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| 1 | Obesity and weight loss could alter the properties of adipose stem cells?显示文摘The discovery that adipose tissue represents an interesting source of multipotent stem cells has led to many studies exploring the clinical potential of these cells in cell-based therapies. Recent advances in understanding the secretory capacity of adipose tissue and the role of adipokines in the development of obesity and associated disorders have added a new dimension to the study of adipose tissue biology in normal and diseased states. Subcutaneous adipose tissue forms the interface between the clinical application of regenerative medicine and the establishment of the pathological condition of obesity. These two facets of adipose tissue should be understood as potentially related phenomena. Because of the functional characteristics of adipose stem cells, these cells represent a fundamental tool for understanding how these two facets are interconnected and could be important for therapeutic applications. In fact, adipose tissue stem cells have multiple functions in obesity related to adipogenic, angiogenic and secretory capacities. In addition, we have also previously described a predominance of larger blood vessels and an adipogenic memory in the subcutaneous adipose tissue after massive weight loss subsequent to bariatric surgery(ex-obese patients). Understanding the reversibility of the behavior of adipose stem cells in obeses and in weight loss is relevant to both physiological studies and the potential use of these cells in regenerative medicine. | Leandra S Baptista Karina R Silva Radovan Borojevic | 2015 | World Journal of Stem Cells2015，7，1： | 4 |
| 2 | Adipose stromal/stem cells in regenerative medicine:Potentials and limitations显示文摘This article presents the stem and progenitor cells from subcutaneous adipose tissue,briefly comparing them with their bone marrow counterparts,and discussing their potential for use in regenerative medicine.Subcutaneous adipose tissue differs from other mesenchymal stromal/stem cells(MSCs)sources in that it contains a pre-adipocyte population that dwells in the adventitia of robust blood vessels.Pre-adipocytes are present both in the stromal-vascular fraction(SVF;freshly isolated cells)and in the adherent fraction of adipose stromal/stem cells(ASCs;in vitro expanded cells),and have an active role on the chronic inflammation environment established in obesity,likely due their monocyticmacrophage lineage identity.The SVF and ASCs have been explored in cell therapy protocols with relative success,given their paracrine and immunomodulatory effects.Importantly,the widely explored multipotentiality of ASCs has direct application in bone,cartilage and adipose tissue engineering.The aim of this editorial is to reinforce the peculiarities of the stem and progenitor cells from subcutaneous adipose tissue,revealing the spheroids as a recently described biotechnological tool for cell therapy and tissue engineering.Innovative cell culture techniques,in particular 3D scaffold-free cultures such as spheroids,are now available to increase the potential for regeneration and differentiation of mesenchymal lineages.Spheroids are being explored not only as a model for cell differentiation,but also as powerful 3D cell culture tools to maintain the stemness and expand the regenerative and differentiation capacities of mesenchymal cell lineages. | Leandra Santos Baptista | 2020 | World Journal of Stem Cells2020，12，1： | 2 |
| 3 | Purification, characterization and crystallization of Jararacussin-I,a fibrinogen-clotting enzyme isolated from the venom of Sothrops jararacussu 显示文摘 | Raquel K Bortoleto Leandra Watanabe | 2002 | Toxieon2002，40，18： | 1 |
| 4 | The H63D genetic variant of the HFE gene is independently associated with the virological response to interferon and ribavirin therapy in chronic hepatitis C显示文摘 | Marcos V. Carneiro Fernanda F. Souza Andreza C. Teixeira José F.C. Figueiredo Marcia G. Villanova Marie Secaf Afonso Passos Leandra N.Z. Ramalho Fabiana P. Carneiro Sérgio Zucoloto Ana L. Candolo Martinelli | 2010 | European Journal of Gastroenterology & Hepatology2010，，10： | 1 |
