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| 1 | Narrow-band imaging with magnifying endoscopy is accurate for detecting gastric intestinal metaplasia显示文摘AIM:To investigate the predictive value of narrowband imaging with magnifying endoscopy (NBI-ME) for identifying gastric intestinal metaplasia (GIM) in unselected patients. METHODS:We prospectively evaluated consecutive patients undergoing upper endoscopy for various indications, such as epigastric discomfort/pain, anaemia, gastro-oesophageal reflux disease, suspicion of peptic ulcer disease, or chronic liver diseases. Patients underwent NBI-ME, which was performed by three blinded, experienced endoscopists. In addition, five biopsies (2 antrum, 1 angulus, and 2 corpus) were taken and examined by two pathologists unaware of the endoscopic findings to determine the presence or absence of GIM. The correlation between light blue crest (LBC) appearance and histology was measured. Moreover, we quantified the degree of LBC appearance as less than 20% (+), 20%-80% (++) and more than 80% (+++) of an image field, and the semiquantitative evaluation of LBC appearance was correlated with IM percentage from the histological findings. RESULTS:We enrolled 100 (58 F/42 M) patients who were mainly referred for gastro-esophageal reflux disease/dyspepsia (46%), cancer screening/anaemia (34%), chronic liver disease (9%), and suspected celiac disease (6%); the remaining patients were referred for other indications. The prevalence of Helicobacter pylori (H. pylori ) infection detected from the biopsies was 31%, while 67% of the patients used proton pump inhibitors. LBCs were found in the antrum of 33 patients (33%); 20 of the cases were classified as LBC+, 9 as LBC++, and 4 as LBC+++. LBCs were found in the gastric body of 6 patients (6%), with 5 of them also having LBCs in the antrum. The correlation between the appearance of LBCs and histological GIM was good, with a sensitivity of 80% (95%CI:67-92), a specificity of 96% (95%CI:93-99), a positive predictive value of 84% (95%CI:73-96), a negative predictive value of 95% (95%CI:92-98), and an accuracy of 93% (95%CI:90-97). The NBI-ME examination overlooked GIM in 8 cases, but the GIM was less than 5% in 7 of the cases. Moreover, in the 6 false positive cases, the histological examination showed the presence of reactive gastropathy (4 cases) or H. pylori active chronic gastritis (2 cases). The semiquantitative correlation between the rate of LBC appearance and the percentage of GIM was 79% (P < 0.01). CONCLUSION:NBI-ME achieved good sensitivity and specificity in recognising GIM in an unselected population. In routine clinical practice, this technique can reliably target gastric biopsies. | Edoardo Savarino Marina Corbo Pietro Dulbecco Lorenzo Gemignani Elisa Giambruno Luca Mastracci Federica Grillo Vincenzo Savarino | 2013 | World Journal of Gastroenterology2013，19，17： | 23 |
| 2 | Evaluation of latent links between irritable bowel syndrome and sleep quality显示文摘AIM:To examine the links between quality of sleep and the severity of intestinal symptoms in irritable bow-el syndrome(IBS).METHODS:One hundred and forty-two outpatients(110female,32 male)who met the Rome Ⅲ criteria for IBS with no psychiatric comorbidity were consecutively en-rolled in this study.Data on age,body mass index(BMI),and a set of life-habit variables were recorded,and IBS symptoms and sleep quality were evaluated using the questionnaires IBS Symptom Severity Score(IBS-SSS)and Pittsburgh Sleep Quality Index(PSQI).The associa-tion between severity of IBS and sleep disturbances was evaluated by comparing the global IBS-SSS and PSQI score(Pearson's correlation and Fisher's exact test)and then analyzing the individual items of the IBS-SSS and PSQI questionnaires by a unitary bowel-sleep model based on item response theory(IRT).RESULTS:IBS-SSS ranged from mild to severe(120-470).The global PSQI score ranged from 1 to 17(median 5),and 60 patients were found to be poor sleepers(PSQI>5).The correlation between the global IBS-SSS and PSQI score indicated a weak association(r=0.2 and 95% CI:-0.03 to 0.35,P<0.05),which becomes stronger using our unitary model.Indeed,the IBS and sleep disturbances severities,estimated as latent variables,resulted significantly high intra-subject cor-relation(posterior mean of r=0.45 and 95% CI:0.17 to 0.70,P<0.05).Moreover,the correlations between patient features(age,sex,BMI,daily coffee and alcohol intake)and IBS and sleep disturbances