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| 1 | Water in the upper mantle and deep crust of eastern China: concentration, distribution and implications显示文摘Understanding the concentration and distribution of water in the Earth's mantle plays a substantial role in studying its chemical, physical and dynamic processes. After a decade of research, a comprehensive dataset of water content in upper-mantle samples has been built for eastern China, which is now the only place with water-content data from such diverse types of natural samples, and provides an integrated picture of the water content and its distribution in the upper mantle at a continental scale. The main findings include the following:(i) the temporal heterogeneity of the water content in the lithospheric mantle from early Cretaceous(~120 Ma) to Cenozoic(<40 Ma) was tightly connected with the stability of the North China Craton(from its destruction to its consolidation);(ii) the heterogeneous water content in the Cenozoic lithospheric mantle beneath different blocks of eastern China was not only inherited from tectonic settings from which they came, but was also affected later by geological processes they experienced;(iii) the distinct water content between the lowermost crust and lithospheric mantle of eastern China and its induced rheological contrast at the base of the crust indicate that the continental crust–mantle boundary could behave either in a coupled or decoupled manner beneath different areas and/or at different stages;(iv) the alkali basalts of eastern China demonstrate a heterogeneous distribution of water content in the mantle;local and regional comparisons of the water content between the lithospheric mantle and basalts' source indicate that the Cenozoic alkali basalts in eastern China were not sourced from the lithospheric mantle.Instead, the inferred high water contents in the mantle sources suggest that the Cenozoic eastern China basalts were likely sourced from the mantle transition zone(MTZ); and(v) both oceanic and continental crusts may carry a certain amount of water back into the deep mantle of eastern China by plate subduction.Such recycled crustal materials have not only created a local water-rich zone, but have also introduced crustal geochemical signatures into the mantle, both accounting for crustal geochemical imprints in the intra-plate magmatic rocks of eastern China. | Qun-Ke Xia Jia Liu István Kovács Yan-Tao Hao Pei Li Xiao-Zhi Yang Huan Chen Ying-Ming Sheng | 2019 | National Science Review2019，6，1： | 16 |
| 2 | 血清netrin-1增加与缺血性脑卒中预后改善相关显示文摘先前的实验研究表明,血清netrin-1与缺血性脑卒中进展相关。进一步了解缺血性脑卒中患者中netrin-1的变化可能为缺血性脑卒中的预后评估提供新的思路。该研究旨在探讨血清netrin-1与缺血性脑卒中预后的关系。研究人员测定3346例中国急性缺血性脑卒中抗高血压试验(China antihypertensive trial in acute ischemic stroke,CATIS)中缺血性脑卒中患者基线血清netrin-1水平,所有患者均在脑卒中发病后3个月进行随访。主要观察指标是脑卒中发病后3个月内死亡和严重残疾(改良Rankin 量表评分≥3)。 | 刘莉 叶鹏 Guo D Zhu Z Zhong C Peng H Wang A Xu T Peng Y Xu T Chen CS Li Q Ju Z Geng D Chen J Zhang Y He J | 2019 | 中华高血压杂志2019，27，5： | 6 |
| 3 | Elderly healthcare service at the community health centers in the Pearl River Delta region,China显示文摘Objective:The recent population census showed China had officially become a graying society.In the meantime,China also faces a growing burden of non-communicable diseases.Since 2009,a series of policies have been implemented to enhance primary care at the community level.This study describes the elderly care services provided in the differently organized community health centers(CHCs).Methods:It covered 13 CHCs of six cities located within the Pearl River Delta(PRD)region.In-depth interviews were conducted with a total of 59 health administrators,CHC managers,and CHC doctors regarding elderly care.Results:The study found that accessibility of healthcare for elders has been improved due to the development of health insurance schemes as well as preferential policy to encourage