|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 非酒精性脂肪性肝病中脂毒性肝细胞来源的外泌体miR-192-5p通过Rictor/Akt/FoxO1信号通路激活巨噬细胞显示文摘【据Hepatology 2020年5月报道】题:非酒精性脂肪性肝病中脂毒性肝细胞来源的外泌体miR-192-5p通过Rictor/Akt/FoxO1信号通路激活巨噬细胞(作者Liu XL等)肝脏巨噬细胞可被多种因素如肠道菌群代谢物以及受损的肝细胞释放物等激活。在非酒精性脂肪性肝病(NAFLD)的发生发展中,巨噬细胞向促炎表型(M1)的极化是一个重要的病理生理过程。外泌体可传递多种生物学成分如microRNA、蛋白质以及脂质等,因此被作为细胞间通讯的重要媒介。在NAFLD的发生发展过程中,外泌体在肝细胞与巨噬细胞对话中的作用尚未明确。 | 刘晓琳 范建高 LIU XL PAN Q CAO HX | 2020 | 临床肝胆病杂志2020，36，10： | 28 |
| 2 | Clarithromycin resistance in Helicobacter pylori and its clinical relevance显示文摘 | Xia HX Fan XG Talley NJ | 1999 | World Journal of Gastroenterology1999，5，3： | 26 |
| 3 | Use of second generation contrast-enhanced ultrasound in the assessment of focal liver lesions显示文摘Ultrasound (US) is often the first imaging modality employed in patients with suspected focal liver lesions. The role of US in the characterisation of focal liver lesions has been transformed with the introduction of specific contrast media and the development of specialized imaging techniques. Ultrasound now can fully characterise the enhancement pattern of hepatic lesions, similar to that achieved with contrast enhanced multiphasic computed tomography (CT) and magnetic resonance imaging (MRI). US contrast agents are safe, well-tolerated and have very few contraindications. Furthermore, real-time evaluation of the vascularity of focal liver lesions has become possible with the use of the newer microbubble contrast agents. This article reviews the enhancement pattern of the most frequent liver lesions seen, using the second generation US contrast media. The common pitfalls for each type of lesion are discussed. The recent developments in US contrast media and specific imaging techniques have been a major advance and this technique, in view of the intrinsic advantages of US, will undoubtedly gain popularity in the years to come. | Stanislas HX Morin Adrian KP Lim eremy FL Cobbold Simon D Taylor-Robinson | 2007 | World Journal of Gastroenterology2007，13，45： | 16 |
| 4 | DSA analysis of hepatic arteriovenous fistula concurrent with hepatic cancer and its clinical significance显示文摘INTRODUCTIONIntervention therapy has become one of the maintherapies of hepatic cancer.Theintroduction of hepatic arterial perfusion andembolization has provided opportunities for asecondary operation on patients with intermediateand advanced cancer,thus | Guo WP Zhang HX Wang ZM Wang YQ Ni DH Li WX Guan Y | 2000 | World Journal of Gastroenterology2000，6，6： | 11 |
| 5 | The production of polyhydroxyalkanoates in recombinant Escherichia coli显示文摘 | Li, R Zhang, HX Qi, QS | 2007 | 中国生物学文摘2007，21，10： | 8 |
| 6 | Expression of aspartyl beta-hydroxylase and its clinicopathological significance in hepatocellular carcinoma显示文摘 | Xian ZH Zhang SH Cong WM Yan HX Wang K Wu MC | 2006 | 第二军医大学学报2006，27，5： | 6 |
| 7 | Celecoxib-related gastroduodenal ulcer and cardiovascular events in a randomized trial for gastric cancer prevention显示文摘AIM: To evaluate the long-term risk of gastroduodenal ulcer and cardiovascular events induced by celecoxib in a population-based, randomized, double-blind, placebo-controlled study.METHODS: From 2004 to 2006, a total of 1024 Chinese patients (aged 35 to 64 years) with severe chronic atrophic gastritis, intestinal metaplasia or dysplasia were randomly assigned to receive 200 mg of celecoxib twice daily or placebo in Linqu County (Shandong Province, China), a high-risk area of gastric cancer. All gastroduodenal ulcer and cardiovascular events occurred were recorded and the patients were followed up for 1.5 years after treatment. At the end of the trial, a systematic interview survey about other adverse events was conducted. RESULTS: Gastroduodenal ulcer was detected in 19 of 463 (3.72%) patients who received celecoxib and 17 of 473 (3.31%) patients who received placebo, respectively (odds ratio = 1.13, 95% CI = 0.58-2.19). Cardiovascular (CV) events occurred in 4 patients who received celecoxib and in 5 patients who received placebo, respectively. Compared with those who received placebo, patients who received celecoxib had no signif icant increase in occurrence of CV events (hazard ratio = 0.84, 95% CI = 0.23-3.15). Among the adverse events acquired by interview survey, only the frequency of bloating was signif icantly higher in patients treated with celecoxib than in those treated with placebo. CONCLUSION: Treatment of gastric cancer with celecoxib is not associated with increased risk of gastroduodenal ulcer and cardiovascular events. | Guo-Shuang Feng Jun-Ling Ma Benjamin CY Wong Lian Zhang Wei-Dong Liu Kai-Feng Pan Lin Shen Xiao-Dong Zhang Jie Li Harry HX Xia Ji-You Li Shiu Kum Lam Wei-Cheng You | 2008 | World Journal of Gastroenterology2008，14，28： | 4 |