| 5 | Cartilage and bone tissue engineering using adipose stromal/stem cells spheroids as building blocks显示文摘Scaffold-free techniques in the developmental tissue engineering area are designed to mimic in vivo embryonic processes with the aim of biofabricating,in vitro,tissues with more authentic properties.Cell clusters called spheroids are the basis for scaffold-free tissue engineering.In this review,we explore the use of spheroids from adult mesenchymal stem/stromal cells as a model in the developmental engineering area in order to mimic the developmental stages of cartilage and bone tissues.Spheroids from adult mesenchymal stromal/stem cells lineages recapitulate crucial events in bone and cartilage formation during embryogenesis,and are capable of spontaneously fusing to other spheroids,making them ideal building blocks for bone and cartilage tissue engineering.Here,we discuss data from ours and other labs on the use of adipose stromal/stem cell spheroids in chondrogenesis and osteogenesis in vitro.Overall,recent studies support the notion that spheroids are ideal'building blocks'for tissue engineering by“bottom-up”approaches,which are based on tissue assembly by advanced techniques such as three-dimensional bioprinting.Further studies on the cellular and molecular mechanisms that orchestrate spheroid fusion are now crucial to support continued development of bottom-up tissue engineering approaches such as three-dimensional bioprinting. | Gabriela S Kronemberger Renata Akemi Morais Matsui Guilherme de Almeida Santos de Castro e Miranda JoséMauro Granjeiro Leandra Santos Baptista | 2020 | World Journal of Stem Cells2020，12，2： | 1 |
| 6 | A randomized controlled trial of child FIRST: A comprehensive home-based intervention translating research into early childhood practice显示文摘 | Darcy IL Alice SC Leandra G | 2011 | Child Development2011，82，1： | 1 |
| 7 | RET/PTCI oncogene signaling in PCC1 3 thyroid ceils requires the smallGTP-binding protein Rho显示文摘 | Maria Vittoria Barone Leandra Sepe Rosa Marina Melillo | 2001 | Oncogene2001，20，： | 1 |
| 8 | Nonalcoholic Steatohepatitis: A Search for Factual Animal Models显示文摘 | Sheila Cristina L. Sanches Leandra Naira Z. Ramalho Marlei Josiele Augusto Deisy Mara da Silva Fernando Silva Ramalho Monica Fedele | 2015 | BioMed Research International2015，，： | 1 |
| 9 | Liver cirrhosis and hepatic stellate cells显示文摘 | Daniel F B Leandra N Z R Fernando S R | 2006 | Acta Cirurgiea Brasileira2006，21，1： | 1 |
| 10 | Etiopathogenesis of Hepatic Osteodystrophy in Wistar Rats with Cholestatic Liver Disease显示文摘 | F. A. Pereira Inalda Facincani Vanda Jorgetti Leandra N. Z. Ramalho José B. Volpon Luciene M. dos Reis Francisco J. A. Paula | 2009 | Calcified Tissue International2009，，1： | 1 |
| 11 | Wnt/β-Catenin Pathway Deregulation in Childhood Adrenocortical Tumors显示文摘 | Letícia F. Leal Lívia M. Mermejo Leandra Z. Ramalho Carlos E. Martinelli José A. Yunes Ana Luiza Seidinger Maria José Mastellaro Izilda A. Cardinalli Silvia R. Brandalise Ayrton C. Moreira Luiz G. Tone Carlos A. Scrideli Margaret Castro Sonir R. Antonini | 2011 | The Journal of Clinical Endocrinology & Metabolism2011，，： | 1 |
| 12 | Low genetic diversity and significant structuring in the endangered Mentha cervina populations and its implications for conservation 显示文摘 | Leandra R C 6 ssio van den B Orlanda P | 2013 | Biochemical Systematics and Ecology2013，50，： | 1 |
| 13 | Purification and Characterization of Jararassin-I, A Thrombin-like Enzyme from Bothrops jararaca Snake Venom显示文摘A thrombin-like serine protease, jararassin-I, was isolated from the venom of Bothrops jararaca. The protein was obtained in high yield and purity by a single chromatographic step using the affinity resin Benzamidine-Sepharose CL-6B. SDS-PAGE and dynamic light scattering analyses indicated that the molecular mass of the enzyme was about 30 kD. The enzyme possessed fibrinogenolytic and coagulant activities. The jararassin-I degraded the Bβ chain of fibrinogen while theAα chain and γ chain were unchanged. Proteases inhibitors, PMSF and benzamidine inhibited the coagulant activity. These results showed jararassin- I is a serine protease similar to coagulating thrombin-like snake venom proteases, but it specifically cleaves Bβ chain of bovine fibrinogen. Single crystals of enzyme were obtained (0.2 mm×0.2 mm×0.2 mm) and used for X-ray diffraction experiments. | Débora F. VIEIRA Leandra WATANABE Carolina D. SANT'ANA Silvana MARCUSSI Suely V. SAMPAIO Andreimar M. SOARES Raghuvir K. ARNI | 2004 | Acta Biochimica et Biophysica Sinica2004，36，12： | 1 |
