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| 1 | Incidence of human papilloma virus in esophageal squamous cell carcinoma in patients from the Lublin region显示文摘AIM:To assess the prevalence of human papilloma virus(HPV) in esophageal squamous cell carcinoma(ESCC) in the south-eastern region of Poland.METHODS:The study population consisted of 56 ESCC patients and 35 controls.The controls were patients referred to our department due to other nonesophageal and non-oncological disorders with no gross or microscopic esophageal pathology as confirmed by endoscopy and histopathology.In the ESCC patients,samples were taken from normal mucosa(56 mucosa samples) and from the tumor(56 tumor samples).Tissue samples from the controls were taken from normal mucosa of the middle esophagus(35 control samples).Quantitative determination of DNA was carried out using a spectrophotometric method.Genomic DNA was isolated using the QIAamp DNA Midi Kit.HPV infection was identified following PCR amplification of the HPV gene sequence,using primers MY09 and MY11 complementary to the genome sequence of at least 33 types of HPV.The sequencing results were computationally analyzed using the basic local alignment search tool database.RESULTS:In tumor samples,HPV DNA was identified in 28 of 56 patients(50%).High risk HPV phenotypes(16 or/and 18) were found in 5 of 56 patients(8.9%),low risk in 19 of 56 patients(33.9%) and other types of HPV(37,81,97,CP6108) in 4 of 56 patients(7.1%).In mucosa samples,HPV DNA was isolated in 21 of 56 patients(37.5%).High risk HPV DNA was confirmed in 3 of 56 patients(5.3%),low risk HPV DNA in 12 of 56 patients(21.4%),and other types of HPV in 6 of 56 patients(10.7%).In control samples,HPV DNA was identified in 4 of 35 patients(11.4%) with no high risk HPV.The occurrence of HPV in ESCC patients was significantly higher than in the controls [28 of 56(50%) vs 4 of 35(11.4%),P < 0.001].In esophageal cancer patients,both in tumor and mucosa samples,the predominant HPV phenotypes were low risk HPV,isolated 4 times more frequently than high risk phenotypes [19 of 56(33.9%) vs 5 of 56(8.9%),P < 0.001].A higher prevalence of HPV was identified in female patients(71.4% vs 46.9%).Accordingly,the high risk phenotypes were isolated more frequently in female patients and this difference reached statistical significance [3 of 7(42.9%) vs 2 of 49(4.1%),P < 0.05].Of the pathological characteristics,only an infiltrative pattern of macroscopic tumor type significantly correlated with the presence of HPV DNA in ESCC samples [20 of 27(74.1%) vs 8 of 29(27.6%) for ulcerative or protruding macroscopic type,P < 0.05].The occurrence of total HPV DNA and both HPV high or low risk phenotypes did not significantly differ with regard to particular grades of cellular differentiation,phases in depth of tumor infiltration,grades of nodal involvement and stages of tumor progression.CONCLUSION:Low risk HPV phenotypes could be one of the co-activators or/and co-carcinogens in complex,progressive,multifactorial and multistep esophageal carcinogenesis. | Andrzej Dabrowski Wojciech Kwasniewski Tomasz Skoczylas Wiesawa Bednarek Dorota Kuzma Anna Gozdzicka-Józefiak | 2012 | World Journal of Gastroenterology2012，18，40： | 55 |
| 2 | Alteration of peripheral blood lymphocyte subsets in acute pancreatitis显示文摘AIM: To evaluate peripheral blood lymphocyte subsets in patients with acute pancreatitis (AP).METHODS: Twenty patients with mild AP (M-AP) and 15 with severe AP (S-AP) were included in our study. Pe-ripheral blood lymphocytes were examined at d 1-3, 5, 10 and 30 by means of ? ow cytometry. RESULTS: A signifi cant depletion of circulating lympho-cytes was found in AP. In the early AP, the magnitude of depletion was similar for T- and B- lymphocytes. In the late course of S-AP, B-lymphocytes were much more depleted than T-lymphocytes. At d 10, strong shift in the CD7+/CD19+ ratio implicating predominance of T- over B-lymphocytes in S-AP was found. Among T-lym-phocytes, the signifi cant depletion of the CD4+ popula-tion was observed in M-AP and S-AP, while CD8+ cells were in the normal range. Lymphocytes