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| 1 | The versatile functions of Sox9 in development,stem cells,and human diseases显示文摘The transcription factor Sox9 was first discovered in patients with campomelic dysplasia,a haploinsufficiency disorder with skeletal deformities caused by dysregulation of Sox9 expression during chondrogenesis.Since then,its role as a cell fate determiner during embryonic development has been well characterized;Sox9 expression differentiates cells derived from all three germ layers into a large variety of specialized tissues and organs.However,recent data has shown that ectoderm-and endoderm-derived tissues continue to express Sox9 in mature organs and stem cell pools,suggesting its role in cell maintenance and specification during adult life.The versatility of Sox9 may be explained by a combination of posttranscriptional modifications,binding partners,and the tissue type in which it is expressed.Considering its importance during both development and adult life,it follows that dysregulation of Sox9 has been implicated in various congenital and acquired diseases,including fibrosis and cancer.This review provides a summary of the various roles of Sox9 in cell fate specification,stem cell biology,and related human diseases.Ultimately,understanding the mechanisms that regulate Sox9 will be crucial for developing effective therapies to treat disease caused by stem cell dysregulation or even reverse organ damage. | Alice Jo Sahitya Denduluri Bosi Zhang Zhongliang Wang Liangjun Yin Zhengjian Yan Richard Kang Lewis L.Shi James Mok Michael J.Lee Rex C.Haydon | 2014 | Genes & Diseases2014，1，2： | 16 |
| 2 | 老年女性蔬菜硝酸盐的摄入与颈动脉粥样硬化和缺血性脑血管病的相关性显示文摘膳食硝酸盐的短期增加可通过形成一氧化氮和其他氮氧化物来改善血管健康。其是否可降低长期血管疾病风险尚未得到验证,为了明确这一点,Bondonno教授团队调查了植物来源的硝酸盐摄入与老年女性颈总动脉内膜中层厚度(common carotid artery intimamedia thickness,CCA-IMT)、斑块严重程度和缺血性脑血管疾病事件的关系(n=1226),方法:纳入研究对象,确定基线时(1998年)的蔬菜硝酸盐摄入量、生活方式因素和心血管病危险因素。 | 刘莉 叶鹏 Bondonno CP Blekkenhorst LC Prince RL Ivey KL Lewis JR Devine A Woodman RJ Lundberg JO Croft KD Thompson PL Hodgson JM | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 3 | Sequence-specific inhibition of the tumor necrosis factor receptor I gene by oligodeoxynucleotides containing N7 modified 2'-deoxyguanosine显示文摘 | Ojwang JO Lewis AF Revankar GR | 1997 | Antisense Nucleic Acid Drug1997，7，5： | 1 |
| 4 | Proactive Intrusion Detection and Distributed Denial of Service Attacks—A Case Study in Security Management显示文摘 | Jo?o B. D. Cabrera Lundy Lewis Xinzhou Qin Wenke Lee Raman K. Mehra | 2002 | Journal of Network and Systems Management2002，，2： | 1 |
| 5 | Long-term remision durability and functional status of patients treated for diffuse histiocytic lymphoma with the CHOP Regimen显示文摘 | Armitage JO Fyfe MA Lewis J | 1984 | J Clin Oncol1984，2，： | 1 |
| 6 | Long-term proton pump inhibitor therapy and risk of hip fracture显示文摘 | Yang YX Lewis JO Epstein S | 2006 | JAMA2006，296，24： | 1 |
| 7 | The Drosophila sin- gle-minded gene encodes a helix-loop-helix protein that acts as a master regulator of CNS midline development显示文摘 | Nambu JR Lewis JO Wharton KA Jr | 1991 | Cell1991，67，6： | 1 |
| 8 | IgG and IgE avidity characteristics of peanut allergic individuals显示文摘 | El-Khouly F Lewis SA Pons L Burks AW Hourihane JO | 2007 | Pediatr Allergy Immunol2007，18，7： | 1 |
| 9 | Fabrication and characterization of a smart drug delivery system:microsphere in hydrogel显示文摘 | Zhang Xian-Zheng Lewis Patti Jo Chu Chih- Chang | 2005 | Biomaterials2005，26，16： | 1 |
| 10 | The relation of ag- gression, hostility, and anger to lipopolysaccharide- stimulated tumor necrosis factor (TNF)-alpha by blood monocytes from normal men显示文摘 | Suarez EC Lewis JO Kuhn C | 2002 | Brain Behav Immun2002，16，6： | 1 |
| 11 | Development of a purification process for adenovirus: controlling virus aggregation to improve the clearance of host cell DNA显示文摘 | Konz JO Lee AL Lewis JA | 2005 | Biotechnol Prog2005，21，2： | 1 |
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