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| 1 | Sarcopenia in heart failure: mechanisms and therapeutic strategies显示文摘长期的心失败(CHF ) 是一个高度流行的条件在之中老并且与可观的病态, institutionalization 和死亡被联系。在它的先进阶段, CHF 被肌肉质量和力量的损失经常伴随。Sarcopenia 是活跃地与大量不利健康结果由于它的协会在最近的年里被学习了的衰老老人症候群。这评论的目标是讨论在 CHF 和 sarcopenia 之间的关系,与分享的 pathophysiological 小径和处理的一个焦点。营养不良,全身的发炎,内分泌的不平衡,和氧化应力看起来连接 sarcopenia 和 CHF。在肌肉发达的水平, ubiquitin proteasome 系统,发信号的 myostatin,和 apoptosis 的改变在 sarcopenia 和 CHF 被描述了并且能在肌肉质量和功能的损失起一个作用。阻碍肌肉在 CHF 病人浪费的前进的可能的治疗学的策略包括变换血管收缩素的酶禁止者和 β 的蛋白质和维生素 D 补充,结构化的物理锻练,和管理; -blockers。有生长荷尔蒙,睾丸激素,和 ghrelin 的神经质的补充也作为潜在的治疗被讨论。 | Agnese Collamati Emanuele Marzetti Riccardo Calvani Matteo Tosato Emanuela D'Angelo Alex N Sisto Francesco Landi | 2016 | Journal of Geriatric Cardiology2016，13，7： | 25 |
| 2 | Magnetic resonance diffusion tensor imaging and fibertracking diffusion tensor tractography in the management of spinal astrocytomas显示文摘Some specially imaging of magnetic resonance imaging,the diffusion-weighted imaging(DWI),the diffusion tensor imaging and fractional anisotropy(FA),are useful to described,detect,and map the extent of spinal cord lesions.FA measurements may are used to predicting the outcome of patients who have spinal cord lesions.Fiber tracking enable to visualizing the integrity of white matter tracts surrounding some lesions,and this information could be used to formulating a differential diagnosis and planning biopsies or resection.In this article,we will describe the current uses for DWI and fiber tracking and speculate on others in which we believe these techniques will be useful in the future. | Alessandro Landi Valeria Palmarini Alessandro D'Elia Nicola Marotta Maurizio Salvati Antonio Santoro Roberto Delfini | 2016 | World Journal of Clinical Cases2016，4，1： | 6 |
| 3 | MicroRNA Signature in Metastatic Colorectal Cancer Patients Treated With Anti-EGFR Monoclonal Antibodies显示文摘 | Federico Cappuzzo Andrea Sacconi Lorenza Landi Vienna Ludovini Francesca Biagioni Armida D’Incecco Alessandra Capodanno Jessica Salvini Enrichetta Corgna Samanta Cupini Cecilia Barbara Gabriella Fontanini Lucio Crinò Giovanni Blandino | 2013 | Clinical Colorectal Cancer2013，，： | 3 |
| 4 | Biomarker-guided sequential targeted therapies to overcome therapy resistance in rapidly evolving highly aggressive mammary tumors显示文摘组合指向的治疗在由堵住治疗癌症是更有效的绕过机制或导致的合成致命性。然而,他们的临床的申请被抵抗和毒性妨碍。遇见这重要挑战,我们用 ErbB2-overexpressing/PTEN-low 开发了并且测试各种各样的指向的治疗的指导 biomarker 的顺序的应用程序的一个新奇概念,高度好攻击的乳癌作为我们的模型。惊人地,从遗传上设计的鼠标与 intratumoral 异质从病人和乳房的肿瘤在两 PTEN-low/trastuzumab-resistant 乳癌支撑了 ErbB2 和下游的小径驱动器 trastuzumab 抵抗的激活。尽管 lapatinib 开始禁止了 trastuzumab 抵抗的鼠标肿瘤,肿瘤由激活表明由量的蛋白质数组出现的网络的 PI3K/mTOR 绕过抑制。有趣地,小径也是的 mTOR 的激活在 neoadjuvant 观察了表明 lapatinib 抵抗的对待 lapatinib 的病人。Trastuzumab + lapatinib 抵抗被一个 PI3K/mTOR 双 kinase 禁止者(BEZ235 ) 的顺序的申请有效地没有重要毒性克服。然而,我们的 p-RTK 数组分析证明 BEZ235 治疗在遗传上设计的老鼠肿瘤导致了增加的 ErbB2 表示和 phosphorylation,导致 BEZ235 抵抗并且在 3-D,然而并非 2-D,文化。机械学地,我们作为 BEZ235 抵抗的新奇机制识别了 ErbB2 蛋白质稳定和激活,它被随后的治疗与 lapatinib + BEZ235 联合颠倒。显著地, biomarker 指导的指向的治疗的这个顺序的应用程序在很快发展加倍的抵抗的肿瘤改变忍受极其好攻击的肿瘤的鼠标的寿命。使用的这条根本上新奇的途径有效地在一个顺序的顺序罐头指向了治疗目标和改编在在治疗期间发展抵抗的癌症的发信号的网络。 | Ozgur Sahin Qingfei Wang Samuel W Brady Kenneth Ellis Hai Wang Chia-Chi Chang Qingling Zhang Preety Priya Rui Zhu Stephen T Wong Melissa D Landis William J Muller Francisco J Esteva Jenny Chang Dihua Yu | 2014 | Cell Research2014，24，5： | 2 |
