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| 1 | Neutrophil extracellular traps mediate the crosstalk between glioma progression and the tumor microenvironment via the HMGB1/RAGE/IL-8 axis显示文摘Objective:Neutrophil extracellular traps(NETs)produced by tumor-infiltrating neutrophils(TINs)are associated with poor prognosis in patients with several types of cancer.However,the mechanisms underlying the involvement of NETs in glioma progression remain largely unknown.This study aimed to elucidate the roles of NETs in biological processes that drive the crosstalk between glioma progression and the tumor microenvironment.Methods:Neutrophil infiltration and NETs formation were investigated in glioma tissue through immunohistochemistry,and their relationships with clinicopathological features and outcomes were statistically evaluated.The effects of NETs on glioma cell progression were studied in a co-culture system.In vivo and in vitro experiments validated the reactive oxygen species activity and cytokine production of TINs,as well as the ERK signaling pathway activation and the metastasis of gliomas.Results:Neutrophil infiltration and NETs formation were induced in high-grade glioma compared with low-grade glioma.NETs induced by TINs were determined to be an oncogenic marker of high-grade gliomas and to be involved in cell proliferation and invasion.NETs overproduction promoted glioma cell proliferation,migration,and invasion.Furthermore,HMGB1 was found to bind to RAGE and activate the NF-κB signaling pathway in vitro.In addition,NETs stimulated the NF-κB signaling pathway,thus promoting IL-8 secretion in glioblastoma.Subsequently,IL-8 recruited neutrophils which in turn mediated NETs formation via the PI3 K/AKT/ROS axis in TINs.Conclusions:Our results suggest that NETs produced by TINs mediate the crosstalk between glioma progression and the tumor microenvironment by regulating the HMGB1/RAGE/IL-8 axis.Targeting NETs formation or IL-8 secretion may be an effective approach to inhibit glioma progression. | Caijun Zha Xiangqi Meng Lulu Li Shan Mi Da Qian Ziwei Li Pengfei Wu Shaoshan Hu Shihong Zhao Jinquan Cai Yanhong Liu | 2020 | Cancer Biology & Medicine2020，17，1： | 19 |
| 2 | A Diagnostic Study of the Asymmetric Distribution of Rainfall during the Landfall of Typhoon Haitang(2005)显示文摘The precipitation during landfall of typhoon Haitang(2005) showed asymmetric structures(left side/right side of the track). Analysis of Weather Research and Forecasting model simulation data showed that rainfall on the right side was more than 15 times stronger than on the left side. The causes were analyzed by focusing on comparing the water vapor flux,stability and upward motion between the two sides. The major results were as follows:(1) Relative humidity on both sides was over80%,whereas the convergence of water vapor flux in the lower troposphere was about 10 times larger on the right side than on the left side.(2) Both sides featured conditional symmetric instability [MPV(moist potential vorticity) <0],but the right side was more unstable than the left side.(3) Strong(weak) upward motion occurred throughout the troposphere on the right(left) side. The Q vector diagnosis suggested that large-scale and mesoscale forcing accounted for the difference in vertical velocity. Orographic lift and surface friction forced the development of the asymmetric precipitation pattern. On the right side,strong upward motion from the forcing of different scale weather systems and topography caused a substantial release of unstable energy and the transportation of water vapor from the lower to the upper troposphere,which produced torrential rainfall. However,the above conditions on the left side were all much weaker,which led to weaker rainfall. This may have been the cause of the asymmetric distribution of rainfall during the landfall of typhoon Haitang. | YUE Caijun GAO Shouting LIU Lu LI Xiaofan | 2015 | Advances in Atmospheric Sciences2015，32，10： | 6 |
| 3 | A new charging scheme in an emergency department observation unit under Beijing's basic medical insurance显示文摘 | He Xinhua Gao Li Teng Fei Liu Changhai Wang Shuo Wu Caijun Xu Li Li Chunsheng | 2014 | Chinese Medical Journal2014，，18： | 3 |
