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| 1 | Chronic myeloid leukemia-from the Philadelphia chromosome to specific target drugs:A literature review显示文摘Chronic myeloid leukemia(CML)is a myeloproliferative neoplasm and was the first neoplastic disease associated with a well-defined genotypic anomaly―the presence of the Philadelphia chromosome.The advances in cytogenetic and molecular assays are of great importance to the diagnosis,prognosis,treatment,and monitoring of CML.The discovery of the breakpoint cluster region(BCR)-Abelson murine leukemia(ABL)1 fusion oncogene has revolutionized the treatment of CML patients by allowing the development of targeted drugs that inhibit the tyrosine kinase activity of the BCR-ABL oncoprotein.Tyrosine kinase inhibitors(known as TKIs)are the standard therapy for CML and greatly increase the survival rates,despite adverse effects and the odds of residual disease after discontinuation of treatment.As therapeutic alternatives,the subsequent TKIs lead to faster and deeper molecular remissions;however,with the emergence of resistance to these drugs,immunotherapy appears as an alternative,which may have a cure potential in these patients.Against this background,this article aims at providing an overview on CML clinical management and a summary on the main targeted drugs available in that context. | Mariana Miranda Sampaio Maria Luísa Cordeiro Santos Hanna Santos Marques Vinícius Lima de Souza Gonçalves Glauber Rocha Lima Araújo Luana Weber Lopes Jonathan Santos Apolonio Camilo Santana Silva Luana Kauany de SáSantos Beatriz Rocha Cuzzuol Quézia Estéfani Silva Guimarães Mariana Novaes Santos Breno Bittencourt de Brito Filipe Antônio França da Silva Márcio Vasconcelos Oliveira Cláudio Lima Souza Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，2： | 3 |
| 2 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 3 | Human neural stem cells improve cognitive function of aged brain 显示文摘 | Brannen CL Kim HM | 2001 | Neuroreport2001，12，6： | 1 |
| 4 | The short- and long-term outcomes of laparoscopic versus open surgery for colorectal cancer: a meta-analysis显示文摘 | Wang CL Qu G Xu HW | 2014 | Int J Colorectal Dis2014，29，3： | 1 |
| 5 | GABAergic modulation is involved in the ventrolateral orbital cortex 5-HT1A-induced antinociception in the rat 显示文摘 | Huo FQ Qu CL Li YQ | 2008 | Pain2008，139，： | 1 |
| 6 | Human neural stem cells improve cognitive function of aged brain显示文摘 | Qu T Brannen CL Kim HM | 2001 | Neuroreport2001，12，6： | 1 |
| 7 | Comparison between microwave and conventional thermal reactivations of spent activated carbon generated from vinyl acetate synthesis显示文摘 | Zhengyong Zhang Wenwen Qu Jinhui Peng et cl | 2009 | Desalination2009，，249： | 1 |
| 8 | Amyloid precursor protein regulates differentiation of human neural stem cells显示文摘 | Kwak YD Brannen CL Qu T | 2006 | Stem Cells Dev2006，15，3： | 1 |
| 9 | Involvement of GABAergic modulation of antinociception induced by morphine microinjected into the ventrolateral orbital cortex显示文摘 | QU CL TANG JS JIA H | 2006 | Brain Res2006，，2： | 1 |
| 10 | Human neural stem cells improve cognitive function of aged brain 显示文摘 | Qu T Brannen CL Kim HM | 2001 | Neuroreport2001，12，6： | 1 |
| 11 | Human neural stem cells improve cognitive function of aged brain显示文摘 | Qu T Brannen CL Kim HM | 2001 | Nuroreport2001，12，6： | 1 |
| 12 | Fluorimetric and mass spec- trometric study of the interaction of 13-eyelodextrin and osthole 显示文摘 | Zhang HR Zhang HQ Qu CL | 2007 | Spectroehim Aeta A2007，68，3： | 1 |
| 13 | Human neural stem cells improve cognitive function of aged brain 显示文摘 | Qu T Brannen CL Kim H | 2001 | Neuroreport2001，12，6： | 1 |
| 14 | The short- and long-term outcomes of laparoscopic versus open surgery for colorectal cancer: a meta-analysis 显示文摘 | Wang CL Qu G Xu HW | 2014 | Int J Colorectal Dis2014，29，3： | 1 |
| 15 | The thalamic nucleus submedius and ventrolateral orbital cortex are involved in nociceptive modulation: a novel pain modulation pathway 显示文摘 | Tang JS Qu CL Huo FQ | 2009 | Prog Neurobiol2009，89，： | 1 |
| 16 | GABAergic modulation is involved in the ventrolateral orbital cortex 5-HT 1A receptor activation-induced antinociception in the rat显示文摘 | HUO FQ QU CL LI YQ | 2008 | Pain2008，139，2： | 1 |
| 17 | The short-and long-term outcomes of laparoscopic versus open surgery for colorectal cancer: a meta- analysis 显示文摘 | Wang CL Qu G Xu HW | 2014 | Int J Colorectal Dis2014，29，3： | 1 |
| 18 | Human neural stem cells improve cognitive function of aged brain显示文摘 | Branner CL Kim HM | 2001 | Neuro Report2001，12，： | 1 |
| 19 | Human neural stem cells improve cognitive function of aged brain显示文摘 | Qu T Brannen CL Kim HM | 2001 | Neuroreport2001，12，： | 1 |
| 20 | Isolation and charac- terization of a novel nitrobenzene-degrading bacterium with high salinity tolerance: Micrococcus luteus显示文摘 | Zheng CL Qu BC Wang J | 2009 | Jour- nal of Hazardous Materials2009，165，11： | 1 |
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