the CHC utilization by the elderly.All the CHCs provide health examinations and chronic disease management to the permanent elderly within their catchment district.However,some preventative care such as fall prevention,immunization and mental health management are not provided.Conclusion:Key barriers include low capacity of health service providers in the CHCs,and a lack of government investment in CHCs.Our report provides an empirical evidence for the health care reform in China. | NAN YANG XIAOLIN WEI HAITAO LI ZHENZHEN ZHANG JAMIE RODAS SAMUEL YS WONG MARTIN CS WONG YANG GAO JIAJI WANG DONALD KT LI JINLING TANG SIAN GRIFFITHS | 2013 | Family Medicine and Community Health2013，1，1： | 5 |
| 4 | A meta-analysis of soluble suppression of tumorigenicity 2 (sST2) and clinical outcomes in pulmonary hypertension显示文摘 | King Sum Luk Christina Ip Meng-Qi GONG Sunny Hei WONG William KK Wu Mei DONG Guang-Ping LI Ka Pang Chan Yi-Mei DU Tong LIU Martin CS Wong David Shu Cheong Hui Gary Tse | 2017 | Journal of Geriatric Cardiology2017，14，12： | 5 |
| 5 | Air quality monitoring using mobile microscopy and machine learning显示文摘Rapid,accurate and high-throughput sizing and quantification of particulate matter(PM)in air is crucial for monitoring and improving air quality.In fact,particles in air with a diameter of≤2.5μm have been classified as carcinogenic by the World Health Organization.Here we present a field-portable cost-effective platform for high-throughput quantification of particulate matter using computational lens-free microscopy and machine-learning.This platform,termed c-Air,is also integrated with a smartphone application for device control and display of results.This mobile device rapidly screens 6.5 L of air in 30 s and generates microscopic images of the aerosols in air.It provides statistics of the particle size and density distribution with a sizing accuracy of~93%.We tested this mobile platform by measuring the air quality at different indoor and outdoor environments and measurement times,and compared our results to those of an Environmental Protection Agency–approved device based on beta-attenuation monitoring,which showed strong correlation to c-Air measurements.Furthermore,we used c-Air to map the air quality around Los Angeles International Airport(LAX)over 24 h to confirm that the impact of LAX on increased PM concentration was present even at 47 km away from the airport,especially along the direction of landing flights.With its machinelearning-based computational microscopy interface,c-Air can be adaptively tailored to detect specific particles in air,for example,various types of pollen and mold and provide a cost-effective mobile solution for highly accurate and distributed sensing of air quality. | Yi-Chen Wu Ashutosh Shiledar Yi-Cheng Li Jeffrey Wong Steve Feng Xuan Chen Christine Chen Kevin Jin Saba Janamian Zhe Yang Zachary Scott Ballard Zoltán Göröcs Alborz Feizi Aydogan Ozcan | 2017 | Light(Science & Applications)2017，6，1： | 5 |
| 6 | Discovery and validation of prognostic markers in gastric cancer by genome-wide expression profiling显示文摘AIM: To develop a prognostic gene set that can predict patient overall survival status based on the whole genome expression analysis. METHODS: Using Illumina HumanWG-6 BeadChip followed by semi-supervised analysis, we analyzed the expression of 47 296 transcripts in two batches of gastric cancer patients who underwent surgical resection. Thirty-nine samples in the first batch were used as the training set to discover candidate markers correlated to overall survival, and thirty-three samples in the second batch were used for validation. RESULTS: A panel of ten genes were identified as prognostic marker in the first batch samples and classified patients into a lowand a high-risk group with significantly different survival times (P = 0.000047). This prognostic marker was then verified