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| 1 | Diabetes and cardiovascular disease: Epidemiology, biological mechanisms, treatment recommendations and future research显示文摘The incidence of diabetes mellitus(DM) continues to rise and has quickly become one of the most prevalent and costly chronic diseases worldwide. A close link exists between DM and cardiovascular disease(CVD), which is the most prevalent cause of morbidity and mortality in diabetic patients. Cardiovascular(CV) risk factors such as obesity, hypertension and dyslipidemia are common in patients with DM, placing them at increased risk for cardiac events. In addition, many studies have found biological mechanisms associated with DM that independently increase the risk of CVD in diabetic patients. Therefore, targeting CV risk factors in patients with DM is critical to minimize the long-term CV complications of the disease. This paper summarizes the relationship between diabetes and CVD, examines possible mechanisms of disease progression, discusses current treatment recommendations, and outlines future research directions. | Benjamin M Leon Thomas M Maddox | 2015 | World Journal of Diabetes2015，6，13： | 39 |
| 2 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 3 | Standard forward-viewing colonoscopy versus full-spectrum endoscopy: an international, multicentre, randomised, tandem colonoscopy trial显示文摘 | Ian M Gralnek Peter D Siersema Zamir Halpern Ori Segol Alaa Melhem Alain Suissa Erwin Santo Alan Sloyer Jay Fenster Leon M G Moons Vincent K Dik Ralph B D’Agostino Douglas K Rex | 2014 | Lancet Oncology2014，，3： | 6 |
| 4 | Abnormal liver enzymes: A review for clinicians显示文摘Liver biochemical tests are some of the most commonly ordered routine tests in the inpatient and outpatient setting,especially with the automatization of testing in this technological era.These tests include aminotransferases,alkaline phosphatase,gamma-glutamyl transferase,bilirubin,albumin,prothrombin time and international normalized ratio(INR).Abnormal liver biochemical tests can be categorized based on the pattern and the magnitude of aminotransferases elevation.Generally,abnormalities in aminotransferases can be classified into a hepatocellular pattern or cholestatic pattern and can be further sub-classified based on the magnitude of aminotransferase elevation to mild[<5×upper limit of normal(ULN)],moderate(>5-<15×ULN)and severe(>15×ULN).Hepatocellular pattern causes include but are not limited to;non-alcoholic fatty liver disease/non-alcoholic steatohepatitis,alcohol use,chronic viral hepatitis,liver cirrhosis(variable),autoimmune hepatitis,hemochromatosis,Wilson’s disease,alpha-1 antitrypsin deficiency,celiac disease,medication-induced and ischemic hepatitis.Cholestatic pattern causes include but is not limited to;biliary pathology(obstruction,autoimmune),other conditions with hyperbilirubinemia(conjugated and unconjugated).It is crucial to interpret these commonly ordered tests accurately as appropriate further workup,treatment and referral can greatly benefit the patient due to prompt treatment which can improve the natural history of several of the diseases mentioned and possibly reduce the risk of progression to the liver cirrhosis. | M Ammar Kalas Luis Chavez Monica Leon Pahnwat Tonya Taweesedt Salim Surani | 2021 | World Journal of Hepatology2021，13，11： | 5 |
| 5 | Correlations for flame speed and explosion overpressure of dust clouds inside industrial enclosures 显示文摘 | Silvestrinia M Genovaa B Leon Trujillob F J | 2008 | Journal of Loss Prevention in the Process Industries2008，21，1： | 1 |
| 6 | Loss of glom erular function and tubulointerstitial fibrosis cause or effect显示文摘 | Albert C M O Leon G F | 1994 | Kidney Internationall1994，45，： | 1 |
| 7 | Induction and maintenance of intravenous anaesthesia using targetted- controlled infusion systems显示文摘 | VIVIAND X LEONE M | 2001 | Best Practice & Research Clinical Anesthesiology2001，15，1： | 1 |
| 8 | Neutron Irradiation Effects on Optical Absorption of KU1 and KS-4V Quartz Glasses and Infrasi1301显示文摘 | Leon M Marti n P Vila R | 2009 | Fusion Engineering and Design2009，84，71819110111： | 1 |
| 9 | Facilitated transport of copper through bulk liquid membranes containing different carriers : compared kinetic study 显示文摘 | Leon G Guzman M A | 2008 | Desalination2008，223，13： | 1 |
| 10 | Coregulator exchange and sphingosinesensitive eooperativity of steroidogenic factor-1, general control nonderepressed5 ,p54 ,and p160 coaetivators regulate cyclic adenosine 3, 5-monophosphatedependent cytochromeP450e17 transcription rate 显示文摘 | Dammer E B Leon A Sewer M B | 2007 | Mol Endocrinol2007，，： | 1 |
| 11 | Water content, organic carbon and dry bulk density in flooded sediments显示文摘 | Avnimelech Y Gad R Leon E M | 2001 | Aquacultural engineering2001，25，： | 1 |
| 12 | Effect of norepinephrine on the outcome of septic shock显示文摘 | Martin C Viviand X Leone M | 2000 | Crit Care Med2000，28，： | 1 |
| 13 | Free DNA in the serum of cancer patients and the effect of therapy显示文摘 | Leon S A Shapiro B Sklaroff D M | 1977 | Cancer Res1977，37，： | 1 |
| 14 | Clinical and pathologic prognostic indicators in colorectal cancer:A population-based study显示文摘 | Ponz de Leon M Sant M Micheli A | 1992 | Cancer1992，69，3： | 1 |
| 15 | Existence and construction of finite frames显示文摘 | CASAZZA P G LEON M | 2006 | J Concr Appl Math2006，4，3： | 1 |
| 16 | Free DNA in the serum of cancer patients and the effect of therapy显示文摘 | LEON S A SHAPIRO B SKLAROFF D M | 1997 | Cancer Res1997，37，3： | 1 |
| 17 | Effect of norepinephrine on the outcome of septic shock 显示文摘 | Martin C Viviand X leone M | 2000 | Crit Care Med2000，28，8： | 1 |
| 18 | Terlipressin in catecholamine resistant septic shock patients显示文摘 | Leone M Albanese J | 2004 | Shock2004，22，4： | 1 |
| 19 | Amphiphilic block glycopolymers via atom transfer radical polymerization: Synthesis, self-assembly and biomolecular recognition 显示文摘 | Leon O Alexandra M Vanesa B | 2011 | J Polym Sci A: Polym Chem2011，49，12： | 1 |
| 20 | Cancer prevention by tea polyphenols is linked to their direct inhibition of antiapoptotic bcl-2-family proteins显示文摘 | M Leone D Zhai S Sareth et d | 2003 | Cancer Research2003，63，： | 1 |
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