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| 1 | Expression of IGF-Ⅱ,p53,p21 and HBxAg in precancerous events of hepatocarcinogenesis induced by AFBI and/or HBV in tree shrews显示文摘INTRODUCTIONIn order to study the relationship between oncogeneexpression and HCC generation,we observed theprecancerous hepatic GGT loci,IGF-Ⅱ,p53 andp21 expression during hepatocarcinogenesis of treeshrew induced by hepatitis B virus (HBV) and/oraflatoxin B1 (AFB1). | Qin LL Su JJ Li Y Yang C Ban KC Yian RQ | 2000 | World Journal of Gastroenterology2000，6，1： | 37 |
| 2 | Identification of tumor associated single-chain Fv by panning and screening antibody phage library using tumor cells显示文摘AIM:To study the feasibility of panning and screeningphage-displaying recombinant single-chain variablefragment (ScFv) of anti-tumor monoclonal antibodiesfor fixed whole cells as the carriers of mAb-bindingantigens.ME,ODS: The recombinant phage displaying librariesfor anti-colorectal tumor mAb MC3Ab, MC5Ab andanti-gastric tumor mAb MGD1 was constructed.Panning and screening were carried outby means ofmodified fixation of colorectal and gastric tumor cellsexpressed the mAb-binding antigens. Concordance ofbinding specificity to tumor cells between phageclones and parent antibodies was analyzed. Thephage of positive clones was identified withcompetitive ELISA, and infected by E.coli HB2151 toexpress soluble ScFv.RESULTS:The ratio of positive clones to MC3-ScF-MC5-ScFv and MGD1-ScFv were 60 %, 24 % and 30 %. MC3-ScFv had Mr 32 000 confirmed by Western blot. Thespecificity to antigen had no difference between 4positive recombinant phage antibodies and MC3Ab.CONCLUSION:The modified process of fixing wholetumor cells is efficient, convenient and feasible to panand screen the phage-displaying ScFv of anti-tumormonoclonal antibodies. | Nie, YZ He, FT Li, ZK Wu, KC Cao, YX Chen, BJ Fan, DM | 2002 | World Journal of Gastroenterology2002，8，4： | 12 |
| 3 | Plastins regulate ectoplasmic specialization via its actin bundling activity on microfilaments in the rat testis显示文摘Plastins 是在哺乳动物的房间为交叉结合肌动朊微细丝所知的肌动朊绑定蛋白质(ABP ) 的一个家庭,创造必要的肌动朊微细丝捆授与房间极性和房间形状。Plastins 也在环境响应变化支持房间运动,在房间 / 织物生长和开发包含了。他们也响应感染或另外的病理学的条件授与粘性到房间和纸巾(例如,发炎) 。在睾丸,房间房间对在血睾丸障碍(BTB ) 并且在 Sertoli-spermatid 在 Sertoli 房间房间接口被发现的睾丸唯一的抛锚的连接(例如,在老鼠睾丸的 8-19 spermatids ) 基础并且顶端的 ectoplasmic 专门化(ES ) 分别地。ES 是抛锚的 F-actin-rich 最尤其是肌动朊微细丝捆组成的连接。3 关于由 plastin, 3 调整肌动朊微细丝的地位的机制产出一些深刻信息的用明确地将 plastin 击倒的 RNAi 的一份最近的报告经由它的内在的肌动朊细丝捆绑活动在 ES 绑。此处,我们考虑到这份报告在睾丸在 plastins 的角色上提供简短评论,它和这块地里的最近的调查结果,我们建议由哪个 plastins 在老鼠睾丸在肌动朊微细丝组织上经由他们的内在的活动在精子发生的上皮的周期期间调整 ES 功能的一个可能的模型。 | Nan Li Chris KC Wong C Yan Cheng | 2016 | Asian Journal of Andrology2016，18，5： | 3 |
| 4 | Liver transplantation for a giant mesenchymal hamartoma of the liver in an adult: Case report and review of the literature显示文摘Mesenchymal hamartomas of the liver(MHLs) in adults are rare and potentially premalignant lesions, which present as solid/cystic neoplasms. We report a rare case of orthotopic liver transplantation in a patient with a giant MHL. In 2013, a 34-year-old female sought medical advice after a 2-year history of progressive abdominal distention and respiratory distress. Physical examination revealed an extensive mass in the abdomen. Computed tomography(CT) of her abdomen revealed multiple liver cysts, with the diameter of largest cyst being 16 cm × 14 cm. The liver hilar structures were not clearly displayed. The adjacent organs were compressed and displaced. Initial laboratory tests, including biochemical investigations and coagulation profile, were unremarkable. Tumor markers, including levels of AFP, CEA and CA19-9, were within the normal ranges. The patient underwent orthotopic liver transplantation in November 2013, the liver being procured from a 40-year-old man after cardiac death following traumatic brain injury. Warm ischemic time was 7.5 min and cold ischemic time was 3 h. The recipient underwent classical orthotopic liver transplantation. The recipient operative procedure took 8.5 h, the anhepatic phase lasting for 1 h without the