in an independent validation sample batch (P = 0.0009). By comparing with the traditional Tumor-node-metastasis (TNM) staging system, this ten-gene prognostic marker showed consistent prognosis results. It was the only independent prognostic value by multivariate Cox regression analysis (P = 0.007). Interestingly, six of these ten genes are ribosomal proteins, suggesting a possible association between the deregulation of ribosome related gene expression and the poor prognosis. CONCLUSION: A ten-gene marker correlated with overall prognosis, including 6 ribosomal proteins, was identified and verified, which may complement the predictive value of TNM staging system. | Yue-Zheng Zhang Lian-Hai Zhang Yang Gao Chao-Hua Li Shu-Qinjia Ni Liu Feng Cheng De-Yun Niu William CS Cho Jia-Fu Ji Chang-Qing Zeng | 2011 | World Journal of Gastroenterology2011，17，13： | 5 |
| 7 | 持续气道正压通气在预防阻塞性睡眠呼吸暂停患者心血管事件中的作用显示文摘阻塞性睡眠呼吸暂停(obstructive sleep apnea,OSA)导致阵发性低氧血症,夜间交感神经系统激活,血压、氧化应激和炎症指标的升高以及高凝血症。较大的胸内负压波动也会给心脏和大血管施加机械应力。基于人群和睡眠诊所的队列研究显示,OSA与心脑血管事件,特别是脑卒中相关。 | McEvoy RD Antic NA Heeley E Luo Y Ou Q Zhang X Mediano O Chen R Drager LF Liu Z Chen G Du B McArdle N Mukherjee S Tripathi M Billot L Li Q Lorenzi-Filho G Barbe F Redline S Wang J Arima H Neal B White DP Grunstein RR Zhong N Anderson CS 练桂丽 叶鹏 | 2016 | 中华高血压杂志2016，24，11： | 4 |
| 8 | The gene expression fingerprint of human heart failure显示文摘 | Tan FL Moravec CS Li J | 2002 | Proc Natl Acad Sci U S A2002，99，11： | 2 |
| 9 | Attitudes of Ch-inesemedical students towardthe IIME GlobalMinimum Essential Require-ments显示文摘 | Zhang X Li X Wan X Zeng C Scott CS Schaad DC | 2004 | Teaching and Learning in Medicine2004，16，2： | 1 |
| 10 | Simultaneous determination and pharmacokinetic studies on (3,4-Dihydroxyphenyl)-lactic acid and protocatechuic aldehyde in rat serum after oral administration of Radix Salviae miltiorrhizae extract显示文摘 | Ye G Wang CS Li YY | 2003 | J Chromatogr Sci2003，41，6： | 1 |
| 11 | Cellular versus acellular ma- trix devices in treatment of diabetic foot ulcers : study protocol for a comparative efficacy randomized controlled trial 显示文摘 | Lev-Tov H Li CS Dahle S | 2013 | Trials2013，14，： | 1 |
| 12 | Diffusion tensor imaging in the assessment of normal appearing brain tissue damage in relap- sing neuromyelitis optiea显示文摘 | Yu CS Lin FC Li KC | 2006 | Am J Neuroradiol2006，27，5： | 1 |
| 13 | Less is More:Ebola Surface GlycoproteinExpression Levels Regulate Virus Production and Infectivity显示文摘 | Mohan CS Ye L Li IW | 2014 | Jour-nal of virology2014，89，2： | 1 |
| 14 | Responsiweness to reduced dosage of rituximab in Chinese patients with neuromyelitis optica 显示文摘 | Yang CS Yang L Li T | 2013 | Neurology2013，81，8： | 1 |
| 15 | Cancer prevention by tea: evidence from laboratory studies 显示文摘 | Yang CS Wang H Li GX | 2011 | Pharmacol Res2011，64，2： | 1 |
| 16 | Covalent functlonalization of chemically converted graphene sheets via silane and its reinforcement显示文摘 | Yang HF Li FH Shan CS | 2009 | Journal of Materials Chemistry2009，19，26： | 1 |
| 17 | Circulating adipo-neetin levels are associated with better glyeernie control, more favorable liquid profile, and reduced inflammation in women with type 2 diabetes显示文摘 | Mantzoros CS Li T Mansn JE | 2005 | Clin Eedocrinol Metab2005，90，： | 1 |
| 18 | Surgical improvement of brain edema related to hypertensive intracerebral hemorrahage 显示文摘 | Huang CF Tsai ZP Li CS | 2002 | Zhonghua Yi Xue Za Zhi( TAIBEI )2002，65，6： | 1 |
| 19 | Brain self-protection: the role of endogenous neural progenitor cells in adult brain after cer- ebral cortical ischemia显示文摘 | Li B Piao CS Liu XY | 2010 | Brain Res2010，1327，1： | 1 |
| 20 | Extracranial carotid artery disease in nasopharyngeal carcinoma patients with post-irradiation ischemic stroke显示文摘 | Li CS Schminke U Tan TY | 2010 | Clin Neurol Neurosurg2010，112，： | 1 |
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