| 4 | Anti-β2GPI/β2GPI complexes induce platelet activation and promote thrombosis via p38MAPK: a pathway to targeted therapies显示文摘Anti-β2 glycoprotein I(anti-β2GPI)antibodies are important contributors to the development of thrombosis.Anti-β2GPI antibody complexes withβ2GPI are well known to activate monocytes and endothelial cells via the intracellular NF-kB pathway with prothrombotic implications.By contrast,the interaction of anti-β2GPI/β2GPI complexes with platelets has not been extensively studied.The p38 mitogen-activated protein kinase(MAPK)pathway has been recognized to be an important intracellular signaling pathway in the coagulation cascade and an integral component of arterial and venous thrombosis.The present study reveals that levels of anti-β2GPI/β2GPI complexes in sera are positively associated with p38MAPK phosphorylation of platelets in thrombotic patients.Furthermore,SB203580 inhibits anti-β2GPI/β2GPI complex-induced platelet activation.Thrombus formation decreased in p38MAPK−/−mice after treatment with anti-β2GPI/β2GPI complexes.In conclusion,p38MAPK may be a treatment target for anti-β2GPI antibody-associated thrombotic events. | Wenjing Zhang Caijun Zha Xiumin Lu Ruichun Jia Fei Gao Qi Sun Meili Jin Yanhong Li | 2019 | Frontiers of Medicine2019，13，6： | 3 |
| 5 | Comparative Study of Three Warm-season Forage Varieties in Southern China显示文摘The plant height,tiller number,yield of three warm-season forage varieties in Southern China were studied for consecutive two years.The result showed that the three varieties all adapted to the environmental conditions.The annual fresh grass yield of Pennisetum purpureum Schum ev.Taiwan,Guimu-1 hybrid P.purpureum and P.sinese Roxb were 220.85,163.18,186.20 t/hm^2;the crude protein content were 17.39%,19.02%and 20.91%;the crude fat content were 6.37%,5.37%and 4.69%;and the crude fiber content were 33.49%,32.22%and 33.58%,respectively.P.purpureum Schum ev.Taiwan had stronger cold resistance,fast growth after overwintering and strong resistance,and no plant diseases and insect pests were found during the test.P.purpureum Schum ev.Taiwan is a high yield and high quality forage variety,which is worth popularizing and applying. | Sun Ao Deng Huifen Li Caijun Jiang Guitao Zhang Xu Li Jianbo | 2019 | Animal Husbandry and Feed Science2019，11，3： | 2 |
| 6 | RESEARCH ON THE DEFORMATIONS IN QINGHAI_TIBET PLATEAU AND ITS MARGINS BY INVERTING SEISMIC MOMENT TENSORS AND GPS VELOCITIES显示文摘We have determined approximate average rates of deformation in the Qinghai_Tibet plateau and its margins from the GPS data for last 10 years and the moment tensors from earthquakes between 1900 and 1999.We also determined the strain rate (seismic strain rate) associated with the seismic deformation using 254 M w ≥5.0 earthquakes,and estimated the shortening and extension rates for every block in the area as well.We also estimated the strain rate (geodetic strain rate)by 80 GPS sites’ velocity vectors and analyzed characteristic of kinematics by two kinds of strain rates and discussed earthquake potential in the area.As a result,the deformation rates from seismic moment tensors and from GPS velocities are basically agreed with each other.It is feasible to analyze seismic risk by comparing geodetic strain rate with seismic strain rate based on the opinion that strain energy will be released through earthquake.It is concluded that there is no strong earthquake potential (>M7) in the Qinghai_Tibet plateau and its margins,but there is earthquake potential (>M5) in middle Tibet in a few years. | Xu Caijun Liu Jingnan Li Zhicai Dong Lixiang | 2000 | Geo-Spatial Information Science2000，3，4： | 2 |
| 7 | Distinct properties and metabolic mechanisms of postresuscitation myocardial injuries in ventricular fibrillation cardiac arrest versus asphyxiation cardiac arrest in a porcine model显示文摘 | Wu Caijun Li Chunsheng Zhang Yi Yang Jun | 2014 | Chinese Medical Journal2014，，14： | 1 |