were also ana-lyzed through our unitary model.Age was a signif icant regressor,with patients≤50 years old showing more severe bowel disturbances(posterior mean=-0.38,P<0.05)and less severe sleep disturbances(posterior mean=0.49,P<0.05)than older patients.Higher daily coffee intake was correlated with a lower sever-ity of bowel disturbances(posterior mean=-0.31,P<0.05).Sex(female)and daily alcohol intake(modest)were correlated with less severe sleep disturbances.CONCLUSION:The unitary bowel-sleep model based on IRT revealed a strong positive correlation between the severity of IBS symptoms and sleep disturbances. | Massimo Bellini Angelo Gemignani Dario Gambaccini Simona Toti Danilo Menicucci Cristina Stasi Francesco Costa Maria Gloria Mumolo Angelo Ricchiuti Remo Bedini Nicola de Bortoli Santino Marchi | 2011 | World Journal of Gastroenterology2011，17，46： | 17 |
| 3 | Clinical and microbiological efficacy of colistin therapy alone or in combination as treatment for muhidrug resistant Pseudomonas aeruginosa diabetic foot infections with or without osteomyelitis显示文摘 | Tascini C Gemignani G Palumbo F | 2006 | Chemother2006，18，6： | 1 |
| 4 | Polymorphisms within micro-RNA-binding sites and risk of sporadic colorectal cancer显示文摘 | Landi D Gemignani F Naccarati A | | 0，，03： | 1 |
| 5 | Sentinel lymph node biopsy in the management of early-stage cervical carcinoma显示文摘 | Diaz JP Gemignani ML Pandit-Taskar N | 2011 | Gynecol Oncol2011，120，3： | 1 |
| 6 | Prophylactic surgery in hereditary breast/ovarian cancer syndrome显示文摘 | Levine DA Gemignani ML | 2003 | Oncology2003，17，： | 1 |
| 7 | Total laparoscopic radical hysterectomy with pelvic lymphadenecomy using argon-beam coagulator: pilot data and comparison to laparotomy 显示文摘 | Abu-Rustum NR Gemignani ML Moore K | 2003 | Gynecol Oncol2003，91，： | 1 |
| 8 | Oesophageal motility and bo- lus transit abnormalities increase in parallel with the severity of gas- tro-oesophageal reflux disease 显示文摘 | Savarino E Gemignani L Pohl D | 2011 | Aliment Pharmacol Ther2011，34，4： | 1 |
| 9 | Linezolid treatment for gram-positive infections: a retrospective comparison with teicoplanin 显示文摘 | Tascini C Gemignani G Doria R | 2009 | J Chemother2009，21，3： | 1 |
| 10 | Total laparoscopic radical hysterectomy with pelvic lymphadenectomy using the argon-beam coagulator:pilot data and comparison to laparotomy显示文摘 | Abu-Rustum NR Gemignani ML Moore K | 2003 | Gynecol Oncol2003，91，2： | 1 |
| 11 | DNA microarray based on ar- rayed- primer extension technique for identification of pathogenic fungi responsible for invasive and superficial mycoses 显示文摘 | Campa D Tavanti A Gemignani F | 2008 | J Clin Microbiol2008，46，3： | 1 |
| 12 | Total laparoscopic radical hysterectomy with pelvic lymphadenectomy using the argon-beam coagulator:pilot data and comparison to laparotomy显示文摘 | Abu-Rustum NR Gemignani ML Moore K | | 0，，2： | 1 |
| 13 | Real-Time Measurement System for Evaluation of the Carotid Intima-Media Thickness with a Robust Edge Operator显示文摘 | Faita F Gemignani V Bianchini E | 2008 | Journal of Ultrasound in Medicine2008，27，9： | 1 |
| 14 | Splenectomy in recur- rent epithelial ovarian cancer显示文摘 | Gemignani ML Chi DS Gurin CC | 1999 | Gynecol Oncol1999，72，3： | 1 |
| 15 | Linezolid treatment for gram-positive infecti0ns:aretrospective comparison with teicoplanin 显示文摘 | Taseini C Gemignani G Doria R | 2009 | J Chemother2009，21，3： | 1 |
| 16 | Generation of a DNA microarray for determination of E6 natural variants of human papillomavirus type 16 显示文摘 | Gemignani F Landi S Chabrier A | 2004 | J Virol Methods2004，119，： | 1 |
| 17 | Radieal surgical resection and high-dose intraoperative radiation therapy (HDR-IORT) in patients with recurrent gynecologic ean- cers 显示文摘 | Gemignani ML Alektiar KM Leitao M | 2001 | Int J Radiat Oncol Biol Phys2001，50，3： | 1 |
| 18 | Single photon emission computed tomograpby SPECT - CT improves sentinel node detection and localization in cervical and uterine malignancy 显示文摘 | Pandit -Taskar N Gemignani ML Lyall A | 2010 | Gyn Oncol2010，117，1： | 1 |
| 19 | Restles legs syndrome in diabetic neuropathy a frequest manifestation of small fibber neu- ropathy显示文摘 | Gemignani F Brindari F Vitetta F | 2007 | J Pe@her Nerv Syst2007，112，1： | 1 |
| 20 | Assessment of carotid stiffness and intima-media thickness from ultrasound data, comparison between two methods 显示文摘 | Bianchini E Bozec E Gemignani V | 2010 | J Ultrasound Med2010，29，： | 1 |
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