| 14 | Functional and structural changes in internal pudendal arteries underlie erectile dysfunction induced by androgen deprivation显示文摘雄激素缺乏强烈与可勃起的机能障碍(编辑) 被联系。不适当的阴茎动脉的血流动是到阴茎海绵体的血流动主要是的编辑的原因从内部 pudendal 动脉(国际语音学协会) 导出的专业之一;然而,没有学习在国际语音学协会功能上评估了雄激素剥夺的效果。我们假设了那阉割损害国际语音学协会反应和结构,在我们的学习贡献编辑, Wistar 雄的老鼠, 8-week-old,被阉割并且在 orchiectomy 以后学习了 30 天。老鼠国际语音学协会的功能、结构的性质是坚定的分别地使用电线和压力肌动描记器系统。蛋白质表示被西方的污点和 immunohistochemistry 决定。血浆睾丸激素层次用 IMMULITE 1000 免疫分析系统被决定。展出的阉割的老鼠损害了可勃起的功能,由减少的 intracavernosal 压力 / 平均数代表了动脉的压力比率。从阉割的老鼠的国际语音学协会展出了减少的 phenylephrine- ,电场刺激(EFS ) 导致了收缩并且减少导致醋胆素、导致 EFS 的 vasodilatation。从阉割的老鼠的国际语音学协会展出了减少的内部直径,外部直径,动脉的墙的厚度,和代表性的区域。阉割减少了 nNOS 和肌动朊表示和增加的骨胶原表示, p38 (Thr180/Tyr182 ) phosphorylation,以及 caspase 3 劈开。在结论,雄激素缺乏与国际语音学协会反应和结构的缺陷被联系并且增加了表明标记的 apoptosis。我们的调查结果建议导致缺乏的脉管的机能障碍是的那雄激素包含 hypotrophic 的一个事件国际语音学协会的脉管的改变。 | Rheure Alves-Lopes Karla B Neves Marcondes AB Silva Vania C Olivon Silvia G Ruginsk Jose Antunes-Rodrigues Leandra NZ Ramalho Rita C Tostes Fernando Silva Carneiro | 2017 | Asian Journal of Andrology2017，19，5： | 1 |
| 15 | 转让定价与避税地:唇齿还是盾矛?显示文摘转让定价与避税地同为跨国企业进行避税的重要手段。跨国企业通过避税地成立基地公司进行转让定价,利用转让定价将利润更多地转移和滞留在避税地,从而实现整体税收利益的最大化。考虑到两者的紧密联系,在反避税制度建设和征管实践中对转让定价和避税地进行综合协调,有利于提高反避税工作效率。 | 何杨 Leandra Lederman | 2008 | 涉外税务2008，，3： | 1 |
| 16 | Neuroprotection induced by NMDA preconditioning as a strategy to understand brain tolerance mechanism显示文摘Excitotoxicity refers to toxicity caused by abnormal concentrations of glutamate in the synaptic cleft that may lead to neuronal death.Since its description,the phenomenon of glutamatergic excitotoxicity has been implicated in the physiopathology of a wide range of neurological and psychiatric disorders,from acute brain | Leandra C.Constantino Samuel Vandresen-Filho Carla I.Tasca | 2015 | Neural Regeneration Research2015，10，4： | 0 |
| 17 | Adipose-derived stromal/stem cells from different adipose depots in obesity development显示文摘The increasing prevalence of obesity is alarming because it is a risk factor for cardiovascular and metabolic diseases(such as type 2 diabetes). The occurrence of these comorbidities in obese patients can arise from white adipose tissue(WAT) dysfunctions, which affect metabolism, insulin sensitivity and promote local and systemic inflammation. In mammals, WAT depots at different anatomical locations(subcutaneous, preperitoneal and visceral) are highly heterogeneous in their morpho-phenotypic profiles and contribute differently to homeostasis and obesity development, depending on their ability to trigger and modulate WAT inflammation. This heterogeneity is likely due to the differential behavior of cells from each depot. Numerous studies suggest that adiposederived stem/stromal cells(ASC; referred to as adipose progenitor cells, in vivo)with depot-specific gene expression profiles and adipogenic and immunomodulatory potentials are keys for the establishment of the morphofunctional heterogeneity between WAT depots, as well as for the development of depot-specific responses to metabolic challenges. In this review, we discuss depot-specific ASC properties and how they can contribute to the pathophysiology of obesity and metabolic disorders, to provide guidance for researchers and clinicians in the development of ASC-based therapeutic approaches. | Karina Ribeiro Silva Leandra Santos Baptista | 2019 | World Journal of Stem Cells2019，11，3： | 0 |
| 18 | 友情长存显示文摘医师实习培训期刚结束,我就在一家小型社区医院的急诊部就职。作为这组中最新来的成员,在轮班问题上我没有优先权。没有一个人想在平安夜上班,所以那天的班自然而然地就落到了我头上。夜里九点,急救车带来了一个60多岁的男人,他心脏病发作了。病人的病情很不稳定,但我尽了全力,他也在顽强地坚持着。 | Leandra Lynch Fancy | 2007 | 英语教师2007，0，1： | 0 |
| 19 | Work Organization Model Applied on Smallholder Dairy Farms in Brazil显示文摘 | Claudilaine Caldas de Oliveira Antonio Renato Pereira Moro Leandra Ulbricht | 2017 | Journal of Agricultural Science and Technology(A)2017，7，8： | 0 |
| 20 | 5G mobile communication applications for surgery:An overview of the latest literature显示文摘Fifth-generation wireless network,5G,is expected to bring surgery to a next level.Remote surgery and telementoring could be enabled and be brought into routine medical care due to 5G characteristics,such as extreme high bandwidth,ultrashort latency,multiconnectivity,high mobility,high availability,and high reliability.This work explores the benefits,applications and demands of 5G for surgery.Therefore,the development of previous surgical procedures from using older networks to 5G is outlined.The current state of 5G in surgical research studies is discussed,as well as future aspects and requirements of 5G in surgery are presented. | Leandra Börner Valdez Rabi R Datta Benjamin Babic Dolores T Müller Christiane J Bruns Hans F Fuchs | 2021 | Artificial Intelligence in Gastrointestinal Endoscopy2021，2，1： | 0 |
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