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| 1 | Wnt/b-catenin signaling plays an ever-expanding role in stem cell self-renewal,tumorigenesis and cancer chemoresistance显示文摘Wnt signaling transduces evolutionarily conserved pathways which play important roles in initiating and regulating a diverse range of cellular activities,including cell proliferation,calcium homeostasis,and cell polarity.The role of Wnt signaling in controlling cell proliferation and stem cell self-renewal is primarily carried out through the canonical pathway,which is the best-characterized the multiple Wnt signaling branches.The past 10 years has seen a rapid expansion in our understanding of the complexity of this pathway,as many new components of Wnt signaling have been identified and linked to signaling regulation,stem cell functions,and adult tissue homeostasis.Additionally,a substantial body of evidence links Wnt signaling to tumorigenesis of cancer types and implicates it in the development of cancer drug resistance.Thus,a better understanding of the mechanisms by which dysregulation of Wnt signaling precedes the development and progression of human cancer may hasten the development of pathway inhibitors to augment current therapy.This review summarizes and synthesizes our current knowledge of the canonical Wnt pathway in development and disease.We begin with an overview of the components of the canonical Wnt signaling pathway and delve into the role this pathway has been shown to play in stemness,tumorigenesis,and cancer drug resistance.Ultimately,we hope to present an organized collection of evidence implicating Wnt signaling in tumorigenesis and chemoresistance to facilitate the pursuit of Wnt pathway modulators that may improve outcomes of cancers in which Wnt signaling contributes to aggressive disease and/or treatment resistance. | Maryam K.Mohammed Connie Shao Jing Wang Qiang Wei Xin Wang Zachary Collier Shengli Tang Hao Liu Fugui Zhang Jiayi Huang Dan Guo Minpeng Lu Feng Liu Jianxiang Liu Chao Ma Lewis L.Shi Aravind Athiviraham Tong-Chuan He Michael J.Lee | 2016 | Genes & Diseases2016，3，1： | 70 |
| 2 | Dual targeting of mTORC1/C2 complexes enhances histone deacetylase inhibitor-mediated anti-tumor efficacy in primary HCC cancer in vitro and in vivo显示文摘 | Huanjie Shao Chun Gao Haikuo Tang Hao Zhang Lewis R. Roberts Bonnie L. Hylander Elizabeth A. Repasky Wen W. Ma Jingxin Qiu Alex A. Adjei Grace K. Dy Chunrong Yu | 2011 | Journal of Hepatology2011，，1： | 2 |
| 3 | Epidemic of mumps in a partially immune population显示文摘 | Lewis JE Chemesky MA Rawls ML | 1979 | Can Med Assoe J1979，121，6： | 1 |
| 4 | Improvement in histologic response but not survival in osteosarcoma patients treated with intensified chemotherapy:a randomized phase Ⅲ trial of the Europe an Osteosarcoma Intergroup显示文摘 | Lewis IJ Nooij MA Whelan J | 2007 | J Natl Cancer Inst2007，99，2： | 1 |
| 5 | Uncomplicated general anesthesia in the elderly results in cognitive decline:does cognitive decline predict morbidity and mortality显示文摘 | Lewis MC Nevo I Paniagua MA | | 0，，03： | 1 |
| 6 | In vivo assessment of tumor hypoxia in lung cancer with 60Cu-ATSM显示文摘 | Dehdashti F Mintun MA Lewis JS | 2003 | Eur J Nucl Med Mol Imaging2003，30，6： | 1 |
| 7 | Outcome of Henoch - Sch~nlein- purpura nephritis treated with long - term immune - suppression 显示文摘 | Shenoy M Bradbury MG Lewis MA | 2007 | Pediatr Nephrol2007，22，10： | 1 |
| 8 | In vivo site-directed muta- genesis using oligonucleotides 显示文摘 | Storici F Lewis LK Resnick MA | 2001 | Nat Biotechnol2001，19，8： | 1 |
| 9 | A compari- son of capillary-scale LC-NMR with alternative tech- niques: spectroscopic and practical considerations显示文摘 | Lewis RJ Bemstein MA Duncan S J | 2005 | Magn Reson Chem2005，43，9： | 1 |
| 10 | An ENU--induced mutation of miR--96 associated with progressive hearing loss in mice显示文摘 | Lewis MA Quint E Glazier AM | 2009 | Nature Genetics2009，41，： | 1 |
| 11 | Prevalence of Gard- nerella vaginalis in prepubertal males 显示文摘 | Wahl NG Castilla MA Lewis - Abney K | 1998 | Arch Pediatr Adolese Med1998，152，11： | 1 |
| 12 | Pertussis caused by an erythromycin-resistant strain of Bordetella pertussis 显示文摘 | Lewis K Saubolle MA Tenover FC | 1995 | Pediatr Infect Dis J1995，14，5： | 1 |
| 13 | Outcome of Henoch Schnlein purpura nephritis treated with long-term immunosupres- sion显示文摘 | Shenoy M Bradbury MG Lewis MA | 2007 | Pediatr Nephrol2007，22，10： | 1 |
| 14 | Oral medicine in practice:the medically compromised patient显示文摘 | Lamey PJ Lewis MA | 1990 | Br Dent J1990，168，： | 1 |
| 15 | In vivo assessment of tumor hypoxia in lung cancer with ^60Cu-ATSM 显示文摘 | Dehdashti F Mintun MA Lewis JS | 2003 | Eur J Nucl Med Mol Imaging2003，30，： | 1 |
| 16 | Outcome of Henoeh- Schnlein purpura nephritis treated with long-term immunosupres- sion显示文摘 | Shenoy M Bradbury MG Lewis MA | 2007 | Pediatr Nephrol2007，22，10： | 1 |
| 17 | Serf-effica- cy impacts self-care and HbAlc in young adults with type 1 Diabetes显示文摘 | Johnson-Brooks CH Lewis MA Garg S | 2002 | Psychosomatic Medicine2002，64，1： | 1 |
| 18 | Identification of Candida species by ' PCR and restriction fragment length polymorphism analysis of intergenic spacer regions of ribosomal DNA 显示文摘 | Williams DW Wilson M J Lewis MA | 1995 | J Clin Microbiol1995，33，9： | 1 |
| 19 | Nurse bullying:organizational considerations in the maintenance and perpetration of health care bullying cultures显示文摘 | Lewis MA | 2006 | J Nurs Manage2006，14，： | 1 |
| 20 | An ENU-induced mutation of miR-96 associated with progressive hearing loss in mice 显示文摘 | Lewis MA Quint E Glazier AM | 2009 | Nat Genet2009，41，5： | 1 |
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