| 8 | Coseismic fault model of the 2017 M_(W)6.5 Jiuzhaigou earthquake and implications for the regional fault slip pattern显示文摘On August 8,2017,an M_(W)6.5 earthquake occurred in Jiuzhaigou County,Sichuan Province,China,on the eastern margin of the Qinghai-Tibet Plateau.This study investigates the coseismic deformation field and fault model with ascending and descending Sentinel-1 synthetic aperture radar(SAR)images,aftershock distribution,and elastic half-space dislocation model.The regional fault slip pattern is then quantita-tively examined using the boundary element method.The results show that the ascending and descending interferometric synthetic aperture radar(InSAR)coseismic deformation fields display an overall NNW-SSE trend,with more significant deformation on the southwest side of the fault.The coseismic fault geometry is divided into NW and SE sub-faults with strikes of 162.1°and 149.3°,respectively.The coseismic fault slip is dominated by a left-lateral strike-slip movement with an average rake of-2.31°,mainly occurring at a depth of 0-13.04 km with a shape of an approximately inverted triangle.The fault slip features two peak slip zones,with a maximum of 1.39 m.The total seismic moment is 6.34×10^(18) N·m(M_(W)6.47).The boundary element calculation quantitatively indicates that the regional fault slip pattern may be mainly attributable to the changing strike and dip.The strike changes from NNWeSSE to nearly NS direction,and the dip gradually decreases from the Jiuzhaigou earthquake fault in the north to the Huya fault in the south.With these characteristics,the Huya and the Jiuzhaigou earthquake faults form the eastern boundary of the Minshan uplift zone and accommodate the accumulated deformation. | Yang Liu Yangmao Wen Zhicai Li Ying Peng Caijun Xu | 2022 | Geodesy and Geodynamics2022，13，2： | 1 |
| 9 | Evaluation on the applicability of ERA5 reanalysis dataset to tropical cyclones affecting Shanghai显示文摘Based on the 16 historical tropical cyclones(TCs)affecting Shanghai from 2007 to 2019,the suitability of ERA5 for studying TCs affecting Shanghai is systematically evaluated from the perspective of TC track,intensity,10-m and upper-level wind,using TC best-track data of China Meteorological Administration and surface observations and sounding data.Corresponding to tropical storm(TS),strong tropical storm(STS),typhoon(TY),strong typhoon(STY)and super typhoon(SuperTY),the median TC track bias is 68.1,52.9,42.5,25.4,and 18.2 km,respectively,the median maximum 10-m wind speed(VMAX10m)bias is-3.7,-6.5,-11.4,-21.7,and-32.2 m·s-1,respectively,and the median minimum mean sea level pressure(MSLPmin)bias is 2.2,5.6,8.1,28.2,and 48.7 hPa,respectively.With the increase of TC intensity,the median TC track bias decreases,while the median VMAX10m and MSLPmin bias increase.In general,VMAX10m in ERA5 is lower than observed,and MSLPmin is larger than observed.Under influence of TS,STS,TY and STY,the median 10-m wind speed(V10m)bias in the city is 3.2,4.2,4.7,and 5.4 m·s-1,respectively,and is 4.4-5.2 m·s-1 near the east coast,respectively.V10m is mostly biased high,showing an'M'type pattern with the distance between TC and Shanghai.The median 10 m wind direction(WD10m)bias is in a range of-7° to+7°.The median upper-level wind speed(Vupper)bias decreases with height,with a maximum of~5 m·s-1 at 975 hPa.Below 900 hPa Vupperin ERA5 is typically larger than the radiosonde observation,and its mean bias error(MBE)increases with TC intensity.The upper-level wind direction(WDupper)matches the sounding data well,with a maximum bias of a few degrees only.The results provide a reference for the application of ERA5 to coastal cities affected by TCs. | Zhihui HAN Caijun YUE Changhai LIU Wen GU Yuqi TANG Yongyu LI | 2022 | Frontiers of Earth Science2022，16，4： | 0 |
| 10 | Application of Interval Newton Method to Solve Nonlinear Equations and Global Optimization显示文摘The basic principle of interval arithmetic and the basic algorithm of the interval Newton methods are introduced.The prototype algorithm can not find any zero in an interval that has zero sometimes,that is,it is instable.So the prototype relaxation procedure is improved in this paper.Additionally,an immediate test of the existence of a solution following branch_and_bound is proposed,which avoids unwanted computations in those intervals that have no solution.The numerical results demonstrat that the improved interval Newton method is superior to prototype algorithm in terms of solution quality,stability and convergent speed. | LI Shuang XU Caijun WANG Xinzhou | 2003 | Geo-Spatial Information Science2003，6，1： | 0 |