use of venovenous bypass. The immunosuppressive regimen includedintraoperative induction with basiliximab and high-dose methylprednisolone, and postoperative maintenance with tacrolimus, mycophenolate mofetil, and prednisone. The recipient's diseased liver weighed 21 kg(dry weight) and measured 41 cm × 32 cm × 31 cm. Histopathological examination confirmed the diagnosis of an MHL. The patient did not experience any acute rejection episode or other complication. All the laboratory tests returned to normal within one month after surgery. Three months after transplantation, the immunosuppressive therapy was reduced to tacrolimus monotherapy, and the T-tube was removed after cholangiography showed no abnormalities. Twelve months after transplantation, the patient remains well and is fulfilling all normal activities. Adult giant MHL is extremely rare. Symptoms, physical signs, laboratory results, and radiographic imaging are nonspecific and inconclusive. Surgical excision of the lesion is imperative to make a definite diagnosis and as a cure. Liver transplantation should be considered as an option in the treatment of a non-resectable MHL. | Jiang Li Jin-Zhen Cai Qing-Jun Guo Jun-Jie Li Xiao-Ye Sun Zhan-Dong Hu David KC Cooper Zhong-Yang Shen | 2015 | World Journal of Gastroenterology2015，21，20： | 3 |
| 5 | Another to treat Ktimmell's disease with cord compression显示文摘 | Li KC Li AF Hsich CH | 2007 | Eur Spine J2007，16，9： | 1 |
| 6 | Diffusion tensor imaging in the assessment of normal appearing brain tissue damage in relap- sing neuromyelitis optiea显示文摘 | Yu CS Lin FC Li KC | 2006 | Am J Neuroradiol2006，27，5： | 1 |
| 7 | Altered spinal microRNA-146a and the microRNA-183 cluster contribute to osteoarthritic pain in knee joints显示文摘 | Li X Kroin JS Kc R | 2013 | J Bone Miner Res2013，28，12： | 1 |
| 8 | Glutamine modulates LPS-induced IL-8 production through IkappaB/NF-kappaB in human fetal and adult intestinal epithelium显示文摘 | Liboni KC Nan Li Seumpia PO | 2005 | J Nutr2005，135，2： | 1 |
| 9 | Staging of Kümmell′s disease显示文摘 | Li KC Wong TU Kung FC | 2004 | J Musculoskeletal Res2004，8，2： | 1 |
| 10 | Another option to treat Kümmell′s disease with cord compression显示文摘 | Li KC Li AF Hsieh CH | 2007 | Eur Spine J2007，16，9： | 1 |
| 11 | Blood pressure components and end-stage renal disease in persons with chronic kidney disease : the kidney early evaluation program (KEEP)显示文摘 | Peralta CA Norris KC Li S | 2012 | Arch Intern Med2012，172，1： | 1 |
| 12 | Synthesis and biological evaluation of 12,13-cyclopropyl and 12,13-cyclobutyl epothilone 显示文摘 | Nicolaou KC Namoto K Li J | 2001 | Chembiochem2001，2，1： | 1 |
| 13 | Elevated plasma CD105 and vitreous VEGF levels in diabetic retinopathy显示文摘 | Malik RA Li C Aziz W Oslon JA Vohra A McHardv KC | 2005 | J Cell Mol Med2005，9，3： | 1 |
| 14 | Ethyl pyruvate reducesventilation - induced neutrophil infiltration and oxidative stress显示文摘 | Li LF Kao KC Yang GT | 2012 | Exp Biol Med (Maywood)2012，237，6： | 1 |
| 15 | Effect of oral contraceptives on the transport of chlorpromazine across the CACO-2 intestinal epithelial cell line显示文摘 | Cheng KC Li C Hsieh YS | 2003 | Eur J Pharm Biopharm2003，56，2： | 1 |
| 16 | Another option to treat Kummell S disease with cord compression 显示文摘 | Li KC Li AF Hsieh CH | 2007 | Eur Spine J2007，16，9： | 1 |
| 17 | Diffusion tensor imaging in the assessment of normal-appearing brain tissue damage in relap- sing neuromyelitis optica 显示文摘 | Yu CS Lin FC Li KC | 2006 | AJNR2006，27，： | 1 |
| 18 | BRAF V600E mutation andits association with clinicopathological features of papillary thyroidcancer:a meta-analysis显示文摘 | Li C Lee KC Schneider EB | 2012 | J Clin Endocrinol Metaib2012，97，45： | 1 |
| 19 | Medical and neurological complieations of isehemic stroke:experience from the RANTTAS trial显示文摘 | Johnston KC Li JY Lyden PD | 1998 | Stroke1998，29，： | 1 |
| 20 | Medical and neurological complications of isehemic stroke: Experience from the RAN TTAS trial显示文摘 | Johonston KC Li JY Luden PD | 1998 | Sroke1998，29，： | 1 |
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