| 8 | Mismatch repair processing of carcinogenDNA adducts triggers apoptosis 显示文摘 | Wu JX Gu LY Wang HX | 1999 | Mol Cell Biol1999，19，12： | 2 |
| 9 | Partitioning regularity of nonionic organic mixtures in organic phase/water system显示文摘The partitioning regularity of nonionic organic mixtures in organic phase/water system is revealed. The equation for calculating the partition coefficients of mixtures (KMD), together with the determination model, is derived from the equilibrium partitioning models (EPMs). Based on these derived equations, the KMD values of 20 mixtures containing halogenated benzenes are obtained. The results show that stronger hydrophobidty of an individual chemical in the mixture results in the stronger hydrophobidty of the mixture and the greater the proportion of this chemical, the stronger the hydrophobidty of the mixture will be. This partitioning regularity is helpful to the study of the toxicity for mixtures and the environmental behavior, such as transfer or accumulation, for mixed organic pollutants. | Lin, ZF Yu, HX Huang, LM Feng, JF Wang, LS | 2001 | Chinese Science Bulletin2001，46，17： | 2 |
| 10 | Altered expression of MAP-2,GAP-43,and synaptophysin in the hippocampus of rats with chronic cerebral hypoperfusion correlates with cognitive impairment显示文摘 | Liu HX Zhang JJ Zheng P | | Brain Research Molecular Brain Research0，，： | 2 |
| 11 | Effect of Prior Deformation on Aging Process in a Cu-30Ni-25Fe Spinodal Alloy显示文摘The efFect of prior deformation on the mechanical properties and microstructural evolution ofaging process in a Cu-30Ni-25Fe (in at. pct) alloy has been studied by tensile test, hardness measurement. SEM and optical microscopy analysis. The results show that spinodal decomposition and recovery process interact on each other when aged at low temperature (600℃),and most of the defects induced by cold-work did not disappear in 100 h. When aged at high temperature (850℃), the discontinuous coarsening of the spinodal products takes place. The increase in yield strength and elongation of the sample aged at 850℃ for 5 h after deformation mainly results from the submicrometer grains produced by discontinous coarsening of | Hao, XJ Li, HX Zhao, G Hao, SM | 1999 | Journal of Materials Science & Technology1999，15，6： | 2 |
| 12 | 人血清对幽门螺杆菌生长的影响显示文摘将幽门螺杆菌 (Hp)分别接种于含有新鲜羊血、不同状况人血清或小牛血清的培养基行微需氧培养 ,然后计数生长的菌落数。结果显示Hp可在含人血清或小牛血清培养基上生长 ,但生长效果略差于含羊血培养基 (P >0 .0 5 )。人血清抗Hp IgG抗体不影响Hp的生长 ,但未经补体灭活的人血清明显抑制Hp生长 (P <0 .0 1)。提示在条件受限的医院可用补体灭活的人血清或小牛血清替代羊血用于Hp培养 ;人血清对Hp的杀伤活性与抗Hp抗体无关 ,而与补体介导作用密切相关。 | 范学工 李铁刚 Harry HX Xia | 2000 | 湖南医科大学学报2000，5，4： | 2 |
| 13 | Insulin-like growth factor(IGF) gene expression is reduced in neural tissues and liver from rats with non-insulin-dependent diabetes mellitus,and IGF treatment ameliorates diabetic neuropathy显示文摘 | Wuarin L Fei ZJ | 1997 | J Pharmacol Exp Ther1997，283，1： | 1 |
| 14 | Haemolytic activity and adjuvant effect of Notoginsenoside K from the roots of Panax notoginseng显示文摘 | Sun HX Ye YP | 2006 | Chemistry & Biodiversity2006，3，10： | 1 |
| 15 | Dual knockdown of N-ras and epiregulin synergistically suppressed the growth of human hepatoma cells显示文摘 | Zhao M He HW Sun HX | 2009 | Biochem Biophys Res Commun2009，387，2： | 1 |
| 16 | Short telomeres and prognosis of hypertension in a Chinese popula- tion显示文摘 | Yang ZW Huang X Jiang H Zhang YR Liu HX Qin C | 2009 | Hypertension2009，53，4： | 1 |
| 17 | The transmembranehyaluronidase receptor (CD44):multiple functions,multipleforms显示文摘 | Haynes BF Liao HX Patton KL | 1991 | Cancer Cell1991，3，9： | 1 |
| 18 | Pregnancy outcome in gestational diabetes显示文摘 | Fan ZT Yang HX Gao XL | | 0，，： | 1 |
| 19 | Risk factors of pre-eclampsia in Chinese pregnant women with abnormal glucose metabolism显示文摘 | Sun Y Yang HX Sun WJ | 2008 | Int J Gynecol Obstet2008，99，7： | 1 |
| 20 | Endotoxin accumulation prevents car-cinogen-induced apoptosis and promotes liver tumorigenesis inrodents显示文摘 | Yu LX Yan HX Liu Q | 2010 | Hepatology2010，52，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员