|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Effects of glutamine supplementation on gut barrier,glutathione content and acute phase response in malnourished rats during inflammatory shock显示文摘AIM: To evaluate the effect of glutamine on intestinal mucosa integrity,glutathione stores and acute phase response in protein-depleted rats during an inflammatory shock. METHODS: Plasma acute phase proteins (APP),jejunal APP mRNA levels,liver and jejunal glutathione concentrations were measured before and one,three and seven days after turpentine injection in 4 groups of control,protein-restricted,protein-restricted rats supplemented with glutamine or protein powder. Bacterial translocation in mesenteric lymph nodes and intestinal morphology were also assessed. RESULTS: Protein deprivation and turpentine injection significantly reduced jejunal villus height,and crypt depths. Mucosal glutathione concentration significantly decreased in protein-restricted rats. Before turpentine oil,glutamine supplementation restored villus heights and glutathione concentration (3.24 ± 1.05 vs 1.72 ± 0.46 μmol/g tissue,P < 0.05) in the jejunum,whereas in the liver glutathione remained low. Glutamine markedly increased jejunal α1-acid glycoprotein mRNA level after turpentine oil but did not affect its plasma concentration. Bacterial translocation in protein-restricted rats was not prevented by glutamine or protein powder supplementation. CONCLUSION: Glutamine restored gut glutathione stores and villus heights in malnourished rats but had no preventive effect on bacterial translocation in our model. | Liliana Belmonte Mose Co■ffier Florence Le Pessot Olga Miralles-Barrachina Martine Hiron Antony Leplingard Jean-Franois Lemeland Bernadette Hecketsweiler Maryvonne Daveau Philippe Ducrotté Pierre Déchelotte | 2007 | World Journal of Gastroenterology2007，13，20： | 6 |
| 2 | Circular RNA circCCNB1 inhibits the migration and invasion of nasopharyngeal carcinoma through binding and stabilizing TJP1 mRNA显示文摘Nasopharyngeal carcinoma(NPC)is a malignant tumor that usually occurs in people from Southeast Asia and Southern China.NPC is prone to migration and invasion,leading to poor prognosis.A large number of circular RNAs(circ RNAs)exacerbate the process of metastasis in NPC;however,their underlying mechanisms remain unclear.We found that the circular RNA circ CCNB1,encoded by the oncogene CCNB1,was downregulated in NPC biopsies and cell lines.In vitro assays show that circ CCNB1 inhibits NPC cell migration and invasion.Moreover,circ CCNB1 induces a protein,nuclear factor 90(NF90),to bind and prolong the half-life of tight junction protein 1(TJP1)m RNA.Upregulation of TJP1 enhances tight junctions between cancer cells and inhibits NPC cell migration and invasion.This study reveals a novel biological function of circ CCNB1 in the migration and invasion of NPC by enhancing the tight junctions of cancer cells by binding to NF90 proteins and TJP1 m RNA,and may provide a potential therapeutic target for NPC. | Mengyao Zhao Yian Wang Fenghua Tan Lingyun Liu Xiangchan Hou Chunmei Fan Le Tang Yongzhen Mo Yumin Wang Qijia Yan Zhaojian Gong Zheng Li Qianjin Liao Can Guo He Huang Xi Zeng Guiyuan Li Zhaoyang Zeng Wei Xiong Fuyan Wang | 2022 | Science China(Life Sciences)2022，65，11： | 4 |
| 3 | Lodging Resistance Related to Root Traits for Mechanized Wet-Seeding of Two Super Rice Cultivars显示文摘Mechanical hill wet-seeded rice machine is beneficial for establishing and growing uniform rows of seedlings.However,there is limited knowledge regarding the effects of the establishment of furrows on growth,lodging and yield,and their relationships with root traits.In this study,field experiments were conducted during 2012 and 2013 using two super rice varieties(hybrid rice Peizataifeng and inbred rice Yuxiangyouzhan)under three furrow establishment treatments(T1,both water and seed furrows were established by the machine;T2,only seed furrows were established by the machine;and T3,neither water nor seed furrows were established by the machine).Lodging index,lodging-related traits,grain yield,above-ground dry weight and root traits were measured.The results showed that the lodging index was significantly affected by the treatments with furrows(T1 and T2).The strongest lodging resistance was detected in the mechanical hill wet-seeded rice with furrow treatment(T1)in both 2012 and 2013.Lodging resistance was strongly related to the breaking resistance.No significant difference was found in grain yield or dry weight of the mechanical hill wet-seeded rice.Therefore,the mechanical hill wet-seeded rice with furrow treatment increased rice lodging resistance,which was related to root traits. | ZHANG Minghua MO Zhaowen LIAO Juan PAN Shenggang CHEN Xiongfei ZHENG Le LUO Xiwen WANG Zaiman | 2021 | Rice science2021，28，2： | 3 |
| 4 | Pharmacokinetic study and cardiovascular monitoring of nebivolol in normal and obese subjects显示文摘 | G. Cheymol R. Woestenborghs E. Snoeck R. Ianucci J.-P. Le Moing L. Naditch J. C. Levron J. M. Poirier | 1997 | European Journal of Clinical Pharmacology1997，，6： | 1 |