were found to strongly express activation markers: CD69, CD25, CD28, CD38 and CD122. Serum interleukin-2 (IL-2), IL-4, IL-5, IL-10, interferon-γ (IFN-γ) and tumor necrosis factor-α (TNF-α) levels were signifi cantly increased in both forms of AP. The magnitude of elevation of cytokines known to be produced by Th2 was much higher than cytokines produced by Th1 cells.CONCLUSION: AP in humans is characterized by significant reduction of peripheral blood T- and B-lymphocytes. | Miroslawa Pietruczuk Milena I Dabrowska Urszula Wereszczynska-Siemiatkowska Andrzej Dabrowski | 2006 | World Journal of Gastroenterology2006，12，33： | 15 |
| 3 | Endoscopic management of gastrointestinal perforations, leaks and fistulas显示文摘Gastrointestinal perforations, leaks and fistulas may be serious and life-threatening. The increasing number of endoscopic procedures with a high risk of perforation and the increasing incidence of leakage associated with bariatric operations call for a minimally invasive treatment for these complications. The therapeutic approach can vary greatly depending on the size,location, and timing of gastrointestinal wall defect recognition. Some asymptomatic patients can be treated conservatively, while patients with septic symptoms or cardio-pulmonary insufficiency may require intensive care and urgent surgical treatment.However, most gastrointestinal wall defects can be satisfactorily treated by endoscopy. Although the initial endoscopic closure rates of chronic fistulas is very high, the long-term results of these treatments remain a clinical problem. The efficacy of endoscopic therapy depends on several factors and the best mode of treatment will depend on a precise localization of the site, the extent of the leak and the endoscopic appearance of the lesion. Many endoscopic tools for effective closure of gastrointestinal wall defects are currently available. In this review, we summarized the basic principles of the management of acute iatrogenic perforations, as well as of postoperative leaks and chronic fistulas of the gastrointestinal tract. We also described the effectiveness of various endoscopic methods based on current research and our experience. | Pawel Rogalski Jaroslaw Daniluk Andrzej Baniukiewicz Eugeniusz Wroblewski Andrzej Dabrowski | 2015 | World Journal of Gastroenterology2015，21，37： | 8 |
| 4 | Unusual clinical course of metachronous melanomas of the upper digestive system显示文摘Melanoma of the gastrointestinal tract is a rare, highly malignant neoplasm of poor prognosis. This is description of an unusual case of surgically treated patient with two metachronous malignant melanomas of the stomach and the esophagus. The former lesion was located in the cardia and effectively treated with R0 total gastrectomy. The latter was recognized after 67 mo and appeared as irregular, flat, pigmented areas located in the mid esophagus. Subtotal esophagectomy via right-sided thoracotomy, laparotomy and left-sided cervicotomy was performed, but neoplastic cells were found in distal margin (R1). Fourteen months after esophagectomy multiple lung metastases were detected. Patient died 2 mo later. | Andrzej Dabrowski Krzysztof Zinkiewicz Justyna Szumilo Witold Zgodzinski Grzegorz Cwik Tomasz Skoczylas Grzegorz Wallner | 2005 | World Journal of Gastroenterology2005，11，14： | 5 |
| 5 | Overview of Identity Management显示文摘In recent years there has been a fast grow of various electronic services.Each service requires specif-ic credentials for authenticating and authorizing user ac-cess or specific subset of user's personal information for transactions the service offers.Such a situation causes problems with remembering multiple,service-specific authentication data,with controlling user's personal data spread across different services-problems with managing user's identities.This paper is an overview on Identity Management(IdM).It introduces basic terms connected with IdM,shows current and emerging appli-cation areas,enumerates the most important IdM activi-ties,describes the most representative identity manage-ment specifications and frameworks and at the end,it points out important problems in identity management which need to be addressed in the near future. | Marcin Dabrowski Piotr Pacyna | 2008 | China Communications2008，5，4： | 2 |