| 5 | Structure-property relations in processing high-performance polyisoimide-imide resins显示文摘 | CHOW A W HAMLIN R D LANDIS A L | 1992 | Journal of Rheology1992，36，8： | 1 |
| 6 | Histologic changes induced by intraperitoneal chemotherapy with 5-fluorouracil and mitomycin C in patients with peritone al carcinomatosis and cystadenocarcinoma of the colon or appendix 显示文摘 | Landy D Jaffe G | 1990 | Cancer1990，65，： | 1 |
| 7 | Plastic surgery at the time of membrane removal around mandibular endosseous implants:a modified technique for implant uncovering显示文摘 | Landi L Sabatucci D | 2001 | Int J Periodonics Restorstive Dent2001，21，3： | 1 |
| 8 | Polymorphisms within micro-RNA-binding sites and risk of sporadic colorectal cancer显示文摘 | Landi D Gemignani F Naccarati A | | 0，，03： | 1 |
| 9 | Cyclodextrins : A new effi- cient absorbent to treat waste gas streams 显示文摘 | Blach P Fourmentin S Landy D | 2008 | Chemosphere2008，70，： | 1 |
| 10 | On the path-dependence of the J-integral near a stationary crack in an elastic-plastic material显示文摘 | Carka D Landis CM | | 0，，： | 1 |
| 11 | Complexation efficiency of cyclodextrins for volatile flavor compounds显示文摘 | Ciobanu A Landy D Fourmentin S | 2013 | Food Research International2013，53，1： | 1 |
| 12 | Modeling the Roadside Walking Environment: A Pedestrian level of Service显示文摘 | Landis B W VattikutiV R Otten berg R M McLeod D S Guttenplan M | | Transportation Research Record: Journal of the Transportation Research Board 200 I 17730，，： | 1 |
| 13 | Carbon nanotubes for lithium ion batteries 显示文摘 | Landi B J Canter M J Cress C D | 2009 | Energy Environ Sei2009，2，6： | 1 |
| 14 | Structures and Process of Social Support 显示文摘 | House J Umberson D Landis K | 1988 | Annual Review of Sociology1988，，14： | 1 |
| 15 | Discovery of a unique Ig heavy-chain isotype (IgT)in rainbow trout: implications for a distinctive B cell developmental pathway in teleost fish 显示文摘 | Hansen J D Landis E D Phillips R B | 2005 | Proceedings of the National Academy of Sciences of the United States of America2005，102，19： | 1 |
| 16 | Development differ-ences in the comprehension of semantic relations显示文摘 | Landis T Herrmann D Chaffin R | 1987 | Zeitschrift für Psychologie mit Zeitschrift für Angewandte Psychologie1987，195，2： | 1 |
| 17 | Scheduling semiconductor burn-in operations to minimize total flowtime显示文摘 | HOCHBAUM D S LANDY D | 1997 | Oper Res1997，45，6： | 1 |
| 18 | Managing and Supporting Large Integrated and Interdisciplinary Field Studies:The Boreas Example显示文摘 | Newcomer JA Huemmrich K F Landis D | 2001 | Journal of Geophysical Research-Atmospheres2001，106，33： | 1 |
| 19 | Vertebral artery hypoplasia:apredisposing factor for posterior circulation stroke?显示文摘 | Perren F Poglia D Landis T | 2007 | Neurology2007，68，1： | 1 |
| 20 | Appendicitis and cholecystitis in pregnancy显示文摘 | Gilo NB Amini D Landy HJ | 2009 | Clin Obstet Gynecol2009，52，4： | 1 |
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