| 5 | Toward understanding evi- dence uptake: Semirecumbent for pneumonia prevention显示文摘 | Cook DJ Meade MO Hand LE | 2002 | Crit Care Med2002，30，7： | 1 |
| 6 | High-density lipoprotein regulates angiogenesis by long non-coding RNA HDRACA显示文摘Normal high-density lipoprotein(nHDL)can induce angiogenesis in healthy individuals.However,HDL from patients with coronary artery disease undergoes various modifications,becomes dysfunctional(dHDL),and loses its ability to promote angiogenesis.Here,we identified a long non-coding RNA,HDRACA,that is involved in the regulation of angiogenesis by HDL.In this study,we showed that nHDL downregulates the expression of HDRACA in endothelial cells by activating WW domain-containing E3 ubiquitin protein ligase 2,which catalyzes the ubiquitination and subsequent degradation of its transcription factor,Kruppel-like factor 5,via sphingosine 1-phosphate(S1P)receptor 1.In contrast,dHDL with lower levels of S1P than nHDL were much less effective in decreasing the expression of HDRACA.HDRACA was able to bind to Ras-interacting protein 1(RAIN)to hinder the interaction between RAIN and vigilin,which led to an increase in the binding between the vigilin protein and proliferating cell nuclear antigen(PCNA)mRNA,resulting in a decrease in the expression of PCNA and inhibition of angiogenesis.The expression of human HDRACA in a hindlimb ischemia mouse model inhibited the recovery of angiogenesis.Taken together,these findings suggest that HDRACA is involved in the HDL regulation of angiogenesis,which nHDL inhibits the expression of HDRACA to induce angiogenesis,and that dHDL is much less effective in inhibiting HDRACA expression,which provides an explanation for the decreased ability of dHDL to stimulate angiogenesis. | Zhi-Wei Mo Yue-Ming Peng Yi-Xin Zhang Yan Li Bi-Ang Kang Ya-Ting Chen Le Li Mary GSorci-Thomas Yi-Jun Lin Yang Cao Si Chen Ze-Long Liu Jian-Jun Gao Zhan-Peng Huang Jia-Guo Zhou Mian Wang Guang-Qi Chang Meng-Jie Deng Yu-Jia Liu Zhen-Sheng Ma Zuo-Jun Hu Yu-Gang Dong Zhi-Jun Ou Jing-Song Ou | 2023 | Signal Transduction and Targeted Therapy2023，8，9： | 1 |
| 7 | Selection of probiotic bacteria for prevention of allergic diseaes: immunomodulation of neonatal dendritic cells 显示文摘 | Niers LE Hoekstra MO Timmerman HM | 2007 | Clin Exp Immunol2007，149，2： | 1 |
| 8 | Integrated population pharmacokinetic analysis of voriconazole in children,adolescents, and adults显示文摘 | FRIBERG LE RAVVA P KARLSSON MO | 2012 | Antimicrob Agents Chemother2012，56，6： | 1 |
| 9 | Patient reported outcome measures following specialistnurse - led clinics in preparation for breast reconstructionsurger显示文摘 | Caroline LE Osbome Fiona G Court Joseph MO Donoghue | 2010 | The Breast2010，19，： | 1 |
| 10 | A study of the physiologic responses to a lung recruitment maneuver in acute lung injury and acute respiratory distress syn- drome显示文摘 | Meade MO Cook DJ Griffith LE | 2008 | Respir Care2008，53，11： | 1 |
| 11 | Familial and non-familial benign infantile seizures:A homogeneous entity显示文摘 | Bourel-Ponchel E Le Moing AG Delignieres A | | 0，，： | 1 |
| 12 | Toward understanding evdence uptake:semirecumbency for pneumonia prevention显示文摘 | Cook DJ Meade MO Hand LE | | 0，，7： | 1 |
| 13 | Toward understanding evidence uptake:semirecumbency for pneumonia prevention显示文摘 | Cook DJ Meade MO Hand LE | 2002 | Crit Care Med2002，30，： | 1 |
| 14 | A Modified Non-Homogeneous Model for Codon Preference and Primary Sequence Structure in Protein-Coding Regions显示文摘Based on non-homogeneous model, a modified model is proposed. The new model deals with codon preference in protein-coding regions, reflects more accurately the key biological features of the regions. In addition, it is demonstrated, via an example, the modified model offers better solutions than previous model does. | Han Le,Mo Zhong-xi School of Mathematics and Statistics, Wuhan University, Wuhan 430072 ,Hubei, China | 2002 | Wuhan University Journal of Natural Sciences2002，7，2： | 1 |
| 15 | Toward understanding evidence uptake: semirecumbency for pneumonia prevention显示文摘 | Cook DJ Meade MO Hand LE | 2002 | Crit Care Med2002，30，7： | 1 |
| 16 | A study of the physiologic respon- ses to a lung ver in acute lung injury and acute respira- tory distress syndrome 显示文摘 | Meade MO Cook DJ Griffith LE | 2008 | Respir Care2008，53，11： | 1 |
| 17 | Clinical outcome of patients with HIV-1infection according to immunologic and virologic response after 6 months of highly active antiretroviral therapy显示文摘 | Grabar S Le Moing V Goujard C | 2000 | Ann Intern Med2000，133，6： | 1 |
| 18 | A study of the physiologic responses to a lung recruitment maneuver in acute lung injury and acute respiratory distress syndrome显示文摘 | Meade MO Cook DJ Griffith LE | 2008 | Respir Care2008，53，11： | 1 |
| 19 | Hepatoprotecdve role of in-terleukin 10in galactosamine/lipopolysaccharide mouse liver injury显示文摘 | Louis H Le Moine O Peny MO | 1997 | Gastroenterology1997，112，3： | 1 |
| 20 | Multicytokine detection improves latent tuberculosis diagnosis in health care workers显示文摘 | Rubbo PA Nagot N Le Moing V | | 0，，05： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员