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| 1 | Serum concentration of sFas and sFasL in healthy HBsAg carriers,chronic viral hepatitis B and C patients显示文摘AIM: To estimate the amount of apoptosis among healthy HBsAg carriers, patients with chronic HBV infection treated with lamivudine and patients with chronic HCV infedJon treated with interferon alpha and ribavirin. Activity of apoptosis was evaluated by serum sFas/sFasL concentration measurement.Moreover dependence between apoptosis and HBV-DNA or HCV-RNA levels was studied.METHODS: Eighty-six persons were included into study: 34 healthy HBsAg carriers, 33 patients with chronic HBV infection and 19 patients with chronic HCV infection. Serum levels of sFas/sFasL were measured by ELISA assay. HBV-DNA and HCV-RNA were measured by RT-PCR assay. Levels of sFas/sFasL were determined before and 2 and 12 wk after therapy in patients with chronic hepatitis B and C infection.HBV-DNA or HCV-RNA was detected before treatment and 6 mo after treatment.RFSULTS: Twenty-four (71%) healthy HBsAg carriers showed HBV-DNA over 10^5/mL, which was comparable to the patients with chronic hepatitis B. Independently from HBV-DNA levels,the concentration of sFas among healthy HBsAg carriers was comparable to healthy persons. Among patients with chronic hepatitis B and C, the concentration of sFas was significantly higher in comparison to healthy HBsAg carriers and healthy persons. In chronic hepatitis B patients the concentration of sFas was decreased during lamivudine treatment. Among chronic hepatitis C patients the concentration of sFas was increased during IFN alpha and ribavirin treatment, sFasL was not detected in control group. Furthermore sFasL oo:urred more frequently in chronic hepatitis C patients in comparison to chronic hepatitis B patients.CONCLUSION: There are no correlations between apoptosis and HBV-DNA levels. However ther is an association between apoptosis and activity of inflammation in patients with chronic HBV infection. Apoptosis can be increased in patients with chronic hepatitis C by effective treatment which may be a result of apoptosis stimulation by IFN-α. | Tadeusz Wojciech Lapinski Oksana Kowalczuk Danuta Prokopowicz Lech Chyczewski | 2004 | World Journal of Gastroenterology2004，10，24： | 7 |
| 2 | The mRNA expression of pro- and anti-inflammatory cytokines in T regulatory cells in children with type 1 diabetes显示文摘 | Luczynski Wlodzimierz Stasiak-Barmuta Anna Juchniewicz Agnieszka Wawrusiewicz-Kurylonek Natalia Ilendo Elzbieta Kos Justyna Kretowski Adam Górska Maria Chyczewski Lech Bossowski Artur | 2010 | Folia Histochemica et Cytobiologica2010，，1： | 1 |
| 3 | MDR - 1 gene polymorphisms and clinical course of steroid - responsive nephrotic syndrome in children显示文摘 | Wasilewska A Zalewski G Chyczewski L | 2007 | Pediatr Nephrol2007，22，1： | 1 |
| 4 | Expression of bcl-2 protein in non-small cell lung cancer:Correlation with clinicopathology and patient survival显示文摘 | Laudanski J Chyczewski L Niklinska WE | 1999 | Neoplasma1999，46，1： | 1 |
| 5 | Some markers of proliferative activity in cholesteatoma epithelium in adults 显示文摘 | Olszewska E Chodynicki S Chyczewski L | 2006 | Med Sci Monit2006，12，8： | 1 |
| 6 | MDR- 1 gene polymorphisms and clinical course of steroid- responsive nephrotic syndrome in children 显示文摘 | Wasilewska A Zalewski G Chyczewski L | 2007 | Pediatr Nephrol2007，22，1： | 1 |
| 7 | A preconditioned Navier-Stokes method for two-phase flows with application to cavitation prediction显示文摘 | KUNZ R F BOGER D A STINEBRING D R CHYCZEWSKI T S | 2000 | Comput Fluids2000，29，： | 1 |
| 8 | The impact of immune response on lung cancer and the deve-lopment of new treatment modalities显示文摘 | PLUYGERS E SADOWSKA A CHYCZEWSKI L | 2001 | Lung Cancer2001，，： | 1 |
| 9 | Some markers of proliferative activity in cholesteatoma epithelium in adults显示文摘 | Olszewska E Chodynicki S Chyczewski L | 2006 | Med Sei Monit2006，12，8： | 1 |
| 10 | Immunohistochemical analysis of MMP - 9, MMP - 2 and TIMP - 1, TIMP - 2 expression in the central nervous system following infection with viral and bacterial meningitis显示文摘 | Sulik A Chyczewski L | 2008 | Folia Histochem Cytobiol2008，46，4： | 1 |
| 11 | Expression of vascular endothelial growth factor (VEGF) in non-small cell lung cancer (NSCLC):association with p53 gene mutation and prognosis显示文摘 | Niklinska W Burzykowski T Chyczewski L | 2001 | Lung Cancer2001，34，2： | 1 |
| 12 | Molecular genetic abnormalities in premalignant lung lesions:biological and clinical implications显示文摘 | Niklinski J Niklinska W Chyczewski L | | 0，，： | 1 |
| 13 | Molecular genetic abnormalities in premalignant lung lesions:biological and clinical implications显示文摘 | Niklinski J Niklinska W Chyczewski L | 2001 | Eur J Cancer Prev2001，10，： | 1 |
| 14 | Detection of p53 abnormalities in non-small lung cancer by yeast functional assay显示文摘 | NIKLINSKA W CHYCZEWSKI L LAUDANSKI J | 2001 | Folia Histochem Cytobiol2001，39，2： | 1 |
| 15 | The impact of immune response on lung cancer and the development of new treatment modalities显示文摘 | Pluygers E Sadowska A Chyczewski L | 2001 | Lung Cancer2001，34，2： | 1 |
| 16 | MDR-1 gene polymorphisms and clinical course of steroid-responsive nephrotic syndrome in children显示文摘 | Anna Wasilewska Grzegorz Zalewski Lech Chyczewski Walentyna Zoch-Zwierz | 2007 | Pediatric Nephrology2007，，1： | 1 |
| 17 | Detection of P53 abnormalities in non-small cell lung cancer by yeast functional assay显示文摘 | Niklinska W Chyczewski L Laudanski J | 2001 | Folia Histochem Cytobiol2001，39，2： | 1 |
| 18 | New molecular approaches to lung cancer: biological and clinical implications of P53,P16 and K-RAS studies 显示文摘 | Niklinska W Chyczewski L Niklinski J | 2001 | Folia Histochem Cytobiol2001，39，2： | 1 |
| 19 | The effect of platelet activating factor antagonist (BN 52021) on acute experimental pancreatitis with reference to multiorgan oxidative stress显示文摘 | Andrzej Dabrowski Antoni Gabryelewicz Lech Chyczewski | 1995 | International Journal of Pancreatology1995，，2： | 1 |
| 20 | Morphological and molecular aspects of cancerogenesis in the lung 显示文摘 | Chyczewski L Chuczewska E Niklinski J | 2001 | Folia Histochem Cytobiol2001，39，2： | 1 |
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