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| 1 | Diffusion-weighted magnetic resonance imaging to predict response of hepatocellular carcinoma to chemoembolization显示文摘AIM: To investigate whether intra-procedural diffusion- weighted magnetic resonance imaging can predict response of hepatocellular carcinoma (HCC) during trans- catheter arterial chemoembolization (TACE). METHODS: Sixteen patients (15 male), aged 59 ±11 years (range: 42-81 years) underwent a total of 21 separate treatments for unresectable HCC in a hybrid magnetic resonance/interventional radiology suite. Ana- tomical imaging and diffusion-weighted imaging (b = 0, 500 s/mm2) were performed on a 1.5-T unit. Tumor enhancement and apparent diffusion coefficient (ADC, mm2/s) values were assessed immediately before and at 1 and 3 mo after TACE. We calculated the percent change (PC) in ADC values at all time points. We compared follow-up ADC values to baseline values using a paired t test (α = 0.05). RESULTS: The intra-procedural sensitivity, specificity, and positive and negative predictive values (%) for detecting a complete or partial 1-mo tumor response using ADC PC thresholds of ±5%, ±10%, and ±15% were 77, 67, 91, and 40; 54, 67, 88, and 25; and 46, 100, 100, and 30, respectively. There was no clear predictive value for the 3-mo follow-up. Compared to baseline, the immediate post-procedure and 1-mo mean ADC values both increased; the latter obtaining statistical significance (1.48 ± 0.29 mm2/s vs 1.65 ± 0.35 × 10-3 mm2/s, P < 0.014). CONCLUSION: Intra-procedural ADC changes of > 15% predicted 1-mo anatomical HCC response with the greatest accuracy, and can provide valuable feedback at the time of TACE. | Johnathan C Chung Neel K Naik Robert J Lewandowski Mary F Mulcahy Laura M Kulik Kent T Sato Robert K Ryu Riad Salem Andrew C Larson Reed A Omary | 2010 | World Journal of Gastroenterology2010，16，25： | 13 |
| 2 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 3 | The effect of setup uncertainties on the radiobiological advantage of fractionation in stereotaxic radiotherapy显示文摘 | Lo Y C Ling C C Larson D A | 1996 | In J Radiat Oncol Biol Plays1996，34，5： | 1 |
| 4 | Reli- ability and validity of the 12 - minute distance walk in pa- tients with chronic obstructive pulmonary disease显示文摘 | LARSON J L COVEY M K VITALO C A | 1996 | Nurs Res1996，45，4： | 1 |
| 5 | Direct removal in the mouse of a floxed neo gene from a three-loxp conditional knockout allele by two novel approaches 显示文摘 | Li C Garrett-Beal L Larson D Wynshaw-Boris A Deng CX | 2001 | Genesis2001，30，1： | 1 |
| 6 | Nephrectomy induced chronic renal insufficiency is associated with increased risk of cardiovascular death and death from any cause in patients with localized cT1b renal masses显示文摘 | WEIGHT C J LARSON B T FERGANY A F | 2010 | J Urol2010，183，4： | 1 |
| 7 | Safety and tolerability of intraputaminal delivery of CERE-120 (adeno-associated virus serotype 2–neurturin) to patients with idiopathic Parkinson’s disease: an open-label, phase I trial显示文摘 | William J Marks Jill L Ostrem Leonard Verhagen Philip A Starr Paul S Larson Roy AE Bakay Robin Taylor Deborah A Cahn-Weiner A Jon Stoessl C Warren Olanow Raymond T Bartus | 2008 | Lancet Neurology2008，，5： | 1 |
| 8 | Predicting the effects of tillage and crop residue management on soil erosion显示文摘 | GUPTA S C ONSTAD C A LARSON W E | 1979 | Soil Water Conserv1979，34，： | 1 |
| 9 | Ne- phrectomy induced chronic renal insufficiency is associ- ated with increased risk of cardiovascular death and death from any cause in patients with localized cTlb re- nal masses显示文摘 | Weight C J Larson B T Fergany A F | 2010 | J Urol2010，183，4： | 1 |
| 10 | Development of an alternative approach to protein crystallization 显示文摘 | McPherson A Nguyen C Larson S B | 2007 | J Struct Funct Gen2007，8，4： | 1 |
| 11 | Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans显示文摘 | Rhee Eugene P Cheng Susan Larson Martin G Walford Geoffrey A Lewis Gregory D McCabe Elizabeth Yang Elaine Farrell Laurie Fox Caroline S O’Donnell Christopher J Carr Steven A Vasan Ramachandran S Florez Jose C Clish Clary B Wang Thomas J Ger | 2011 | Journal of Clinical Investigation2011，，4： | 1 |
| 12 | NCSOIL, a model of nitrogen and carbon transformation in soil: Description, calibration, and behavior显示文摘 | Moiina j A E Clapp C E Shaffer M J Chichester F W Larson W E | 1983 | Soil Science Society of America Journal1983，47，1： | 1 |
| 13 | Nephrectomy induced chronic renal insufficiency is associated with increased risk of cardiovascular death and death from any cause in pa- tients with localized cTlb renal masses 显示文摘 | Weight C J Larson B T Fergany A F Gao T Lane B R Campbell S C | 2010 | J Urol2010，183，： | 1 |
| 14 | Therapeutic use of the chemokines显示文摘 | Bone Larson C Matsukawa A | 2000 | Cur Pharma Des2000，6，6： | 1 |
| 15 | Monoterpenes in the glandular trichomes of tomato are synthesized from a neryl diphosphate precursor rather than geranyl diphosphate显示文摘 | Schilmiller A.L Schauvinhold I Larson M Xu R Charbonneau A.L Schmidt A Wilkerson C Last R.L and Pichersky E | | 0，，： | 1 |
| 16 | Apparatus dependence of normal brain tissue dose in stereotactic radiosurgery for multiple brain metastases显示文摘 | Ma L Petti P Wang B Descovich M Chuang C Barani IJ Kunwar S Shrieve DC Sahgal A Larson DA | 2011 | 中国神经肿瘤杂志2011，9，1： | 1 |
| 17 | Crystal size distribution in continuous crystallizer when growth rate is size-dependent 显示文摘 | Abegg C F Stevens J D Larson M A | 1968 | AIChE J1968，14，： | 1 |
| 18 | Long-term follow-up of Cancer and Leukemia Group B studies in acute myeloid leukemia显示文摘 | Schiffer C A Dodge R Larson R A | 1997 | Cancer1997，80，11： | 1 |
| 19 | Therapist burnout: Perspectives on a critical issue 显示文摘 | Larson C C Gilbertson D L Powell J A | 1978 | Social Casework1978，，59： | 1 |
| 20 | Wet air Regeneration of PAC: Comparison of Carbons with Different surface oxygen characteristics 显示文摘 | Wedeking C A Snoeyink V L Larson R | 1987 | Water Res1987，21，： | 1 |
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