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| 1 | Direct reprogramming of human fibroblasts into dopaminergic neuron-like cells显示文摘外长的 dopaminergic 神经原(DA 神经原) 的移植是为治疗 Parkinson 的疾病(PD ) 的一条有希望的途径。然而,主要跌倒块是施主 DA 神经原的可靠来源的缺乏。这里,我们证明五 transcriptional 因素 Mash1, Ngn2, Sox2, Nurr1,和 Pitx3 的联合直接并且有效地装改编人成纤维细胞进 DA 像神经原的房间。为为 DA 神经原的各种各样的标记积极的染色的 reprogrammed 房间。他们也显示出典型 DA 举起和生产性质。而且,他们展出了 DA 神经原特定的 electrophysiological 侧面。最后,他们在一个老鼠 PD 模型提供了征兆的地势。因此,我们的直接 reprogrammed DA 像神经原的房间是为 PD 的房间代替治疗的有希望的来源。 | Xinjian Liu Fang Li Elizabeth A Stubblefield Barbara Blanchard Toni L Richards Gaynor A Larson Yujun He Qian Huang Aik-Choon Tan Dabing Zhang Timothy A Benke John R Sladek Nancy R Zahniser Chuan-Yuan Li | 2012 | Cell Research2012，22，2： | 14 |
| 2 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 3 | Evidence for a 15; 17translocation in every patient with acute promyelmytic leukemia显示文摘 | LARSON R A KONDO K VARDIMAN J W BUTLER A E GOLOMB H M ROWLEY J D | 1984 | Am J Med1984，76，5： | 1 |
| 4 | Time Temperature Relation for Rupture and Creep Stresses显示文摘 | Larson F R Miller J A | 1952 | Trans ASME1952，74，： | 1 |
| 5 | Clonal origin of recurrent meningiomas显示文摘 | von Deimling A Larson J Wellenreuther R | 1999 | Brain Pathol1999，9，4： | 1 |
| 6 | Diurnal variation of radon and mixing heights along a coast: a case study 显示文摘 | Hsu S A Larson R E Bressan D J | 1980 | Journal of Geophysical Research1980，85，： | 1 |
| 7 | Pollen-medi- ated gene flow from Kentucky bluegrass under cultivated field conditions显示文摘 | JOHNSON P G Larson S R Anderton A L | 2006 | Crop Science2006，46，5： | 1 |
| 8 | Rapid com- munication: restriction fragment length polymorphisms at the porcine transporter associated with antigen processing 1 (TAP1) locus显示文摘 | Vaske D A Ruohonen M K Larson R ~ | 1994 | JAnim Sci1994，72，1： | 1 |
| 9 | Efficacy and safety of gemtuzumab ozogamicin in patients with CD33positive acute myeloid leukemia in first relapse显示文摘 | Sievers E L Larson R A Stadtmauer E A | 2001 | J Clin Oncol2001，，： | 1 |
| 10 | Reimmunization after allogeneic bone marrow transplan taton显示文摘 | Somani J Larson R A | | 0，，： | 1 |
| 11 | Scope: Easy and efficient parallel processing of massive data sets显示文摘 | Chaiken R Jenkins B Larson P A | 2008 | Proc of the VLDB Endowment2008，1，2： | 1 |
| 12 | Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia显示文摘 | O'Brien S G Guilhot F Larson R A | | New England Journal of Medicine0，，： | 1 |
| 13 | Local Derivations and Automorphisms of B(X)显示文摘 | Larson D R Sourour A R | | 0，，： | 1 |
| 14 | Oxidative polymerization of dissolved phenols by soluble and insoluble inorganic species 显示文摘 | LARSON R A Hufnal J M | 1980 | Limnology and Oceanography1980，25，2： | 1 |
| 15 | Relationship between age of blastocyst formation and interferon-τ secretion by in vitro-derived bovine embryos 显示文摘 | Kubisch H M Larson M A Roberts R M | 1998 | Mol Reprod Dev1998，49，： | 1 |
| 16 | Evolution and phylogenetic information content of mitochondrial genomic structural features illustrated with acrodont lizards显示文摘 | Macey J R Schulte J A Larson A | 2000 | Systematic Biology2000，49，2： | 1 |
| 17 | The antioxidants of higher plants 显示文摘 | Larson R A | 1988 | Phytochemistry1988，27，4： | 1 |
| 18 | Reactivity of the carbonate radical with aniline derivatives显示文摘 | Larson R A Zepp R G | 1998 | Environ Toxicol Chem1998，7，4： | 1 |
| 19 | The antioxidants of higher plants显示文摘 | Larson R A 1988 | 1988 | Phytochem1988，27，： | 1 |
| 20 | The economics of air pollution health risks in Russia: a case study of Volgograd 显示文摘 | Larson B A Avaliani S Golub A Rosen S Shaposhnikov D Strukova E Vincent J R Wolff S K | 1999 | World development1999，27，10： | 1 |
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