| 11 | An Improved Method of Joint Inversion Using GPS and Gravity Observation Data显示文摘On the basis of the dislocation theory and gravity observation, a joint inversion model is presented with a fitting factor λ scaling amplitudes between the gravity and GPS observation data. The test results show that the new joint model is better than that taking the scale factor λ as a constant from the inversion result of MSE (mean square error). In addition, the random cost method used in the inversion algorithm is revised and improved, which shows that the improved random cost method can easily get the local minimum value and greatly decrease the iteration steps. | LI Zhicai XU Caijun | 2005 | Geo-Spatial Information Science2005，8，3： | 0 |
| 12 | Modulation of Antiviral Immunity and Therapeutic Efficacy by 25-Hydroxycholesterol in Chronically SIV-Infected, ART-Treated Rhesus Macaques显示文摘Cholesterol-25-hydroxylase(CH25 H)and its enzymatic product 25-hydroxy cholesterol(25 HC)exert broadly antiviral activity including inhibiting HIV-1 infection.However,their antiviral immunity and therapeutic efficacy in a nonhuman primate model are unknown.Here,we report that the regimen of 25 HC combined with antiretroviral therapy(ART),provides profound immunological modulation towards inhibiting viral replication in chronically SIVmac239-infected rhesus macaques(RMs).Compared to the ART alone,this regimen more effectively controlled SIV replication,enhanced SIVspecific cellular immune responses,restored the ratio of CD4/CD8 cells,reversed the hyperactivation state of CD4^(+)T cells,and inhibited the secretion of proinflammatory cytokines by CD4^(^(+))and CD8^(+)T lymphocytes in chronically SIVinfected RMs.Furthermore,the in vivo safety and the preliminary pharmacokinetics of the 25 HC compound were assessed in this RM model.Taken together,these assessments help explain the profound relationship between cholesterol metabolism,immune modulation,and antiviral activities by 25 HC.These results provide insight for developing novel therapeutic drug candidates against HIV-1 infection and other related diseases. | Chunxiu Wu Jin Zhao Ruiting Li Fengling Feng Yizi He Yanjun Li Runhan Huang Guangye Li Heng Yang Genhong Cheng Ling Chen Feng Ma Pingchao Li Caijun Sun | 2021 | Virologica Sinica2021，36，5： | 0 |
| 13 | Response of organic aerosol characteristics to emission reduction in Yangtze River Delta region显示文摘Organic aerosol(OA)is a major component of atmospheric particulate matter(PM)with complex composition and formation processes influenced by various factors.Emission reduction can alter both precursors and oxidants which further affects secondary OA formation.Here we provide an observational analysis of secondary OA(SOA)variation properties in Yangtze River Delta(YRD)of eastern China in response to large scale of emission reduction during Chinese New Year(CNY)holidays from 2015 to 2020,and the COVID-19 pandemic period from January to March,2020.We found a 17%increase of SOA proportion during the COVID lockdown.The relative enrichment of SOA is also found during multi-year CNY holidays with dramatic reduction of anthropogenic emissions.Two types of oxygenated OA(OOA)influenced by mixed emissions and SOA formation were found to be the dominant components during the lockdown in YRD region.Our results highlight that these emission-reduction-induced changes in organic aerosol need to be considered in the future to optimize air pollution control measures. | Jinbo Wang Jiaping Wang Wei Nie Xuguang Chi Dafeng Ge Caijun Zhu Lei Wang Yuanyuan Li Xin Huang Ximeng Qi Yuxuan Zhang Tengyu Liu Aijun Ding | 2023 | Frontiers of Environmental Science & Engineering2023，17，9： | 0 |
