make treatment decisions based on the actual situation. | Hongtao Zhang Haitao Lu Wenge Li Gengru Jiang Hongbin Zou Expert Group of Nephrology Branch of China Academy of Chronic Disease Urology Nephrology and Blood Purification Commission of China Medical Education Association | 2021 | Chronic Diseases and Translational Medicine2021，7，4： | 3 |
| 19 | Effectiveness and safety of endoscopic submucosal dissection for intraepithelial neoplasia of the esophagogastric junction显示文摘 | Wen Jing Linghu Enqiang Yang Yunsheng Liu Qingsen Yang Jing Wang Shufang Wang Xiangdong Du Hong Meng Jiangyun Wang Hongbin Lu Zhongsheng | 2014 | Chinese Medical Journal2014，，3： | 3 |
| 20 | Retrievals of over-ocean precipitable water from SSM/I by SOM network model显示文摘An SOM network model was developed for retrievals of the oceanic total precipitable water (PW) from the SSM/I, by using the SSM/I and radiosonde observation data set provided by the NASDA (Japan). The model was first trained by 5/6 of the data, and the other data were used to test the retrieval ability of the model. The retrieval results showed that the SOM network model was better than the routine operational algorithm. | Jianchun Bian Hongbin Chen Peicai Yang Daren Lu | 1999 | Chinese Science Bulletin1999，44，11： | 3 |
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