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| 1 | 皮质下小血管病诊断的共识声明显示文摘血管性认知损害是用于描述一组涉及大血管和小血管的散发性和遗传性异质性疾病的诊断术语。皮质下小血管病可导致腔隙性梗死和进行性白质损害。被称为宾斯旺格病(Binswanger's disease, BD)的进行性白质损害患者构成了从单纯血管性疾病到合并神经变性病变的疾病谱。BD患者是一个相对同质性的亚组,存在缺氧缺血、腔隙性梗死和炎症,它们协同作用破坏血脑屏障和髓鞘。通过临床、脑脊液、神经心理学和影像学检查获得的多模式疾病标记物能促进该亚组患者的鉴别。本共识声明确定了一系列基于基础病理学改变的潜在生物学标记物,这将有助于诊断以及将来协作性治疗试验的患者选择。 | Gary A Rosenberg Anders Wallin Joanna M Wardlaw Hugh S Markus Joan Montaner Leslie Wolfson Costantino Iadecola Berislav V Zlokovic Anne Joutel Martin Dichgans Marco Duering Reinhold Schmidt Amos D Korczyn Lea T Grinberg Helena C Chui Vladimir Hachinski 王训师 张劼 陈涵丰 俞娅美 徐子奇 罗本燕 | 2016 | 国际脑血管病杂志2016，24，6： | 18 |
| 2 | Bile leakage after loop closure vs clip closure of the cystic duct during laparoscopic cholecystectomy:A retrospective analysis of a prospective cohort显示文摘BACKGROUND Laparoscopic cholecystectomy(LC)is one of the most frequently performed surgical procedures.Cystic stump leakage is an underestimated,potentially life threatening complication that occurs in 1%-6%of the patients.With a secure cystic duct occlusion technique during LC,bile leakage becomes a preventable complication.AIM To investigate the effect of polydioxanone(PDS)loop closure of the cystic duct on bile leakage rate in LC patients.METHODS In this retrospective analysis of a prospective cohort,the effect of PDS loop closure of the cystic duct on bile leakage complication was compared to patients with conventional clip closure.Logistic regression analysis was used to develop a risk score to identify bile leakage risk.Leakage rate was assessed for categories of patients with increasing levels of bile leakage risk.RESULTS Of the 4359 patients who underwent LC,136(3%)underwent cystic duct closure by a PDS loop.Preoperatively,loop closure patients had significantly more complicated biliary disease compared to the clipped closure patients.In the loop closure cohort,zero(0%)bile leakage occurred compared to 59 of 4223(1.4%)clip closure patients.For patients at increased bile leakage risk(risk score≥1)rates were 1.6%and up to 13%(4/30)for clip closure patients with a risk score≥4.This risk increase paralleled a stepwise increase of actual bile leakage complication for clip closure patients,which was not observed for loop closure patients.CONCLUSION Cystic duct closure with a PDS loop during LC may reduce bile leakage in patients at increased risk for bile leakage. | Sandra C Donkervoort Lea M Dijksman Aafke H van Dijk Emile A Clous Marja A Boermeester Bert van Ramshorst Djamila Boerma | 2020 | World Journal of Gastrointestinal Surgery2020，12，1： | 4 |
| 3 | Activity of antioxidant en-zymes in response to cadmium in Crotalaria juncea显示文摘 | Pereira G J G Molina S M G Lea P J | 2002 | Plant andSoil2002，239，： | 1 |
| 4 | The mechanism of sulphate attack on Portland cement 显示文摘 | LEA F M | 1949 | Can J Res: B-Chem Sci1949，27，4： | 1 |
| 5 | The immunolocali-zation of bcl-2 at the maternal-fatal interface in healthy and failing pregnancies显示文摘 | LEA RG AL-SHAREKH N TULPPALA M | 1997 | Human Reprod1997，12，1： | 1 |
| 6 | The performance of group norms in computer-mediated communication显示文摘 | Postmen T Spears R Lea M | 2010 | Human Communication Research2010，26，3： | 1 |
| 7 | Activity of antioxidant enzymes in response to cadmium in Crotalariajuncea显示文摘 | PEREIRA G J G MOLINA S M G LEA P J | 2002 | Plant and Soil2002，，239： | 1 |
| 8 | Comparison of genomic DNA extraction techniques from whole blood samples: a time, cost and quality evaluation study 显示文摘 | Chaeon-Cortes D Haupt L M Lea R A | 2012 | Mol Biol Rep2012，39，5： | 1 |
| 9 | The JAK2 V617F mutation is rare in RARS but common in RARS - T 显示文摘 | CEESAY M M LEA N C INGRAM W | 2006 | Leukemia2006，20，11： | 1 |
| 10 | Limited heterogeneity in the T cell receptor V-gene usage in lymphocytes infiltrating human coloreetal tumours显示文摘 | Ostenstad B Sioud M Lea T Schlichting E Harboe M | 1994 | Br J Cancer1994，69，： | 1 |
| 11 | Differential expression of four Arabidopsis PAL genes; PAL1 and PAL2 have functional specialization in abiotic environmental- triggered flavonoid synthesis显示文摘 | OLSEN K M LEA U S SLIMESTAD R | 2008 | Journal of Plant Physiology2008，165，： | 1 |
| 12 | Reality check: augmentedreality for school libraries显示文摘 | Green M Lea J H Mcnair C L | 2014 | Teacher Librarian2014，1，5： | 1 |
| 13 | The structure and function of a foot-and-mouth disease virus-oligo saccharide receptor complex显示文摘 | Fry E E Lea S M Jackson T | 1999 | EMBO J1999，18，： | 1 |
| 14 | Silencing of HPV 18 oncoproteins With RNA interference causes growth inhibition of cervical cancer cells显示文摘 | Sunaga N Sato M | 2007 | Reprod Sci2007，14，1： | 1 |
| 15 | Two cytosolic glutamine synthetase isoforms of maize are specifically involved in the control of grain production 显示文摘 | Martin A Lee J Kichey T Gerentes D Zivy M Tatout C Dubois F Balliau T Valot B Davanture M Laforgue T T Quillere I Coque M Gallais A Moro M B G Bethencourt L Habash D Z Lea P J Charcosset A Perez P Murigneux A Sakakibara H Edwards K J Hirel B | 2006 | The Plant Cell2006，18，11： | 1 |
| 16 | The role of inflammation in regulating platelet production and ftmction: Toll-like receptors in platelets and megakaryocytes 显示文摘 | Beaulieu Lea M Freedman | 2010 | Thro- mb Research2010，125，3： | 1 |
| 17 | Mortalities of pond-cultured juvenile shrimp, Penaeus monodon, associated with dominance of luminescent Vibrios in the rearing environment显示文摘 | Lavilla-Pitogo C R Lea?o E M Paner M G | 1998 | Aquaculture1998，164，14： | 1 |
| 18 | Differential expression of four Arabidopsis PAL genes; PAL1 and PAL2 have functional specialization in abiotic environmental-triggered flavonoid synthesis 显示文摘 | OLSEN K M LEA U S LILLO C | 2008 | Journal of Plant Physiology2008，，165： | 1 |
| 19 | Rapid analysis of geosmin and 2-methylisobomeol in water using solid phase microsolid phase micro extraction procedures显示文摘 | Lloyd S W Lea J M Zimba P V | 1998 | Water Research1998，32，7： | 1 |
| 20 | Deficient syncytio-trophoblast tumor necrosis factor-alpha characterizes failing of recrurrent miscarrage patients显示文摘 | Lea RG Tulppala M Critchley HO | 1997 | Hum Reprod1997，12，： | 1 |
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