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| 1 | Serum concentration of sFas and sFasL in healthy HBsAg carriers,chronic viral hepatitis B and C patients显示文摘AIM: To estimate the amount of apoptosis among healthy HBsAg carriers, patients with chronic HBV infection treated with lamivudine and patients with chronic HCV infedJon treated with interferon alpha and ribavirin. Activity of apoptosis was evaluated by serum sFas/sFasL concentration measurement.Moreover dependence between apoptosis and HBV-DNA or HCV-RNA levels was studied.METHODS: Eighty-six persons were included into study: 34 healthy HBsAg carriers, 33 patients with chronic HBV infection and 19 patients with chronic HCV infection. Serum levels of sFas/sFasL were measured by ELISA assay. HBV-DNA and HCV-RNA were measured by RT-PCR assay. Levels of sFas/sFasL were determined before and 2 and 12 wk after therapy in patients with chronic hepatitis B and C infection.HBV-DNA or HCV-RNA was detected before treatment and 6 mo after treatment.RFSULTS: Twenty-four (71%) healthy HBsAg carriers showed HBV-DNA over 10^5/mL, which was comparable to the patients with chronic hepatitis B. Independently from HBV-DNA levels,the concentration of sFas among healthy HBsAg carriers was comparable to healthy persons. Among patients with chronic hepatitis B and C, the concentration of sFas was significantly higher in comparison to healthy HBsAg carriers and healthy persons. In chronic hepatitis B patients the concentration of sFas was decreased during lamivudine treatment. Among chronic hepatitis C patients the concentration of sFas was increased during IFN alpha and ribavirin treatment, sFasL was not detected in control group. Furthermore sFasL oo:urred more frequently in chronic hepatitis C patients in comparison to chronic hepatitis B patients.CONCLUSION: There are no correlations between apoptosis and HBV-DNA levels. However ther is an association between apoptosis and activity of inflammation in patients with chronic HBV infection. Apoptosis can be increased in patients with chronic hepatitis C by effective treatment which may be a result of apoptosis stimulation by IFN-α. | Tadeusz Wojciech Lapinski Oksana Kowalczuk Danuta Prokopowicz Lech Chyczewski | 2004 | World Journal of Gastroenterology2004，10，24： | 7 |
| 2 | The mRNA expression of pro- and anti-inflammatory cytokines in T regulatory cells in children with type 1 diabetes显示文摘 | Luczynski Wlodzimierz Stasiak-Barmuta Anna Juchniewicz Agnieszka Wawrusiewicz-Kurylonek Natalia Ilendo Elzbieta Kos Justyna Kretowski Adam Górska Maria Chyczewski Lech Bossowski Artur | 2010 | Folia Histochemica et Cytobiologica2010，，1： | 1 |
| 3 | MDR-1 gene polymorphisms and clinical course of steroid-responsive nephrotic syndrome in children显示文摘 | Anna Wasilewska Grzegorz Zalewski Lech Chyczewski Walentyna Zoch-Zwierz | 2007 | Pediatric Nephrology2007，，1： | 1 |
| 4 | The effect of platelet activating factor antagonist (BN 52021) on acute experimental pancreatitis with reference to multiorgan oxidative stress显示文摘 | Andrzej Dabrowski Antoni Gabryelewicz Lech Chyczewski | 1995 | International Journal of Pancreatology1995，，2： | 1 |
| 5 | The effect of platelet activating factor antagonist (BN 52021) on cerulein-induced acute pancreatitis with reference to oxygen radicals显示文摘 | Andrzej Dabrowski Antoni Gabryelewicz Lech Chyczewski | 1991 | International Journal of Pancreatology1991，，1： | 1 |
| 6 | Experimental model of hepatic venoocclusive disease (VOD) caused by dactinomy- cin - -preliminary report about hepatoprotective effect of ami- fostine显示文摘 | Czauderna P Chyczewski L Lech K | 2000 | Med Sci Monit2000，6，3： | 1 |
| 7 | Lysosomal activity of pulmonary alveolar macro phages in acute experimental pancreatitis in rats with reference to positive PAF-antagonist (BN 52021) effect显示文摘 | Urszula Wereszczynska-Siemiatkowska Jan W. Dlugosz Andrzej Siemiatkowski Lech Chyczewski Antoni Gabryelewicz | 2000 | Experimental and Toxicologic Pathology2000，，2： | 1 |
| 8 | Changing HCV genotypes distribution in Poland—Relation to source and time of infection显示文摘 | Slawomir Chlabicz Robert Flisiak Oksana Kowalczuk Anna Grzeszczuk Barbara Pytel-Krolczuk Danuta Prokopowicz Lech Chyczewski | 2008 | Journal of Clinical Virology2008，，2： | 1 |
| 9 | Overexpression of epidermal growth factor receptor as a prognostic factor in colorectal cancer on the basis of the Allred scoring system显示文摘 | Marta Rokita Lubomir Bodnar Cezary Szczylik Rafa? Stec Wojciech Koz?owski Jacek Nikliński Lech Chyczewski Marzena Cichowicz Marta Smoter Jan Korniluk Rados?aw Charkiewicz | 2013 | OncoTargets and Therapy (default)2013，，： | 1 |
| 10 | Biological properties of differently-aged human keratinocytes:population doubling time growth curve and cell cycle analysis显示文摘Objective To explore the biological properties of keratinocytes from differently-aged healthy human beings. Methods Keratinocytes from fetus,teenager and middle-aged groups were separated and cultured. The population doubling time (PDT) and cell growth curve in different cells were compared,and the cell cycles were analyzed by flow cytometry. Results ① In primary culture of keratinocytes,the adherence time in middle-aged group was longer than that in fetus and teenager groups. However,all cell morphology showed no obvious differences. In subculture of keratinocytes,with donator's age increasing,time of cell adherence prolonged,passage number decreased and differences in cell morphology were obvious. ② The average PDT of keratinocytes was shorter in fetus group than in teenager and middle-aged groups. But difference in cell growth curve between different passages was not observed. ③ Keratinocytes showed G2/M period in fetus group but G0/G1 period in teenager and middle-aged groups mainly. Conclusion As age increases,the biological properties of keratinocytes change obviously. | Lech Chyczewski Jacek Niklinski | 2009 | Journal of Pharmaceutical Analysis2009，21，2： | 0 |
| 11 | Known and probable risk factors for hepatitis C infection:A case series in north-eastern Poland显示文摘瞄准: 与丙肝在医院里描述病人的风险侧面在波兰的病毒(HCV ) 感染。方法:用一张结构化的问询表,有证实的 HCV 感染的所有病人关于风险因素被会见。结果:在学习的 250 个病人之中,在 1993 前的输送是在 26% 的主要风险因素,在 9% 的静脉内的药使用背景和在在 9% 的保健的职业暴露。女人们是更可能的在 1993 前并且不太多半有职业暴露或输送的历史经历次要的外科。已知的医院的风险因素(在 1993 前的输送,分离) 为 27% 感染负责,可能的医院的因素(在 1992 以后的输送,次要的外科) 为 14% 并且进一步, 9% 是职业结盟获得的感染。结论:小心的历史调查能识别一知道或为在有 HCV 感染的 59% 病人的 HCV 获得的可能的风险因素。在波兰的预防活动应该在保健设定集中于感染控制措施。 | Slawomir Chlabicz Robert Flisiak Anna Grzeszczuk Oksana Kovalchuk Danuta Prokopowicz Lech Chyczewski | 2006 | World Journal of Gastroenterology2006，12，1： | 0 |
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