| 6 | Dissolved oxygen prediction in prawn ponds from a group of one step predictors显示文摘In this paper we have presented a novel approach to predict dissolved oxygen in prawn ponds.It is necessary to maintain dissolved oxygen above a certain level in the ponds for expected growth and survival of the prawns.An accurate prediction of dissolved oxygen can assist farmers to take necessary measures to maintain dissolved oxygen levels ideal for prawn growth.Existing approaches to dissolved oxygen prediction performs well on short term,however incurs high error on long term prediction.We propose a new approach where a group of predictors are developed where each model predicts a certain time stamps ahead.Each predictor is trained on sampled data so that it predicts a step ahead prediction only,however,the sampling process decides on the actual number of time stamp ahead prediction.Since step ahead predictor acts like a short term predictor,it incurs small error even at higher time stamp ahead prediction.Experimental results demonstrate that the proposed approach achieves significantly lower error on long term prediction compared to other existing approaches. | Ashfaqur Rahman Joel Dabrowski John McCulloch | 2020 | Information Processing in Agriculture2020，7，2： | 2 |
| 7 | High-dose intravenous immunoglobulin therapy in juvenile myasthenia gravis 显示文摘 | Selcen D Dabrowski ER Michon AM | 2000 | Pediatr Neurol2000，22，： | 1 |
| 8 | Evaluation of the largest Lyapunov exponent in dynamical systems with time delay显示文摘 | Andrzej Stefanski Artur Dabrowski Tomasz Kapitaniak | 2005 | Chaos Solitons & Fractals2005，23，5： | 1 |
| 9 | Effect of Pollution produced by a cement and lime factory Kujawy on mites associated with young scots pine forests in Bielawy, Poland显示文摘 | Seniczak Stanislaw Janusz Dabrowski | 1997 | Bulletin of the polish Academy of Sciences Biological Sciences1997，45，1： | 1 |
| 10 | Do all fish need ascorbic acid?显示文摘 | Dabrowski K Moreau R | 1996 | Aqua Mag1996，22，5： | 1 |
| 11 | Growth and morphological changes in the digestive tract of rainbow trout (Oncorhynchus mykiss) and pacu (Piaractus mesopotamicus) due to casein replacement with soybean proteins显示文摘 | OSTASZEWSKA T DABROWSKI K PALACIOS M E | 2005 | Aquaculture2005，245，1： | 1 |
| 12 | Interaction between lubricant additiue during friction显示文摘 | DABROWSKI J R MITER K | 1995 | Tribologie and Schmierungstechnik1995，42，6： | 1 |
| 13 | Composition of free and hydrolyzable phenolic acids in defatted flours of ten oilseeds显示文摘 | Dabrowski K J Sosulski F W | 1984 | Journal of Agricultural and Food Chemistry1984，32，1： | 1 |
| 14 | Anthropogenic mercury emissions in South Africa: coal combustion in power plants 显示文摘 | DABROWSKI J M ASHTON P J MURRAY K | 2008 | Atmospheric En- vironment2008，42，27： | 1 |
| 15 | High yield expression and single-step purification of Toxoplasma gondii SAG1,GRA1,and GRA7 antigens in Escherichia coli显示文摘 | Hiszczy(n)ska-Sawicka E Brillowska-Dabrowska A Dabrowski S | 2003 | Protein Expr Purif2003，27，1： | 1 |
| 16 | 显示文摘 | Almeras X Dabrowski F Le Bras M | 2002 | Polym Degrad Stab2002，77，2： | 1 |
| 17 | Effect of the neuropeptide substance P on the rat bone marrow -derived osteogenic cells in vitro显示文摘 | Adamus MA Dabrowski ZJ | 2001 | J Cell Biochem2001，81，3： | 1 |
| 18 | HPLC determination of gossypoland gossypolone enantiomers in fish tissues using simultaneous ECand UV detectors显示文摘 | LEE K J DABROWSKI K | 2002 | J Chromatogr B2002，779，2： | 1 |
| 19 | Anassessment of regression of left ventricular hypertrophy followingalcohol ablation of the interventricular septum in patients withhypertrophic cardiomyopathy with left ventricular outflow tractobstruction显示文摘 | DABROWSKI M CHOJNOWSKA L MAE K | 2012 | Kardiol Pol2012，70，8： | 1 |
| 20 | Molecular definition of the pro-tumorigenic phenotype of glioma-activated mi- croglia 显示文摘 | Ellert-Mik|aszewska A Dabrowski M Lipko M et at | 2013 | Glia2013，61，7： | 1 |
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