| 14 | Electroacupuncture alleviates orofacial allodynia and anxiety-like behaviors by regulating synaptic plasticity of the CA1 hippocampal region in a mouse model of trigeminal neuralgia显示文摘OBJECTIVE To investigate whether electroacupuncture(EA)ameliorates abnormal trigeminal neuralgia(TN)orofacial pain and anxiety-like behavior by altering synaptic plasticity in the hippocampus CA1.METHODS A mouse infraorbital nerve transection model(pTION)of neuropathic pain was established,and EA or sham EA was used to treat ipsilateral acu⁃puncture points(GV20-Baihui and ST7-Xia⁃guan).Golgi-Cox staining and transmission elec⁃tron microscopy(TEM)were administrated to observe the changes of synaptic plasticity in the hippocampus CA1.RESULTS Stable and persistent orofacial allodynia and anxiety-like behav⁃iors induced by pT-ION were related to changes in hippocampal synaptic plasticity.Golgi stain⁃ings showed a decrease in the density of dendritic spines,especially mushroom-type dendritic spines,in hippocampal CA1 neurons of pT-ION mice.TEM results showed that the density of synapses,membrane thickness of the postsynaptic density,and length of the synaptic active zone were decreased,whereas the width of the synaptic cleft was increased in pTION mice.EA attenu⁃ated pT-ION-induced orofacial allodynia and anx⁃iety-like behaviors and effectively reversed the abnormal changes in dendritic spines and syn⁃apse of the hippocampal CA1 region.CONCLU⁃SION EA modulates synaptic plasticity of hippo⁃campal CA1 neurons,and reduces abnormal oro⁃facial pain and anxiety-like behavior,providing evidence for a TN treatment strategy. | JIA Yuzhi LI Haitao ZHANG Guangming WU Hongyun ZHANG Sishuo ZHI Hongwei WANG Yahan ZHU Jingwen WANG Yifan XU Xiangqing TIAN Caijun CUI Wenqiang | 2023 | 中国药理学与毒理学杂志2023，37，S01： | 0 |
| 15 | TEMPORAL SPATIAL VARIATION CHARACTERISTICS OF CRUST DEFORMATION OF ACTIVE TECTONIC BLOCKS IN NORTH CHINA显示文摘Global Positioning System (GPS) observations during four measurement campaigns from 1992 to 1999 are used in a study of the temporal and spatial variation characteristics of crustal deformation of active tectonic blocks in North China. The Euler vectors for these active blocks are determined on the basis of GPS velocities of a group relative stable points in 1992,1995,1996 and in 1996,1999 respectively. We have studied the relative motion between blocks at the boundaries and the intra block deformation field. We have also inverted the strain rate fields for these active blocks by bi cubic spline model based on the GPS velocity field. The results show that the intra block deformation rates are different from those in block boundary zones, and are also different in different periods; the deformational field is generally characterized by intra-block extension in North China. | Xu Caijun, Li Zhicai and Wang Hua (School of Geodesy and Geomatics, Wuhan University, Wuhan 430079,China) | 2003 | 大地测量与地球动力学2003，23，B12： | 0 |
| 16 | Optimization of yield criterion and simulation based on QP980 high strength steel显示文摘QP980 is an ultra high strength steel.First,uniaxial and biaxial tension tests have been done in different loading paths.Then QP980 basic mechanical properties have been obtained.And the stress and strain graph has been drawn.Second,according to the equal principle of the unit volume plastics work and yield stress,QP980 plastic work contour map has been drawn.Third,through comparing Mises,Hill'48,Hosford and Barlat89 yield criterion theoretical curves with the experimental plastic work contour map,the result shows that the Hill'48 yield criterion is in good conformity with the QP980 material.Fourth,Hill'48 yield criterion is optimized by introducing an equivalent plastic strain parameter.The result shows that average error of optimized Hill'48 theoretical yield trajectory is reduced by 8.4%.Last,finite element model about variable cross-section roll forming is established,then applying the optimized Hill'48 parameter yield criterion to the ABAQUS for finite element simulation.The simulation result shows that the forming quality is good,and in agreement with the actual forming parts.Therefore,the optimized Hill'48 yield criterion can be used to precisely describe QP980 ultra high strength steel. | 管延智 Li Caijun Wang Haibo Jiang Yuan | 2020 | High Technology Letters2020，26，1： | 0 |
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